Slowly Delivered Icariin/Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells to Promote the Healing of Calvarial Critical-Size Bone Defects by Tianlin Liu, Xin Zhang, Yuan Luo, Yuanliang Huang, Gang Wu

“…In this study, we developed a 3-dimensional construct by combining icariin (a small-molecule Chinese medicine), allogeneic bone marrow-derived mesenchymal stem cells (BMSCs), and a siliceous mesostructured cellular foams-poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (SMC-PHBHHx) composite scaffold. …”
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Anti-laminin-1 Autoantibodies, Pregnancy Loss and Endometriosis by Junko Inagaki, Akane Kondo, Luis R. Lopez, Yehuda Shoenfeld, Eiji Matsuura

“…ELISA also confirmed that one of the target epitopes for these antibodies was located in a particular region of the laminin-1 molecule, i.e. the carboxyl-terminal globular G domain of α1 chain. …”
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Changing of expression actinbinding proteins in the kidney under dehydration by I. I. Khegay

“…Tropomyosin is related to regulatory components of beta-actin, and due to the expense of longitudinal localization of the molecule in the groove of actin microfilament, stereochemically shields the sites of other actin-binding proteins. …”
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Understanding Cardiovascular Events With JAK Inhibitors: Tofacitinib Reduces Synovial and Vascular Inflammation but not the Prothrombotic Effects of Inflammatory Cytokines on Endot... by Aliki Zavoriti, Pierre Miossec

“…Shortly after tofacitinib treatment, the expression of EC activation markers, specifically IL‐6, IL‐8, vascular cell adhesion molecule 1 (VCAM‐1), and E‐selectin, and of coagulation, including tissue factor and thrombomodulin, was assessed by real‐time polymerase chain reaction. …”
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Role of Leptin/Osteopontin Axis in the Function of Eosinophils in Allergic Rhinitis with Obesity by Wenlong Liu, Qingxiang Zeng, Yanqiu Chen, Ren Zhong Luo

“…Leptin and OPN promote expression of cluster of differentiation 18 (CD-18) and intercellular adhesion molecule 1 (ICAM-1) and inhibit expression of ICAM-1 and L-selectin by eosinophils, which contribute to the adhesion of eosinophils. …”
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Parodontgel® on Wound Healing and Patient-Reported Outcome Measures (PROMs) after Tunneled Coronally Advanced Flap (TCAF) by Leonardo Mancini, Vincenzo Mancini

“…To enhance the healing process and alleviate postoperative discomfort, a healing gel containing hyaluronic acid as the active molecule was applied to the surgical sites. The gel was expected to reduce pain perception and minimize the need for painkiller intake during the critical first week of recovery. …”
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Bacterial quorum sensing and the role of algae in bacterial diseases control in aquaculture by . Wiyoto, Julie Ekasari

“…Quorum sensing is a communication process of a certain bacteria with the same or different species of bacteria which involves the releasing and capturing of signal molecule to and from the environment. This activity will activate a certain target gene which further resulted in the expression of a phenotype by the bacteria. …”
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Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes by Yan-Hua Wang, Shotaro Hagiwara, Hiroshi Kazama, Yuki Iizuka, Norina Tanaka, Junji Tanaka

“…Elotuzumab (Elo) is an immune-stimulatory antibody that targets the signaling lymphocytic activation molecule family 7 (SLAMF7) expressed on the surface of MM and NK cells. …”
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Aortic intimal sarcoma with abdominal metastasis: case report and management approach by Gongji Yao, Gongji Yao, Jianwei Xu, Jianwei Xu

“…Current treatment strategies are non-standardized, but small-molecule inhibitors targeting MDM2 show promise. This case highlights the potential effectiveness of combined surgical and chemotherapeutic approaches for managing abdominal metastasis of aortic intimal sarcoma and provides a foundation for future clinical trials.…”
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PROTACs: Mechanism and Bioavailability enhancement strategies by nanotechnology, RNA viral infections (vaccine strategy) and Prodrug development by Sanaul Mustafa, Md Sabir Hussain Siddiquee

“…Also, when PROTACs are incorporated into sophisticated drug delivery systems, their desirability and selectivity are further improved beyond existing issues related to small-molecule inhibitors. This review also includes new progress, clinical applicability, and development trend of PROTAC for the change of disease therapy and drug delivery. …”
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Pediatric Sickle Cell Disease in Sudan: Complications and Management by Meysaa Talha, Bashier Osman, Safa Abdalla, Hind Mirghani, Iman Abdoon

