DIMETHYL N-CYANODITHIOIMINOCARBONATE AND TRIPHENYLPHOSPHINE OXIDE METAL HALIDE COMPLEXES: MOLECULAR CRYSTAL ELUCIDATION by MOUHAMADOU BIRAME DIOP, MODOU SARR, LIBASSE DIOP, ALLEN G. OLIVER, DAVID HUGHES

“…In the structure, each molecule is linked to height neighbors through H-bonds affording a 3D network. …”
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Prognostic significance of ımmunhistochemical axl expression in pancreas ductal adenocarcinomas by Ozden Oz, Asuman Argon, Tulu Ayata Kebat, Ozlem Ozdemir, Savas Yakan

“…In this respect, it can be promising as a targeted molecule in PDAC patient's individualized treatments.…”
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Chemical Lasers Based on Polyatomic Reaction Dynamics: Research of Vibrational Excitation in a Reactive by José Daniel Sierra Murillo

“…The Gaussian Binning (GB) technique is utilized to more effectively highlight the variation in the total angular momentum (J′) of the excited product molecule, HOD*. A key aim of the study is to explore the reaction dynamics due to their importance in excitation and emission processes, which may contribute to the development of a chemical laser based on this reaction. …”
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Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells by Cristian Doñas, Macarena Fritz, Valeria Manríquez, Gabriela Tejón, María Rosa Bono, Alejandra Loyola, Mario Rosemblatt

“…The forkhead box P3 transcription factor (Foxp3) is a crucial molecule regulating the generation and function of Tregs. …”
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An Overview of the Role of Innate Lymphoid Cells in Gut Infections and Inflammation by Silvia Sedda, Irene Marafini, Michele M. Figliuzzi, Francesco Pallone, Giovanni Monteleone

“…Specifically, ILCs1 express the transcription factor T-bet and secrete T helper type-1- (Th1-) related cytokines, ILCs2 are dependent on the transcription factor RORα and express Gata-3 and the chemokine receptor homologous molecule (CRTH2) and produce Th2-related cytokines, and ILCs3 express the transcription factor RORγt and synthesize interleukin- (IL-) 17, IL-22, and, under specific stimuli, interferon-γ. …”
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Metalloprotease Dependent Release of Placenta Derived Fractalkine by Monika Siwetz, Astrid Blaschitz, Julia Kremshofer, Jelena Bilic, Gernot Desoye, Berthold Huppertz, Martin Gauster

“…The chemokine fractalkine is considered as unique since it exists both as membrane-bound adhesion molecule and as shed soluble chemoattractant. Here the hypothesis was tested whether placental fractalkine can be shed and released into the maternal circulation. …”
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Single-Round Patterned DNA Library Microarray Aptamer Lead Identification by Jennifer A. Martin, Peter A. Mirau, Yaroslav Chushak, Jorge L. Chávez, Rajesh R. Naik, Joshua A. Hagen, Nancy Kelley-Loughnane

“…The sequence demonstrating the highest fluorescence intensity upon target addition was confirmed to bind the target molecule thrombin with specificity by surface plasmon resonance, and a novel imino proton NMR/2D NOESY combination was used to screen the structure for G-quartet formation. …”
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An Emerging Role of Glucagon-Like Peptide-1 in Preventing Advanced-Glycation-End-Product-Mediated Damages in Diabetes by Alessandra Puddu, François Mach, Alessio Nencioni, Giorgio Luciano Viviani, Fabrizio Montecucco

“…These antidiabetic activities highlight GLP-1 as a potential therapeutic molecule in the clinical management of type 2 diabetes, (a disease characterized by progressive decline of beta-cell function and mass, increased insulin resistance, and final hyperglycemia). …”
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Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses by Liping Liu, Jiayu Zhao, Zichao Huang, Yudi Xu, Hongyu Chen, Ruirui Qiao, Wantong Song, Zhaohui Tang, Thomas P. Davis, Xuesi Chen

“…Mannan-decoration as the shell could significantly enhance the lymph node draining ability of the nanovaccines, especially in CD8+ dendritic cells (DCs). Azole molecule end-capped polylactic acid-polyethylenimine (PLA-PEI-4BImi) with innate stimulating activity was applied as the inner core for coordinating antigen-presenting cell activation and antigen cross-presentation. …”
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Deranged Bioenergetics and Defective Redox Capacity in T Lymphocytes and Neutrophils Are Related to Cellular Dysfunction and Increased Oxidative Stress in Patients with Active Syst... by Ko-Jen Li, Cheng-Han Wu, Song-Chou Hsieh, Ming-Chi Lu, Chang-Youh Tsai, Chia-Li Yu

