High-Resolution Northern Blot for a Reliable Analysis of MicroRNAs and Their Precursors by Edyta Koscianska, Julia Starega-Roslan, Katarzyna Czubala, Wlodzimierz J. Krzyzosiak

“…Our protocol is applicable to analyses of all kinds of endogenous and exogenous RNAs, falling within length ranges of 20–30 and 50–70 nt, corresponding to microRNA and pre-microRNA lengths, respectively.…”
Get full text

circCOL1A1 Promotes the Progression of Gastric Cancer Cells through Sponging miR-145 to Enhance RABL3 Expression by Yue Ma, Yanyi Ren, Huitao Wen, Chengcheng Cui

“…One of the most common functions of circular RNA is to regulate microRNA expression by acting as a microRNA sponge. …”
Get full text

Advances in Focal Segmental Glomerulosclerosis Treatment From the Perspective of the Newest Mechanisms of Podocyte Injury by Zhu Y, Xu G

“…Notably, some medications such as Rituximab and Sparsentan, may simultaneously target multiple downstream mechanisms, Furthermore, exploring molecular strategies for established medications and developing novel treatments guided by biomarkers such as Anti-CD40 antibody, blood microRNA, urinary microRNA, and tumor necrosis factor-alpha (TNF-α) may provide additional therapeutic avenues for patients with FSGS.Keywords: focal segmental glomerulosclerosis, podocyte injury, targeted therapies, biomarkers…”
Get full text

High-Throughput Sequencing Reveals Diverse Sets of Conserved, Nonconserved, and Species-Specific miRNAs in Jute by Md. Tariqul Islam, Ahlan Sabah Ferdous, Rifat Ara Najnin, Suprovath Kumar Sarker, Haseena Khan

“…Among a total of 81 identified microRNA families, 116 potential target genes were predicted for 39 families and 11 targets were predicted for 4 among the 17 identified novel microRNAs. …”
Get full text

Quantitative Detection of miRNA-21 Expression in Tumor Cells and Tissues Based on Molecular Beacon by Qingxin Liu, Jialong Fan, Chuang Zhou, Liqun Wang, Bin Zhao, Haibin Zhang, Bin Liu, Chunyi Tong

“…As a new tumor marker, the microRNA-21 (miRNA21) level can provide important information for early diagnosis, drug treatment, and prognosis of gastric cancer. …”
Get full text

Diagnostic Test to Identify Parkinson’s Disease from the Blood Sera of Chinese Population: A Cross-Sectional Study by Guangan Tong, Pingping Zhang, Wenbin Hu, Kun Zhang, Xianwen Chen

“…The expression of potential microRNA (miRNA) candidates isolated from serum and cerebrospinal fluid (CSF) exosomes of PD patients was assessed for their diagnostic value and their potential role as biomarkers for PD was explored. …”
Get full text

Exosome-like nanovesicles derived from kale juice enhance collagen production by downregulating Smad7 in human skin fibroblasts by Peihan Hsu, Yuriko Kamijyo, Emiri Koike, Saki Ichikawa, Yifeng Zheng, Tomohiro Ohno, Shigeru Katayama, Shigeru Katayama

“…These findings suggest that GELNs and their microRNA content enhance collagen production through the downregulation of Smad7.…”
Get full text

SERS Platform Based on Bimetallic Au-Ag Nanowires-Decorated Filter Paper for Rapid Detection of miR-196ain Lung Cancer Patients Serum by Ji Xia, Yifan Liu, Menglin Ran, Dan Lu, Xiaowei Cao, Youwei Wang

“…Detecting microRNA (miRNA) biomarkers expression is of great significance for the diagnosis and treatment of lung cancer. …”
Get full text

Investigating the role of intratumoral Streptococcus mitis in gastric cancer progression: insights into tumor microenvironment by Ping Yang, Gaoli Liang, Yangyue Ni, Xiaojie Chu, Xiaoshan Zhang, Zhongyu Wang, Adeel Khan, Fangfang Jin, Han Shen, Miao Li, Zhipeng Xu

