A 1-year per-patient cost of therapy administration analysis of mosunetuzumab and tisagenlecleucel in relapsed or refractory follicular lymphoma patients receiving two or more lines of systemic therapy by Marco Bellone, Alice Sabinot, Alessandro D’Arpino, Emanuela Omodeo Salè, Daniela Ghislieri, Lorenzo Pradelli

“…Objective: A per-patient cost of therapy administration model was developed to estimate the cost of mosunetuzumab vs. tisagenlecleucel in patients with relapsing or refractory follicular lymphoma (R/R FL) receiving two or more lines of systemic therapy (3L+) from both the Italian hospital and societal perspectives. …”
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Management and outcomes of non–small cell lung cancer patients with rapid progression under second‐or‐more‐line immune checkpoint inhibitors: ERORECI study (GFPC 2016‐04) by Alain Vergnenegre, Margaux Geier, Florian Guisier, Regine Lamy, Bénédicte Comet, Gwenaelle Le Garff, Pascal Do, Henri Janicot, Hugues Morel, Chantal Decroisette, Michel Andre, Lionel Falchero, Nicolas Paleiron, Isabelle Monnet, the GFPC Team

“…Methods This analysis included all consecutive ICI‐treated (second‐or‐more line) patients with RP ≤4 months from 1 September 2016 to 31 August 2017 and compared the clinical characteristics, treatments, and outcomes (overall survival [OS]; responses; PFS, according to treatment line) of NSCLCs that progressed after ≤2 vs 2‐4 months on ICIs. …”
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Pars Plana Vitrectomy versus Intravitreal Injection of Ranibizumab in the Treatment of Diabetic Macular Edema Associated with Vitreomacular Interface Abnormalities by Hassan Elkayal, Ahmed M. Bedda, Hesham El-Goweini, Ahmed A. Souka, Amir Ramadan Gomaa

“…Significant improvement in vision (gain of 2 or more lines) was seen in 45% and 30%, respectively. Worsening of vision (loss of 2 or more lines) was seen only in 2 patients in group II, but none in group I. …”
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Photodynamic therapy for neovascular age-related macular degeneration by Richard P.L. Wormald, MA, MB, BCh, MSc, FRCS, FRCOphth, Jennifer R Evans, PhD, Katherine S Henshaw, Liam L Smeeth, MD

“…The relative risk of losing three or more lines of visual acuity at 24 months comparing the intervention with the control group was 0.77 (95% confidence interval 0.69 to 0.87). …”
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A New Form of Smooth Cubic Surfaces with 9 Lines by Fatma Karaoğlu

“…We describe a way to create some cubic surfaces with 9 or more lines based on a set of six field elements. Conditions on the six parameters are given under which the surface has exactly 9, 15, or 27 lines. …”
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Small Incision Lenticule Extraction (SMILE) versus Femtosecond Laser-Assisted In Situ Keratomileusis (FS-LASIK) for Myopia: A Systematic Review and Meta-Analysis. by Zeren Shen, Keda Shi, Yinhui Yu, Xiaoning Yu, Yuchen Lin, Ke Yao

“…Primary outcome measures included a loss of one or more lines of best spectacle corrected visual acuity (BSCVA), uncorrected visual acuity (UCVA) of 20/20 or better, mean logMAR UCVA, postoperative mean spherical equivalent (SE) and postoperative refraction within ±1.0 D of the target refraction. …”
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Principles of anti-VEGF dosing in the treatment of neovascular age-related macular degeneration by I. E. Ioshin, T. Anoprieva

“…Clinical trials demonstrate that the use of anti-VEGF helps stabilize the vision in at least 90 % of patients, while 30 to 40 % gain three or more lines of vision (15 ETDRS letters). However, observational studies suggest that there are barriers diminishing the efficacy of anti-VEGF treatment in routine clinical practice. …”
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Premacular Subhyaloid Haemorrhage Drainage by Frequency-Doubled (532 nm) Nd:YAG Laser by MK Rathore, Eva Tirkey, Shivcharan Lal Chandravanshi, Jainendra Shivdas Rahud, Rachhana Gupta

“…In this series, visual acuity improvement was defined as an improvement of three or more lines on Snellen′s visual acuity chart. Results:- We found best visual acuity improvement in cases of anaemic and Valsalva retinopathy and limited improvement in proliferative and non proliferative diabetic retinopathy despite successful drainage of haemorrhage. …”
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The Paradox Role of Regulatory T Cells in Ischemic Stroke by Xiaomeng Xu, Min Li, Yongjun Jiang

“…In conclusion, Tregs contributed to the outcome of ischemic stroke, while more lines of evidence are needed to understand how Tregs regulate the immune system and influence the outcome of stroke.…”
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Trastuzumab deruxtecan: A quantum leap in HER2-positive breast cancer by Manikandan Dhanushkodi

