Sigma1 inhibitor suppression of adaptive immune resistance mechanisms mediated by cancer cell derived extracellular vesicles by Paola A. Castagnino, Derick A. Haas, Luca Musante, Nathalia A. Tancler, Bach V. Tran, Rhonda Kean, Alexandra R. Steck, Luis A. Martinez, Elahe A. Mostaghel, D. Craig Hooper, Felix J. Kim

“…At the cell surface, PD-L1 is an immune checkpoint molecule that binds PD-1 on activated T-cells and blocks anti-tumor immunity. …”
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Preferential Expression of B7-H6 in Glioma Stem-Like Cells Enhances Tumor Cell Proliferation via the c-Myc/RNMT Axis by Hanqing Chen, Yundi Guo, Jing Sun, Jun Dong, Qinghua Bao, Xueguang Zhang, Fengqing Fu

“…Thus, our findings suggest B7-H6 as a potential molecule for glioma stem cell targeted immunotherapy.…”
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Vibrational and Quantum Chemical Study of Triphenylantimony(V)-o-salicylate by Tanveer Hasan, P. K. Singh, P. Raj, K. Singhal, Neeraj Misra

“…A complete normal coordinate analysis was performed by two different methods: a classical Wilson G-F matrix method and the semi-empirical molecular orbital PM3 method, for a five coordinate non rigid triphenyl antimony diester SbPh3(O2CR)2,[R=C6H4OH-o], known to be a bioactive molecule. The study of vibrational spectra suggested that the title compound might have secondary bonding interaction between the central antimony atom and the carbonyl oxygen atoms. …”
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Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future Directions by Sandip Patil, Xiaowen Chen, Feiqiu Wen

“…We delve into the bacterium’s virulence factors, discussing existing strategies like antibiotics, bacteriophages, probiotics, and small-molecule inhibitors. Additionally, novel approaches, including RNA interference, CRISPR-Cas systems, and nanotechnology, show promise in preclinical studies. …”
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Clinical Utility of Neutrophil CD64 to Detect Extrapulmonary Tuberculosis in Three Patients with Rheumatoid Arthritis Undergoing Treatment with Biologics by Shinichi Nogi, Yoshiyuki Arinuma, Akiko Komiya, Atsushi Hashimoto, Toshihiro Matsui, Shigeto Tohma

“…The expression of the CD64 molecule on neutrophils (neutrophil CD64) was upregulated by various infections including TB. …”
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RHEOLOGICAL PROPERTIES OF INDOLIC ALKALOIDS OBTAINED FROM NATURAL PRODUCTS by Ana-Maria Neculai, Anamaria Niculescu, Iuliana Cristea

“…The foul-smelling indole molecule is the building block for various natural and chemical products. …”
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Syntheses, Evaluation and Characterization of Some 1, 3, 4-Oxadiazoles as Antimicrobial Agents by Niti Bhardwaj, S. K. Saraf, Pankaj Sharma, Pradeep Kumar

“…It is well known that the synthesis of heterocyclic compounds tend to contain multi-structure in a molecule. The ring formation involves the condensation reaction. …”
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Blastocyst-Derived Lactate as a Key Facilitator of Implantation by Kathryn H. Gurner, David K. Gardner

“…While historically perceived as a metabolic waste product, lactate serves as a signaling molecule which facilitates the invasion of surrounding tissues by cancers and promotes blood vessel formation during wound healing. …”
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Ezetimibe Improves Rosuvastatin Effects on Inflammation and Vascular Endothelial Function in Acute Coronary Syndrome Patients Undergoing PCI by Changqing Sun, Wuyang Zheng, Ling Liang, Zuheng Liu, Wenchao Sun, Rong Tang

“…Lipid profile, type II secretory phospholipase A2 (sPLA2-IIa), interleukin-1β (IL-1β), vascular cell adhesion molecule-1 (VCAM-1), and intercellular cell adhesion molecule-1 (ICAM-1) were measured at baseline and after 7 days. …”
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Stapled peptides: targeting protein-protein interactions in drug development by Qian Zhang, Ziyang Wang, Xiaohan Mei, Quan Chen, Chunqiu Zhang

