CLEC11A-Driven Molecular Mechanisms in Intervertebral Disc Degeneration: A Comprehensive Multi-Omics Study by Jiang N, Wang Q, Hu Z, Tian X

“…Similarly, overexpression of ARTN significantly increased, while knockdown decreased, the expression of these inflammatory markers in nucleus pulposus cells.Conclusion: Our integrative multi-omics analysis indicates that CLEC11A exacerbates IVDD by upregulating ARTN and inducing metabolic dysregulation, thereby amplifying the inflammatory pathways that drive disease progression. …”
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Transcriptomic and enzymatic analysis of peroxidase families at the early growth stage of halophyte ice plant (Mesembryanthemum crystallinum L.) under salt stress by Li-Ching Hsieh, Chia-Che Lee, Kai-Fu Zhang, Hui-Hsien Chang, Cheng-Hsun Li, Hsuan-Jung Huang, Hungchen Emilie Yen

“…GO enrichment analysis indicated that differentially expressed genes (DEGs) with increased transcript abundance were associated with ion transport, antioxidant activity, and stress responses, while DEGs with decreased transcript abundance were linked to metabolic and biosynthesis processes such as ribosomal protein synthesis and cell wall formation. …”
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Association between Brain-Derived Neurotrophic Factor (BDNF) Levels in 2nd Trimester Amniotic Fluid and Fetal Development by Nikolaos Antonakopoulos, Zoe Iliodromiti, George Mastorakos, Christos Iavazzo, Georgios Valsamakis, Nikolaos Salakos, Aris Papageorghiou, Alexandra Margeli, Sophia Kalantaridou, George Creatsas, Efthymios Deligeoroglou, Nikolaos Vrachnis

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Novel anthropometric indices are superior adiposity indexes to portend visual impairment in middle-aged and older Chinese population by Qing Chen, Yanan Hou, Yifan Zhou, Jianfeng Luo, KaiweiSa Abuduxukuer, Chuchu Wang, Jialong Dong, Yiting Wang, Wenming Shi, Fei Shi, Qing Peng

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Inhibition of programmed cell death by melanoma cell subpopulations reveals mechanisms of melanoma metastasis and potential therapeutic targets by Yuepeng An, Fu Zhao, Hongling Jia, Siyu Meng, Ziwei Zhang, Shuxiao Li, Jiusi Zhao

“…Thus, we conducted a single-cell analysis of the cellular composition within melanoma tumor tissues and further subdivided melanoma cells into subpopulations. Through analyzing metabolic pathways, stemness genes, and transcription factors (TFs) among cells in different phases (G1, G2/M, and S) as well as between primary and metastatic foci cells, we investigated the specific mechanisms underlying melanoma metastasis. …”
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Influence of Arbuscular Mycorrhizal Fungi on Nitrogen Dynamics During <i>Cinnamomum camphora</i> Litter Decomposition by Yuehong Gao, Xiaoyu Long, Yiqi Liao, Yonghui Lin, Zaihua He, Qin Kong, Xiangshi Kong, Xingbing He

“…In this study, we investigated the effects of AMF uptake for NH₄⁺ on litter N metabolic characteristics by enriching NH₄⁺ via AMF suppression and nitrification inhibition in a subtropical <i>Cinnamomum camphora</i> forest. …”
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Effect of Cardiac Exercise Rehabilitation on Epicardial Adipose Tissue Thickness in Patients with Coronary Heart Disease by Xing XING, Xinying GE, Ao GENG, Hongyan JIANG

“…The exercise intensity was made according to the metabolic equivalent of anaerobic threshold measured by cardiopulmonary exercise trial in this group. …”
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Implications of hormonal carcinogenesis for transgender and gender-diverse people undergoing gender-affirming hormone therapy: an up-to-date review by Matteo Lambertini, Filippo Pietrantonio, Dario Trapani, Francesco Perrone, Rossana Berardi, Saverio Cinieri, Chiara Cassani, Amelia Barcellini, Filippo Ghelardi, Alberto Giovanni Leone, Stefania Bonadonna, Marianna Sirico, Barbara Tagliaferri, Stefano Maccarone, Davide Dalu, Lorenzo Ruggieri, Simone Nardin, Nicla La Verde

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The association between serum fructosamine and random spot urine fructose levels with the severity of non-alcoholic fatty liver disease – an analytical cross-sectional study by H Kamuzinzi, M Kgomo, P Rheeder, N Dada, P Bester

“…Our local population is burdened with increased metabolic risk factors for NAFLD. Our setting requires a reasonable approach to screen for and aid the diagnosis of NAFLD. …”
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Effect of different diets on the fatty acid composition of buffalo bulk milk by Sebastiana Failla, Giuliano Palocci, Michela Contò, Gianluca Renzi, Chiara Evangelista, Loredana Basiricò, Umberto Bernabucci

“…The feeds supplied attended all metabolic pathways, and in particular, linseed and grass could enrich the milk with functional compounds. …”
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Penyeimbangan Kelas SMOTE dan Seleksi Fitur Ensemble Filter pada Support Vector Machine untuk Klasifikasi Penyakit Liver by Muhammad Amir Nugraha, Muhammad Itqan Mazdadi, Andi Farmadi, Muliadi, Triando Hamonangan Saragih

