Formulation and Evaluation of Guggul Lipid Nanovesicles for Transdermal Delivery of Aceclofenac by Praveen Kumar Gaur, Shikha Mishra, Vidhu Aeri

“…Guggul lipid being a planar molecule might be stacked in vesicle wall with cholesterol. …”
Get full text

N-Acetylcysteine and Other Sulfur-Donors as a Preventative and Adjunct Therapy for COVID-19 by Heidi N du Preez, Colleen Aldous, Hendrik G Kruger, Lin Johnson

“…N-acetylcysteine (NAC) and other sulfur donors contribute to the inorganic sulfate pool, the rate-limiting molecule in sulfation. NAC is not only a precursor to glutathione but also converts to hydrogen sulfide, inorganic sulfate, taurine, Coenzyme A, and albumin. …”
Get full text

Crystal and Molecular Structure of Bis(2,2-diphenyl-N-(di-n-propylcarbamothioyl) acetamido)copper(II) Complex by Hakan Arslan, Ulrich Flörke, Demet Sezgin Mansuroglu

“…This coordination has a slightly distorted square-planar geometry (O1-Cu1-O2: 86.48(11)°, O1-Cu1-S1: 93.85(9)°, O2-Cu1-S2: 94.20(9)° and S1-Cu1-S2: 91.21(4)°). The title molecule shows a cis-arrangement and C–O, C–S and C–N bond lengths of the complex suggest considerable electronic delocalization in the chelate rings.…”
Get full text

Developing non-invasive molecular markers for early risk assessment of Alzheimer's disease by Tapas K. Sur, Tanmoy Mondal, Zarish Noreen, Jheannelle Johnson, Gail Nunlee-Bland, Christopher A. Loffredo, Brent E. Korba, Vijay Chandra, Siddhartha S. Jana, Bernard Kwabi-Addo, Sumit Sarkar, Somiranjan Ghosh

“…Current improvements have unveiled the disease's pathophysiology and clinical diagnostic tests, targeting the neurological changes (neurodegeneration, amyloid precursor protein metabolism and tangle pathology) with precise PET/MRI imaging and xMAP/SIMOA (Multiplex simultaneous detection/single molecule array) to identify and quantify β-amyloids (Aβ40, Aβ42), total tau (T-tau) and phosphorylated tau (P-tau) proteins in the brain and cerebrospinal fluid (CSF) of patients. …”
Get full text

Synthesis and Interface Activity of a Series of Carboxylic Quaternary Ammonium Surfactants in Hydraulic Fracturing by Shixin Dai, Yufei Gong, Feng Wang, Pan Hu

“…The critical micelle concentration (CMC) and surface tension at the CMC (γCMC) increase as increasing methylene segments in the anions, the maximum surface excess concentration (Γmax), and minimum area per molecule (Amin) present an opposite trend with the increase of methylene segments. …”
Get full text

Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-Acetylcysteine by Gang Chen, Jixin Shi, Zhigang Hu, Chunhua Hang

“…In this work, we investigated the effect of NAC administration on cortical expressions of nuclear factor kappa B (NF-κB) and inflammatory proteins such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and intercellular adhesion molecule-1 (ICAM-1) after TBI. As a result, we found that NF-κB, proinflammatory cytokines, and ICAM-1 were increased in all injured animals. …”
Get full text

Sustained Release of Prostaglandin E2 in Fibroblasts Expressing Ectopically Cyclooxygenase 2 Impairs P2Y-Dependent Ca2+-Mobilization by María Pimentel-Santillana, Paqui G. Través, Raquel Pérez-Sen, Esmerilda G. Delicado, Paloma Martín-Sanz, María Teresa Miras-Portugal, Lisardo Boscá

“…The nucleotide uridine trisphosphate (UTP) released to the extracellular milieu acts as a signaling molecule via activation of specific pyrimidine receptors (P2Y). …”
Get full text

Combination Trimodality Therapy Using Vismodegib for Basal Cell Carcinoma of the Face by Alec M. Block, Fiori Alite, Aidnag Z. Diaz, Richard W. Borrowdale, Joseph I. Clark, Mehee Choi

“…Vismodegib, a small-molecule inhibitor of the hedgehog pathway, is approved for advanced and metastatic BCCs. …”
Get full text

Thymic Stromal Lymphopoietin Is Implicated in the Pathogenesis of Bullous Pemphigoid by Dendritic Cells by Si-Zhe Li, Xin-Xing Jin, Xiao-Lei Ge, Ya-Gang Zuo, Hong-Zhong Jin

“…Infiltration of DCs, marked by DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and its relationship with TSLP and TSLP receptors was evaluated by immunofluorescence staining. …”
Get full text

Targeting the NOTCH2/ADAM10/TCF7L2 Axis‐Mediated Transcriptional Regulation of Wnt Pathway Suppresses Tumor Growth and Enhances Chemosensitivity in Colorectal Cancer by Zhen Xiang, Yiwei Wang, Xiao Ma, Shuzheng Song, Yuanqiao He, Jiamin Zhou, Longhai Feng, Su Yang, Yibin Wu, Bingran Yu, Guangkai Xia, Weiqi Xu, Yiming Zhao, Lu Wang

