Effects of Pharmacotherapy Training Course on Improving the Drug Prescription Skills of Medical Students: A Pharmacy-based Intervention by Fatemeh Taheri Asl, Mohammadhossein Taherynejad, Maryam Emadzadeh, Mina Akbari Rad, Mohammad Ali Yaghoubi, Amirreza Rostami, Sepideh Hejazi, Mitra Ahadi, Samaneh Sajjadi, Amirali Moodi Ghalibaf, Ali Moradi, Sahar Ravanshad

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Genetic associations of plasma metabolites with immune cells in hyperthyroidism revealed by Mendelian randomization and GWAS-sc-eQTLs xQTLbiolinks analysis by Yutong Li, Xingyu Song, Yuyang Huang, Sifan Zhou, Linkun Zhong

“…Abstract Mendelian randomization (MR) was employed to investigate the causal relationships between immune cell phenotypes, hyperthyroidism (HD), and potential metabolic mediators. In this study, we acquired 731 immune cell phenotypes from genome-wide association studies (GWAS) (n = 18,622), HD data from the research by Handan Melike Dönertaş et al. (3,731 cases, 480,867 controls), and aggregated statistics of 1,400 blood metabolites from UK Biobank (n = 115,078). …”
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Adolescents with Persistent Symptoms Following Acute SARS-CoV-2 Infection (Long-COVID): Symptom Profile, Clustering and Follow-Up Symptom Evaluation by Marco Floridia, Danilo Buonsenso, Laura Macculi, Liliana Elena Weimer, Marina Giuliano, Flavia Pricci, Leila Bianchi, Domenico Maurizio Toraldo, Graziano Onder, The ISS Long-COVID Study Group

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The StbHLH47 transcription factor negatively regulates drought tolerance in potato (Solanum tuberosum L.) by Peijie Wang, Xiaojuan Wu, Nan Li, Hushuai Nie, Yu Ma, Juan Wu, Zhicheng Zhang, Yanhong Ma

“…Differential gene expression analysis of wild-type plants (WT) and plants overexpressing StbHLH47 (OE-StbHLH47) under drought stress revealed that the significantly differentially expressed genes were enriched in metabolic pathways, biosynthesis of various plant secondary metabolites, biosynthesis of metabolites, plant hormone signal transduction, mitogen-activated protein kinase (MAPK) signalling pathway-plant, phenylpropanoid biosynthesis, and plant‒pathogen interactions. …”
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Protective role of ginsenoside Rg1 in the dynamic progression of liver injury to fibrosis: a preclinical meta-analysis by Lijuan Dan, Xiuyan Li, Shuanglan Chen, Xiaojie You, Dong Wang, Tianyuan Wang, Jia Li, Wenping Liu, Jie Mu, Quansheng Feng, Quansheng Feng

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Integrative application of licorice root extract and melatonin improves faba bean growth and production in Cd-contaminated saline soil by Shimaa A. Abd El Mageed, Ali A. S. Sayed, Ahmed Shaaban, Khaulood A. Hemida, Abdelsattar Abdelkhalik, Wael M. Semida, Ibrahim A. A. Mohamed, Mohammed A. H. Gyushi, Yasmine H. Abd Elmohsen, Taia A. Abd El Mageed

“…Growth characteristics, photosynthetic pigments, nutrient uptake, physiology and metabolic responses, anatomical features, and yield were assessed. …”
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The association between bone density of lumbar spines and different daily protein intake in different renal function by Chia-Lin Lee, Kun-Hui Chen, Wei‑Ju Liu, Ching-Hsien Chen, Shang-Feng Tsai

