MIKRORNA – MOLEKUL VERSATIL DALAM KANSER TIROID by Azliana Mohamad Yusof, Nurul-Syakima Ab Mutalib

“…Sebagai molekul pengawalatur (regulatory molecule), mikroRNA adalah calon kajian yang sesuai untuk penyelidikan kanser tiroid di mana landskap mutasi genomnya secara relatif lebih senyap berbanding kanser lain. …”
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Curcumin inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells via IGF-1/PI3K/Akt pathway by Chao Chen, Qiwu Wang, Jiwen Liu

“…Results The highly expressed PCa-related molecule IGF-1R was down-regulated in CRPC cells after curcumin treatment, as determined by RT-qPCR and western blotting. …”
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Guidance Cue Netrin-1 and the Regulation of Inflammation in Acute and Chronic Kidney Disease by Punithavathi Ranganathan, Riyaz Mohamed, Calpurnia Jayakumar, Ganesan Ramesh

“…The ability of the guidance molecule netrin-1 to repulse or abolish attraction of neuronal cells expressing the UNC5B receptor makes it an attractive candidate for the regulation of inflammatory cell migration. …”
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Zinc Protoporphyrin Upregulates Heme Oxygenase-1 in PC-3 Cells via the Stress Response Pathway by Simon C. M. Kwok

“…Zinc protoporphyrin IX (ZnPP), a naturally occurring molecule formed in iron deficiency or lead poisoning, is a potent competitive inhibitor of heme oxygenase-1 (HO-1). …”
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The Diagnosis and Treatment of Branch Retinal Vein Occlusions: An Update by Diana-Maria Darabuş, Rodica Georgiana Dărăbuş, Mihnea Munteanu

“…Therapeutic interventions, including laser photocoagulation, anti-VEGF therapy, and intravitreal corticosteroids, are critically evaluated, emphasizing emerging treatments such as gene therapy, peptide-based agents, and small-molecule inhibitors. Despite advancements in management strategies, the recurrence of macular edema and treatment resistance remain significant challenges. …”
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Macroprolactinemia: Diagnostic, Clinical, and Pathogenic Significance by Akira Shimatsu, Naoki Hattori

“…The cross-reactivity of macroprolactin varies widely according to the immunoassay systems. The epitope on PRL molecule recognized by the autoantibodies is located close to the binding site for PRL receptors, which may explain that macroprolactin has a lower biological activity. …”
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Process Optimization for Biosingeing of 100% Cotton Terry Towel Fabric Using Box–Behnken Design by Aklilu Azanaw, Asnake Ketema

“…The treated fabric was analyzed using FTIR to know the unknown functional group and the chemical bonds on the fabric molecule. Testing of physical properties of the treated fabric was done and the result was comparable with other untreated fabrics. …”
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Update on New Antigens in the Pathogenesis of Membranous Nephropathy by Maurizio Salvadori, Aris Tsalouchos

“…Through these techniques, four new antigens were first detected, including neural epidermal growth factor 1 and semaphorin 3B in the so-called primary membranous nephropathy, and exostosin 1 and 2 and neural cell adhesion molecule 1 in lupus membranous nephropathy. The aim of this study is to describe the characteristics of the new antigens discovered and their association with other diseases. …”
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Interfacial and Micellization Behavior of Cetyltrimethylammonium Bromide (CTAB) in Water and Methanol-Water Mixture at 298.15 to 323.15 K by Sujit Kumar Shah, Ajaya Bhattarai

“…The effect of methanol on values of critical micelle concentration (cmc), free energies of micellization ΔGmo, and surface properties viz. maximum surface excess concentration Γmax, area occupied by per surfactant molecule Amin, surface pressure πcmc, solution surface tension γcmc, solvent surface tension (γo), free energies of adsorption ΔGadso, the efficiency of adsorption (pC20), effective Gibbs free energy ΔGeffo, and free energy of surface at equilibrium (Gmin) were investigated using surface tension values. …”
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Xanthoxyletin blocks the RANK/RANKL signaling pathway to suppress the growth of human pancreatic cancer cells by Zhang Xin, Li Luming, Wu Yan

