Spinorphin Molecules as Opportunities for Incorporation into Spinorphin@AuNPs Conjugate Systems for Potential Sustained Targeted Delivery to the Brain by Stela Georgieva, Petar Todorov, Jana Tchekalarova

“…<b>Background:</b> This study explores the potential for the synthesis of peptide nanosystems comprising spinorphin molecules (with rhodamine moiety: Rh-S, Rh-S5, and Rh-S6) conjugated with nanoparticles (AuNPs), specifically peptide Rh-S@AuNPs, peptide Rh-S5@AuNPs, and peptide Rh-S6@AuNPs, alongside a comparative analysis of the biological activities of free and conjugated peptides. …”
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Pharmacokinetic and Biodistribution Assessment of a Near Infrared-Labeled PSMA-Specific Small Molecule in Tumor-Bearing Mice by Joy L. Kovar, Lael L. Cheung, Melanie A. Simpson, D. Michael Olive

“…To facilitate preclinical testing of such outcomes, here we developed and characterized a PSMA-targeted small molecule, YC-27. IRDye 800CW was conjugated to YC-27 or an anti-PSMA antibody used for reference. …”
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Adsorption model of non-additive binary gas mixture on square lattice: attraction between molecules of different types by A. V. Myshlyavtsev, M. D. Myshlyavtseva, V. F. Fefelov

“…We have done complete analysis of the ground-state phase diagram for this model on a square lattice taking into account nearest-neighbor attraction between molecules of different types and arbitrary interactions between one type molecules. …”
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Bioactive Molecules, Ethnomedicinal Uses, Toxicology, and Pharmacology of <i>Peltophorum africanum</i> Sond (Fabaceae): Systematic Review by Nkoana I. Mongalo, Maropeng V. Raletsena

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Multistage Regulation Strategy via Fluorine‐Rich Small Molecules for Realizing High‐Performance Perovskite Solar Cells by Xiong Chang, Kunpeng Li, Yong Han, Guohua Wang, Zhishan Li, Dongfang Li, Fashe Li, Xing Zhu, Hua Wang, Jiangzhao Chen, Tao Zhu

“…Herein, a multistage regulation (MSR) strategy for addressing these challenges is proposed via the introduction of fluorine‐rich small molecules with multiple active points (i.e., 1‐[Bis(trifluoromethanesulfonyl)methyl]‐ 2,3,4,5,6‐pentafluorobenzene (TFSP)) into the precursor solution of the perovskite film. …”
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Universal coherent atom-molecule oscillations in the dynamics of the unitary Bose gas near a narrow Feshbach resonance by Ke Wang, Zhendong Zhang, Shu Nagata, Zhiqiang Wang, K. Levin

“…To understand these quench dynamics and how these different particle species are created, we develop a beyond Hartree-Fock-Bogoliubov dynamical framework including a type of cross-correlation between atoms and molecules. This leads to quantitative consistency with the measured frequency. …”
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GutBugDB: a web resource to predict the human gut microbiome-mediated biotransformation of biotic and xenobiotic molecules by Usha Longwani, Ashok K. Sharma, Aditya S. Malwe, Shubham K. Jaiswal, Vineet K. Sharma

“…There has been a growing recognition of the significant role played by the human gut microbiota in altering the bioavailability as well as the pharmacokinetic and pharmacodynamic aspects of orally ingested xenobiotic and biotic molecules. The determination of species-specific contributions to the metabolism of biotic and xenobiotic molecules has the potential to aid in the development of new therapeutic and nutraceutical molecules that can modulate human gut microbiota. …”
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Repression of the stress granule protein G3BP2 inhibits immune checkpoint molecule PD‐L1 by Yanhong Zhang, Changli Yue, Anna M. Krichevsky, Igor Garkavtsev

Subjects: “…a small molecule C108…”
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Evaluation of porphyrin molecules as effective corrosion inhibitors for copper alloy in sulfuric acid using both experimental and computational approaches by Metwally Abdallah, Majda Alfakeer, Rasha N Felaly, Abdulaziz M. Almohyawi, Jabir H. Al-Fahemi, Salih S. Al-Juaid, Doaa F. Seyam, Elsayed M. Mabrouk, Kamal A. Soliman

“…The inhibitory effect of TMPP molecules is explained based on their spontaneous physicochemical adsorption on the surface of C12510. …”
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Altered Expression of Hematopoiesis Regulatory Molecules in Lipopolysaccharide-Induced Bone Marrow Mesenchymal Stem Cells of Patients with Aplastic Anemia by Chandra Prakash Chaturvedi, Naresh Kumar Tripathy, Ekta Minocha, Akhilesh Sharma, Khaliqur Rahman, Soniya Nityanand

“…Our data shows that BM-MSCs of AA patients have altered expression of hematopoiesis regulatory molecules suggesting that they may have a role in the pathogenesis of the disease.…”
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From Molecule to Patient Rehabilitation: The Impact of Transcranial Direct Current Stimulation and Magnetic Stimulation on Stroke—A Narrative Review by Anca Badoiu, Smaranda Ioana Mitran, Bogdan Catalin, Tudor Adrian Balseanu, Aurel Popa-Wagner, Florin Liviu Gherghina, Carmen Valeria Albu, Raluca Elena Sandu