“…However, protein intake is essential for bone health.Methods We studied the database of the National Health and Nutrition Examination Survey, 2005–2010. Basic variables, metabolic diseases, and bone density of different femoral areas were stratified into four subgroups according to different protein intake (DPI) (that is, <0.8, 0.8–1.0, 1.0–1.2, and >1.2 g/kg/day).Results Significant differences were found among all lumbar area bone mineral density (BMD) and T-scores (p < 0.0001). …”
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evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomat... by Jeffrey L. Cummings, Alireza Atri, Howard H. Feldman, Oskar Hansson, Mary Sano, Filip K. Knop, Peter Johannsen, Teresa León, Philip Scheltens

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Validity between dual-energy x-ray absorptiometry and bioelectrical impedance for segmental fat analysis and a novel low-cost model developed using anthropometry in young adults by Malek Mecherques-Carini, Mario Albaladejo-Saura, Francisco Esparza-Ros, Nicolás Baglietto, Raquel Vaquero-Cristóbal

“…Abstract Background Accurate body fat distribution assessment is essential for managing cardiovascular disease and metabolic disorders. Although several methods are available for segmental fat analysis, few studies have examined the validity of affordable methods such as Bioelectrical Impedance Analysis (BIA) against the reference method, Dual-Energy X-ray Absorptiometry (DXA). …”
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Hyaluronic Acid-Based Hybrid Nanoparticles as Promising Carriers for the Intranasal Administration of Dimethyl Fumarate by Serri C, Piccioni M, Guarino V, Santonicola P, Cruz-Maya I, Crispi S, Di Cagno MP, Ferraro L, Dalpiaz A, Botti G, Giunchedi P, Rassu G, Gavini E

“…Carla Serri,1 Miriam Piccioni,2 Vincenzo Guarino,3 Pamela Santonicola,2 Iriczalli Cruz-Maya,3 Stefania Crispi,2 Massimiliano Pio Di Cagno,4 Luca Ferraro,5 Alessandro Dalpiaz,6 Giada Botti,6 Paolo Giunchedi,1 Giovanna Rassu,1 Elisabetta Gavini1 1Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy; 2Institute of Biosciences and Bio-Resources, National Research Council (CNR-IBBR), Naples, Italy; 3Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, Naples, Italy; 4Department of Pharmacy, University of Oslo, Oslo, Norway; 5Department of Life Sciences and Biotechnology, University of Ferrara and LTTA Center, Ferrara, Italy; 6Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, ItalyCorrespondence: Giovanna Rassu, Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy, Email grassu@uniss.itPurpose: Dimethyl fumarate (DMF), the first-line oral therapy for relapsing-remitting multiple sclerosis, is rapidly metabolized into monomethyl fumarate. The DMF oral administration provokes gastrointestinal discomfort causing treatment withdrawal. …”
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In vitro study of size-dependent inhibition of human cytochrome P450 (P450) P450-1A2, P450-2A6, P450-2B6, P450-2C8, P450-2E1, P450-2J2, and P450-3A5 by zinc oxide nanoparticles (Zn... by Lamia Chowdhury, Yuh Fen Pung, Swee Yong Pung, Chin Eng Ong, Cin Kong, Yan Pan

“…In conclusion, the interactions between ZnONP products and co-administered drugs metabolized by these inhibited P450-isozymes should be further investigated using in vivo models. …”
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Serum calcium and its relationship with immunoglobulin G (IgG) levels in prepartum buffaloes from the Venezuelan humid tropics by Juan Pablo Uzcátegui-Varela, Anacelmira Urbina Andueza, Janeth Caamaño Carrero

“…There is evidence of an association between serum calcium concentration and IgG levels that depends on the number of calvings, possibly because different metabolic pathways for Ca 2+ exchange determine the immune response among the categories of buffaloes included in the study. …”
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Better understanding the phenotypic effects of drugs through shared targets in genetic disease networks by Elena Díaz-Santiago, Aurelio A. Moya-García, Jesús Pérez-García, Raquel Yahyaoui, Raquel Yahyaoui, Christine Orengo, Florencio Pazos, James R. Perkins, James R. Perkins, James R. Perkins, Juan A. G. Ranea, Juan A. G. Ranea, Juan A. G. Ranea, Juan A. G. Ranea