“…Abstract   The liver is one of the important organs in the human body that plays a role in the body's metabolic processes. Quoting an article from the American Liver Foundation website, in 2020, as many as 51,642 adults in the United States died from liver disease. …”
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Persistently high concentrations of β-hydroxybutyrate affect hepatic SOD2 expression and blood SOD activity in high-yielding dairy cows by Dominika Grzybowska, Katarzyna Żarczyńska, Przemysław Sobiech, Paweł Brym, Dawid Tobolski

“…The specificity of this response, primarily involving SOD2, highlights the complex interplay between metabolic changes and oxidative mechanisms during the transition period. …”
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Efficacy of Ma'aljobon Aftimouni (Cuscuta Reflexa and whey) on HbA1c and blood glucose levels in patients with Type 2 Diabetes: A randomized triple-blind clinical trial by Fatemeh Mehrabi, Ali Safdari, Azam Moslemi, Mehdi Salehi, Ali Agharazi, Mohammad Reza Rezvanfar

“…Introduction and objective: Type 2 Diabetes is a common and chronic metabolic disease. Complementary and alternative medicine can provide a suitable option for demands for new treatments. …”
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Association of composite dietary antioxidant index with circadian syndrome: evidence from NHANES by Chen Chen, Chenyu Zhao, Hongyu Jin, Zhiping Jiang, Wei Wang, Wen-Yang Li

“…CircS was defined based on metabolic syndrome components, supplemented by short sleep duration and depressive symptoms. …”
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The clinical impact of conventional therapies for adults and adolescents suffering from eosinophilic esophagitis, a type 2 inflammatory chronic disease, and their economic conseque... by Giorgio Walter Canonica, MD, Gherardo Mazziotti, MD, PhD, Alessandro Repici, MD, Massimiliano Povero, PhD, Luca Castello, MSc, Lorenzo Pradelli, MD, Miryana Dobreva, MSc, Francesca Fanelli, MSc, Jean Pierre Saab, MD, Edoardo Vincenzo Savarino, MD, PhD

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The relationship between kidney function and cardiometabolic risk factors, anthropometric indices, and dietary inflammatory index in the Iranian general population: a cross-section... by Samaneh Madani, Seyed Jalil Masoumi, Afsane Ahmadi, Morteza Zare, Najmeh Hejazi, Sahar Foshati

“…Various factors, such as genetic polymorphisms, metabolic disorders, and unhealthy lifestyles, can contribute to the occurrence of CKD. …”
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Effects of Walnut Protein Peptides on Promotion of White Adipose Tissue Browning and Prevention of Obesity by Yankun FU, Yuzheng CAI, Zhiqiang FENG, Siru CHEN, Tianlin WANG, Lianjun SONG, Tiange LI

“…Conclusions: WPP can promote the browning of WAT and prevent obesity and metabolic disorders induced by HFD, which provides potential as a functional food ingredient for preventing obesity.…”
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The Neosartorya (Aspergillus) fischeri antifungal protein NFAP2 has low potential to trigger resistance development in Candida albicans in vitro by Gábor Bende, Nóra Zsindely, Krisztián Laczi, Zsolt Kristóffy, Csaba Papp, Attila Farkas, Liliána Tóth, Szabolcs Sáringer, László Bodai, Gábor Rákhely, Florentine Marx, László Galgóczy

“…Tolerance to NFAP2 did not have significant metabolic fitness cost and could not increase virulence, compared with resistance to FLC.IMPORTANCEDue to the increasing number of (multi)drug-resistant strains, only a few effective antifungal drugs are available to treat infections caused by opportunistic Candida species. …”
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Association of different insulin resistance surrogates with all-cause and cardiovascular mortality among the population with cardiometabolic multimorbidity by Hongqiang Zhang, Zhixin Tu, Sihua Liu, Jumei Wang, Jie Shi, Xingyu Li, Rongdongqing Shi, Minghui Chen, Tong Yue, Sihui Luo, Yu Ding, Xueying Zheng

“…We developed five surrogate markers to assess IR levels: triglyceride-glucose (TyG) index, TyG-waist circumference (TyG-WC), TyG-waist height ratio (TyG-WHtR), homeostatic model assessment of insulin resistance (HOMA-IR), and metabolic score for insulin resistance (METS-IR). To investigate the associations between different IR surrogates and both all-cause and cardiovascular mortality, multivariable Cox proportional hazards models were applied. …”
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Response mechanism of water status and photosynthetic characteristics of Cotoneaster multiflorus under drought stress and rehydrated conditions by Qiu-liang Huang, Miao-miao Zhang, Chang-shun Li, Chang-shun Li, Bo-yang Li, Sheng-lan Zhuo, Yu-shan Yang, Yu-da Chen, An-na Zhong, Hao-yang Liu, Wen-feng Lai, Zhen-bei Huang, Ming-hui Cao, Zong-sheng Yuan, Guo-fang Zhang

“…Finally, C. multiflorus will strengthen the drought defense mechanism by gene regulation of various metabolisms, such as promoting stomatal closure, reducing transpiration water loss, and vigorously regulating water balance. …”
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