Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

“…Relapse rates (RRs) post cessation, time to PD, rechallenge and disease control rate (DCR) after 2nd course were the main outcomes. Random-effects models were preferred, and subgroup and sensitivity analyses were conducted to investigate possible sources of heterogeneity.Results38 and 35 studies were included in qualitative and quantitative synthesis, respectively. …”
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An integrative analysis of ASCL1 in breast cancer and inhibition of ASCL1 increases paclitaxel sensitivity by activating ferroptosis via the CREB1/GPX4 axis by Xiaolu Yang, Xiaolu Yang, Yilun Li, Yilun Li, Yaqi Peng, Yuan Chang, Binglu He, Binglu He, Tianqi Zhang, Tianqi Zhang, Shiyu Zhang, Cuizhi Geng, Yunjiang Liu, Xiaolong Li, Jun Hao, Li Ma

“…Functional assays were conducted on BC cell lines MCF-7 and MDA-MB-231, and nude mouse models were used for in vivo studies.ResultsASCL1 was found to be upregulated in BC and correlated with unfavorable prognosis and mutations in key oncogenes. …”
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Comparison of objectively measured and estimated cardiorespiratory fitness to predict all-cause and cardiovascular disease mortality in adults: A systematic review and meta-analysi... by Ben Singh, Cristina Cadenas-Sanchez, Bruno G.G. da Costa, José Castro-Piñero, Jean-Philippe Chaput, Magdalena Cuenca-García, Carol Maher, Nuria Marín-Jiménez, Ryan McGrath, Pablo Molina-García, Jonathan Myers, Bethany Gower, Francisco B. Ortega, Justin J. Lang, Grant R. Tomkinson

“…Pooled relative risks (RR) for all-cause and CVD mortality per 1-MET (3.5 mL/kg/min) higher level of CRF were quantified using random-effects models. Results: Forty-two studies representing 35 cohorts and 3,813,484 observations (81% male) (362,771 all-cause and 56,471 CVD deaths) were included. …”
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Associations between Children’s Exposure to PM2.5 and their Serum Inflammatory Responses in Taiwan by Wei-Jung Tseng, Jian-He Lu, How-Ran Chao, Ming-Hsien Tsai, Yu-Ting Chang, Liang-Jen Wang, Chih-Cheng Chen, Wan-Nurdiyana-Wan Mansor, Juliana Jalaludin, Chih-Lung Wang, Ying-I Tsai

“…Abstract PM2.5-induced inflammation have been demonstrated in the cellular and animal models, but few studies reported the associations of schoolchildren exposure to PM2.5 with their serum inflammatory biomarkers. …”
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Biointegration of soft tissue-inspired hydrogels on the chorioallantoic membrane: An experimental characterization by Manuel P. Kainz, Mathias Polz, Daniel Ziesel, Marta Nowakowska, Muammer Üçal, Sabine Kienesberger, Sophie Hasiba-Pappas, Raimund Winter, Nassim Ghaffari Tabrizi-Wizsy, Sarah Kager, Theresa Rienmüller, Julia Fuchs, Michele Terzano, Christian Baumgartner, Gerhard A. Holzapfel

“…CAM assays, as an alternative to traditional in vivo models, enabled the evaluation of the compatibility, attachment, and biointegration of hydrogels with three distinct compositions. …”
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Association of pre- and post-diagnosis dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) with overall survival in patients with ovarian cancer... by Dong-Dong Wang, Ming-Qian Jia, He-Li Xu, Yu Li, Jia-Xin Liu, Jia-Cheng Liu, Jia-Nan Sun, Fan Cao, Lang Wu, Fang-Hua Liu, Yi-Zi Li, Yi-Fan Wei, Xiao-Ying Li, Qian Xiao, Song Gao, Dong-Hui Huang, Tao Zhang, Ting-Ting Gong, Qi-Jun Wu

“…Multivariable Cox proportional-hazards models were applied to calculate the hazard ratios (HR) and 95% confidence intervals (CI). …”
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Clonal hematopoiesis of indeterminate potential is a risk factor of gastric cancer: A Prospective Cohort in UK Biobank study by Zhihui Xi, Huolun Feng, Kunling Chen, Xin Guo, Dandan Zhu, Jiabin Zheng, Yong Li

