Intestinal Epithelial Cells as a Source of Inflammatory Cytokines and Chemokines by Andrew W Stadnyk

“…More recently, it has been shown that the cells also secrete chemokines for monocytes and lymphocytes. Some of these chemokines appear to be important in the uninflamed intestine but become increased during disease. …”
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T Lymphocyte Autoreactivity in Inflammatory Mechanisms Regulating Atherosclerosis by Elisabetta Profumo, Brigitta Buttari, Luciano Saso, Raffaele Capoano, Bruno Salvati, Rachele Riganò

“…Both cells of the innate and the acquired immune system, particularly monocytes and T lymphocytes, are implicated in the atherogenic process, producing different cytokines with pro- and anti-inflammatory effects. …”
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The Partial Duplication of the 5′ Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid Leukemia by Hiroko Fukushima, Toru Nanmoku, Sho Hosaka, Yuni Yamaki, Nobutaka Kiyokawa, Takashi Fukushima, Ryo Sumazaki

“…Here, we report on a boy who developed acute monocytic leukemia. Fluorescence in situ hybridization revealed the duplication of the 5′ segment with 2 normal alleles at KMT2A which was eventually found to be fused with MLLT10. …”
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Optimized Method to Generate Well-Characterized Macrophages from Induced Pluripotent Stem Cells by Qimin Hai, Peter Bazeley, Juying Han, Gregory Brubaker, Jennifer Powers, Claudia M. Diaz-Montero, Jonathan D. Smith

“…Human macrophages can be obtained via culturing peripheral blood monocytes; however, this source has limited yields and requires patient contact for each proposed use. …”
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Gene prediction of immune cells association between gut microbiota and colorectal cancer: a Mendelian randomization study by Yan Zhong, Guanglei Chen, Menglu Chen, Junsong Cui, Qianren Tan, Zhenghua Xiao

“…Specifically, CD40 on monocytes (2.82%) and CD45 on CD33+HLA-DR+CD14- cells (12.87%) mediated the causal relationship between Bifidobacterium kashiwanohense and CRC risk. …”
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Innate Immune Cells in Liver Inflammation by Evaggelia Liaskou, Daisy V. Wilson, Ye H. Oo

“…In order to achieve this, the liver innate immune system is equipped with multiple cellular components; monocytes, macrophages, granulocytes, natural killer cells, and dendritic cells which coordinate to exert tolerogenic environment at the same time detect, respond, and eliminate invading pathogens, infected or transformed self to mount immunity. …”
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Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis by Basit Saleem Qazi, Kai Tang, Asma Qazi

“…Many different types of cells, in particular monocytes, neutrophils, epithelial, fibroblast, endothelial, mesothelial, and tumor cells, secrete IL-8. …”
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Mechanisms of Chronic State of Inflammation as Mediators That Link Obese Adipose Tissue and Metabolic Syndrome by Eduardo Fuentes, Francisco Fuentes, Gemma Vilahur, Lina Badimon, Iván Palomo

“…Adiponectin can either act directly on macrophages to shift polarization and/or prime human monocytes into alternative M2-macrophages with anti-inflammatory properties. …”
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Photodynamic Therapy with the Silicon Phthalocyanine Pc 4 Induces Apoptosis in Mycosis Fungoides and Sezary Syndrome by Minh Lam, YooJin Lee, Min Deng, Andrew H. Hsia, Kelly A. Morrissey, Chunlin Yan, Kashif Azzizudin, Nancy L. Oleinick, Thomas S. McCormick, Kevin D. Cooper, Elma D. Baron

“…Our data suggest that Pc 4-PDT preferentially induces apoptosis of CD4+CD7− malignant T-lymphocytes in the blood relative to CD11b+ monocytes and nonmalignant T-cells. In vivo Pc 4-PDT of MF skin also photodamages the antiapoptotic protein Bcl-2.…”
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The impact of glycolysis on ischemic stroke: from molecular mechanisms to clinical applications by Yingquan Liu, Peijia Hu, Hongliang Cheng, Fangyuan Xu, Yu Ye

“…Immune cells, such as monocytes, also contribute to atheromatous plaque formation and thrombi through increased aerobic glycolysis. …”
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Roles of Macrophage Subtypes in Bowel Anastomotic Healing and Anastomotic Leakage by Jinyao Shi, Zhouqiao Wu, Ziyu Li, Jiafu Ji

