Suggested Topics within your search.
Suggested Topics within your search.
- Physics 1
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4441
Effects of polyamines and indole on the expression of ribosome hibernation factors in <i>Escherichia coli</i> at the translational level
Published 2024-03-01“…Polyamines and indole are small regulatory molecules that are involved in the adaptation to stress in bacteria, including the regulation of gene expression. …”
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4442
Extracellular Vesicles in Periodontitis: Pathogenic Mechanisms and Therapeutic Potential
Published 2025-01-01“…They play a key role in intercellular communication by transporting multiple signaling molecules. Recent research has indicated that EVs derived from periodontal pathogens can trigger periodontitis, exacerbate the periodontal damage, and potentially disseminate to other parts of the body, leading to systemic conditions. …”
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4443
Plasma microRNA signatures predict prognosis in canine osteosarcoma patients.
Published 2024-01-01“…MicroRNAs (miRNAs) are small molecules present in all tissues and bodily fluids and are dysregulated in cancer. …”
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4444
Effectiveness of Contrast Agents and Molecular Indicators in Alzheimer's Diagnosis Through PET and SPECT Imaging on Animal Models
Published 2025-01-01“…Early detection and diagnosis of AD are crucial, but current research on the effectiveness of contrast agents and molecules is limited. To address this gap, we conducted a comprehensive study on PET and SPECT imaging to evaluate the role of these agents and indicators in diagnosing the disorder. …”
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4445
A graph neural network approach for hierarchical mapping of breast cancer protein communities
Published 2025-01-01“…Then, a group-lasso algorithm was applied to identify protein communities that are under both mutation burden and survival burden, undergo significant alterations when targeted by specific drug molecules, and show cancer-dependent perturbations. …”
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4446
Zinc oxide seed priming enhances drought tolerance in wheat seedlings by improving antioxidant activity and osmoprotection
Published 2025-01-01“…Experimental and computational methods (time-dependent density functional theory (TD-DFT)) were employed to perform IR and XRD analyses of the isolated molecules of the ZnO NPs/Iso. In conclusion, the application of ZnO NPs or bulk ZnO was found to create effective mechanical and physiological barriers, as confirmed by the analysis of antioxidant enzyme activities, nonenzymatic components, free radical scavenging, and osmoprotectant constituents.…”
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4447
Different MHC class I cell surface expression levels in diverse chicken lines, associations with B blood group, and proposed relationship to antigen-binding repertoire
Published 2025-01-01“…In our study, erythrocytes from 6 diverse and highly inbred lines of chickens, a closed broiler line, and a highly advanced intercross line were evaluated for MHC class I antigen expression level by flow cytometry using monoclonal antibodies to chicken MHC class I molecules. In chickens, the B blood group antigens include the MHC class I antigen expressed from the MHC. …”
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4448
Killer-Cell Immunoglobulin-Like Receptors (KIR) in HIV-Exposed Infants in Cameroon
Published 2021-01-01“…This may be partly due to differences in host immunogenetic factors in highly polymorphic regions of the human genome such as those encoding the killer-cell immunoglobulin-like receptor (KIR) molecules which modulate the activities of natural killer cells. …”
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4449
Sm10.3, a member of the micro-exon gene 4 (MEG-4) family, induces erythrocyte agglutination in vitro and partially protects vaccinated mice against Schistosoma mansoni infection.
Published 2014-03-01“…Among the most promising molecules are the proteins present in the tegument and digestive tract of the parasite.…”
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4450
Relationship between the Molecular Coil Dimension and the Energy Storage Modulus of Polymer Solution Configured with Oilfield-Produced Sewage
Published 2020-01-01“…The elasticity characteristics of the polymer solution are sensitive to the molecular coil dimension. As Dh of polymer molecules becomes larger, the contribution of the elastic portion to the viscosity of the polymer solution increases. …”
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4451
In silico analysis of SNPs and miRNAs of KCTD13, CSDE1, SLC6A1 genes associated with autism spectrum disorder
Published 2025-01-01“…Micro-RNAs (miRNAs) are short, non-coding RNA molecules that control gene expression after transcription. …”
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4452
Timosin alpha-1 immunomodulating properties
Published 2009-02-01“…Direct antiviral mechanism of Timosin alpha-1 consists in increase of expression of major histocompatibility complex molecules of the 1st class on infected cells and direct suppression of virus replication, and also in elevation of endocellular level of glutathione. …”
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4453
Myocardin-Related Transcription Factor A (MRTF-A) Regulates the Balance between Adipogenesis and Osteogenesis of Human Adipose Stem Cells
Published 2020-01-01“…To study the role of MRTF-A activity in the differentiation process, hASCs were cultured in adipogenic and osteogenic media supplemented with inhibitor molecules CCG-1423 or CCG-100602 that have been shown to block the expression of MRTF-A/SRF-activated genes. …”
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4454
Extracellular domain of TREM2 possess two distinct ligand recognition sites: Insights from machine-learning guided docking and all-atoms molecular dynamics simulations
Published 2025-01-01“…Our knowledge-based and machine-learning guided docking and physics-based simulations study unveils deep insights into the endogenous ligand recognition by the positive surface ligand binding site and distant core site pave the way for exploration of other small molecules towards development of novel therapeutics against Alzheimer's disease.…”
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4455
Integrated microRNA and mRNA signatures associated with overall survival in epithelial ovarian cancer.
Published 2021-01-01“…MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression primarily by targeting messenger RNA (mRNA) transcripts. …”
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4456
Pathogenetic therapeutic approaches for endocrine diseases based on antisense oligonucleotides and RNA-interference
Published 2025-01-01“…We also provide an overview of currently developed and available antisense molecules, and describe potentials of antisense-based therapeutics for the treatment of rare and «ultrarare» endocrine diseases.…”
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4457
Cost-effective adsorption of cationic dyes using ZnO nanorods supported by orange peel-derived carbon
Published 2025-02-01“…The calculated adsorption free energy from D-R and Temkin models indicates the adsorption of MB, and CV dye molecules by the OP, PC, and ZnO-NR@PC composite may be physical. …”
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4458
Exploring Clec9a in dendritic cell-based tumor immunotherapy for molecular insights and therapeutic potentials
Published 2025-02-01“…This novel approach leverages Clec9a’s capacity to improve the precision and efficacy of these immunomodulatory molecules in tumor treatment. In summary, this review presents compelling evidence positioning Clec9a as a promising target for DC-based tumor immunotherapy, capable of enhancing the efficacy of vaccines and immune responses while minimizing adverse effects.…”
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4459
Exploring advanced nanostructures and functional materials for efficient hydrogen storage: a theoretical investigation on mechanisms, adsorption process, and future directions
Published 2025-02-01“…Ni-decorated C12N12 nanoclusters demonstrate enhanced storage capacities, binding up to eight H2 molecules with a favorable N-(μ-Ni)-N configuration. …”
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4460
Synthesis, Characterization, and Evaluation of the Remediation Activity of Cissus quadrangularis Zinc Oxide Nanoparticle-Activated Carbon Composite on Dieldrin in Aqueous Solution
Published 2022-01-01“…The calculated thermodynamic parameters (ΔH°, ΔS°, and ΔG°) indicated that the adsorption was spontaneous and exothermic in nature, implying decreasing randomness of dieldrin molecules at the solid-liquid interface. The isotherm and adsorption kinetics for the composite showed that the absorption process followed Langmuir isotherm and pseudo-second-order kinetics. …”
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