Effect of taking a dietary supplement containing Lactobacillus delbrueckii subsp. bulgaricus on clinical manifestations of functional dyspepsia and patients’ quality of life by I.G. Paliy, S.V. Zaika, O.O. Ksenchyn, I.V. Chernova

“…Research aim: to study the effect of a product containing lyophilized lactic acid bacteria Lactobacillus delbrueckii subsp. bulgaricus strain 9702 (IMV B-7085) and its metabolic products on the clinical manifestations of the disease and quality of life of patients with functional dyspepsia. …”
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The MyFlex-ζ Foot: A Variable Stiffness ESR Ankle-Foot Prosthesis by Johnnidel Tabucol, Vera G. M. Kooiman, Marco Leopaldi, Ruud Leijendekkers, Giacomo Selleri, Marcello Mellini, Nico Verdonschot, Magnus Oddsson, Raffaella Carloni, Andrea Zucchelli, Tommaso M. Brugo

“…Most commercially available foot prostheses are passive ESR feet, which store and release energy to reduce metabolic costs and improve comfort but cannot adjust to varying walking conditions. …”
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High prevalence of overweight/obesity and central obesity among women in a rural district of Nepal in 2012–2013: a population-based study by Chandra Yogal, Chandra Yogal, Astrid Kamilla Stunes, Astrid Kamilla Stunes, Sunila Shakya, Biraj Karmarcharya, Rajendra Koju, Mats P. Mosti, Mats P. Mosti, Miriam K. Gustafsson, Miriam K. Gustafsson, Bjørn Olav Åsvold, Bjørn Olav Åsvold, Berit Schei, Unni Syversen, Unni Syversen

“…Instant noodle intake ≥2 times weekly was associated with increased prevalence of central obesity and overweight/obesity.ConclusionWe observed a high prevalence of overweight/obesity and central obesity among women in a rural district of Nepal, which entails an increased risk of metabolic complications and NCDs. Our findings underscore the need for public health programs addressing nutritional patterns and physical activity to prevent obesity.…”
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Effects of refraction and axial length on the development and progression of diabetic retinopathy by M.M. Bikbov, O.I. Orenburkina, A.E. Babushkin, A.A. Fakhretdinova

“…The third authors argue a focal disintegration of retinal pigment epithelium to eliminate metabolic end products through the choroid and sclera. …”
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Polymorphisms in the Glucagon-Like Peptide 1 Receptor (GLP-1R) Gene Are Associated with the Risk of Coronary Artery Disease in Chinese Han Patients with Type 2 Diabetes Mellitus: A... by Xiaowei Ma, Ran Lu, Nan Gu, Xiaowei Wei, Ge Bai, Jianwei Zhang, Ruifen Deng, Nan Feng, Jianping Li, Xiaohui Guo

“…Glucagon-like peptide 1 (GLP-1) bestows protective effects upon the cardiovascular system through direct cardiovascular interactions or by improvements to metabolic function. Both these effects are thought to be at least partly mediated by the GLP-1 receptor (GLP-1R). …”
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Exploring seasonal dynamics of sea spray aerosol bioactivity: Insights into molecular effects on human bronchial epithelial cells by Zixia Liu, Emmanuel Van Acker, Maarten De Rijcke, Filip Van Nieuwerburgh, Colin Janssen, Jana Asselman

“…Downregulation of mTOR, PI3K, Akt, and NF-κB potentially indicates a protective response against tumor-promoting and inflammatory signals, whereas upregulation of AMPK may confer a beneficial effect on metabolic regulation. The number and direction of differentially expressed genes (DEGs) varied depending on the SSA sampling time and correlated with the phytoplankton density and chemical diversity of the SSA samples. …”
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Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review by Jiaojiao Liu, Qiaosheng Ren, Boxuan Du, Xian Liu, Yuqiu An, Peichi Zhang, Lexi Li, Zhenhong Liu, Zhenhong Liu, Kegang Cao, Kegang Cao

“…., The scope of our review included various aspects of migraine such as ictal and interictal phases; episodic or chronic migraine; menstrual-related migraine; and migraine with or without aura (PROSPERO registration number: CRD42024470268).ResultsA total of 38 studies were ultimately included, highlighting a range of genetic variations, transcriptional abnormalities, protein function alterations, and disruptions in metabolic pathways associated with migraine.These multi-omics findings underscore the pivotal roles played by mitochondrial dysfunction, inflammatory responses, and oxidative stress in the pathophysiology of migraine.ConclusionMulti-omics approaches provide novel perspectives and tools for comprehending the intricate pathophysiology of migraine, facilitating the identification of potential biomarkers and therapeutic targets.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?…”
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The curvilinear relationship between Framingham Steatosis Index and depression: insights from a nationwide study by Chunqi Jiang, Bo Wang, Ning Wang, Jun Wang, Yinuo Qu, Guang Zhao, Xin Zhang, Xin Zhang

“…Factors such as inflammation, hormonal levels, and metabolic disruptions could be the underlying mechanisms driving this relationship. …”
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Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats by Michael J. Butler, Stephanie M. Muscat, Maria Elisa Caetano-Silva, Akriti Shrestha, Brigitte M. González Olmo, Sabrina E. Mackey-Alfonso, Nashali Massa, Bryan D. Alvarez, Jade A. Blackwell, Menaz N. Bettes, James W. DeMarsh, Robert H. McCusker, Jacob M. Allen, Ruth M. Barrientos

“…Abstract Background Obesity and metabolic syndrome are major public health concerns linked to cognitive decline with aging. …”
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Determining the mechanism of Shuxuening injection against liver cirrhosis through network pharmacology and animal experiments by Qiyao Liu, Tingyu Zhang, Yongan Ye, Xin Sun, Huan Xia, Xu Cao, Xiaoke Li, Wenying Qi, Yue Chen, Xiaobin Zao

