The dual GLP-1 and GIP receptor agonist tirzapetide provides an unintended interaction with the β-adrenoceptors and plays a role in glucose metabolism in hyperglycemic or senescent... by Dunya Aydos, Zeynep Busra Aksoy, Mehmet Altay Unal, Kamil Can Akcali, Ceylan Verda Bitirim, Belma Turan

“…Furthermore, mechanistically, the cardioprotective effect of TZPD includes significant regulation of the cellular Ca2+, at most, modulating the proteins in β-ARs signaling pathways. …”
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Data Are Power: Addressing the Power Imbalance Around Community Data with the Open-Access Data4HumanRights Curriculum by Monika Kuffer, Dana R. Thomson, Dianne Wakonyo, Nicera Wanjiru Kimani, Divyani Kohli-Poll Jonker, Enyo Okoko, Rasak Toheeb, Bisola Akinmuyiwa, Mohammed Zanna, Dezyno Imole, Andrew Maki

“…To ensure inclusivity, the training covers both basic and advanced topics, with most modules designed to address basic needs that can be followed using a mobile phone, thereby avoiding the need for computers or printed handouts. …”
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Mapping the hippocampal spatial proteomic signature in male and female mice of an early Alzheimer’s disease model by Ana Contreras, Raquel Jiménez-Herrera, Souhail Djebari, Juan D. Navarro-López, Lydia Jiménez-Díaz

“…Thus, 14 proteins related to synaptic-plasticity and/or AD were further studied, showing that most modulated glycogen synthase kinase-3β (GSK-3β), a protein widely involved in synaptic-plasticity induction threshold regulation towards LTD. …”
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Metabolomic Profiling of the Blood of Patients with Chronic Consciousness Disorders by A. A. Orlova, E. A. Kondrat'eva, Ya. A. Dubrovskii, N. V. Dryagina, E. V. Verbitskaya, S. A. Kondratev, A. A. Kostareva, A. N. Kondratev

“…Four major metabolites (at VIP > 0.5), which content was most modulated depending on the study group, were identified including 4 (m/z 124.0867, Rt = 17.67, p < 0.01), 33 (m/z 782.5722, Rt = 17.69, p < 0.01), 6 (m/z 125.0904, Rt = 18.43, p < 0.01) and 1 (m/z 463.2304, Rt = 15.78, p < 0.01), with no significant differences between daytime and nighttime blood samples. …”
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