Beyond Hormone Receptors: liquid biopsy tools to unveil new clinical meanings and empower therapeutic decision-making in Luminal-like metastatic breast cancer by Brenno Pastò, Riccardo Vida, Arianna Dri, Lorenzo Foffano, Serena Della Rossa, Lorenzo Gerratana, Fabio Puglisi

“…The present work aims to summarize the current evidence regarding the clinical meanings of hormone receptors and their downstream molecular pathways, alongside their implications for therapeutic decision-making in Luminal-like mBC.…”
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Biosynthetic Pathways and the Role of the Mas Receptor in the Effects of Angiotensin-(1–7) in Smooth Muscles by Marcio Augusto Fressatto de Godoy, Larissa Pernomian, Ana Maria de Oliveira, Satish Rattan

“…This paper provides an overview of the functional role and the molecular pathways involved in the biosynthesis and activity of Ang-(1–7) in diverse systems.…”
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Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2 by Chuangjiang Chen, Chenlong Wang, Hui Jiang, Mengya Wang, Sajid Ur Rahman, Changjiang Chen, Hongyan Ding, Chang Zhao, Wanyue Huang, Xichun Wang

“…This study investigates the molecular pathways by which rutin alleviates ZEA-induced ESC apoptosis, focusing on the role of Nrf2. …”
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Transcriptomic Approaches to Investigate the Anti-Aging Effects of Blueberry Anthocyanins in a Caenorhabditis Elegans Aging Model by Jie Ding, Jiahui Liu, Qingqi Guo, Na Zhang

“…Transcriptomic analysis was conducted to explore the regulatory effects of BA on anti-aging molecular pathways and key genes in <i>C. elegans</i>. Results showed a significant, dose-dependent extension of lifespan, improvement in locomotion and pharyngeal pumping rate, and reduction in lipofuscin and ROS accumulation. …”
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Cerebral Cavernous Malformation: From Genetics to Pharmacotherapy by Zhuangzhuang Zhang, Jianwen Deng, Weiping Sun, Zhaoxia Wang

“…Results Germline and somatic mutations mediate the onset and development of CCM through several molecular pathways. Medications such as statins, fasudil, rapamycin, and propranolol can alleviate CCM symptoms or hinder its progression by specifically modulating the corresponding targets. …”
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MicroRNA as a Potential Biomarker and Treatment Strategy for Ischemia-Reperfusion Injury by Mingming Cao, Wenjing Song, Runyu Liang, Lili Teng, Mei Zhang, Jiyao Zhang, Luwen Zhu

“…With growing evidence that microRNAs (miRNAs) play an important role as posttranscription gene silencing mediators in many I/R injury, in this review, we highlight the microRNAs that are related to I/R injury and their regulatory molecular pathways. In addition, we discussed the potential role of miRNA as a biomarker and its role as a target in I/R injury treatment. …”
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The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms by Wenli Jiao, Jiayi Lin, Yanfang Deng, Yelin Ji, Chuoyi Liang, Sijia Wei, Xi Jing, Fengxia Yan

“…Peripherally, systemic inflammation, gut immune dysregulation, and immune dysfunction in organs including gut, liver, spleen and adipose tissue influence brain function through neural and molecular pathways. Within the central nervous system, aberrant microglial and astrocytes activation, cytokine imbalances, and compromised blood-brain barrier integrity propagate neuroinflammation, disrupting neurotransmission, impairing neuroplasticity, and promoting neuronal injury. …”
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The heat of the battle: inflammation’s role in prostate cancer development and inflammation-targeted therapies by Ujjawal Sharma, Anidrisha Sahu, Himanshu Shekhar, Bunty Sharma, Shafiul Haque, Damandeep Kaur, Hardeep Singh Tuli, Astha Mishra, Faraz Ahmad

“…This review explores the complex relationship between inflammation and PC, examining the molecular pathways, genetic and environmental factors, and clinical implications involved in inflammation-driven carcinogenesis. …”
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Exosomal miRNAs involvement in pathogenesis, diagnosis, and treatment of rheumatoid arthritis by Mahvash Sadeghi, Jalil Tavakol Afshari, Afsane Fadaee, Mohammadreza Dashti, Fatemeh Kheradmand, Sajad Dehnavi, Mojgan Mohammadi

“…The initiation, and progression of RA involves multiple cellular and molecular pathways, and biological interactions. Micro RNAs (miRNAs) are characterized as a class of small non-coding RNAs that influence gene expression at the post-transcriptional level. …”
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Impact of the Ketogenic Diet on Neurological Diseases: A Review by Carmen Rubio, Alejandro López-Landa, Hector Romo-Parra, Moisés Rubio-Osornio