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AI-enhanced 3D-QSAR screening of fragment-based novel designed molecules targeting Phalaris minor ACCase by Bikash Kumar Rajak, Priyanka Rani, Durg Vijay Singh, Nitesh Singh

“…Using small molecule databases such as ZINC, CHEMBL, and DrugBank, an initial screening based on structural similarity to known ACCase inhibitors is performed. …”
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The N1‐methyladenosine methyltransferase TRMT61A promotes bladder cancer progression and is targetable by small molecule compounds by Jianjian Yin, Xin Fan, Qi Chang, Yuanheng Dai, Tao Wang, Lei Shi, Linlin Yang, Xiaoming Yang, Xudong Zhang, Lei Jin, Tao Liu, Fengmin Shao, Lirong Zhang, Dongkui Song

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Neuronal Transdifferentiation Potential of Human Mesenchymal Stem Cells from Neonatal and Adult Sources by a Small Molecule Cocktail by Lorena V. Cortés-Medina, Herminia Pasantes-Morales, Alejandro Aguilera-Castrejon, Arturo Picones, Cesar O. Lara-Figueroa, Enoch Luis, Juan Jose Montesinos, Victor A. Cortés-Morales, M. P. De la Rosa Ruiz, Erika Hernández-Estévez, Laura C. Bonifaz, Marco Antonio Alvarez-Perez, Gerardo Ramos-Mandujano

“…MSCs can be obtained from many different sources, and the present study compares the potential of neuronal transdifferentiation in MSCs from adult and neonatal sources (Wharton’s jelly (WhJ), dental pulp (DP), periodontal ligament (PDL), gingival tissue (GT), dermis (SK), placenta (PLAC), and umbilical cord blood (UCB)) with a protocol previously tested in bone marrow- (BM-) MSCs consisting of a cocktail of six small molecules: I-BET151, CHIR99021, forskolin, RepSox, Y-27632, and dbcAMP (ICFRYA). …”
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Near‐room‐temperature π‐conjugated nematic liquid crystals in molecules with a flexible seven‐membered ring structure by Riki Iwai, Hiroyuki Yoshida, Yuki Arakawa, Shunsuke Sasaki, Yuuto Iida, Kazunobu Igawa, Tsuneaki Sakurai, Satoshi Suzuki, Masatoshi Tokita, Junji Watanabe, Gen‐ichi Konishi

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Evaluation of the impact of antibody fragments on aggregation of intact molecules via size exclusion chromatography coupled with native mass spectrometry by Jing Xu, John E. Coughlin, Malgorzata Szyjka, Serene Jabary, Sonal Saluja, Zoran Sosic, Yunqiu Chen, Chong-Feng Xu

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A Green Approach to the Production of Hybrid Diindolylmethane-Phenylboronic Acids via a 3MCR: Promising Antineoplasic Molecules by Mónica Zarco Juarez, Joel Omar Martínez, Olivia Noguez Cordova, María Inés Nicolás Vazquez, Teresa Ramírez-Apan, Javier Pérez Flores, René Miranda Ruvalcaba, Gabriel Arturo Arroyo Razo

“…During the FAB+ MS determinations, various artifacts that are associated with the boron atom via an interaction with thioglycerol from the matrix were noted in the corresponding FAB+ mass spectra; in addition, the accurate mass determination of these adducts unequivocally confirmed the presence of the target molecules. Moreover, the activity of these target molecules was evaluated in the presence of six cancer cell lines (U251 = glia of the central nerve system, PC-3 = prostate, K562 = leukemia, HCT-15 = colon, MCF-7 = breast, and SKLU-1 = lung), which resulted in the meta-regioisomer being the most active. …”
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Investigating Raman peak enhancement in carboxyl-rich molecules: insights from Au@Ag core-shell nanoparticles in colloids by Junhao Chen, Zhengjia Chen, Tong Liang, Zhennan Zhang, Dahang Cheng, Shurui Liu, Haiyang Liu, Cuicui Liu, Xiaohui Song

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Interaction of Phospholipid, Cholesterol, Beta-Carotene, and Vitamin C Molecules in Liposome-Based Drug Delivery Systems: An In Silico Study by D. Hudiyanti, V. N. R. Putri, Y. Hikmahwati, S. M. Christa, P. Siahaan, D. S. B. Anugrah

“…The formation of noncovalent interactions indicates that the liposomal structures from phospholipid molecules will not result in chemical changes to the drug or any molecules encapsulated within. …”
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When Photoelectrons Meet Gas Molecules: Determining the Role of Inelastic Scattering in Ambient Pressure X‑ray Photoelectron Spectroscopy by Haoyi Li, Asmita Jana, Angel T. Garcia-Esparza, Xiang Li, Corey J. Kaminsky, Rebecca Hamlyn, Rajiv Ramanujam Prabhakar, Harry A. Atwater, Joel W. Ager, Dimosthenis Sokaras, Junko Yano, Ethan J. Crumlin

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