2019–2020 Florida Citrus Production Guide: Exocortis, Cachexia, and Other Viroids by Ozgur Batuman, Amit Levy, Ronald H. Brlansky

“…Viroids are small, infectious circular-RNA molecules. Exocortis causes dwarfing and bark scaling on rootstocks such as trifoliate orange and many of its hybrids such as Carrizo citrange, Rangpur lime, and others. …”
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Facts about Antioxidants by Kaitlin G. Clark, Wendy J. Dahl

“…Chemical reactions necessary for life are constantly occurring inside our cells, and sometimes they create free radicals — highly reactive molecules that can initiate damaging chain reactions known as oxidative stress. …”
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Metabolism of bile acids, liver diseases and microbiome by Yu. V. Yevsyutina, V. T. Ivashkin

“…Bile acids are important signaling molecules that regulate lipid and glucose metabolism. …”
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Biotechnological tools boost the functional diversity of DNA-based data storage systems by Xiaoyuan Xu, Wen Wang, Zhi Ping

“…We summarize the recent progress of how biotechnological tools, based on sequence specificity, encapsulation, and high-dimensional structures of DNA molecules, facilitate the implementation of various functions. …”
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Immune profiling of human vestibular schwannoma secretions identifies TNF-α and TWEAK as cytokines with synergistic potential to impair hearing by Sasa Vasilijic, Richard Seist, Zhenzhen Yin, Lei Xu, Konstantina M. Stankovic

“…Methods To identify effector molecules involved in VS-induced SNHL, we analyzed 47 immune-related factors secreted by tumor tissue in over 50 patients with sporadic VS and studied their correlation with preoperative hearing ability and tumor size. …”
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A review of quorum-sensing and its role in mediating interkingdom interactions in the ocean by Megan Coolahan, Kristen E. Whalen

“…In this review, we examine how these molecules mediate communication between bacteria and marine eukaryotes; influencing processes such as development, disease pathogenesis, and microbiome regulation within marine ecosystems. …”
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Identification of new ClpC1-NTD binders for Mycobacterium tuberculosis drug development by Katharina Weinhäupl, Louis Meuret, Sandy Desrat, Fanny Roussy, Nelly Morellet, Sandra Beaupierre, Catherine Guillou, Carine van Heijenoort, Olga Abian, Sonia Vega, Ian Wolf, Tatos Akopian, Olga Krandor, Eric Rubin, Adrian Velazquez-Campoy, Diego Gauto, Hugo Fraga

“…While the pharmacological properties of these natural product antibiotics prevent their use in the clinic, similar molecules binding to the same binding pockets can result in new drugs against Mtb. …”
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Metabolomic profiles as a new understanding of disease processes by O. Yu. Zolnikova, M. S. Reshetova, M. N. Ivanova, V. T. Ivashkin

“…A new diagnostic direction is associated with high-sensitive spectral analysis of biomarker molecules. This review will discuss some of the latest advances with an emphasis on the use of metabolomics to identify major metabolic changes in various diseases. …”
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Unveiling the wonders of bacteria-derived extracellular vesicles: From fundamental functions to beneficial applications by Mariam Rima, Mariam Dakramanji, Elie El Hayek, Tia El Khoury, Ziad Fajloun, Mohamad Rima

“…EVs manage numerous physiological processes by transferring bioactive molecules, including proteins, lipids, and nucleic acids, between cells. …”
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A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs. by Jia Li, Ruoling Bai, Yulian Zhou, Xu Song, Ling Li

“…By acting as critical molecules, the nuclear-encoded lncRNAs (nulncRNAs) have been implicated in the nucleus-to-mitochondria anterograde regulation. …”
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Enzyme-secretory activity of digestive glands: non-conventional approach by G. F. Korotko

“…Endosecreted, exosecreted and resorbed enzymes of digestive glands play role not only as accelerators of nutrient hydrolysis, but also signal molecules in modulation of alimentiry and nondigestive body functions. …”
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Breaking the biofilm barrier: Juglone derivatives as dual-action inhibitors and anti-quorum sensing agents by Muhammad Abdullah Bhatti, Atif Ali Khan Khalil, Sayed Muhammad Ata Ullah Shah Bukhari, Faisal Hanif, Mi-Jeong Ahn, Sumra Wajid Abbasi, Nazir Ahmed Lone, Wen-Jun Li, Wasim Sajjad

