Third-Generation Anti-CD47-Specific CAR-T Cells Effectively Kill Cancer Cells and Reduce the Genes Expression in Lung Cancer Cell Metastasis by Huyen Thi La, Dao Bich Thi Tran, Hai Manh Tran, Linh Trong Nguyen

“…CD47 is a cell surface glycoprotein molecule, belonging to the immunoglobulin superfamily, binding to various proteins including integrins, thrombospondin-1, and signal regulatory protein α (SIRPα). …”
Get full text

Development of a cell-penetrating peptide-based nanocomplex for long-term delivery of intact mitochondrial DNA into epithelial cells by Kyrie Wilson, Charles Holjencin, Hwaran Lee, Balasubramaniam Annamalai, Masaaki Ishii, Jeremy L. Gilbert, Andrew Jakymiw, Bärbel Rohrer

“…Gene therapy approaches for mitochondrial DNA (mtDNA)-associated damage/diseases have thus far been limited, and despite advancements in single gene therapy for mtDNA mutations and progress in mitochondrial transplantation, no method exists for restoring the entire mtDNA molecule in a clinically translatable manner. Here, we present for the first time a strategy to deliver an exogenous, fully intact, and healthy mtDNA template into cells to correct endogenous mtDNA mutations and deletions, with the potential to be developed into an efficient pan-therapy for inherited and/or acquired mtDNA disorders. …”
Get full text

Laser-Induced Fluorescence Decay of 2-Methyl-, 2-Methoxy-, and 2-Ethylnaphthlene on α-Alumina during Temperature Programmed Desorption by Bradly B. Baer, Shanan Lau, Hannah E. Ryan, K. A. Martin, A. M. Nishimura

“…In separate experiments, the effect of a molecule that does not fluoresce and has a lower desorption temperature than the fluorophores was studied by deposition of a bilayer. 1-Chlorohexane (1-CH) was chosen as the second layer to the fluorophore and the results gave clues to the complexity of the surface dynamics that occur as the surface is heated. …”
Get full text

Evaluation of terminal blend rubberized asphalt incorporating high crumb rubber content by Yangquan Huang, Kun Long, Chi Qu, Chuanqi Yan, Changfa Ai, Shengxiong Zhou

“…Results show that the terminal blending process leads to CR particle breakdown and rubber molecule depolymerization, enhancing workability and stability up to a rubber dosage limit of approximately 40 %. …”
Get full text

High-density lipoprotein nanoparticles spontaneously target to damaged renal tubules and alleviate renal fibrosis by remodeling the fibrotic niches by Shanshan He, Xiaoyang Li, Yuanyuan He, Ling Guo, Yunzhou Dong, Leilei Wang, Lan Yang, Lin Li, Shiyun Huang, Jiali Fu, Qing Lin, Zhirong Zhang, Ling Zhang

“…In this study, we discover that biomimetic high-density lipoprotein (bHDL) lipid nanoparticles possess excellent targeting ability to injured tubular epithelial cells by kidney injury molecule-1(KIM-1) mediated internalization. Thus, we co-load anti-inflammatory drug triptolide (TP) and anti-fibrotic drug nintedanib (BIBF) on bHDL nanoparticles to treat CKD. …”
Get full text

Preparation of Restricted Access Media-Molecularly Imprinted Polymers for the Detection of Chloramphenicol in Bovine Serum by Shanwen Zhao, Chanling Wei, Zhian Sun, Huachun Liu, Yanqiang Zhou, Xiaoxiao Wang, Jianmin Li, Bolin Gong

“…Chloramphenicol- (CAP-) restricted access media-molecularly imprinted polymers (CAP-RAM-MIPs) were prepared by precipitation polymerization using CAP as a template molecule, 2-diethylaminoethyl methacrylate (DEAEM) as a functional monomer, ethylene glycol dimethyl acrylate (EDMA) as a crosslinking agent, glycidyl methacrylate (GMA) as an outer hydrophilic functional monomer, and acetonitrile as a pore former and solvent. …”
Get full text

Exendin-4 Protects MIN6 Cells from t-BHP-Induced Apoptosis via IRE1-JNK-Caspase-3 Signaling by Wen-Jia Chen, Lin-Xi Wang, Yan-Ping Wang, Zhou Chen, Xiao-Ying Liu, Xiao-Hong Liu, Li-Bin Liu

“…Exendin-4 also inhibited the endoplasmic reticulum transmembrane protein IRE1, the apoptosis-related signaling molecule JNK, and c-Jun activation. Conclusions. Our findings suggest that exendin-4 ultimately reduces t-BHP-induced β-cell apoptosis. …”
Get full text

RS, S (+) - and R (−)-ibuprofen cocrystal polymorphs: Vibrational spectra, XRD measurement and DFT calculation studies by Yaqi Jing, Qiuhui Zhao, Jiale Zhang, Jiadan Xue, Jianjun Liu, Jianyuan Qin, Zhi Hong, Yong Du

“…RS-IBU is a chiral drug with only one chiral center in the molecule, which has two enantiomers (S (+)-IBU and R (−)-IBU). …”
Get full text

