Thermal Treatment of Cerium Oxide and Its Properties: Adsorption Ability versus Degradation Efficiency by Pavel Janoš, Tomáš Hladík, Martin Kormunda, Jakub Ederer, Martin Šťastný

“…The >Ce–OH groups on the sorbent surface are responsible for the dye binding by the surface-complexation mechanism, and probably also for the nucleophilic cleavage of the P–O–aryl bond in the pesticide molecule.…”
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Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria by Cedric Dzidzor Kodjo Amengor, Cynthia Amaning Danquah, Emmanuel Bentil Asare Adusei, Francis Klenam Kekessie, Francis Ofosu-Koranteng, Paul Peprah, Benjamin Kingsley Harley, Emmanuel Orman, Joseph Adu, Yussif Saaka

“…A library of six compounds with new hybrids in a single molecule triazole ring attached to the phosphonium salts was synthesized. …”
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Iguratimod prevents renal fibrosis in unilateral ureteral obstruction model mice by suppressing M2 macrophage infiltration and macrophage–myofibroblast transition by Yueyuan Zhou, Zhilan Li, Shenyi Yu, Xuan Wang, Tingting Xie, Weiru Zhang

“…Iguratimod is a novel synthetic, small-molecule immunosuppressive agent used to treat rheumatoid arthritis. …”
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FusOn-pLM: a fusion oncoprotein-specific language model via adjusted rate masking by Sophia Vincoff, Shrey Goel, Kseniia Kholina, Rishab Pulugurta, Pranay Vure, Pranam Chatterjee

“…These proteins are intrinsically disordered and lack druggable pockets, making them highly challenging therapeutic targets for both small molecule-based and structure-based approaches. Protein language models (pLMs) have recently emerged as powerful tools for capturing physicochemical and functional protein features but have yet to be trained on fusion oncoprotein sequences. …”
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Photophysical Properties of Fluorescent Probe Thioflavin T in Crowded Milieu by Natalia P. Rodina, Maksim I. Sulatsky, Anna I. Sulatskaya, Irina M. Kuznetsova, Vladimir N. Uversky, Konstantin K. Turoverov

“…However, these crowding agents can have a direct effect on the ThT molecule, and this effect must be taken into account. …”
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Innate Immune Recognition of Mycobacterium tuberculosis by Johanneke Kleinnijenhuis, Marije Oosting, Leo A. B. Joosten, Mihai G. Netea, Reinout Van Crevel

“…Among the TLR family, TLR2, TLR4, and TLR9 and their adaptor molecule MyD88 play the most prominent roles in the initiation of the immune response against tuberculosis. …”
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Synthesis, Characterization, and Biological Activity of N′-[(Z)-(3-Methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide and Its Co(II), Ni(II), and... by Jonnie N. Asegbeloyin, Oguejiofo T. Ujam, Emmanuel C. Okafor, Ilknur Babahan, Esin Poyrazoglu Coban, Ali Özmen, Halil Biyik

“…X-ray diffraction analyses of the crystals revealed a nonplanar molecule, existing in the keto-amine form, with intermolecular hydrogen bonding forming a seven-membered ring system. …”
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Single-cell transcriptomics unveils multifaceted immune heterogeneity in early-onset versus late-onset cervical cancer by Qian Chen, Dongfeng Deng, Hong Zhu, Shan Li

“…Epithelial cells in EOCC exhibited a notable dual immunological phenotype, characterized by immune-suppressive properties driven by elevated CXCL production, alongside immune-stimulatory features linked to heightened HLA molecule expression. CD4 + and CD8 + T cells in LOCC demonstrated a heightened activation state, while NK cells exhibited diminished cytotoxicity. …”
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TWEAK-Fn14 signaling protects mice from pulmonary fibrosis by inhibiting fibroblast activation and recruiting pro-regenerative macrophages by Li Liu, Pei Wu, Yuqi Wei, Meng Lu, Haiyan Ge, Ping Wang, Jianlong Sun, Tiffany Horng, Xiucheng Liu, Xiaoyong Shen, Lingyun Sun, Ying Xi

“…Here we found that fibroblast growth factor-inducible molecule 14 (Fn14), the receptor for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is highly induced in myofibroblasts in the lungs of IPF patients and the bleomycin-induced lung fibrosis model. …”
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The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression by Cristoforo Comi, Giuseppe Cappellano, Annalisa Chiocchetti, Elisabetta Orilieri, Sara Buttini, Laura Ghezzi, Daniela Galimberti, Franca Guerini, Nadia Barizzone, Franco Perla, Maurizio Leone, Sandra D’Alfonso, Domenico Caputo, Elio Scarpini, Roberto Cantello, Umberto Dianzani

“…Osteopontin is a proinflammatory molecule, modulating TH1 and TH17 responses. Several reports suggest its involvement in multiple sclerosis (MS) pathogenesis. …”
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Contribution of Statins towards Periodontal Treatment: A Review by Catherine Petit, Fareeha Batool, Isaac Maximiliano Bugueno, Pascale Schwinté, Nadia Benkirane-Jessel, Olivier Huck