Get full text

Relationship between Peripheral Blood miR-181c, miR-101, and Cognitive Impairment in Patients with Diabetes Mellitus Complicated with Acute Stroke by Mengxian Shu, Chunhui Xiang

“…To explore the relationship between peripheral blood microRNA-181c (miR-181c), microRNA-101 (miR-101), and cognitive impairment (CI) in patients with diabetes mellitus (DM) complicated with acute stroke (AS). …”
Get full text

The Ubiquitin-Specific Protease 18 Promotes Hepatitis C Virus Production by Increasing Viral Infectivity by Yujia Li, Max Xuezhong Ma, Bo Qin, Liang-Tzung Lin, Christopher D. Richardson, Jordan Feld, Ian D. McGilvray, Limin Chen

“…Mechanistic roles were sought by quantifying microRNA-122 levels and J6/JFH1 infectivity of Huh7.5 cells. …”
Get full text

Attractor for a Reaction-Diffusion System Modeling Cancer Network by Xueyong Chen, Jianwei Shen, Hongxian Zhou

“…A reaction-diffusion cancer network regulated by microRNA is considered in this paper. We study the asymptotic behavior of solution and show the existence of global uniformly bounded solution to the system in a bounded domain Ω⊂Rn. …”
Get full text

New trends in the treatment of androgenetic alopecia by Szymon Leonik, Michał Smoczok, Beata Bergler-Czop

“…This publication reviews the use of minoxidil, 5a-reductase inhibitors (applied orally, topically and by injection), tretinoin, botulinum toxin, microRNA, and osteopontin as treatment options for androgenetic alopecia in men.…”
Get full text

Circulating C19MC MicroRNAs in Preeclampsia, Gestational Hypertension, and Fetal Growth Restriction by Ilona Hromadnikova, Katerina Kotlabova, Marketa Ondrackova, Andrea Kestlerova, Veronika Novotna, Lucie Hympanova, Jindrich Doucha, Ladislav Krofta

“…The association analysis pointed to no relationship between C19MC microRNA plasmatic concentrations and expression profile and identified risk factors for a poorer perinatal outcome. …”
Get full text

Noncoding RNA in the Regulation of Acute Aortic Dissection: From Profile to Mechanism by Ruibin Wei, Yingqing Feng

“…Recently, research on acute aortic dissection has mainly focused on microRNA (miRNA). Studies have found that miRNA plays a critical regulatory role in the occurrence and development of acute aortic dissection. …”
Get full text

Nongenomic Mechanisms of PTEN Regulation by Jimmie E. Fata, Shawon Debnath, Edmund C. Jenkins, Marcia V. Fournier

“…Here we discuss PTEN ubiquitination, PTEN complex formation with components of the adherens junction, PTEN nuclear localization, and microRNA regulation of PTEN as essential regulatory mechanisms that determine PTEN function independent of gene mutations and epigenetic events.…”
Get full text

Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications by Tao Sun, Xiangyu Kong, Yiqi Du, Zhaoshen Li

“…Numerous studies have proved that microRNA (miRNA) may play a vital role in a wide range of malignancies, including PDAC, and dysregulated miRNAs, including circulating miRNAs, are associated with PDAC proliferation, invasion, chemosensitivity, and radiosensitivity, as well as prognosis. …”
Get full text

Shortening of 3'UTRs correlates with poor prognosis in breast and lung cancer. by Antonio Lembo, Ferdinando Di Cunto, Paolo Provero

“…Proliferating cells partly escape this type of negative regulation by expressing shorter 3' UTRs, depleted of microRNA binding sites, compared to non-proliferating cells. …”
Get full text

The Emerging Perspective of Morphine Tolerance: MicroRNAs by Teng J. Zhang, Yong Qiu, Zhen Hua

“…This review covers some of the most striking microRNA functions involved in morphine tolerance and presents limitations on our knowledge of their physiological roles.…”
Get full text

Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies by Silvia Consalvi, Martina Sandoná, Valentina Saccone

“…The novel exciting role of exosome-bound microRNA in mediating epigenetic information transfer is also discussed. …”
Get full text