Fluid flow impacts endothelial-monocyte interactions in a model of vascular inflammatory fibrosis by Isabelle Linares, Kaihua Chen, Ava Saffren, Mehran Mansouri, Vinay V. Abhyankar, Benjamin L. Miller, Stefano Begolo, Hani A. Awad, James L. McGrath

“…Under physiological shear stress consistent with postcapillary venules, we found a significant increase in the endothelial leukocyte activation marker intercellular adhesion molecule 1 (ICAM-1), as well as enhanced adhesion and transmigration of circulating monocytes across the endothelial barrier. …”
Get full text

Metformin Ameliorates Podocyte Damage by Restoring Renal Tissue Podocalyxin Expression in Type 2 Diabetic Rats by Limin Zhai, Junfei Gu, Di Yang, Wei Wang, Shandong Ye

“…Podocalyxin (PCX) is a signature molecule of the glomerular podocyte and of maintaining integrity of filtration function of glomerulus. …”
Get full text

Mechanistic Framework for Establishment, Maintenance, and Alteration of Cell Polarity in Plants by Pankaj Dhonukshe

“…In plants, auxin efflux carrier PIN proteins display polar localizations in various cell types and play major roles in directional cell-to-cell transport of signaling molecule auxin that is vital for plant patterning and response programs. …”
Get full text

Antigen Presenting Cells and Stromal Cells Trigger Human Natural Killer Lymphocytes to Autoreactivity: Evidence for the Involvement of Natural Cytotoxicity Receptors (NCR) and NKG2... by Alessandro Poggi, Maria Raffaella Zocchi

“…Further, the natural cytotoxicity receptors (NCR) NKp30 and NKp46 are responsible for the delivery of lethal hit to DC, whereas NKG2D activating receptor, the ligand of the MHC-related molecule MIC-A and the UL16 binding protein, is involved in stromal cell killing. …”
Get full text

Glutathione: A Key Regulator of Extracellular Matrix and Cell Death in Intervertebral Disc Degeneration by Fudong Li, Shaofei Li, Yangyang Shi, Feng Lin, Lining Rui, Jiangang Shi, Kaiqiang Sun

“…In addition, we summarized the regulatory effects of small molecule compounds on GSH to explore potential ways to regulate the level of GSH. …”
Get full text

Quinoline-Based Materials: Spectroscopic Investigations as well as DFT and TD-DFT Calculations by Mahmoud A. S. Sakr, Samy A. El-Daly, El-Zeiny M. Ebeid, Sadeq M. Al-Hazmy, Mohammed Hassan

“…Also, the influence of pH on the absorption spectra of the DDP molecule was studied. The molecular structures of these quinoline derivatives have been optimized via utilizing the B3LYP/6-31G (d) level of theory. …”
Get full text

Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity by Manfred Kunz, Saleh M. Ibrahim

“…Since a plethora of new treatment approaches using antibodies or small molecule inhibitors specifically targeting cytokines, cellular receptors, or signalling mechanisms has emerged in recent years, more individualized treatment for affected patients may be within reach in the future.…”
Get full text

A Simplified Method of Microscopic Polarizability Tensor Differential of Hyper-Raman Spectroscopy Based on the Bond Additivity Model by Yuan Wang, Liping Huang

“…In this paper, we use the bond additivity model (BAM) combined with experimental corrections to address the carbon dioxide (CO2) molecule and present the simplified scheme for differentiation of hyper-Raman microscopic polarizability tensor elements β′i′j′k′. …”
Get full text

A Novel Metal-Organic Framework Composite, MIL-101(Cr)@MIP, as an Efficient Sorbent in Solid-Phase Extraction Coupling with HPLC for Tribenuron-Methyl Determination by Xinyuan Zheng, Junping Wang

“…The MIL@MIP was prepared by surface molecular-imprinting technique, specially using MIL-101 as core, TBM as template molecule, methacrylic acid (MAA) as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross-linker, and azobisisobutyronitrile (AIBN) as initiator. …”
Get full text

Effect of Adiponectin Variant on Lipid Profile and Plasma Adiponectin Levels: A Multicenter Systematic Review and Meta-Analysis by Guiqing Wang, Yufeng Wang, Zhi Luo

“…Adiponectin is a recognized antiatherogenic molecule; this study was aimed at clarifying the effects of adiponectin variants on lipid and adiponectin levels. …”
Get full text

Promoting Seed Germination of Some Plant Species by Rhamnolipid Produced by Pseudomonas aeruginosa by Zeena Ghazi Faisal

“…Thus, this biological molecule demonstrates promising results in enhancing seed germination of the studied species by protecting them from phytopathogens and then aiding plant growth.…”
Get full text

SO2 Gas Physicochemical Removal through Pulse Streamer Discharge Technique Assisted by Vapor Additive by Xiaojun Wang, Lianshui Zhang

“…Emission spectra diagnosis experimentally indicates that the SO2 molecule has been physically dissociated into SO and O radicals by electron collision and can be remediated through further chemical reactions during and after discharge. …”
Get full text