Increased Death of Peripheral Blood Mononuclear Cells after TLR4 Inhibition in Sepsis Is Not via TNF/TNF Receptor-Mediated Apoptotic Pathway by Chien-Ming Chu, Li-Chung Chiu, Chung-Chieh Yu, Li-Pang Chuang, Kuo-Chin Kao, Li-Fu Li, Huang-Pin Wu

“…The cell death of LPS and HMGB1-stimulated CD8 lymphocytes and monocytes increased after TLR4 inhibition. The cell death of CD4 lymphocytes was unchanged. …”
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Prognostic assessment of early-stage liver cirrhosis induced by HCV using an integrated model of CX3CR1-associated immune infiltration genes by Haozheng Cai, Jing Zhang, Chuwen Chen, Junyi Shen, Xiaoyun Zhang, Wei Peng, Chuan Li, Haopeng Lv, Tianfu Wen

“…Notably, high infiltration of plasma cells and low infiltration of monocytes were predictive of poor prognosis in early-stage cirrhosis. …”
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Genetic coupling of enhancer activity and connectivity in gene expression control by Helen Ray-Jones, Chak Kei Sung, Lai Ting Chan, Alexander Haglund, Pavel Artemov, Monica Della Rosa, Luminita Ruje, Frances Burden, Roman Kreuzhuber, Anna Litovskikh, Eline Weyenbergh, Zoï Brusselaers, Vanessa Xue Hui Tan, Mattia Frontini, Chris Wallace, Valeriya Malysheva, Leonardo Bottolo, Elena Vigorito, Mikhail Spivakov

“…Here, we study the effects of expression quantitative trait loci (eQTLs) on enhancer activity and promoter contacts in primary monocytes isolated from 34 male individuals. Using eQTL-Capture Hi-C and a Bayesian approach considering both intra- and inter-individual variation, we initially detect 19 eQTLs associated with enhancer-eGene promoter contacts, most of which also associate with enhancer accessibility and activity. …”
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Biogenic silver nanoparticles produced by Trichoderma reesei inhibit SARS-CoV-2 infection, reduce lung viral load and ameliorate acute pulmonary inflammation by Marcus V.M.V. Amaral, Cláudia B. Carraro, Amanda C.C. Antoniêto, Mariana N. Costa, Thais F.C. Fraga-Silva, Ualter G. Cipriano, Rodrigo P.F. Abuná, Tamara S. Rodrigues, Ronaldo B. Martins, Andreia M. Luzenti, Glaucia R. Caruso, Priscyla D. Marcato, Vania L.D. Bonato, Dario S. Zamboni, Bergman M. Ribeiro, Sônia N. Báo, Joao S. da Silva, Flávio P. Veras, Roberto N. Silva

“…Additionally, AgNPs impair caspase-1 activation, lactate dehydrogenase release and IL-1β production by human monocytes. Moreover, our study reveals that AgNPs treatment significantly alleviated acute lung injury induced by SARS-CoV-2 infection in Syrian hamsters. …”
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GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway by Yajing Wang, Ping Lu, Weifeng Zhang, Qianming Du, Jingjing Tang, Hong Wang, Jinrong Lu, Rong Hu

“…The results indicated that GEN-27 inhibited the proliferation of human colon tumor HCT116 cells stimulated by culture supernatants of LPS-induced human monocytes THP-1 cells and significantly decreased LPS-induced secretion of proinflammatory cytokines interleukin-6 and interleukin-1β in THP-1 cells. …”
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Effect of Curry Leaf (Murraya koenigii) as Edwardsiellosis Treatment on Gourami Fish (Osphronemus goramy) by Muyassar H. Abualreesh, Agus Pariawan, Annisa Isti Fauziyyah, Farid Mukhtar Riyadi, Mohammad Fadjar, Arief Prajitno, Arif Syaifurrisal, Muhammad Browijoyo Santanumurti, Suciyono Suciyono

