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  1. 101

    OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma by Kinjal Desai, Siyi Wanggou, Erika Luis, Heather Whetstone, Chunying Yu, Robert J. Vanner, Hayden J. Selvadurai, Lilian Lee, Jinchu Vijay, Julia E. Jaramillo, Jerry Fan, Paul Guilhamon, Michelle Kushida, Xuejun Li, Gregory Stein, Santosh Kesari, Benjamin D. Simons, Xi Huang, Peter B. Dirks

    Published 2025-02-01
    “…Targeting this rare OLIG2-driven proliferative programme with a small molecule inhibitor, CT-179, dramatically attenuates early tumour formation and tumour regrowth post-therapy, and significantly increases median survival in vivo. …”
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  2. 102

    Lunar and Martian gravity alter immune cell interactions with endothelia in parabolic flight by Yu Du, Bing Han, Katharina Biere, Nathalie Abdelmalek, Xinyu Shu, Chaoyang Song, Guangyao Chen, Ning Li, Marina Tuschen, Huan Wu, Shujin Sun, Alexander Choukér, Mian Long, Dominique Moser

    Published 2025-02-01
    “…Focus was set on floating speed, cell adhesion, surface molecule expression and cytoskeletal reorganization under basal and TNF-induced inflammatory environment. …”
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  3. 103

    Physics for Scientists and Engineers with Modern physics / by Giancoli, Douglas C.

    Published 2008
    Table of Contents: “…Introduction, measurement, estimating -- Mechanics -- Describing motion -- Kinematics in two or three dimensions -- Dynamics -- Using Newton's laws -- Gravitation and Newton's synthesis -- Work and energy -- Conservation of energy -- Linear momentum -- Rotational motion -- Angular momentum -- Static equilibrium -- Fluids, vibrations, waves, sound -- Fluids -- Oscillations -- Wave motion -- Sound -- Kinetic theory and thermodynamics -- Temperature, thermal expansion, and the ideal gas law -- Kinetic theory of gases -- Heat and the first law of thermodynamics -- Second law of thermodynamics -- Electricity and magnetism -- Electric charge and electric field -- Gauss's law -- Electric potential -- Capacitance, dielectrics, electric energy storage -- Electric currents and resistance -- DC circuits -- Magnetism -- Sources of magnetic field -- Electromagnetic induction and faraday's Law -- Inductance, electromagnetic oscillations -- Maxwell's equations and electromagnetic waves -- Light -- Lenses and optical instruments -- The wave nature of light -- Diffraction and polarization -- Modern physics -- Special theory of relativity -- Early quantum theory and models of the atom -- Quantum mechanics -- Quantum mechanics of atoms -- Molecules and solids -- Nuclear physics and radioactivity -- Nuclear energy -- Elementary particles -- Astrophysics and cosmology.…”
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  4. 104

    CD32B1, a versatile non-signaling antibody-binding scaffold for enhanced T cell adhesion to tumor stromal cognate antigens by Sara W. Feigelson, Tali Dadosh, Nehora Levi, Anita Sapoznikov, Hadas Weinstein-Marom, Hadas Weinstein-Marom, Dayana Blokon-Kogan, Dayana Blokon-Kogan, Yahel Avraham, Tamar Unger, Gideon Gross, Gideon Gross, Rony Dahan, Ronen Alon

    Published 2025-02-01
    “…To broaden the utility of this scaffold, we have also generated a new fusion protein in which the entire Fc binding domain was truncated (tILCD32B1) and replaced with a monomeric streptavidin variant, mSA2, via a CD8 hinge. The molecule, termed mSA2-CD8h-tILCD32B1, was also successfully expressed in T cells, readily and stably bound biotinylated IgG mAbs in vitro and once decorated with the biotin labeled mAbs, conferred the T cells with high adhesiveness to multiple surface-coated antigens. mSA2-CD8h-tILCD32B1 expressing human T cells decorated ex vivo with a biotin-labeled mAb retained the antibody for hours after accumulation inside breast tumors implanted in immunodeficient recipient mice. …”
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  5. 105

    Frk positively regulates innate antiviral immunity by phosphorylating TBK1 by Xiaomei Zhang, Ying You, Tingrong Xiong, Tingrong Xiong, Xiaokai Zhang, Haibo Wang, Jinxia Geng, Miao Wang, Yanyan Xu, Shanshan Gao, Shanshan Gao, Xiaoyan Wu, Yue Zheng, Xianhua Wen, Haoyu Yang, Yu Wang, Yu Wang, Xiaohua Wen, Congcong Zhao

    Published 2025-02-01
    “…In this study, we validated the function of Fyn-related kinase (Frk) in the antiviral innate immune response and identified the direct target molecule of Frk in the IFN-β signaling pathway. Furthermore, we elucidated the mechanism by which Frk phosphorylates TBK1 during infection and the role of Frk in IFN-β production. …”
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  6. 106

    Sensitive Detection of Lasalocid Residue in Chicken by Surface Enhanced Raman Spectroscopy by Yao WANG, Yingying SUN, Yubing JING, Xiyan YANG, Yanfei LI, Jiaxiang HUANG, Xiujin CHEN, Zhaozhou LI, Li CAO, Huaibin KANG

