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54861
Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in Hepatocellular Carcinoma
Published 2021-04-01“…The existence of sGPC3 significantly inhibited the release of cytokines and the cytotoxicity of anti-GPC3 CAR-T cells in vitro. In animal models, mice carrying Hep3B xenograft tumors expressing sGPC3 exhibited a worse response to the treatment with CAR-T cells under both a low and high tumor burden. sGPC3 bound to CAR-T cells but failed to induce the effective activation of CAR-T cells. …”
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54862
PET/CT-derived coronary calcium score may predict cardiac complications in anthracycline-treated patients with lymphoma
Published 2025-02-01“…Logistic and Cox regression models were used to assess associations between CVR, CACS categories (CACS = 0, CACS 1-400, CACS >400), and new cardiac events. …”
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54863
Antimicrobial Profiling of Bacteria Isolated from Fish Sold at Informal Market in Mufakose, Zimbabwe
Published 2019-01-01“…These significant findings call for effective risk assessment models and management plans that protect human, animal, and environmental health.…”
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54864
Ovarian Reserve: A Critical Indicator of Female Reproductive Health
Published 2025-01-01“…Newly approaches, like machine learning models and AMH-based screening programs in countries like Portugal emerge. …”
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54865
Efficacy of Early Endoscopic Ultrasound-Guided Transluminal Drainage for Postoperative Pancreatic Fistula
Published 2021-01-01“…Factors prolonging hospital stay were also analyzed using Cox proportional hazard models. Results. Thirty patients (median age, 64.5 years) were enrolled. …”
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54866
Longitudinal health-related quality of life in patients with pancreatic cancer stratified by treatment: a nationwide cohort studyResearch in context
Published 2025-02-01“…HRQoL was assessed using the EORTC QLQ-C30 and -PAN26 questionnaires at baseline, during treatment, and at 0–3 months and 3–6 months after treatment. Linear mixed models were used to analyze changes in HRQoL over time, with clinically relevant changes defined as a minimal mean difference of 10 points in absolute scores and reported with 95% confidence intervals. …”
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54867
Associations of maternal PM2.5 exposure with preterm birth and miscarriage in women undergoing in vitro fertilization: a retrospective cohort study
Published 2025-01-01“…Our study used multinomial logistic regression models to explore the potential associations between PM2.5 exposure and adverse pregnancy outcomes. …”
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54868
NLRP3 activation maintains intestinal epithelial barrier and reduces liver injury in alcoholic liver disease mice
Published 2024-12-01“…Methods We established ALD mice models of WT, Nlrp3−/− and Gsdmd−/− through chronic alcohol consumption feeding and acute alcohol induction. …”
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54869
Colon Epithelial MicroRNA Network in Fatty Liver
Published 2018-01-01“…This study investigates an epithelial-focused miR network in colorectal cell models based on the previously reported MetS-FL miR trio of hsa-miR-142-3p, hsa-miR-18b, and hsa-miR-890. …”
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54870
Prevalence and determinants of intimate partner violence in pregnancy: a multicentre, binational study
Published 2025-02-01“…Factors found to be statistically significant were subjected to binary logistic regression modelling to determine the predictors of IPV. The level of statistical significance was set at a p-value of < 0.05. …”
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54871
Response of South Asia PM2.5 pollution to ammonia emission changes and associated impacts on human health
Published 2025-01-01“…Using an advanced regional atmospheric chemistry and transport modelling system (WRF-EMEP) with a new estimate of anthropogenic NH3 emissions inputs, we estimate the influence of agricultural NH3 emissions on surface PM2.5 in South Asia and evaluate the health impacts and the economic losses attributable to PM2.5 in 2018. …”
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54872
Cardiomyopathy and kidney function in agalsidase beta‐treated female Fabry patients: a pre‐treatment vs. post‐treatment analysis
Published 2020-06-01“…Methods and results Self‐controlled pretreatment and post‐treatment comparison (piecewise mixed linear modelling) included Fabry female patients ≥18 years at treatment initiation who received agalsidase beta (0.9–1.1 mg/kg every other week) for ≥2 years, with ≥2 pretreatment and ≥2 post‐treatment outcome measurements during 10‐year follow‐up. …”
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54873
Serum advanced glycation end products as a putative biomarker in Type2 DKD patients’ prognosis
Published 2025-01-01“…The association between corrected lgAGEs and renal outcomes was assessed using Cox proportional hazards models. Receiver operating characteristic (ROC) curve was utilized to evaluate the predictive performance of corrected lgAGEs alone and in combination with the urinary albumin-to-creatinine ratio (UACR).ResultsHigh level of corrected lgAGEs was independently associated with adverse renal outcomes [hazard ratio (HR), 3.252; 95% confidence interval (CI), 1.461–7.243; p = 0.003]. …”
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54874
Pathogenic variants of TUBB8 cause oocyte spindle defects by disrupting with EB1/CAKP5 interactions and potential treatment targeting microtubule acetylation through HDAC6 inhibiti...