“…The most effective dose in treating Edwardsiellosis in gourami fish was found to be 600 mg/L, as it significantly improved various hematological parameters, including hematocrit, hemoglobin, erythrocyte count, leukocyte count, lymphocytes, monocytes, and neutrophils. Additionally, histopathological analysis showed improvements in tissue conditions, with lower scores for degeneration, congestion, and necrosis. …”
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RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia by Tim Kong, Angelo B. A. Laranjeira, Christopher T. Letson, LaYow Yu, Shuyang Lin, Jared S. Fowles, Daniel A. C. Fisher, Sherwin Ng, Wei Yang, Fan He, Minyoung Youn, Kailen Mark, Ana San Jose, Jingxian Liu, Alexander B. Kim, Maggie J. Cox, Mary C. Fulbright, Aarthi Jayanthan, Gerrit Los, Stacey L. Rentschler, Li Ding, Kathleen M. Sakamoto, Sandra E. Dunn, Grant A. Challen, Stephen T. Oh

“…Here, we establish a comprehensive transcriptional atlas across the spectrum of myeloproliferative neoplasms (MPN) and secondary acute myeloid leukemia (sAML) through RNA-sequencing of 158 primary samples encompassing CD34+ hematopoietic stem/progenitor cells and CD14+ monocytes. Supported by mass cytometry (CyTOF) profiling, we reveal aberrant networks of PI3K/AKT/mTOR signalling and NFκB-mediated hyper-inflammation. …”
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Key oncogenes and candidate drugs for hepatitis-B-driven hepatocellular carcinoma progression by Liqin Ruan, Ningbo Fang, Xinhua Zhao, Weili Chen, Zhaoping Wu, Xiaoyong Wu

“…Overall, HB-LC genes were significantly negatively correlated with Th17, MAIT, monocytes, and CD4 Naive cells, while they were positively correlated with B cells, nTreg cells, and Tr1 cells. …”
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Intravenous Transplantation of Mesenchymal Stem Cells Reduces the Number of Infiltrated Ly6C+ Cells but Enhances the Proportions Positive for BDNF, TNF-1α, and IL-1β in the Infarct... by Yunqian Guan, Xiaobo Li, Wenxiu Yu, Zhaohui Liang, Min Huang, Renchao Zhao, Chunsong Zhao, Yao Liu, Haiqiang Zou, Yanli Hao, Zhiguo Chen

“…Circulation-derived infiltrating cells in the brain were identified by Ly6C, a majority of which were monocytes/macrophages. Without MSC transplantation, among the infiltrated Ly6C+ cells, some were positive for BDNF, IL-1β, or TNF-α. …”
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Association of Chronic Toxoplasma gondii Infection with Pro-Inflamatory Cytokine Interleukin (IL)-12 Responses in Type-2 Diabetes Mellitus Patients of Bangladesh by Tamanna Ashraf, Pankaj Kumar Sarker, Md. Ismail Hosen, Atiqur Rahman, A. K. M. Mahbub Hasan, Taibur Rahman

“…On the other hand, the levels of lymphocytes (P=0.0204) and monocytes (P=0.0067) were significantly higher in patients. …”
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Identification of mitophagy-related biomarkers and immune infiltration in polycystic ovarian syndrome by bioinformatic study by Hongjuan Ye, Xicheng Wang, Zhiying He

“…Specifically, the hub gene GRN showed a positive correlation with monocytes and plasmacytoid dendritic cells, while hub gene NAPA was negatively correlated with gamma delta T cell. …”
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Measurement of Several Hematological and Serological Parameters in Patients with Scabies by Mariam Y. Al-Fadhly, Wasan A. Al-Marsomy, Hiba H. Maqdasi .

“…There were also significant differences at the 0.001 level between the two groups of patients and the control group for white blood cells (WBC), lymphocytes, neutrophils, eosinophils, monocytes, and basophils. These were (11.09±0.20, 7.50 ±0.16), (5.05±0.16, 2.27 ±0.06), (8.23±0.10, 3.75±0.11), (0.828±0.7, 0.415±0.03), (0.498±0.02, 0.459±0.03), and (0.329±0.02, 0.102 ± 0.01), respectively. …”
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Investigation of the healing effects of Afyon Province hot spring waters on experimentally-induced fatty liver in mice by Bülent Elitok, Ibrahim Kişlalioğlu, Yavuz Ulusoy, Bahadır Kilinç