“…Enrichment analysis showed that these genes were associated with cancer-related pathways, including phosphoinositide-3-kinase/Akt and mitogen-activated protein kinase signaling and various cellular processes, such as responses to chemicals and metabolic regulation. In vivo experiments demonstrated that SXN treatment significantly improved liver function and pathology in CCl4-induced LC mice by reducing inflammation and collagen deposition. …”
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Dose-response relationship between the fatty liver index and asthma risk: NHANES 2001~2018 by Tengfei Sun, Kexin Fan, Zhuoxiao Han, Hua Qiao

“…The correlation of obesity and metabolic abnormalities with asthma and non-alcoholic hepatic steatosis has been extensively studied. …”
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Nonlinear association between depressive symptoms and homeostasis model assessment of insulin resistance: a cross-sectional analysis in the American population by Chunqi Jiang, Bo Wang, Yinuo Qu, Jun Wang, Xin Zhang

“…The intricate interplay between these two domains holds promising implications for understanding the multifaceted nature of depressive symptom and its impact on metabolic health.MethodsWe used weighted multivariable logistic regression models with subgroup analysis to explore the relationship between depressive symptom and homeostasis model assessment of insulin resistance. …”
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Multi-omics integration and immune profiling identify possible causal networks leading to uterine microbiome dysbiosis in dairy cows that develop metritis by S. Casaro, J. G. Prim, T. D. Gonzalez, F. Cunha, A. C. M. Silva, H. Yu, R. S. Bisinotto, R. C. Chebel, J. E. P. Santos, C. D. Nelson, S. J. Jeon, R. C. Bicalho, J. P. Driver, Klibs N. Galvão

“…Conclusions This work provides robust mechanistic hypotheses for how prepartum BW may impact peripartum immune and metabolic profiles, which may lead to uterine opportunistic pathogens overgrowth and metritis development.…”
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Inhibition of the Ubiquitin-Activating Enzyme UBA1 Suppresses Diet-Induced Atherosclerosis in Apolipoprotein E-Knockout Mice by Jiawei Liao, Xiaolei Yang, Qiuyue Lin, Shuang Liu, Yunpeng Xie, Yunlong Xia, Hui-Hua Li

“…Inactivation of UBA1 by the specific inhibitor PYR-41 did not alter the main metabolic parameters during atherogenic diet feeding but suppressed atherosclerosis development with less macrophage infiltration and plaque necrosis. …”
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Cancer stem cell populations are resistant to 5-aminolevulinic acid-photodynamic therapy (5-ALA-PDT) by Chantel P. J. Rice, Vipin Shankar Chelakkot, Noah T. Conohan, Kensuke Hirasawa

“…Activated PS leads to the generation of singlet oxygen and other reactive oxygen species (ROS), promoting cancer cell death. 5-aminolevulinic acid (5-ALA) is a naturally occurring PS precursor, which is metabolically converted to the PS, protoporphyrin IX (PPIX). …”
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Exiguobacterium acetylicum transformed poultry feathers into amino acids through an extracellular secretion of keratinolytic enzymes by Tutuka Dlume, Nonso E. Nnolim, Uchechukwu U. Nwodo

“…The present study evaluated the metabolic diversity of bacterial isolates from municipal dumpsites for keratinase production and poultry feather valorization. …”
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A systematic review and meta-analysis: prevalence and clinical implications of anatomical variants of the hepatic portal vein by Juan José Valenzuela-Fuenzalida, Benjamín Rodríguez-Osorio, Cristian Salgado-Torres, Pablo Nova-Baeza, Mathias Orellana-Donoso, Alejandro Bruna-Mejías, Roberto Avila-Sepulveda, Álvaro Becerra-Farfán, Macarena Rodríguez-Luengo, Juan Sanchis-Gimeno, Guinevere Granite, Héctor Gutiérrez-Espinoza

“…Its key function is to metabolize the components acquired from the blood. The objective of this study was to analyze the characteristics of HPV variants and understand the possible clinical considerations that arise with them. …”
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Short-term costs of alcohol-associated hepatitis care in different clinical settings by Chi Mai Nguyen, Jing Su, Yang Li, Ryan Healey, Shihui Jiang, Jiangqiong Li, Naga Chalasani, Samer Gawrieh, Suthat Liangpunsakul, Wanzhu Tu

“…Significant cost drivers in IP included comorbidities associated with moderate-to-severe liver disease, metabolic syndrome, liver transplant, and mortality during the 30-day follow-up period. …”
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Comparisons of adverse events associated with immune checkpoint inhibitors in the treatment of non-small cell lung cancer: a real-world disproportionality analysis based on the FDA... by Ruichen Gao, Wenjun Liang, Jintao Chen, Mingxia Yang, Xiaowei Yu, Xiaohua Wang

“…In terms of endocrine and metabolic AEs, durvalumab (OR = 7.80, 95% CI: 1.33–45.90) and nivolumab (OR = 5.20, 95% CI: 1.17–23.03) exhibited a higher risk compared to ipilimumab. …”
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AozC, a zn(II)2Cys6 transcription factor, negatively regulates salt tolerance in Aspergillus oryzae by controlling fatty acid biosynthesis by Wenbin Yu, Zeying Zhao, Yufei Zhang, Yayi Tu, Bin He

“…The Zn(II)2Cys6 family of transcription factors, known for their zinc binuclear cluster-containing proteins, are key regulators in fungi, modulating various cellular functions such as stress adaptation and metabolic pathways. Results Overexpression of AozC decreased growth rates in the presence of salt, while its knockdown enhanced growth, the number of spores, and biomass, particularly under conditions of 15% salt concentration, doubling these metrics compared to the wild type. …”
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