Published 2025-01-01“…Methods Using microinjection mRNA and genome engineering to reintroduce the conserved pathogenic missense variants into oocytes or in generating TUBB8 variant knock‐in mouse models, we investigated that the human deleterious variants alter microtubule nucleation and spindle assembly during meiosis. …”
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54875
Risk factors for ocular biological parameters in Chinese preschool children: a cohort study from the Beijing whole childhood eye study
Published 2025-02-01“…One-way analysis of variance, univariate analysis, and multiple linear regression models (with age, sex, height, weight, parental myopia, continuous near-work time, electronic products use, and outdoor activity time as variables) were used to compare the effects of different variables on the AL, CR, and AL/CR ratio.ResultsOverall, 1,353 participants (708 boys; mean age, 4.37 ± 0.82 years) were included in this study. …”
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54876
Early-life tobacco smoke elevating later-life osteoporosis risk: Mediated by telomere length and interplayed with genetic predisposition
Published 2025-02-01“…Linear, Cox, and Laplace regression models were mainly used for data analysis. Results: Individuals with IUTSE showed a higher OP risk [hazard ratio (HR): 1.06, 95 % confidence interval (CI): 1.01, 1.11] and experienced earlier OP onset by 0.30 years [50th percentile difference = -0.30, 95 % CI: −0.51, −0.09] compared to those without. …”
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54877
Potential impact and mechanism of aged polyethylene microplastics on nitrogen assimilation of Lactuca sativa L.
Published 2025-02-01“…Structural equation modeling showed that soil nitrogen positively affected total nitrogen (TN) (0.359), chlorophyll (0.665), Rubisco (0.441), soluble protein (0.383), and biomass (0.460), and negatively affected phosphoenolpyruvate carboxylase (PEPC) (-0.325), soluble sugar (-0.134). …”
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54878
Relevance of the synergy of surveillance and populational networks in understanding the Usutu virus outbreak within common blackbirds (Turdus merula) in Metropolitan France, 2018
Published 2025-01-01“…Using generalised additive mixed models on REZOP data, we also highlighted the decline in common blackbird population trends in areas with medium and even more with high USUV pressure (areas defined based on SAGIR-AFVPZ data) following the 2018 outbreak (respectively −7.4% [−11.4; −3.9]95% and −15.7% [−16.2; −9.1]95%). …”
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54879
A digital intervention to reduce home-office workers’ sedentary behaviour: protocol for the evaluation of the Click2Move programme, a cluster randomised controlled trial
Published 2025-01-01“…Focus groups will be conducted with employees post-intervention. Linear mixed models, accounting for covariates, will be employed to determine the effects of the intervention. …”
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54880
Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma
Published 2025-01-01“…The in vivo antitumoral efficacy of CM272 was evaluated in PDAC xenograft and syngeneic mouse models, both alone and in combination with anti-PD1 immunotherapy. …”
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