“…Main outcomes and measures: Odds ratio (OR) of CHIP with gastric cancer risk was estimated using multivariable logistic regression models. Participants were grouped based on age and CHIP status to examine if there are differences in the cumulative incidence of gastric cancer. …”
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Tobacco control environment: cross-sectional survey of policy implementation, social unacceptability, knowledge of tobacco health harms and relationship to quit ratio in 17 low-inc... by Annika Rosengren, Li Wei, Khalid Yusoff, Martin McKee, Clara K Chow, Rajeev Gupta, Koon Teo, Sumathy Rangarajan, Patricio Lopez-Jaramillo, Rafael Diaz, Alvaro Avezum, Fernando Lanas, Noorhassim Ismail, Romaina Iqbal, Jephat Chifamba, Gilles Dagenais, Salim Yusuf, Anna B Gilmore, Scott Lear, Wang Yang, Omar Rahman, Katarzyna Zatonska, Prem Mony, Rajesh Kumar, Afzalhussein Yusufali, Daniel J Corsi, Ehimario Igumbor, V Mohan, Annamarie Kruger, Krishnapillai Vijayakumar, Yuksel Altuntas, Ahmad Bahonar

“…Objectives This study examines in a cross-sectional study ‘the tobacco control environment’ including tobacco policy implementation and its association with quit ratio.Setting 545 communities from 17 high-income, upper-middle, low-middle and low-income countries (HIC, UMIC, LMIC, LIC) involved in the Environmental Profile of a Community's Health (EPOCH) study from 2009 to 2014.Participants Community audits and surveys of adults (35–70 years, n=12 953).Primary and secondary outcome measures Summary scores of tobacco policy implementation (cost and availability of cigarettes, tobacco advertising, antismoking signage), social unacceptability and knowledge were associated with quit ratios (former vs ever smokers) using multilevel logistic regression models.Results Average tobacco control policy score was greater in communities from HIC. …”
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High-resolution 4D electrical resistivity tomography and below-ground point sensor monitoring of High Arctic deglaciated sediments capture zero-curtain effects, freeze–thaw transit... by M. O. Cimpoiasu, O. Kuras, H. Harrison, P. B. Wilkinson, P. Meldrum, J. E. Chambers, D. Liljestrand, C. Oroza, S. K. Schmidt, P. Sommers, L. Vimercati, T. P. Irons, Z. Lyu, A. Solon, J. A. Bradley, J. A. Bradley

“…Novel insights into soil moisture dynamics throughout the spring melt will help parameterize models of biological activity to build a more predictive understanding of newly emerging terrestrial landscapes and their impact on carbon and nutrient cycling.…”
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Exosomal mir-126-3p derived from endothelial cells induces ion channel dysfunction by targeting RGS3 signaling in cardiomyocytes: a novel mechanism in Takotsubo cardiomyopathy by Xuehui Fan, Guoqiang Yang, Yinuo Wang, Haojie Shi, Katja Nitschke, Katherine Sattler, Mohammad Abumayyaleh, Lukas Cyganek, Philipp Nuhn, Thomas Worst, Bin Liao, Gergana Dobreva, Daniel Duerschmied, Xiaobo Zhou, Ibrahim El-Battrawy, Ibrahim Akin

“…The immunofluorescence staining, flow cytometry, qPCR, single-cell contraction, intracellular calcium transients, patch-clamp, dual luciferase reporter assay and western blot were performed for the study. Results Modeling TTC with high doses of epinephrine (Epi) treatment in hiPSC-CMs shows suppression of depolarization velocity (Vmax), prolongation of action potential duration (APD), and induction of arrhythmic events. …”
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Agro-Ecological Assessment of Lands in Behshahr County for Lentil (Lens culinaris Medik.) Cultivation by Karim Reyahi, Hossein Kazemi, Afshin Soltani, Fardin Sadeghzadeh

“…Thematic maps for each variable were created using various models in ArcGIS 10.8 and then overlaid with AHP weights. …”
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Outcome differences in acute vs. acute on chronic heart failure and cardiogenic shock by Tara L. Jones, Michael C. Tan, Vidang Nguyen, Kathleen E. Kearney, Charles C. Maynard, Emily Anderson, Claudius Mahr, James M. McCabe