“…Sickle cell disease (SCD) is a life-threatening genetic disorder due to the formation of sickle hemoglobin molecule (HbS) that polymerizes in hypoxic conditions leading to SCD-related complications. …”
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Integrated analysis of cellulose structure and properties using solid-state low-field H-NMR and photoacoustic spectroscopy by Levente Csóka, Worakan Csoka, Ella Tirronen, Ekaterina Nikolskaya, Yrjö Hiltunen, Bunsho Ohtani

“…Specifically, we employ low-field proton nuclear magnetic resonance (H-NMR) to delve into the diverse hydrogen atom types within the cellulose molecule. The low-field H-NMR technique allows us to discern these hydrogen atoms based on their distinct chemical shifts, providing valuable insights into the various functional groups present in cellulose. …”
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Compatibility of Environmentally Friendly Insulating Gases CF3I and c-C4F8 with Cu Contacts by Can Ding, Zhenjiang Gao, Xing Hu, Zhao Yuan

“…Research indicates that there is no obvious charge transfer between the I atom and the Cu atom in the four adsorption sites of Cu (1 1 1) for the CF3I molecule. There is a charge transfer between the F atoms and the Cu top surface. …”
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Comparative Analysis on Single- and Multiherb Strategies in Coronary Artery Atherosclerosis Therapy by Yu Cao, Yang Liu, Tian Zhang, Wei Lei, Boli Zhang

“…In order to analyze their similarities and differences in controlling coronary artery atherosclerosis, we investigated each herb of four strategies and revealed that the number of active components and molecule targets is increasing with the herb category of herbal strategy. …”
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Interference in Macrophage Balance (M1/M2): The Mechanism of Action Responsible for the Anti-Inflammatory Effect of a Fluorophenyl-Substituted Imidazole by Julia Salvan da Rosa, Eduarda Talita Bramorski Mohr, Tainá Larissa Lubschinski, Guilherme Nicácio Vieira, Thais Andreia Rossa, Marcus Mandolesi Sá, Eduardo Monguilhott Dalmarco

“…These facts suggest that this molecule could be used as an alternative scaffold for the development of a new medicine to treat inflammatory conditions, where the anti-inflammatory and proregenerative properties of M2a macrophages are desired.…”
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Formulation of new drug delivery systems for insulin from natural bioactive biocompatible polymers by Howida A. Fetouh, Engy E. A. Aleem, Najiyah H. Mohammed, Jihad M. Abd-Almajeed Aldesouky, Amel M. Ismail

“…Release data obeyed pseudo second order kinetic model indicating that IDDs is heterogeneous solid surface of energetically different active sites. Each insulin molecule occupied two active sites. The slow release at pH 1.2 indicated protection against stomach juice. …”
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Clinical, immune and genetic risk factors of malaria-associated acute kidney injury in Zambian children: A study protocol. by Chisambo Mwaba, Sody Munsaka, David Mwakazanga, David Rutagwerae, Owen Ngalamika, Suzanna Mwanza, Mignon McCulloch, Evans Mpabalwani

“…In addition, we intend to assess a modified renal angina index (mRAI), kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and soluble urokinase receptor (suPAR), when done on the first day of admission, for the ability to predict AKI two days later (day 3) in children admitted with malaria.…”
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Distinguishing classes of neuroactive drugs based on computational physicochemical properties and experimental phenotypic profiling in planarians. by Danielle Ireland, Christina Rabeler, Sagar Rao, Rudy J Richardson, Eva-Maria S Collins

“…Identification of novel drugs to treat such conditions is intrinsically challenging due to the complexity of neuropsychiatric diseases and the need for a systems-level understanding that goes beyond single molecule-target interactions. Thus far, drug discovery approaches focused on target-based in silico or in vitro high-throughput screening (HTS) have had limited success because they cannot capture pathway interactions or predict how a compound will affect the whole organism. …”
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MicroRNA functions in osteogenic differentiation of periodontal ligament stem cells: a scoping review by Pirawish Limlawan, Pirawish Limlawan, Anjalee Vacharaksa, Anjalee Vacharaksa, Anjalee Vacharaksa

“…Alternatively, the addition of miRNA as a bioactive molecule also increases the success of PDLSCs therapy to enhance their osteogenic differentiation. …”
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Analysis of the VERNALIZATION-A1 exon-4 polymorphism in polyploid wheat by A. F. Muterko, E. A. Salina

“…To identify the VRN-A1 exon-4 haplotypes, a co-dominant marker was designed, based on modulation of the curvature of the DNA molecule. Polymorphism of the VRN-A1 exon-4 was revealed only in hexaploid wheat accessions and was associated with the presence of not less than two copies of VRN-A1 per genome. …”
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