“…Stapled peptides, as the most promising therapeutic candidate for interfering with PPIs, have a higher degree of α-helicity, improved binding affinity, more resistance to proteolytic digestion, longer serum half-life, and enhanced cell permeability, which exhibits higher pharmacological activity compared with small molecule drugs and biologics. This review outlined the continuous progress of stapled peptides mainly concerning the design principle, structural stability, bioactivity, cell permeability, and potential applications in therapeutics, which is aimed at providing a broad reference for the design and exploration of stapled peptides with enhanced biological and pharmacokinetic properties as the next-generation therapeutic peptide drugs targeting various diseases.…”
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Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect by Chunying Cui, Yuji Wang, Yaonan Wang, Ming Zhao, Shiqi Peng

“…Alsterpaullone, a small molecule cyclin-dependent kinase (CDK) inhibitor, regulates the cell cycle progression. …”
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Male antennae of Armadillidium vulgare discriminate Wolbachia-infected females by Mouret, Nicolas, Tolassy, Vincent, Richard, Freddie-Jeanne

“…Further experiments are required to identify the involved molecule explaining the sexual preference of males towards Wolbachia-free females.…”
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Desensitization: Overcoming the Immunologic Barriers to Transplantation by Supreet Sethi, Jua Choi, Mieko Toyoda, Ashley Vo, Alice Peng, Stanley C. Jordan

“…These include IgG inactivating agents, anti-cytokine antibodies, costimulatory molecule blockers, complement inhibitors, and agents targeting plasma cells. …”
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Adsorption Properties of O2 onCr5 Nanostructures: A DFT Study by Mohammad T. Baei, Ali Kazemi Babaheydari, Parviz Torabi

“…Based on the density functional theory (DFT) adsorption properties of oxygen molecule on Cr5 nanostructures at various positions (top, bridge and central sites) were investigated. …”
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Le limonène dans les huiles essentielles  : énantiomères et activités biologiques by Aribi-Zouioueche, Louisa

“…Literature data are used to identify the enantiomeric diversity of limonene in 54 essential oils composed of between 0.3–99.7% of this molecule. Significant enantiomeric excesses are observed, either in (R)-(+)-, or in (S)-(–)-limonene, and more rarely, the two enantiomers in equal proportion. …”
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Targeted SPP1 Inhibition of Tumor‐Associated Myeloid Cells Effectively Decreases Tumor Sizes by Benan Kartal, Christopher S. Garris, Hyung Shik Kim, Rainer H. Kohler, Jasmine Carrothers, Elias A. Halabi, Yoshiko Iwamoto, Anne‐Gaëlle Goubet, Yuxuan Xie, Pratyaksha Wirapati, Mikaël J. Pittet, Ralph Weissleder

“…Here, on a phenotypic screen is reported to identify small molecule SPP1 modulators in macrophages. Several hits and incorporated them into a TAM‐avid systemic nanoformulation are identified. …”
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Ammonium Ion Exchanged Zeolite for Laser Desorption/Ionization Mass Spectrometry of Phosphorylated Peptides by Mengrui Yang, Tatsuya Fujino

“…α-Cyano-4-hydroxycinnamic acid (CHCA), an organic matrix molecule for matrix-assisted laser desorption/ionization mass spectrometry, was adsorbed to NH4+-type zeolite surface, and this new matrix was used for the detection of low-molecular-weight compounds. …”
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HSV-1 Encephalitis in an Elderly Man Receiving Ibrutinib for Waldenstrom’s Macroglobulinemia by Mark R. Wallace

“…Though ibrutinib has proven to be a revolutionary new small molecule agent, and has relatively minimal toxicity as compared to traditional chemotherapy, infections have emerged as a major complication of therapy. …”
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Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity by T. N. Sharapova, E. A. Romanova, L. P. Sashchenko, D. V. Yashin

“…These cells can induce lysis of HLA-negative tumor cell lines. The Hsp70 stress molecule on the surface of the tumor cells is used as a recognition target, while the Tag7 protein on the lymphocyte membrane acts as a receptor for Hsp70. …”
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Epidermal Growth Factor Receptor Gene in Non-Small-Cell Lung Cancer: The Importance of Promoter Polymorphism Investigation by Vladimir Jurišić, Jasmina Obradovic, Sonja Pavlović, Nataša Djordjevic

“…Recently, epidermal growth factor receptor (EGFR) was a key molecule in investigation of lung cancer, and it was a target for a new therapeutic strategy, based on molecular analyses. …”
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