“…Macrophages are characterized by high heterogeneity, which can polarize into at least two major extremes, M1-type macrophages (classical activation) which are normally derived from monocytes and M2-type macrophages (alternative activation) which are mostly those tissue-resident macrophages. …”
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Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma by Li Zhang, Matthew Crocker, Lawrence Fong, Lisa M Coussens, Charles D Lopez, Shamilene Sivagnanam, Meenal Sinha, Brandon Chen, Jaqueline Marquez, Alexander Cheung, Whitney Tamaki, Jacob Stultz, Kendra Todd, Courtney Betts, Madeline J Griffith, Isabelle Solman, Eric Liu, Denise Pener, Anne Fahlman, Erin Taber, Kimberly Lerner, Brindha Rajagopalan, Clarisha Ware, Mark Bridge, Johnson Vo, Hannah Dragomanovich, Julie Sudduth-Klinger, Gina Vaccaro, Margaret Tempero

“…Patients with partial clinical responses had more diverse T and B cell receptor repertoires prior to therapy initiation.Conclusion Ibrutinib monotherapy skewed the immune landscape both in the circulation and TME towards activated T cells, monocytes and DCs. These effects were not observed when combining ibrutinib with standard of care chemotherapy. …”
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Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance by Henna Lehtonen, Heli Jokela, Julian Hofmann, Lauriina Tola, Arfa Mehmood, Florent Ginhoux, Burkhard Becher, Melanie Greter, Gennady G. Yegutkin, Marko Salmi, Heidi Gerke, Pia Rantakari

“…Importantly, all pitMØs originate from early yolk sac progenitors and maintain themselves through self-renewal, independent of bone marrow-derived monocytes. Macrophage depletion experiments unveil the role of macrophages in regulating intrapituitary hormonal balance through extracellular ATP-mediated intercellular signaling. …”
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Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In Vivo by Liliana M. R. Silva, Tamara Muñoz-Caro, Rafael A. Burgos, Maria A. Hidalgo, Anja Taubert, Carlos Hermosilla

“…Professional mononuclear phagocytes such as polymorphonuclear neutrophils (PMN), monocytes, and macrophages are considered as the first line of defence against invasive pathogens. …”
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Comparison of transcriptomic profiles between intracellular and extracellular Bartonella henselae by Shiva Kumar Goud Gadila, John R. Caskey, Edward B. Breitschwerdt, Ricardo G. Maggi, Monica E. Embers

“…These bacteria can grow outside of cells, replicate in erythrocytes and invade endothelial and monocytic cells. We have previously reported reduced antibiotic susceptibility of intracellular Bartonella. …”
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Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies by Junko Okabe-Kado, Takashi Kasukabe, Yasuhiko Kaneko

“…The extracellular NM23-H1 protein promotes the in vitro growth and survival of acute myelogenous leukemia (AML) cells and inversely inhibits the in vitro survival of normal peripheral blood monocytes in primary culture at concentrations equivalent to the levels found in the serum of AML patients. …”
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Postnatal Hematopoiesis and Gut Microbiota in NOD Mice Deviate from C57BL/6 Mice by Dina Silke Malling Damlund, Stine Broeng Metzdorff, Jane Preuss Hasselby, Maria Wiese, Mia Lundsager, Dennis Sandris Nielsen, Karsten Stig Buschard, Axel Kornerup Hansen, Hanne Frøkiær

“…Furthermore, a distinct splenic cell profile high in a granulocytic phenotype was evident in the neonatal NOD mice whereas neonatal C57BL/6 mice showed a profile rich in monocytes. Neonatal expression of Reg3g and Muc2 in the gut was deviating in NOD mice and coincided with fewer bacteria attaching to the Mucosal surface in NOD compared to C57BL/6 mice.…”
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Stigmasterol Modulates Allergic Airway Inflammation in Guinea Pig Model of Ovalbumin-Induced Asthma by Aaron Opoku Antwi, David Darko Obiri, Newman Osafo

“…Stigmasterol at 10–100 mg/kg reduced proliferation of eosinophils, lymphocytes, and monocytes while reducing peribronchiolar, perivascular, and alveolar infiltration of inflammatory cells. …”
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Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab by Panagiotis I. Georgianos, Vasilios Vaios, Eleni Leontaridou, Georgia Karayannopoulou, Triantafyllia Koletsa, Athanasios Sioulis, Elias V. Balaskas, Pantelis E. Zebekakis

“…A renal biopsy showed severe interstitial inflammatory infiltration of T-cells, monocytes, and eosinophils without interstitial granulomas and normal appearance of glomeruli, indicating acute interstitial nephritis (AIN) as the cause of AKI. …”
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The Role of Proteinase-Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease by E. S. Rovai, M. Holzhausen

“…PAR1 is expressed by the periodontal cells such as human gingival fibroblasts, gingival epithelial cells, periodontal ligament cells, osteoblasts, and monocytic cells and can be activated by thrombin, matrix metalloproteinase 1 (MMP-1), MMP-13, fibrin, and gingipains from Porphyromonas gingivalis. …”
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