“…Conclusion: Multiple molecular mechanisms have been identified to explain the benefits of the KD in neurological diseases; however, further experimental and clinical studies are needed to address various molecular pathways in order to achieve conclusive results.…”
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Recent advances in pancreatic α-cell transdifferentiation for diabetes therapy by Yanjiao Li, Yanjiao Li, Jinyu Zhu, Congyang Yue, Siyuan Song, Limin Tian, Yi Wang, Yi Wang, Yi Wang

“…Future research directions include optimizing molecular pathways, enhancing transdifferentiation efficiency, and ensuring the long-term stability of β-cell identity. …”
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Exploring the Revolutionary Impact of YAP Pathways on Physical and Rehabilitation Medicine by Carmelo Pirri

“…However, the detailed molecular pathways through which these therapies interact with tissues and influence gene expression are not yet fully understood. …”
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Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation by Shahida A. Khan, Ashraf Ali, Sarah A. Khan, Solafa A. Zahran, Ghazi Damanhouri, Esam Azhar, Ishtiaq Qadri

“…Increases in mortality and morbidity in obesity related inflammation have initiated studies to explore different lipid mediated molecular pathways of attempting resolution that uncover newer therapeutic opportunities of anti-inflammatory components. …”
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Molecular Insights in the Anticancer Activity of Natural Tocotrienols: Targeting Mitochondrial Metabolism and Cellular Redox Homeostasis by Raffaella Chiaramonte, Giulia Sauro, Domenica Giannandrea, Patrizia Limonta, Lavinia Casati

“…Tocotrienols (TTs), specifically the δ- and γ-TT isoforms, are vitamin E-derived biomolecules widely shown to possess striking anticancer properties since they regulate several intracellular molecular pathways. Herein, we provide for the first time an overview of the mitochondrial metabolic reprogramming and redox homeostasis perturbation occurring in cancer cells, highlighting their involvement in the anticancer properties of TTs. …”
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Epigenetic Alterations in Bladder Cancer and Their Potential Clinical Implications by Han Han, Erika M. Wolff, Gangning Liang

“…The characterization of the genetic alterations associated with UC has revealed the presence of two mutually exclusive molecular pathways along which distinct genetic abnormalities contribute to the formation of invasive and noninvasive tumors. …”
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Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities by Jiarui Zhang, Jinan Zhang, Chen Yang

“…The discussion would focus on the molecular pathways that control autophagy in brain tumors, and its dual role as a tumor suppressor and a supporter of tumor survival. …”
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The Impact of COVID-19 on Gametes and Endometrium: A Narrative Review by Esra Karatas, Ali Can Gunes, Bilal Esat Temiz, Sezcan Mumusoglu, Gurkan Bozdag

“…Whereas the available data suggest that SARS-CoV-2 interferes with various types of molecular pathways in the oocyte, spermatozoa, and endometrium, the lack of co-expression in angiotensin-converting enzyme 2 and transmembrane protease serine 2 in those cell lines theoretically avoid concerns by patients and reproductive endocrinologists. …”
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Podocyturia: A Clue for the Rational Use of Amiloride in Alport Renal Disease by H. Trimarchi, R. Canzonieri, A. Muryan, A. Schiel, A. Araoz, M. Paulero, J. Andrews, T. Rengel, M. Forrester, F. Lombi, V. Pomeranz, R. Iriarte, E. Zotta

“…The present case illustrates the reduction rate of urinary podocyte loss and proteinuria after amiloride administration and suggests the molecular pathways involved in Alport renal disease. Finally, podocyturia rather than proteinuria should be considered as an earlier biomarker of kidney involvement and disease progression in Alport disease.…”
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Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology by Monica Neagu, Carolina Constantin, Marinela Bostan, Constantin Caruntu, Simona Rebeca Ignat, Sorina Dinescu, Marieta Costache

“…Proteomics has identified new molecular pathways of this process and brought important insights to develop new therapy targets. …”
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Epigenetics and Shared Molecular Processes in the Regeneration of Complex Structures by Labib Rouhana, Junichi Tasaki

“…While heterogeneity exists in the basic processes displayed during regenerative events in different species—most notably the cellular source contributing to formation of new tissue—activation of conserved molecular pathways is imperative for proper regulation of cells during regeneration. …”
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