Peripapillary retinal nerve fiber layer and ganglion cell complex in Alzheimer’s disease by R.N. Gulieva

“…Exclusion criteria were ametropia greater than 5 diopters or axial length more than 25 mm, severe dementia, cerebrovascular disorders, metabolic and mental disorders, glaucoma, uveitis, retinal diseases, diabetes, and anamnestic stroke. …”
Get full text

Comparison of 10-year atherosclerotic cardiovascular disease (ASCVD) risk in metropolitan and rural areas of South of Iran by Mohammad Javad Zibaeenezhad, Mehrab Sayadi, Hossein Pourmontaseri, Davood Khalili, Mojtaba Farjam, Ehsan Bahramail, Nader Parsa, Azizallah Dehghan, Seyyed Saeed Mohammadi, Iman Razeghian-Jahromi, Hamed Bazrafshan drissi, Matin Sepehrinia

Get full text

A proof-of-concept study in small and large animal models for coupling liver normothermic machine perfusion with mesenchymal stromal cell bioreactors by Umberto Cillo, Caterina Lonati, Alessandra Bertacco, Lucrezia Magnini, Michele Battistin, Liver NMP Consortium, Lara Borsetto, Francesco Dazzi, David Al-Adra, Enrico Gringeri, Maria Laura Bacci, Andrea Schlegel, Daniele Dondossola

Get full text

High clinical burden of classical homocystinuria in the United States: a retrospective analysis by Mahim Jain, Mehul Shah, Kamlesh M. Thakker, Andrew Rava, Agnes Pelts Block, Colette Ndiba-Markey, Lionel Pinto

“…Abstract Background Classical homocystinuria (HCU) is a rare genetic metabolic disorder resulting in elevated homocysteine and methionine levels. …”
Get full text

Mechanism of <italic>Hindu Datura</italic> in the Treatment of Rheumatoid Arthritis from the Perspective of Network Pharmacology by Changlong FU, Yangyang MEI, Xihai LI, Zhiwei QIU, Changxing CHEN, Chunsong ZHENG

“…Objective:To construct the active component target of <italic>Hindu datura</italic> and the disease target of rheumatoid arthritis by using network pharmacology, to predict the specific molecular signal and pathway of <italic>hindu datura</italic> in the treatment of rheumatoid arthritis, and to analyze its potential therapeutic target and molecular mechanism.Methods:All the chemical components of <italic>hindu datura</italic> were summarized and screened through Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)database, retrieval was performed with the preset oral bioavailability(OB)≥30%and drug like(DL)≥0.18.Uniprot database was used to screen the entire correlation basis of the effective chemical compound.After screening the disease target with"rheumatoid arthritis"as the retrieval word using GeneCards and OMIM database, the superimposed target area between the drug target of <italic>hindu datura</italic> and the disease target of rheumatoid arthritis was summarized and analyzed, and it could be used as the prediction target gene of <italic>hindu datura</italic> for treating rheumatoid arthritis.Network targets were constructed and analyzed for the exported data based on Cytoscape 3.7.1 software and STRING 7.8 database.Finally, GO functional enrichment analysis and KEGG signal pathway analysis were performed to further screen the main targets and signal pathways.Results:①Through screening and analysis, 27 effective compounds, 318 corresponding target genes and 125 predicted target genes were obtained for the treatment of rheumatoid arthritis.②The core genes in PPI network mainly included JUN, AKT1, RELA, MAPK1, etc.③GO functional enrichment analysis showed that the biological process(BP)for the treatment of rheumatoid arthritis by <italic>hindu datura</italic> mainly involves response to lipopolysaccharide, response to lipopolysaccharide, response to molecule of bacterial origin, response to metalion, response to oxidative stress, response to steroid hormone, cellular response to oxidative stress, reactive oxygen species metabolic process, response to oxygen levels, etc..The cell component(CC)consisted of membrane raft, membrane region, plasma membrane raft and presynaptic membrane; molecular functions(MF)mainly involved the nuclear receptor activity, transcription factor activity(direct ligand regulated sequence-specific DNA binding), steroid hormone receptor activity, cytokine receptors, cytokine activity, DNA-binding transcription activator activity, RNA polymeraseⅡtranscription factor binding, kinase regulator activity, receptor ligand activity, etc.The analysis of KEGG signaling pathway showed that the obvious pathway of <italic>hindu datura</italic> in the treatment of rheumatoid arthritis may involve IL-17 signaling pathway, TNF signal pathway, HIF-1signalpathway, Toll-like receptor signal pathway, etc.Conclusion:The potential mechanism of <italic>hindu datura</italic> for the treatment of rheumatoid arthritis is to exert anti-inflammatory, analgesic and antioxidant effects, which involve a number of interactive signal pathways.…”
Get full text