“…Compared to normal cells, SLE-PMN showed decreased intracellular GSH levels, and GGT enzyme activity was found in SLE-PMN and enhanced expression of CD53, a coprecipitating molecule for GGT. We conclude that deranged cellular bioenergetics and defective redox capacity in T and PMN are responsible for cellular immune dysfunction and are related to increased oxidative stress in active SLE patients.…”
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The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent by Sebastiaan ter Horst, Aleksandra Siekierska, Ann-Sofie De Meulemeester, Arno Cuvry, Laura Cools, Johan Neyts, Peter de Witte, Joana Rocha-Pereira

“…To study RVFV pathogenesis and identify small-molecule antivirals, we established a novel In Vivo model using zebrafish larvae. …”
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Mechanisms for Covalent Immobilization of Horseradish Peroxidase on Ion-Beam-Treated Polyethylene by Alexey V. Kondyurin, Pourandokht Naseri, Jennifer M. R. Tilley, Neil J. Nosworthy, Marcela M. M. Bilek, David R. McKenzie

“…A high concentration of free radicals can give multiple covalent bonds to the protein molecule and destroy the native conformation and with it the catalytic activity. …”
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Mixed Ligand Complexes of N-Methyl-N-phenyl Dithiocarbamate: Synthesis, Characterisation, Antifungal Activity, and Solvent Extraction Studies of the Ligand by Anthony C. Ekennia, Damian C. Onwudiwe, Cyril Ume, Eno E. Ebenso

“…The infrared spectra showed that symmetrical bidentate coordination occurred with the dithiocarbamate moiety through the sulfur atoms, while neutral monodentate coordination occurred through the nitrogen atom for the pyridine molecule in the complexes. The electronic spectra, elemental analysis, and magnetic moment results proved that the complexes adopted octahedral geometry. …”
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Identification of MORF4L1 as an endogenous substrate of CRBN and its potential role as a therapeutic target in cancer by Luyao Zhang, Shunfang Liu, Jingliang He, Zhongke Hu, Lan Zhu, Hongyi Huang, Qi Gao, Dan Wang, Lu Chen, Xingyu Zhang, Ruotong Liu, Jiayun Wang, Yizhuo Song, Kaile Zeng, Xiuming Li, Yulu Chen, Xun Zou, Shaojie Ma, Xiujun Wang, Guofeng Xu, Wei Liu, Bin Liu

“…The cereblon (CRBN) E3 ubiquitin ligase complex is a crucial component of the UPS, particularly in modulating protein degradation in response to small-molecule modulators like thalidomide. However, the endogenous substrates of CRBN in solid tumors like HCC remain poorly characterized. …”
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Label-Free Glucose Detection Using Cantilever Sensor Technology Based on Gravimetric Detection Principles by Shuchen Hsieh, Shu-Ling Hsieh, Chiung-wen Hsieh, Po-Chiao Lin, Chun-Hsin Wu

“…The Con A/APS-modified probes were then used to detect glucose by monitoring shifts in the cantilever resonance frequency. To confirm the molecule-specific interaction, AFM topographical images were acquired of identically treated silicon substrates which indicated a specific attachment for glucose-Con A and not for galactose-Con A. …”
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H2S Loss through Nalophan™ Bags: Contributions of Adsorption and Diffusion by Lidia Eusebio, Laura Capelli, Selena Sironi

“…Hydrogen-sulfide (H2S) is a molecule of small dimensions typically present in the odor emissions from different plants. …”
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Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applications by Youlu Diao, Jia Gao, Yue Ma, Guoqing Pan

“…., proteins and nucleic acids), enables to target the entire molecule through recognizing partial epitopes exposed on it, greatly expanding the applicability and simplifying synthesis process of molecularly imprinted polymers (MIPs). …”
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Coordination Reactions and Noncovalent Interactions of Polyamines with Nucleotides in Binary Systems and with Nucleotides and Copper(II) Ion in Ternary Systems by Lechoslaw Lomozik, Anna Gasowska, Grzegorz Krzysko, Romualda Bregier-Jarzebowska

“…The mode of coordination in the complex is realised mainly through the phosphate groups of the nucleotide with involvement of the endocyclic nitrogen atoms in a manner which depends upon the steric conditions and in particular on the number of the methylene groups in the polyamine molecule.…”
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Plant Sources, Extraction Methods, and Uses of Squalene by M. Azalia Lozano-Grande, Shela Gorinstein, Eduardo Espitia-Rangel, Gloria Dávila-Ortiz, Alma Leticia Martínez-Ayala

“…Squalene (SQ) is a natural compound, a precursor of various hormones in animals and sterols in plants. It is considered a molecule with pharmacological, cosmetic, and nutritional potential. …”
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Beyond destruction: emerging roles of the E3 ubiquitin ligase Hakai by Juan-José Escuder-Rodríguez, Andrea Rodríguez-Alonso, Lía Jove, Macarena Quiroga, Gloria Alfonsín, Angélica Figueroa

“…The development of the first small-molecule inhibitor that targets its atypical substrate binding domain is a promising step that could eventually lead to patient benefit, and we would cover its discovery and ongoing efforts toward its use in clinic. …”
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