Ensemble learning-based predictor for driver synonymous mutation with sequence representation. by Chuanmei Bi, Yong Shi, Junfeng Xia, Zhen Liang, Zhiqiang Wu, Kai Xu, Na Cheng

“…Notably, the incorporation of DNA shape features and deep learning-derived features from chemical molecule represents a pioneering effect in assessing the impact of synonymous mutations in cancer. …”
Get full text

Unzipping of knotted DNA via nanopore translocation by Antonio Suma, Cristian Micheletti

“…DNA unzipping by nanopore translocation has implications in diverse contexts, from polymer physics to single-molecule manipulation to DNA–enzyme interactions in biological systems. …”
Get full text

Trichostatin A suppresses hearing loss by reducing oxidative stress and inflammation in an Alport syndrome model. by Yoon Seok Nam, Eun-Ji Gi, Yoo-Seung Ko, Sungsu Lee, Hyong-Ho Cho

“…These findings suggest that TSA represents a promising candidate molecule for mitigating the progression of hearing loss in AS.…”
Get full text

Density Functional Theoretical Computational Studies on 3-Methyl 2-Vinyl Pyridinium Phosphate by N. Kanagathara, V. J. Thanigaiarasu, V. Sabari, S. Elangovan

“…The dipole moment, total polarizability, and the first-order hyperpolarizability calculations have been carried out for the studied molecule. Hirshfeld surface analysis has been done to study the intermolecular interactions in the studied complex.…”
Get full text

Synthesis and Growth Stimulant Properties of 2-Acetyl-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one Derivatives by Vergush A. Pivazyan, Emma A. Ghazaryan, Roza S. Shainova, Rafael A. Tamazyan, Armen G. Ayvazyan, Aleksandr P. Yengoyan

Get full text

Synthesis of Arginase Inhibitors: An Overview by Maria Cristina Molaro, Chiara Battisegola, Marica Erminia Schiano, Mariacristina Failla, Maria Grazia Rimoli, Loretta Lazzarato, Konstantin Chegaev, Federica Sodano

“…For each molecule, its inhibitory activity in terms of IC₅₀ towards ARG-1 and ARG-2 will be reported specifying the type of assay conducted.…”
Get full text

Flexible Dual Fe-based Catalyst: MIL-53(Fe) Loaded with Deep Eutectic Solvent for Discontinuous Selective Oxidation of H2S by Fengke Wang, Chaofan Li, Weizhen Kong, Shucan Qin, Qianqian Peng, Lihua Zang, Yunqian Ma, Yi Nie, Guihuan Yan

“…Both elemental sulfur and DES can induce the flexible deformation of MOF as the guest molecule to relieve the passivation of catalyst.…”
Get full text

Synthesis and structural characterization of s-triazine derivatives and their photophysical properties by Hessa H. Al-Rasheed, Sizwe J. Zamisa, Ihab Shawish, Assem Barakat, Ayman El-Faham, Beatriz G. de la Torre, Fernando Albericio, Anamika Sharma

“…In 2 and 3, intermolecular N—H…O were observed between the H7 atom of the amine group and O4 atom of the methanol molecule. In 4, the same intramolecular C—H…N hydrogen bonds mentioned in 2 and 3 were found. …”
Get full text

cGAS-STING targeting offers therapy choice in lung diseases by Yu Wang, Xuan Zhang, Weixue Wang, Yi Zhang, Joshua S. Fleishman, Hongquan Wang

“…Insights into the biology of the cGAS-STING pathway have enabled the discovery of small-molecule agents which have the potential to inhibit the cGAS-STING axis in lung diseases. …”
Get full text

Smac127 Has Proapoptotic and Anti-Inflammatory Effects on Rheumatoid Arthritis Fibroblast-Like Synoviocytes by D. Lattuada, R. Gualtierotti, K. Crotta, P. Seneci, F. Ingegnoli, C. Corradini, R. Viganò, O. Marelli, C. Casnici