“…Overall, this study provides a promising candidate for the development of small‐molecule inhibitors and reveals a potential therapeutic target for CRC.…”
Get full text

IFN-γ reprograms cardiac microvascular endothelial cells to mediate doxorubicin transport and influences the sensitivity of mice to doxorubicin-induced cardiotoxicity by Haoyu Ji, Wenya Ma, Xu Liu, Hongyang Chen, Yining Liu, Zhongyu Ren, Daohong Yin, Ao Cai, Zizhen Zhang, Xin Wang, Wei Huang, Leping Shi, Yanan Tian, Yang Yu, Xiuxiu Wang, Yang Li, Yu Liu, Benzhi Cai

“…In vitro and in vivo studies with small-molecule drugs were conducted. DIC-insensitive mice displayed preserved ejection fractions, lower DOX levels in cardiac tissues and higher levels in the serum. …”
Get full text

Maxwellian Eye Fixation during Natural Scene Perception by Jean Duchesne, Vincent Bouvier, Julien Guillemé, Olivier A. Coubard

“…For each participant, the probability density function (PDF) of eye movement amplitude during fixation obeyed the law established by Maxwell for describing molecule velocity in gas. Only the mean amplitude of eye movements varied with expertise, which was lower in experts than novice participants. …”
Get full text

Role of aquaporins in brain water transport and edema by Yuyuan Li, Yining Wang, Xingda Huang, Hao Zhang, Youfei Guan, Xiaoyan Zhang

“…Water serves as the primary substance in all living cells and is an essential molecule involved in numerous biological processes critical for maintaining homeostasis in the central nervous system (CNS). …”
Get full text

Proinflammatory Responses of Heme in Alveolar Macrophages: Repercussion in Lung Hemorrhagic Episodes by Rafael L. Simões, Maria Augusta Arruda, Cláudio Canetti, Carlos H. Serezani, Iolanda M. Fierro, Christina Barja-Fidalgo

“…Taken together, the data support a dual role for heme in the inflammatory response associated with lung hemorrhage, acting as a proinflammatory molecule that can either act as both an adjuvant of the innate immunity and as an amplifier of the inflammatory response, leading tissue injury. …”
Get full text

The Stability-Indicating Ultra High-Performance Liquid Chromatography with Diode Array Detector and Tandem Mass Spectrometry Method Applied for the Forced Degradation Study of Ritl... by Jelena Kovačić, Daniela Amidžić Klarić, Nikša Turk, Željko Krznarić, Emma Riordan, Ana Mornar

“…Background/Objectives: Janus kinase inhibitors open new horizons for small-molecule drugs in treating inflammatory bowel disease, with ritlecitinib demonstrating significant efficacy in clinical trials for ulcerative colitis and Crohn’s disease. …”
Get full text

Management of asynchronous multifocal adult glioblastoma with loss of BRAFV600E -mutant clonality: a case report by Hannah Haile, Pavan S. Upadhyayula, Esma Karlovich, Michael B. Sisti, Brian J. A. Gill, Laura E. Donovan

“…This mutation can be targeted by small molecule inhibitors, offering therapeutic potential for GBM. …”
Get full text

Inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles by Jacob R. Shaw, Nicholas Caprio, Nhu Truong, Mehari Weldemariam, Anh Tran, Nageswara Pilli, Swarnima Pandey, Jace W. Jones, Maureen A. Kane, Ryan M. Pearson

“…NP coronas alter cell associations in a disease-dependent manner, induce differential co-stimulatory and co-inhibitory molecule expression, and influence cytokine release. …”
Get full text

Characterization of IXINITY® (Trenonacog Alfa), a Recombinant Factor IX with Primary Sequence Corresponding to the Threonine-148 Polymorph by Dougald M. Monroe, Richard J. Jenny, Kevin E. Van Cott, Shelly Buhay, Laura L. Saward

“…Trenonacog alfa migrated as a single band on Coomassie-stained gels; activity assays were normal and showed <0.002 IU of activated factor IX (FIXa) per IU of FIX. The molecule has >97%  γ-carboxylation and underwent the appropriate structural change upon binding calcium ions. …”
Get full text

A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy by Youmei Xiao, Zhuoying He, Wanqiong Li, Danhong Chen, Xiaoshuang Niu, Xin Yang, Wenxuan Zeng, Mengfan Wang, Yuzhen Qian, Ye Su, Feiyu Luo, Guanyu Chen, Juan Liu, Xinghua Sui, Xiuman Zhou, Yanfeng Gao

“…However, the synthesis of LYTACs, antibody-small molecule conjugates, is challenging. The ability of antibody-based LYTACs to penetrate solid tumor is limited as well, especially to cross the blood-brain barrier (BBB). …”
Get full text

Characterization of Autoantibodies against the E1𝜶 Subunit of Branched-Chain 2-Oxoacid Dehydrogenase in Patients with Primary Biliary Cirrhosis by Tsutomu Mori, Hiromasa Ohira, Masahito Kuroda, Masaki Kato, Yoshiki Yamaguchi, Hideo Kochi

“…Multiple epitopes are present on the surface of the BCOADC-E1𝛼 molecule, and the major epitope overlaps with the active center. …”
Get full text