Asthma and obesity increase inflammatory markers in children by Harshita Shailesh, Safa Noor, Lena Hayati, Antonisamy Belavendra, Nicholas Van Panhuys, Abdul Badi Abou-Samra, Stefan Worgall, Ibrahim Janahi, Ibrahim Janahi

Get full text

Thyroid hormone receptor- and stage-dependent transcriptome changes affect the initial period of Xenopus tropicalis tail regeneration by Shouhong Wang, Liezhen Fu, Bin Wang, Yanmei Cai, Jianping Jiang, Yun-Bo Shi

“…Results We discovered that GO (gene ontology) terms related to inflammatory response, metabolic process, cell apoptosis, and epithelial cell migration were highly enriched among commonly regulated genes during wound healing at either stage 56 or 61 or with either wild type (WT) or TRDKO tadpoles, consistent with the morphological changes associated with wound healing occurring in both regenerative (WT stage 56, TRDKO stage 56, TRDKO stage 61) and nonregenerative (WT stage 61) animals. …”
Get full text

Daidzein improves muscle atrophy caused by lovastatin by regulating the AMPK/FOXO3a axis by Keke Wang, Hao Zeng, Hua Yang

“…Daidzein, an isoflavone derived from soybeans and many Chinese medicines, shows therapeutic potential in treating muscle-related diseases and metabolic disorders. However, whether daidzein can improve lovastatin-induced muscle atrophy and the specific mechanism needs to further study. …”
Get full text

Characterizing microcycles’ workload when combining two days structure within single training sessions during congested fixtures in an elite male soccer team by Antonio Gómez-Díaz, Fábio Yuzo Nakamura, Pedro Menezes, João Barreira, Pedro Figueiredo, Diogo Coutinho

“…The MD+1 MD−2 showed higher total distance covered ( F = 116.92, p < 0.001) and player load ( F = 56.67, p < 0.001) values than the other three training days, while both the MD+1 MD−2 and MD-2 MD+2 revealed higher distance covered at high-speed running ( F = 22.43, p < 0.001) and high metabolic load distance covered ( F = 75.98, p < 0.001) than both MD-1 sessions. …”
Get full text

Perennial disaster patterns in Central Europe since 2000 and implications for hospital preparedness planning – a cross-sectional analysis by Maik von der Forst, Maximilian Dietrich, Felix C. F. Schmitt, Erik Popp, Markus Ries

Get full text

Association between dietary betaine intake and overweight or obesity by Maierheba Kuerbanjiang, Wenzhuo Yu, Ting Shang, Yuchen Liu, Dina Muheyati, Mei-Xia Lv, Muhairemu Jielili, Jia Han

“…Abstract Betaine exhibits significant physiological functions in organisms and has positive impacts on obesity, alcohol-induced and metabolic-associated liver disease, diabetes, cardiovascular diseases, and certain cancers. …”
Get full text

A common mechanism of detoxification for lambda-cyhalothrin and abamectin in Cydia pomonella by Di Ju, Chao Hu, Peirong Li, Ping Gao, Yuting Li, Xueqing Yang

“…Conclusion The up-regulation of these detoxification genes is a common metabolic mechanism employed by C. pomonella to counteract the effects of insecticides, although the extent of gene expression change varies depending on the specific insecticide.…”
Get full text