“…Furthermore, all three ligand molecules were docked into the binding site of the S. aureus coagulase protein. …”
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TCF1-positive and TCF1-negative TRM CD8 T cell subsets and cDC1s orchestrate melanoma protection and immunotherapy response by Saraí G De León-Rodríguez, Cristina Aguilar-Flores, Julián A Gajón, Ángel Juárez-Flores, Alejandra Mantilla, Raquel Gerson-Cwilich, José Fabián Martínez-Herrera, Diana Alejandra Villegas-Osorno, Claudia T Gutiérrez-Quiroz, Sergio Buenaventura-Cisneros, Mario Alberto Sánchez-Prieto, Edmundo Castelán-Maldonado, Samuel Rivera Rivera, Ezequiel M Fuentes-Pananá, Laura C Bonifaz

“…Notably, these TCF1− TRMs express cytotoxic molecules and are associated with apoptotic melanoma cells. …”
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Biological therapy for inflammatory bowel disease: cyclical rather than lifelong treatment? by Christian Philipp Selinger, Konstantina Rosiou, Marco V Lenti

“…There are now multiple biologics and increasingly novel small molecules licensed for the treatment of IBD. Treatment guidelines highlight the need for effective control of inflammation and early escalation to advanced therapies to avoid long-term complications. …”
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The tetracycline resistome is shaped by selection for specific resistance mechanisms by each antibiotic generation by Kevin S. Blake, Yao-Peng Xue, Vincent J. Gillespie, Skye R. S. Fishbein, Niraj H. Tolia, Timothy A. Wencewicz, Gautam Dantas

“…Abstract The history of clinical resistance to tetracycline antibiotics is characterized by cycles whereby the deployment of a new generation of drug molecules is quickly followed by the discovery of a new mechanism of resistance. …”
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Intestinal Permeability Assays: a Review by A. A. Iakupova, S. R. Abdulkhakov, R. K. Zalyalov, A. G. Safin, R. A. Abdulkhakov

“…The intestinal barrier integrity and permeability assays differ by the application setting (in vivo or ex vivo), subject (human or animal), marker molecules used to assess permeability (ions, various size carbohydrates, macromolecules, antigens, bacterial products and bacteria), biomaterial for the marker concentration assays (peripheral blood, portal venous blood, urine, stool). …”
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IL-23 tunes inflammatory functions of human mucosal-associated invariant T cells by Laetitia Camard, Tharshana Stephen, Hanane Yahia-Cherbal, Vincent Guillemot, Sébastien Mella, Victoire Baillet, Hélène Lopez-Maestre, Daniele Capocefalo, Laura Cantini, Claire Leloup, Julie Marsande, Katherine Garro, Juan Sienes Bailo, Ambre Dangien, Natalia Pietrosemoli, Milena Hasan, Huimeng Wang, Sidonia B.G. Eckle, Anne M. Fourie, Carrie Greving, Barbara Joyce-Shaikh, Raphaelle Parker, Daniel J. Cua, Elisabetta Bianchi, Lars Rogge

“…IL-23, in particular, affects key molecules and pathways related to autoimmunity and cytotoxic functions. …”
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Divergent alkynylative difunctionalization of amide bonds through C–O deoxygenation versus C–N deamination by Feng Liu, Xueyuan Yan, Fangfang Cai, Wenjuan Hou, Jianyu Dong, Shuang-Feng Yin, Genping Huang, Tieqiao Chen, Michal Szostak, Yongbo Zhou

“…The particularly wide substrate scope, including late-stage modification of bioactive molecules, demonstrates its potential broad applications in organic synthesis.…”
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An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice by Xiaojuan Wang, Guohui Zhang, Zhiwei Bian, Vimanda Chow, Marina Grimaldi, Coralie Carivenc, Savannah Sirounian, Hao Li, Lucia Sladekova, Stefano Mott, Yulia Luperi, Yufeng Gong, Cait Costello, Linhao Li, Matthew Jachimowicz, Miao Guo, Shian Hu, Derek Wilson, Patrick Balaguer, William Bourguet, Sridhar Mani, Laura Bonati, Hui Peng, John March, Hongbing Wang, Shengpeng Wang, Henry M. Krause, Jiabao Liu

“…Abstract The literature documenting the value of drug-like molecules found in natural products is vast. Although many dietary and herbal remedies have been found to be effective for treating intestinal inflammation, the identification of their active components has lagged behind. …”
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Vaccine adjuvants for immunotherapy: type, mechanisms and clinical applications by Nimeet Desai, Sherrin Gotru, Sagar Salave, Lalitkumar K. Vora

“…We explore a range of innovative agents, including non-inflammatory nucleic acid adjuvants, bacterial derivatives, and synthetic molecules, which are redefining the role of adjuvants in immunotherapy. …”
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