Suggested Topics within your search.
Suggested Topics within your search.
- Physics 1
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101
OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma
Published 2025-02-01“…Targeting this rare OLIG2-driven proliferative programme with a small molecule inhibitor, CT-179, dramatically attenuates early tumour formation and tumour regrowth post-therapy, and significantly increases median survival in vivo. …”
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102
Lunar and Martian gravity alter immune cell interactions with endothelia in parabolic flight
Published 2025-02-01“…Focus was set on floating speed, cell adhesion, surface molecule expression and cytoskeletal reorganization under basal and TNF-induced inflammatory environment. …”
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103
Physics for Scientists and Engineers with Modern physics /
Published 2008Table of Contents: “…Introduction, measurement, estimating -- Mechanics -- Describing motion -- Kinematics in two or three dimensions -- Dynamics -- Using Newton's laws -- Gravitation and Newton's synthesis -- Work and energy -- Conservation of energy -- Linear momentum -- Rotational motion -- Angular momentum -- Static equilibrium -- Fluids, vibrations, waves, sound -- Fluids -- Oscillations -- Wave motion -- Sound -- Kinetic theory and thermodynamics -- Temperature, thermal expansion, and the ideal gas law -- Kinetic theory of gases -- Heat and the first law of thermodynamics -- Second law of thermodynamics -- Electricity and magnetism -- Electric charge and electric field -- Gauss's law -- Electric potential -- Capacitance, dielectrics, electric energy storage -- Electric currents and resistance -- DC circuits -- Magnetism -- Sources of magnetic field -- Electromagnetic induction and faraday's Law -- Inductance, electromagnetic oscillations -- Maxwell's equations and electromagnetic waves -- Light -- Lenses and optical instruments -- The wave nature of light -- Diffraction and polarization -- Modern physics -- Special theory of relativity -- Early quantum theory and models of the atom -- Quantum mechanics -- Quantum mechanics of atoms -- Molecules and solids -- Nuclear physics and radioactivity -- Nuclear energy -- Elementary particles -- Astrophysics and cosmology.…”
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104
CD32B1, a versatile non-signaling antibody-binding scaffold for enhanced T cell adhesion to tumor stromal cognate antigens
Published 2025-02-01“…To broaden the utility of this scaffold, we have also generated a new fusion protein in which the entire Fc binding domain was truncated (tILCD32B1) and replaced with a monomeric streptavidin variant, mSA2, via a CD8 hinge. The molecule, termed mSA2-CD8h-tILCD32B1, was also successfully expressed in T cells, readily and stably bound biotinylated IgG mAbs in vitro and once decorated with the biotin labeled mAbs, conferred the T cells with high adhesiveness to multiple surface-coated antigens. mSA2-CD8h-tILCD32B1 expressing human T cells decorated ex vivo with a biotin-labeled mAb retained the antibody for hours after accumulation inside breast tumors implanted in immunodeficient recipient mice. …”
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105
Frk positively regulates innate antiviral immunity by phosphorylating TBK1
Published 2025-02-01“…In this study, we validated the function of Fyn-related kinase (Frk) in the antiviral innate immune response and identified the direct target molecule of Frk in the IFN-β signaling pathway. Furthermore, we elucidated the mechanism by which Frk phosphorylates TBK1 during infection and the role of Frk in IFN-β production. …”
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106
Sensitive Detection of Lasalocid Residue in Chicken by Surface Enhanced Raman Spectroscopy
Published 2025-02-01“…In this study, gold nanoparticles (AuNPs) with different particle sizes were first prepared, AuNPs with the optimal particle size were selected as the substrate according to SERS effect, and 4-aminophenthiophenol (PATP) was used as the probe molecule to evaluate the recurrence of AuNPs substrate. …”
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107
A novel high-throughput screen identifies phenazine-1-carboxylic acid as an inhibitor of African swine fever virus replication in primary porcine alveolar macrophages
Published 2025-02-01“…Using the HTS platform established with rASFV-Gluc/EGFP, we screened and identified phenazine-1-carboxylic acid (PCA) as an effective inhibitor of ASFV replication from 246 small molecule compounds in PAMs. Importantly, PCA was found to reduce ASFV replication by as much as 100-fold at a concentration of 25 μM. …”
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108
Modulating the sulfurization procedure to decrease by-product formation for one-step catalytic synthesis of sulfur-containing chemicals
Published 2025-04-01“…Otherwise, the strong bonding of Mo-S(O) bond with CO molecule over K-decorated 2H-MoS2 phase can lead to the breakage of CO bond, promoting the formation of CHx species and the occurrence of methanation side reaction. …”
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109
Exometabolomic exploration of culturable airborne microorganisms from an urban atmosphere
Published 2025-02-01“…These microbial exometabolites predominantly comprised aliphatic/peptide-like and carboxyl-rich alicyclic molecule (CRAM)-like compounds. Significant variations in metabolites were observed among different microbial strains. …”
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110
Neuroprotective role of epigallocatechin-3-gallate, albeginin and melanoxetin in alzheimer's disease
Published 2025-02-01“…Melanoxetin, a phenolic molecule, chelates toxic metals, lowers ROS, and protects neurons at 15–40 mg/kg/day in animal models and 50–150 mg/day in humans. …”
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111
Ultrasensitive interferons quantification reveals different cytokine profile secretion in inflammatory myopathies and can serve as biomarkers of activity in dermatomyositis
Published 2025-02-01“…Patients were classified as active if PGA>5.Serum IFN-α and IFN-γ levels was measured using the single molecule array (SIMOA) technique. Serum IFN-β level was measured by Elisa. …”
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Ultrafast emergence of ferromagnetism in antiferromagnetic FeRh in high magnetic fields
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114
Long non-coding RNA involved in the carcinogenesis of human female cancer - a comprehensive review
Published 2025-02-01“…Several phytochemicals, small molecules, RNA-based regulators, oligos and gene editing tools show promise as a therapeutic strategy. …”
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115
Identification and prioritization of novel therapeutic candidates against glutamate racemase from Klebsiella pneumoniae.
Published 2025-01-01“…The binding free energy values, which came out to be -27.26±3.06 kcal/mol and -29.53±4.29 kcal/mol for Z1542321346 and Z2356864560 molecules, respectively, favoured these molecules in terms of inhibition potential towards targeted protein.…”
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116
Finding the best column for polar basic analytes across reversed-phase and hydrophilic interaction liquid chromatography
Published 2025-02-01“…On the other hand, these types of molecules can behave vastly differently despite their similarities. …”
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117
Two mechanisms of membrane digestion: enzymatic-transport ensemble exists
Published 2010-11-01“…In enterocyte brush border of animals there is enzymatic-transport ensemble splitting molecules of maltose in two molecules of glucose which are immediately transferred to transport system entrance (A.M. …”
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118
Quest and designing of organic molecular frameworks for efficient hole transport materials
Published 2025-04-01“…We have also performed time-dependant density functional theory (TD-DFT) calculations to investigate the optical, electronic and charge transport properties of designed molecules. Calculated results infer that the designed molecules display characteristic traits of a HTM. …”
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119
Molecular basis for azetidine-2-carboxylic acid biosynthesis
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120
Approved antibacterial drugs in the last 10 years: from the bench to the clinic
Published 2023-06-01“…A focus will be made on studies describing the structure and activity of the organic molecules and their interactions with their respective biological targets.…”
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