“…In December 2019, the Food and Drug Administration announced accelerated approval of trastuzumab deruxtecan for HER2-positive advanced breast cancer patients who were prior exposed to two or more lines of anti-HER2 therapy in a metastatic setting.…”
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Upfront maintenance poly(Adenosine Diphosphate Ribose) polymerase inhibitors in ovarian cancer: A ray of hope or just a mirage! by Avinash Pandey, Joydeep Ghosh

“…Olaparib and rucaparib as monotherapy are also indicated in patients who have progressed on three or more lines of chemotherapy, irrespective of platinum sensitivity, in germline or somatic BRCA 1/2-mutated, PARPi-naive patients. …”
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Excimer Laser Phototherapeutic Keratectomy for the Treatment of Clinically Presumed Fungal Keratitis by Liang-Mao Li, Li-Quan Zhao, Ling-Hui Qu, Peng Li

“…Thirty-four eyes (82.9%) showed an improvement in best spectacle-corrected visual acuity of two or more lines. PTK complications included mild to moderate corneal haze, hyperopic shift, irregular astigmatism, and thinning cornea. …”
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ANALOG COMPUTER FOR STUDYING DIATOMIC MOLECULAR SPECTRA IN TERAHERTZ FREQUENCY by Usman Malik, Muhamad Hamdi, Salomo Salomo

“…As temperature increases, more lines are observed, and line intensities decrease due to the population being spread over more rotational levels. …”
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Investigation of Blood Supply to the Macular Region of the Retina in Chronic Myeloproliferative Diseases by E. M. Yunusova, T. R. Mukhamadeev, B. A. Bakirov, G. M. Idrisova

“…Chronic myeloproliferative diseases (CMPD) are tumor diseases of hematopoietic tissue with increased proliferation of one or more lines of myelopoiesis. Quite often with this pathology there are find references to damage to the organ of vision. …”
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Posterior Chamber Phakic Intraocular Lenses for Correcting Ametropia in Stable Keratoconus by Osvaldo Berger, Naveen Garikapati, Hasan Naveed, Aida Hajjar-Sese, Artemis Matsou, Zisis Gatzioufas, Samer Hamada, Mohamed Elalfy

“…Seventy percent of the cases increased 3 or more lines of UDVA while none of the eyes lost more than 2 lines of CDVA. …”
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Outcomes of MyoRing Implantation in Eyes with Keratoconus in the Eastern Province of Saudi Arabia: “A Single-Arm Cohort Study” by Yousef Saad Alshammari, Abdulaziz Ismail Al Somali

“…The UCVA and BCVA improved by 2 or more lines in 9 (75%) eyes, remained stable in 2 (16.7%) eyes, and decreased in 2 (16.7%) eyes. …”
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Elotuzumab in the treatment of patients with refractory and relapsed multiple myeloma Experience of the Lapino Clinical Hospital Oncohematology Department by Yu. E. Ryabukhina, P. A. Zeynalova, F. M. Abbasbeyli, O. L. Timofeeva, N. A. Kupryshina, T. T. Valiev

“…One potential immunotherapeutic target is signaling lymphocyte activation molecules (SLAMs), and the anti-SLAMF7 monoclonal antibody elotuzumab is used in combination with either lenalidomide and dexamethasone (Elo-Rd regimen) after 1 prior line of therapy, or with pomalidomide and dexamethasone (Elo-Pd regimen) after 2 or more lines of therapy. The results of studies demonstrated a survival benefit in all subgroups of patients with refractory or relapsed multiple myeloma when using elotuzumab. …”
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Visual Outcomes of the FemtoLASIK Technology Using Excimer Lasers with Frequency More 1000 Hz in Low to Moderate Myopia Correction by A. V. Doga, I. A. Mushkova, A. N. Karimova, E. V. Kechin, A. E. Kopylov

“…In the “Schwind Amaris 1050 Hz” group gain of one or more lines of the CDVA was 14 %, in the “Microscan Visum 1100 Hz” group — in 12.2 % (p > 0.05). …”
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Differences in Surgical Management of Corneal Perforations, Measured over Six Years by Katarzyna Krysik, Dariusz Dobrowolski, Anita Lyssek-Boron, Judyta Jankowska-Szmul, Edward A. Wylegala

“…Final improvement of the visual acuity, within a gain of 2 or more lines with the Snellen test, was achieved in 56 operated eyes. …”
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Treatment of double-refractory multiple myeloma by S. V. Semochkin

“…Usually, these are severely pretreated patients who have accumulated drug toxicity after 2 or more lines of therapy, with limited reserves of bone marrow hematopoiesis and often decompensated comorbidities. …”
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