“…On day 21 of the experiment, the animals of the experimental group demonstrated a significant (p < 0.05) decrease in the total number of leukocytes, neutrophils, monocytes, as well as in the levels of aspartate aminostatesferase, alanine aminopenesferase, gamma-glutamyltransferase, low-density lipoproteins, total cholesterol, triglycerides. …”
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Exploration and Verification of Prognostic Value of Endothelial Cells in Glioblastoma by Hengchao MA, Yuyang LIU, Jun XU, Bingyan TAO, Jun ZHANG

“…Seven groups of cells were obtained after GBM single-cell sequencing analysis, including AC-like tumor cells, endothelial cells, monocytes/macrophages, NB-like tumor cells, neurons, OC-like tumor cells, and OPC-like tumor cells. …”
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CD226 Deficiency Alleviates Murine Allergic Rhinitis by Suppressing Group 2 Innate Lymphoid Cell Responses by Yang Xie, Yuan Zhang, Tianxiao Zhu, Jingchang Ma, Chujun Duan, Lu Yang, Tingting Wang, Ran Zhuang, Ka Bian, Lianjun Lu

“…CD226 is a costimulatory molecule associated with inflammatory response and is mainly expressed on T cells, natural killer cells, and monocytes. This study is aimed at elucidating the role of CD226 in allergic inflammatory responses in murine AR using global and CD4+ T cell-specific Cd226 knockout (KO) mice. …”
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The Prognostic Significance of TRs in Hepatocellular Carcinoma: Insights from TCGA and GEO Databases by Hao Zhou, Weijie Wang, Ruopeng Liang, Rongtao Zhu, Jiahui Cao, Chenguang Sun, Yuling Sun

“…Additionally, single-cell RNA sequencing revealed that THRB was primarily expressed in CD16+ monocytes within tumor tissues and was associated with a poor OS rate. …”
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The profiles of immunosuppressive microenvironment in the Lauren intestinal-type gastric adenocarcinoma by Qingyuan Wang, Jia Chen, Yaohui Wang, Xiang Li, Xiaochun Ping, Jiajia Shen, Sheng Yang, Lizong Shen

“…Furthermore, TNFRSF12A + cancer-associated fibroblasts (CAFs), CTSB + macrophages, and SOD2 + monocytes were found to be involved in maintaining the immunosuppressive milieu. …”
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Haematobiochemical alterations and lesion characterization induced by haemonchosis in slaughtered sheep at Gondar ELFORA abattoir, Ethiopia by Birhan Anagaw Malede, Mersha Chanie Kebede, Asnakew Mulaw Berihun, Muluken Yayeh Mekonnen, Mohammed Yesuf, Tadegegn Mitiku, Mastewal Birhan, Ambaye Kenubih, Abraham Belete Temesgen

“…However, white blood cells, monocytes, neutrophils, and eosinophils were significantly higher in the infected group. …”
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Single-cell transcriptomics identify a novel macrophage population associated with bone invasion in pituitary neuroendocrine tumors by Xinzhi Wu, Xueshuai Han, Haibo Zhu, Mingxuan Li, Lei Gong, Sicheng Jing, Weiyan Xie, Zhaoqi Liu, Chuzhong Li, Yazhuo Zhang

“…TNF-α+ TAMs, in turn, communicate with CD14 + monocytes to promote their differentiation into osteoclasts and leading to bone invasion. …”
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Single-cell RNA sequencing of circulating immune cells supports inhibition of TNFAIP3 and NFKBIA translation as psoriatic arthritis biomarkers by Ameth N. Garrido, Rohan Machhar, Omar F. Cruz-Correa, Darshini Ganatra, Sarah Q. Crome, Sarah Q. Crome, Joan Wither, Joan Wither, Joan Wither, Igor Jurisica, Igor Jurisica, Igor Jurisica, Dafna D. Gladman, Dafna D. Gladman, Dafna D. Gladman

“…Differentially expressed genes (DEGs) identified through scRNA-seq were validated on classical monocytes, and CD4+ and CD8+ T cell subsets derived from an independent cohort of patients using the NanoString nCounter® platform. …”
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