“…Conclusions Current definitions and risk stratification models for CS based on clinical trials performed in the setting of acute coronary syndrome may not accurately reflect CS in patients with acute on chronic HF. …”
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Measurement report: Analysis of aerosol optical depth variation at Zhongshan Station in Antarctica by L. Chen, L. Chen, L. Zhang, Y. She, Z. Zeng, Y. Zheng, B. Tian, W. Zhang, Z. Liu, H. Che, M. Ding

“…These findings help us infer AOD variation patterns in the coastal Antarctic based on meteorological changes, providing valuable insights for climate modeling in the context of global climate change.</p>…”
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Impact of Population-Based Screening for Diabetes and Prediabetes Among 67-Year-Olds Using Point-of-Care HbA1c on Healthcare Ultilisation, Results from the VISP Cohort by Andersen JW, Høgh A, Lindholt JS, Søgaard R, Støvring H, Yderstræde KB, Sandbæk A, Dahl M

“…Statistical analyses were performed using Poisson and logistic regression models to compare ratios of healthcare utilization before and after screening.Results: Of the participants, 16.5% had pre-DM, and 3.4% had DM. …”
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Effect of nonsteroidal anti-inflammatory drugs on neonatal calf diarrhea when administered at a disease alert generated by automated milk feeders by A. Welk, M.C. Cantor, H.W. Neave, J.H.C. Costa, J.L. Morrison, C.B. Winder, D.L. Renaud

“…Mixed linear regression models were used to assess the association of study treatment with the duration of diarrhea after the alert and to evaluate the association of study treatment with milk intake, drinking speed, lying time, overall activity for 5 d following the alert, and ADG for 3 wk following the alert. …”
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Loose cigarette purchase and adolescent smoking in Indonesia: a mixed-methods study by Vid Adrison, Dian Kusuma, Gea Melinda, Fariza Zahra Kamilah, Syifa Rizki Amelia, Sofwatun Nida

“…We analysed the secondary data from a national survey, the 2019 Global Youth Tobacco Survey, using multivariable logistic regression models to examine the association between loose cigarette purchase and smoking frequency and intensity and nicotine dependence. …”
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Socioeconomic indicators related to the global burden of breast cancer in women in 2020: an analysis of WHO data by Tingting XU, Ruoyu YANG, Jingjing LI, Yiying FANG

“…Correlation analysis and multiple linear regression models were used to analyze the socioeconomic factors influencing the global burden of breast cancer in women. …”
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Evolution of burnout syndrome in Spanish healthcare professionals during and after the COVID-19 pandemic: psychosocial variables involved by Fernanda Gil-Almagro, Fernanda Gil-Almagro, Fernanda Gil-Almagro, F. Javier Carmona-Monge, Fernando J. García-Hedrera, Cecilia Peñacoba-Puente

“…The results of the repeated measures General Linear Models, after controlling for the effect of the covariates show that the evolution of emotional exhaustion is associated with the levels of depression at T1 (p = 0.031), of cognitive fusion at T2 (p &lt; 0.001) and of resilience at T2 (p = 0.039). …”
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Effets du braconnage et des mutilations sur les budgets d’activités et les rapports sociaux des chimpanzés sauvages de Sebitoli dans le parc national de Kibale (Ouganda) by Marie Cibot, Justine Philippon, Romain Laurent, Emmanuelle Pouydebat, Sabrina Krief

“…Les chimpanzés ayant subi des mutilations dues au piégeage constituent un modèle d’étude unique des conséquences de ces blessures sur la flexibilité comportementale des individus. …”
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Episiotomies and obstetric anal sphincter injuries following a restrictive episiotomy policy in France: An analysis of the 2010, 2016, and 2021 National Perinatal Surveys. by Raphaele Houlbracq, Camille Le Ray, Béatrice Blondel, Nathalie Lelong, Anne Alice Chantry, Thomas Desplanches, ENP2021 Study Group

“…Variations between 2010 (reference), 2016, and 2021 were analyzed by Cochran-Armitage tests and using Poisson regression models adjusted for maternal age, BMI, country of birth, antenatal classes, suspicion of fetal macrosomia, and neuroaxial analgesia during labor, the professional who attended the birth, the annual number of deliveries, and the maternity unit status to account for changes in women's characteristics and obstetric practices. …”
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