“…Collectively, xanthoxyletin targets the RANK/RANKL signaling pathway in pancreatic cancer cells to induce cell apoptosis and may prove to be an important lead molecule.…”
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Chlorogenic acid complex (CGA7), standardized extract from green coffee beans exerts anticancer effects against cultured human colon cancer HCT-116 cells by K. Gouthamchandra, H.V. Sudeep, B.J. Venkatesh, K. Shyam Prasad

“…Overall findings indicated that CGA7 complex a potent anticancer molecule found in green coffee beans could be a safe bioactive ingredient for prevention of cancer.…”
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RNA Viruses: ROS-Mediated Cell Death by Mohammad Latif Reshi, Yi-Che Su, Jiann-Ruey Hong

“…Moreover, ROS may play an important role as a signal molecule in the regulation of viral replication and organelle function, potentially providing new insights in the prevention and treatment of RNA viruses and retrovirus infections.…”
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Analysis of the composition, characteristics, and antifungal properties of cutin in goji berry fruits at different developmental stages by Yueli Zhou, Dayuan Chen, Cong Wang, Huaiyu Zhang, Lunaike Zhao, Junjie Wang, Qiding Peng

“…Fatty acids, alkanes, aromatic acids, and small molecule acids were the main components of goji berry cutin, which are related to the formation of cutin structures. …”
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Immunological Mechanisms in Allergic Diseases and Allergen Tolerance: The Role of Treg Cells by D. Calzada, S. Baos, L. Cremades-Jimeno, B. Cárdaba

“…A central role in this balance is played by regulatory T cells (Tregs) through various ways of actions. By means of molecule secretion and cell-cell contact mechanisms, Tregs may have the capacity to modulate effector T cells and suppress the action of proinflammatory cytokines across a broad range of cell types. …”
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High School Students Are a Target Group for Fight against Self-Medication with Antimalarial Drugs: A Pilot Study in University of Kinshasa, Democratic Republic of Congo by Ramsès Kabongo Kamitalu, Michel Ntetani Aloni

“…The level of self-prescribing quinine is relatively high among students and is disturbing for a molecule reserved for severe disease in Congolese health care policy in management of malaria.…”
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Role of Fractalkine/CX3CL1 and Its Receptor in the Pathogenesis of Inflammatory and Malignant Diseases with Emphasis on B Cell Malignancies by Elisa Ferretti, Vito Pistoia, Anna Corcione

“…Fractalkine/CX3CL1, the only member of the CX3C chemokine family, exists as a membrane-anchored molecule as well as in soluble form, each mediating different biological activities. …”
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Nutritional Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health by Vincent J. Miller, Frederick A. Villamena, Jeff S. Volek

“…Furthermore, the ketone β-hydroxybutyrate (BHB), which is elevated during nutritional ketosis to levels no greater than those resulting from fasting, acts as a signaling molecule in addition to its traditionally known role as an energy substrate. …”
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Implication of Fructans in Health: Immunomodulatory and Antioxidant Mechanisms by Elena Franco-Robles, Mercedes G. López

“…Fructans are nonreducing carbohydrates composed of fructosyl units and terminated by a single glucose molecule. These carbohydrates may be straight or branched with varying degrees of polymerization. …”
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Study of Millimeter-Wave Rotational Spectra ofTrioxane in Ground, v(A), v1(E) = 1 and v2(E) = 1 States by Masoud Motamedi, Najmehalsadat Khademi

“…The millimeter-wave rotational spectra of the ground and excited vibrational states v(A), v1 (E) =1 and v2 (E ) =1 of the oblate symmetric top molecule, (CH2O)3, have been analyzed again. The B0 = 5273.25747MHz, D J = 1.334547 kHz, D Jk = -2.0206 kHz, H J (-1.01 mHz), H JK (-3.80 mHz), and HKJ (4.1 mHz) have been determined for ground state. …”
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Modulating DDAH/NOS Pathway to Discover Vasoprotective Insulin Sensitizers by Li Lai, Yohannes T. Ghebremariam

“…Asymmetric dimethylarginine (ADMA) is an endogenous molecule that competitively inhibits all the NOS enzymes and contributes to metabolic perturbations including IR. …”
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