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Development and validation of a predictive model and tool for functional recovery in patients after postero-lateral interbody fusion by Shuai Zhou, Zhenbang Yang, Wei Zhang, Shihang Liu, Qian Xiao, Guangzhao Hou, Rui Chen, Nuoman Han, Jiao Guo, Miao Liang, Qi Zhang, Yingze Zhang, Hongzhi Lv

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Analysis of mRNA Pentatricopeptide Repeat Domain 1 as a prospective oncogene in clear cell renal cell carcinoma that accelerates tumor cells proliferation and invasion via the Akt/... by Zhongbao Zhou, Yulong Li, Yumeng Chai, Yong Zhang, Pu Yan

“…Abstract Background Although pentatricopeptide repeat domain 1 (PTCD1) has been found to modulate mitochondrial metabolic and oxidative phosphorylation, its contribution in the growth of clear cell renal cell carcinoma (ccRCC) remains unknown. …”
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Effect of self-paced sprint interval training and low-volume HIIT on cardiorespiratory fitness: the role of heart rate and power output by Katie L. Hesketh, Katie L. Hesketh, Sam O. Shepherd, Anton J. M. Wagenmakers, Matthew Cocks, Juliette A. Strauss

“…Sessions were completed 3×/week using WattBikes, and a target of &gt;80% HRmax was suggested during the intervals. Markers of cardio-metabolic health were assessed before and after each intervention.ResultsTraining increased VO2peak (SIT +3.1 ± 0.4 mL kg−1 min−1, LV-HIIT +2.7 ± 1.2 mL kg−1 min−1, P &lt; 0.001) and decreased body fat % (P = 0.002), aortic pulse wave velocity (P = 0.002) and glucose tolerance 120 min following an oral glucose tolerance test (P = 0.024), with no difference between protocols (P &gt; 0.05). …”
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Deciphering Regulatory Networks Governing Seedling Emergence in Deep-Sown Direct-Seeded Rice Cultivation by Jasneet Singh, Nitika Sandhu, Aman Kumar, Om Prakash Raigar, Sutej Bains, Gaurav Augustine, Muskan Gupta, Ekta Kharche, Anu Kalia, Navtej Singh Bains, Arvind Kumar

“…Notably, high fold changes in LOC_Os03g22720 and LOC_Os07g01960 underscore their importance in early stress responses and metabolic adjustments. The transcriptome analysis also highlighted the role of 29 heat shock proteins in response to deep sowing stress. …”
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Investigation into the influence of mild hypothermia on regulating ferroptosis through the P53-SLC7A11/GPX4 signaling pathway in sepsis-induced acute lung injury by Liujun Tao, Jie Xu, Liangyan Jiang, Juntao Hu, Zhanhong Tang

“…Mild hypothermia (32–34 °C) has been shown to inhibit inflammatory responses, reduce oxidative stress, and regulate metabolic processes. P53 has been reported to downregulate the transcriptional activity of solute carrier family 7 member 11 (SLC7A11), thereby limiting cystine uptake. …”
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Central Obesity Is Associated with Variations in TSH and ACTH Levels among Euthyroid Obese Individuals by Difei Lu, Zhenfang Yuan, Ying Gao, Wei Liu, Junqing Zhang

“…Thyroid function, morning serum ACTH and cortisol levels, thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), body composition, and metabolic indicators, including liver function and the lipid profile, were measured at the first visit. …”
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Prediction of Colorectal Cancer Risk Using a Genetic Risk Score: The Korean Cancer Prevention Study-II (KCPS-II) by Jaeseong Jo, Chung Mo Nam, Jae Woong Sull, Ji Eun Yun, Sang Yeun Kim, Sun Ju Lee, Yoon Nam Kim, Eun Jung Park, Heejin Kimm, Sun Ha Jee

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