“…They control periodontal inflammation through inhibition of proinflammatory cytokines and promotion of anti-inflammatory and/or proresolution molecule release, mainly, through the ERK, MAPK, PI3-Akt, and NF-κB pathways. …”
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Danhong Huayu Koufuye Prevents Diabetic Retinopathy in Streptozotocin-Induced Diabetic Rats via Antioxidation and Anti-Inflammation by Wenpei Chen, Xiaolan Yao, Chenghao Zhou, Ziyang Zhang, Gang Gui, Baoqin Lin

“…Moreover, DHK markedly reduced the serum levels of vascular endothelial growth factor (VEGF) and intercellular adhesion molecule-1 (ICAM-1). Furthermore, DHK significantly downregulated protein expressions of VEGF and inducible NO synthase (iNOS) and mRNA expression of ICAM-1 in retinas. …”
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The complete mitochondrial genome of Ophiocordyceps gracilis and its comparison with related species by Aifeire Abuduaini, Yuan-Bing Wang, Hui-Ying Zhou, Rui-Ping Kang, Ming-Liang Ding, Yu Jiang, Fei-Ya Suo, Luo-Dong Huang

“…As the second largest mitogenome reported in the family Ophiocordycipitaceae, the mitogenome of O. gracilis (voucher OG201301) is a circular DNA molecule of 134,288 bp that contains numerous introns and longer intergenomic regions. …”
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High Relative Humidity‐Induced Growth of Perovskite Nanowires from Glass toward Single‐Mode Photonic Nanolasers at Sub‐100‐nm Scale by Zhiqiang Wang, Xinkuo Li, Chenduan Chen, Minhan Lou, Jiajia Wu, Kai Gao, Zengling Li, Ke Sun, Zhou Li, Zhu Xiao, Linhan Li, Pan Wang, Sai Bai, Jianrong Qiu, Dezhi Tan

“…Nanowires (NWs) with tunable length and composition are obtained under 85% RH air, and water molecule‐induced facet engineering of perovskite is established for anisotropic growth. …”
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Busting the Breast Cancer with AstraZeneca’s Gefitinib by S. Chemmalar, A. R. Intan Shameha, Che Azurahanim Che Abdullah, Nor Asma Ab Razak, Loqman Mohamad Yusof, Mokrish Ajat, Kim Wei Chan, Md Zuki Abu Bakar Zakaria

“…With EGFR having four homologues: EGFR1, EGFR2, EGFR3, and EGFR4, in-depth understanding of EGFR biology led to the discovery of small-molecule inhibitors and antibodies against this receptor. …”
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Combination of ERG9 Repression and Enzyme Fusion Technology for Improved Production of Amorphadiene in Saccharomyces cerevisiae by Rama Raju Baadhe, Naveen Kumar Mekala, Sreenivasa Rao Parcha, Yalavarthy Prameela Devi

“…Our main objective was to overproduce amorpha 4-11-diene, which is a key precursor molecule of artemisinin (antimalarial drug) produced naturally in plant Artemisia annua through mevalonate pathway. …”
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Role of Cathepsin S in Periodontal Inflammation and Infection by S. Memmert, A. Damanaki, A. V. B. Nogueira, S. Eick, M. Nokhbehsaim, A. K. Papadopoulou, A. Till, B. Rath, S. Jepsen, W. Götz, C. Piperi, E. K. Basdra, J. A. Cirelli, A. Jäger, J. Deschner

“…Our findings provide original evidence that cathepsin S is increased in periodontal cells and tissues under inflammatory and infectious conditions, suggesting a critical role of this autophagy-associated molecule in the pathogenesis of periodontitis.…”
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Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Alter the Gut-Brain Communication by L. A. Ballsmider, A. C. Vaughn, M. David, A. Hajnal, P. M. Di Lorenzo, K. Czaja

“…Microglia activation was determined by quantifying changes in the fluorescent staining of hindbrain sections against an ionizing calcium adapter binding molecule 1 (Iba1). Reorganization of vagal afferents in the hindbrain was studied by fluorescent staining against isolectin 4 (IB4). …”
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Chemokine (C-X-C) Ligand 12 Facilitates Trafficking of Donor Spermatogonial Stem Cells by Zhiyv Niu, Shaun M. Goodyear, Mary R. Avarbock, Ralph L. Brinster

“…Inhibition of CXCR4 signaling using a small molecule inhibitor (AMD3100) during the critical window of homing also significantly lowered the efficiency of donor-derived SSCs to establish spermatogenic colonies in recipient mice; however, the self-renewal of SSCs was not affected by exposure to AMD3100. …”
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The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes by Yanan Wang, Jixin Zhong, Xiangzhi Zhang, Ziwei Liu, Yuan Yang, Quan Gong, Boxu Ren

“…High-mobility group box 1 (HMGB1), a nonhistone nuclear protein regulating gene expression, was rediscovered as an endogenous danger signal molecule to trigger inflammatory responses when released into extracellular milieu in the late 1990s. …”
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