Identification of a binding site for small molecule inhibitors targeting human TRPM4 by Babatunde Ekundayo, Prakash Arullampalam, Christian E. Gerber, Anne-Flore Hämmerli, Sabrina Guichard, Mey Boukenna, Daniela Ross-Kaschitza, Martin Lochner, Jean-Sebastien Rougier, Henning Stahlberg, Hugues Abriel, Dongchun Ni

“…We found that the small molecules NBA and IBA were bound in a pocket formed between the S3, S4, and TRP helices and the S4-S5 linker of TRPM4. …”
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Fatty Acid Composition, Phospholipid Molecules, and Bioactivities of Lipids of the Mud Crab Scylla paramamosain by Thi Phuong Lan Nguyen, Van Tuyen Anh Nguyen, Thi Thanh Trung Do, Trung Nguyen Quang, Quoc Long Pham, Tat Thanh Le

“…Fifty-four different molecules belonging to six types of phospholipids were identified. …”
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Traffic Control of Bacteria-Derived Molecules: A New System of Host-Bacterial Crosstalk by Hiroaki Konishi, Mikihiro Fujiya, Yutaka Kohgo

“…This paper highlights the intestinal trafficking systems of bacteria-derived molecules that affect the bacterial functions and modulate epithelial signaling cascades. …”
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A White-Light-Emitting Small Molecule: Synthesis, Crystal Structure, and Optical Properties by Sin-Kai Fang, Hsing-Yang Tsai, Jiun-Wei Hu, Kew-Yu Chen

“…A white-light-emitting small molecule (1) was synthesized and characterized by single-crystal X-ray diffraction. …”
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Polyamines Interaction with Gaseous Signaling Molecules for Resilience Against Drought and Heat Stress in Plants by Nidhi, Noushina Iqbal, Nafees A. Khan

“…The key regulators of plant stress responses include polyamines (PAs) and gaseous signaling molecules (GSM), such as hydrogen sulfide (H₂S), nitric oxide (NO), methane (CH₄), carbon monoxide (CO), carbon dioxide (CO₂), and ethylene (ET). …”
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Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions by Tiantian Wang, Dong Zhou, Zhen Hong

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A new perspective on apoptosis: Its impact on meat and organoleptic quality in different animals by Boin Lee, Young Min Choi

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Single-cell morphological tracking of cell states to identify small-molecule modulators of liver differentiation by Rebecca E. Graham, Runshi Zheng, Jesko Wagner, Asier Unciti-Broceta, David C. Hay, Stuart J. Forbes, Victoria L. Gadd, Neil O. Carragher

“…These findings could significantly advance research on liver cell regeneration mechanisms and facilitate the development of cell-based and small-molecule therapies.…”
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Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile by Konstantin V. Kudryavtsev, Anna O. Markevich, Oleksandr V. Virchenko, Tetyana M. Falalyeyeva, Tetyana V. Beregova, Lyudmyla I. Ostapchenko, Dmitry V. Zabolotnev, Nikolay S. Zefirov

“…This study was designed to determine novel small-molecule agents influencing the pathogenesis of gastric lesions induced by stress. …”
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Targeting Endothelial Adhesion Molecule Transcription for Treatment of Inflammatory Disease: A Proof-of-Concept Study by Liam M. Ashander, Binoy Appukuttan, Yuefang Ma, Dione Gardner-Stephen, Justine R. Smith

“…However, these molecules also participate in leukocyte migration for immune surveillance, and inhibiting the physiological level of an adhesion molecule might promote infection or malignancy. …”
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A Comprehensive Machine Learning Approach for COVID-19 Target Discovery in the Small-Molecule Metabolome by Md. Shaheenur Islam Sumon, Md Sakib Abrar Hossain, Haya Al-Sulaiti, Hadi M. Yassine, Muhammad E. H. Chowdhury

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Small Molecules Greatly Improve Conversion of Human-Induced Pluripotent Stem Cells to the Neuronal Lineage by Sally K. Mak, Y. Anne Huang, Shifteh Iranmanesh, Malini Vangipuram, Ramya Sundararajan, Loan Nguyen, J. William Langston, Birgitt Schüle

“…Here, we describe our neurodifferentiation protocol using small molecules that very efficiently promote neural induction in a 5-stage EB protocol from six induced pluripotent stem cells (iPSC) lines from patients with Parkinson’s disease and controls. …”
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Chronic Restraint Stress Induces an Isoform-Specific Regulation on the Neural Cell Adhesion Molecule in the Hippocampus by K. Touyarot, C. Sandi

“…Prior studies have shown that hippocampal expression of cell adhesion molecules is modified by such stress treatment, with the neural cell adhesion molecule (NCAM) decreasing and L1 increasing, their expression, at both the mRNA and protein levels. …”
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How Adhesion Molecule Patterns Change While Neutrophils Traffic through the Lung during Inflammation by Franziska M. Konrad, Julia Wohlert, Jutta Gamper-Tsigaras, Kristian-Christos Ngamsri, Jörg Reutershan

“…Current knowledge of changes in the expression pattern of adhesion molecules mainly derives from in vitro studies or from studies in extrapulmonary organ systems, where regulation of adhesion molecules differs significantly. …”
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FT-IR, Laser-Raman, UV-Vis, and NMR Spectroscopic Studies of Antidiabetic Molecule Nateglinide by Tuba Özdemir Öge

“…The research was performed to provide detailed spectroscopic information of antidiabetic nateglinide molecule’s monomer conformations.…”
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Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes by Alessandra Puddu, Roberta Sanguineti, Fabrizio Montecucco, Giorgio Luciano Viviani

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Neutrophil Migration and Adhesion Molecule Expression after Acute High-Intensity Street Dance Exercise by Leandro Borges, Alexandre Dermargos, Stuart Gray, Maysa B. Barros Silva, Vinicius Santos, Tania Cristina Pithon-Curi, Renata Gorjão, Elaine Hatanaka

“…Herein, we investigated the effect of street dancing on inflammation, adhesion molecules, and neutrophil function. Fifteen amateur dancers (mean ± SE: age 22.4 ± 1.08 years, BMI 24.8 ± 0.69 kg/m2, and body fat 12.3 ± 1.52%) participated in a single high-intensity street dance class. …”
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Coherent Control of Single Molecules via Phase-Shaped Two-Photon Excitation at Room Temperature by Xin-peng Xu, Tobias M. Herkenrath, Ullrich Scherf, Richard Hildner

“…Coherent control has been achieved in atoms and small molecules in gas phase during the past few decades. …”
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Tumor Metastasis to the Liver, and the Roles of Proteinases and Adhesion Molecules: New Concepts from In Vivo Videomicroscopy by Alan C Groom, Ian C MacDonald, Eric E Schmidt, Vincent L Morris, Ann F Chambers

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Expression of Functional MHC Class II Molecules By aMouse Pro-B Cell Clone by Suzanne Lombard-Platet, Amanda G. Fisher, Valérie Meyer, Rhodri Ceredig

Subjects: “…MHC class II molecules…”
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