Impact of Prior Chronic Kidney Disease and Newly Detected eGFR Impairment at Admission on Outcomes and Prognosis of Hospitalized COVID-19 Patients &ndash; A Single-Center Cohort St... by Kania M, Terlecki M, Batko K, Rajzer M, Malecki MT, Krzanowski M

“…Micha&lstrok; Kania,1,2 Micha&lstrok; Terlecki,2,3 Krzysztof Batko,2 Marek Rajzer,2,3 Maciej T Malecki,1,2 Marcin Krzanowski2,4 1Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland; 2University Hospital, Krakow, Poland; 3Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jagiellonian University Medical College, Krakow, Poland; 4Department of Nephrology and Transplantology, Jagiellonian University Medical College, Krakow, PolandCorrespondence: Marcin Krzanowski, Jagiellonian University Medical College, Department of Nephrology, 2 Jakubowskiego Str, 30-688, Krakow, Poland, Email marcin.krzanowski@uj.edu.plBackground and Hypothesis: Chronic kidney disease (CKD) is a major prognostic factor in COVID-19. …”
Get full text

Therapeutic Potential of Ginger Ethanolic Extract, Ginger-Loaded Chitosan ‎Nanoparticles, and Chitosan Nanoparticles in Induced Type 2 Diabetes Mellitus in Dogss in Induced Type 2... by Rasema M Hameed, Alaa K Mahmood

“…Compared to the diabetic Positive Control, oral GEE, GEE-CNPs, and CNPs ‎treatments significantly (P<0.05) improved ‎fasting glucose levels, insulin sensitivity, lipid profiles (reduced total cholesterol, ‎triglycerides, and LDL-C), liver function markers, and antioxidant status, indicating ‎enhanced metabolic health and reduced oxidative stress. The findings suggest that GEE, GEE-CNPs, and CNPs offer potential as therapeutic agents for T2DM in dogs, demonstrating ‎significant benefits in glycemic control, lipid normalization, liver function, and oxidative ‎stress reduction. …”
Get full text

Efficacy and prognosis of dapagliflozin in the treatment of patients with acute myocardial infarction complicated with type 2 diabetes in Xining area by Jinping Chai, Delian Li, Yanmin Liu, Xiaoling Su

“…The presence of type 2 diabetes not only signifies a chronic metabolic disorder, but also serves as a catalyst for various cardiovascular and cerebrovascular ailments such as coronary heart disease and stroke. …”
Get full text

Targeted inhibition of the PTEN/PI3K/AKT pathway by YSV induces cell cycle arrest and apoptosis in oral squamous cell carcinoma by Lin Qiu, Qian Gao, Yiheng Liao, Xinxin Li, Cuiying Li

Get full text

Association of triglyceride-glucose related indices with mortality among individuals with MASLD combined with prediabetes or diabetes by Yiheng Zhang, Juanli Wu, Tao Li, Yundong Qu, Yan Wang

“…Abstract Background The prognostic significance of triglyceride-glucose (TyG)-related indices in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) combined with prediabetes or diabetes is not yet fully understood. …”
Get full text

Childhood BMI trajectories and sociodemographic factors in an Italian pediatric population by Erich Batzella, Joaquin Gutierrez de Rubalcava Doblas, Gloria Porcu, Silvia Bressan, Elisa Barbieri, Carlo Giaquinto, Anna Cantarutti, Cristina Canova

Get full text

Digital-based emergency prevention and control system: enhancing infection control in psychiatric hospitals by Mi Yang, Xiaojun Zhu, Fei Yan, Xincheng Huang, Zhixue Wu, Xin Jiang, Yan Huang, Zezhi Li

Get full text

Preoperative prediction of multiple biological characteristics in colorectal cancer using MRI and machine learning by Qiao-yi Huang, Hui-da Zheng, Bin Xiong, Qi-ming Huang, Kai Ye, Shu Lin, Jian-hua Xu

Get full text