“…We evaluated the proapoptotic and anti-inflammatory activity of the small molecule Smac127 on RA-FLSs cultured in synovial fluid (SF), in order to reproduce the physiopathological environmental characteristic of RA joints. …”
Get full text

On Computation of Face Index of Certain Nanotubes by Ansheng Ye, Aisha Javed, Muhammad Kamran Jamil, Kanza Abdul Sattar, Adnan Aslam, Zahid Iqbal, Asfand Fahad

“…Topological index is a number that can be used to characterize the graph of a molecule. Topological indices describe the physical, chemical, and biological properties of a chemical structure. …”
Get full text

Ethyl Lactate Ameliorates Hepatic Steatosis and Acute‐on‐Chronic Liver Injury in Alcohol‐Associated Liver Disease by Inducing Fibroblast Growth Factor 21 by Yang Jiang, Shuang Wei, Shiming Shen, Yuxiao Liu, Weitong Su, Dong Ding, Zengpeng Zheng, Haokai Yu, Tingting Zhang, Qiuli Yang, Jiuxiang Zhao, Yi Shen, Xia Fang, Liangcai Lin, Dongguang Xiao, Aoyuan Cui, Qin Wan, Yadong Zhang, Yu Li, Cuiying Zhang

“…Here the discovery of a small molecule that activates the production and secretion of fibroblast growth factor 21 (FGF21) is reported. …”
Get full text

Determination of Crizotinib in Mouse Tissues by LC-MS/MS and Its Application to a Tissue Distribution Study by Fang Zhao, Yuan Wei, Yiming Yan, Han Liu, Sitong Zhou, Bo Ren, Ruijuan Liu

“…Toxicity induced by crizotinib, a small-molecule tyrosine kinase inhibitor, is a significant clinical issue during treatment. …”
Get full text

Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease by Vincent N. Azzolino, Ala M. Shaqra, Akbar Ali, Nese Kurt Yilmaz, Celia A. Schiffer

“…The development of antiviral therapeutics, such as small-molecule inhibitors that target conserved proteins like the enteroviral 3C protease, remains to be achieved. …”
Get full text

Water-Based Assembly and Purification of Plasmon-Coupled Gold Nanoparticle Dimers and Trimers by Sébastien Bidault, Albert Polman

“…This approach combines a cross-linking molecule and a hydrophilic passivation layer to control the level of induced aggregation. …”
Get full text

Synthesis of Novel Peptide Dendrimers PDL-GB2 and PDL-G2 by Lin Yunzhu, Weng Lingling, Qi Qingrong

“…In this paper, novel peptide dendrimers PDL-GB2 and PDL-G2 were prepared according to divergent procedure with four-orientation molecule as the core and L-lysine as the branch unit. …”
Get full text

Pawlak Algebra and Approximate Structure on Fuzzy Lattice by Ying Zhuang, Wenqi Liu, Chin-Chia Wu, Jinhai Li

“…We also investigate molecule Pawlak algebra and obtain some related properties.…”
Get full text

Detection of Ammonia in Liquids Using Millimeter Wave Spectroscopy by Hilmi Ozturk, Hakki Nazli, Korkut Yegin, Mehmet Sezgin

“…The inversion of ammonia molecule results in split rotational spectral lines and transitions of these lines can be detected. …”
Get full text

Analysis of Whole Transcriptome Sequencing Data: Workflow and Software by In Seok Yang, Sangwoo Kim

“…RNA is a polymeric molecule implicated in various biological processes, such as the coding, decoding, regulation, and expression of genes. …”
Get full text

Theoretical Study of CO Adsorption on Perfect and Defective Gold Surfaces by Yingying Wang, Bing Xu, Wanyi Shen

“…The results clearly show that the activity of Au surfaces towards CO adsorption is attributable to the presence of low-coordinated gold atoms to which the molecule binds. The results may enrich the understanding of CO adsorption on Au surfaces.…”
Get full text