    Published 2025-02-01
    “…In this study, gold nanoparticles (AuNPs) with different particle sizes were first prepared, AuNPs with the optimal particle size were selected as the substrate according to SERS effect, and 4-aminophenthiophenol (PATP) was used as the probe molecule to evaluate the recurrence of AuNPs substrate. …”
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  7. 107

    A novel high-throughput screen identifies phenazine-1-carboxylic acid as an inhibitor of African swine fever virus replication in primary porcine alveolar macrophages by Jing Lan, Rui Luo, Di Liu, Changxing Qi, Xin Song, Zhanhao Lu, Ruojia Huang, Yuying Yang, Yuan Sun, Yonghui Zhang, Tao Wang, Hua-Ji Qiu

    Published 2025-02-01
    “…Using the HTS platform established with rASFV-Gluc/EGFP, we screened and identified phenazine-1-carboxylic acid (PCA) as an effective inhibitor of ASFV replication from 246 small molecule compounds in PAMs. Importantly, PCA was found to reduce ASFV replication by as much as 100-fold at a concentration of 25 μM. …”
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  8. 108

    Modulating the sulfurization procedure to decrease by-product formation for one-step catalytic synthesis of sulfur-containing chemicals by ZhiZhi Xu, Jian Fang, Min Luo, Dedong He, Dingkai Chen, Jichang Lu, Yongming Luo

    Published 2025-04-01
    “…Otherwise, the strong bonding of Mo-S(O) bond with CO molecule over K-decorated 2H-MoS2 phase can lead to the breakage of CO bond, promoting the formation of CHx species and the occurrence of methanation side reaction. …”
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  9. 109

    Exometabolomic exploration of culturable airborne microorganisms from an urban atmosphere by R. Jin, W. Hu, W. Hu, P. Duan, M. Sheng, D. Liu, Z. Huang, M. Niu, L. Wu, J. Deng, P. Fu, P. Fu

    Published 2025-02-01
    “…These microbial exometabolites predominantly comprised aliphatic/peptide-like and carboxyl-rich alicyclic molecule (CRAM)-like compounds. Significant variations in metabolites were observed among different microbial strains. …”
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  10. 110

    Neuroprotective role of epigallocatechin-3-gallate, albeginin and melanoxetin in alzheimer's disease by Arif Malik, Mehreen Hassan, Sulayman Waquar, Muhammad Wasim, Anam Naz, Faryal M. Awan, Muhammad T. Khan, Ali I. Khawaja, Sumera Zaib, Jamshed Iqbal, Ayesha Zahid, Marvi Marvi, Javeid Iqbal, Heng Wang, Dong-Qing Wei

    Published 2025-02-01
    “…Melanoxetin, a phenolic molecule, chelates toxic metals, lowers ROS, and protects neurons at 15–40 mg/kg/day in animal models and 50–150 mg/day in humans. …”
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  11. 111
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  14. 114

    Long non-coding RNA involved in the carcinogenesis of human female cancer - a comprehensive review by Nazia Afroze, Madhumitha K. Sundaram, Shafiul Haque, Arif Hussain

    Published 2025-02-01
    “…Several phytochemicals, small molecules, RNA-based regulators, oligos and gene editing tools show promise as a therapeutic strategy. …”
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  15. 115

    Identification and prioritization of novel therapeutic candidates against glutamate racemase from Klebsiella pneumoniae. by Ankit Kumar, Farah Anjum, Md Imtaiyaz Hassan, Anas Shamsi, Rashmi Prabha Singh

    Published 2025-01-01
    “…The binding free energy values, which came out to be -27.26±3.06 kcal/mol and -29.53±4.29 kcal/mol for Z1542321346 and Z2356864560 molecules, respectively, favoured these molecules in terms of inhibition potential towards targeted protein.…”
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  16. 116

    Finding the best column for polar basic analytes across reversed-phase and hydrophilic interaction liquid chromatography by József Simon, Márton Kovács, Pál T. Szabó

    Published 2025-02-01
    “…On the other hand, these types of molecules can behave vastly differently despite their similarities. …”
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  17. 117

    Two mechanisms of membrane digestion: enzymatic-transport ensemble exists by S. T. Metelsky, V. T. Ivashkin

    Published 2010-11-01
    “…In enterocyte brush border of animals there is enzymatic-transport ensemble splitting molecules of maltose in two molecules of glucose which are immediately transferred to transport system entrance (A.M. …”
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  18. 118

    Quest and designing of organic molecular frameworks for efficient hole transport materials by Priya Singh, Aditya Kumar, Ajeet Singh

    Published 2025-04-01
    “…We have also performed time-dependant density functional theory (TD-DFT) calculations to investigate the optical, electronic and charge transport properties of designed molecules. Calculated results infer that the designed molecules display characteristic traits of a HTM. …”
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  19. 119
  20. 120

    Approved antibacterial drugs in the last 10 years: from the bench to the clinic by Miguel García-Castro, Francisco Sarabia, Amelia Díaz-Morilla, Juan Manuel López-Romero

    Published 2023-06-01
    “…A focus will be made on studies describing the structure and activity of the organic molecules and their interactions with their respective biological targets.…”
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