Portulaca oleracea L. (purslane) extract ameliorates intestinal inflammation in diet-induced obese mice by inhibiting the TLR4/NF-κB signaling pathway by Lingchao Miao, Meng Sam Cheong, Haolin Zhang, Haroon Khan, Haroon Khan, Hongxun Tao, Yuxiao Wang, Wai San Cheang

“…In the present study, we hypothesized that purslane extract could reduce intestinal inflammation associated with metabolic disorder.ResultsMale C57BL/6J mice were fed a high-fat diet (HFD, 60% kcal% of fat) for a total duration of 14 weeks to establish an obesity model; further, the treatment group was orally administered purslane extract (200 mg/kg/day) during the last 4 weeks. …”
Get full text

Association between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based study by Jiayu Qiu, Yueming Yu, Dingwei Liu, Sihai Chen, Youhua Wang, Jianxiang Peng, Jinliang Xie, Chengyun Wu, Feng Zhou, Hui Fang, Qirui Lai, Yong Xie

“…This study aimed to investigate the association between non-insulin-based surrogate markers of IR, including the triglyceride glucose (TyG) index, triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and the metabolic score for IR (METS-IR), and H. pylori infection in U.S. populations. …”
Get full text

Multigenerational family coaggregation study of obsessive-compulsive disorder and cardiometabolic disorders by David Mataix-Cols, Christian Rück, Lorena Fernández de la Cruz, Kayoko Isomura, Henrik Larsson, Paul Lichtenstein, Brian M D’Onofrio, Anna Sidorchuk, Zheng Chang, James J Crowley, Ralf Kuja-Halkola, Isabell Brikell, Josep Pol-Fuster, Anna Holmberg, Lina Martinsson

“…We estimated the risk of cardiovascular diseases (CVD) and metabolic disorders (including obesity, type 2 diabetes and hyperlipidaemia), comparing the relatives of probands with and without OCD. …”
Get full text

Evaluation of the dynamics of fattening of lactating cows of the newly created Ukrainian red dairy breed by Liliya Roman, Olena Bezaltychna, Serhiy Vyrvykyshka, Artem Iovenko, Tetyana Pushkar

“…According to the observations during the current lactation, it was found that the fattening of lactating cows did not have time to reach optimum levels at the end of the lactation period, which indicated significant metabolic disorders in the body of females, especially of young age, which require finding ways to correct the system of feeding the dairy herd of the newly created breed. …”
Get full text

Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus... by Minrui Xu, Mingtao Huang, Deren Qiang, Jianxin Gu, Yong Li, Yingzi Pan, Xingjuan Yao, Wenchao Xu, Yuan Tao, Yihong Zhou, Hongxia Ma

“…To determine whether hypertriglyceridemic waist (HTGW) and high lipid accumulation product (LAP) preceded the incidence of type 2 diabetes mellitus (T2DM), and to investigate the interactions of HTGW and LAP with other components of metabolic syndrome on the risk of T2DM. Methods. A total of 15,717 eligible participants without baseline T2DM and aged 35 and over were included from a Chinese rural cohort. …”
Get full text

Apoptosis in the liver of male <em>db/db</em> mice during the development of obesity and type 2 diabetes by S. V. Michurina, I. Yu. Ishchenko, S. A. Arkhipov, M. A. Cherepanova, D. V. Vasendin, E. L. Zavjalov

“…Obesity and diabetes mellitus are known to lead to the development of metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). …”
Get full text

Response of the gut microbiome and metabolome to dietary fiber in healthy dogs by Amrisha Bhosle, Matthew I. Jackson, Aaron M. Walsh, Eric A. Franzosa, Dayakar V. Badri, Curtis Huttenhower

“…However, very few studies have established the metabolic consequences of interactions among specific fibers, microbiome composition, and function in either human or representative animal models. …”
Get full text

Assessment of Nutritional Status in Patients with Head and Neck Cancer Before Radiotherapy: A Single-center, Cross-sectional Study by Susetyowati SUSETYOWATI, Fuadiyah Nila KURNIASARI, Amalia Sarah SHOLIKHATI, Mardiah HARDIANTI, Ericko EKAPUTRA

“…The findings showed a significant relationship between PG-SGA and nutritional status based on body weight, weight loss, MUACs, handgrip strength, visceral fat, resting metabolic rate (RMR), and hemoglobin (p&lt;0.05). A better nutritional status was associated with higher parameter values. …”
Get full text

A Case of Tumour Twins: A Rare Presentation of Simultaneous Breast and Endometrial Malignancies by Sreenidhi Sreeram, Barathi Gunabooshanam, Vasugi Gramani Arumugam, Gouthaman

“…Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) imaging were also done which revealed a thickened endometrium with increased metabolic activity. Patient underwent a right Modified Radical Mastectomy (MRM), total abdominal hysterectomy with bilateral salpingo-oophorectomy, and lymph node sampling. …”
Get full text

Genome-wide association analysis of key genes for feed efficiency in Qingyuan Partridge chickens by Fei Ye, Hongwei Jie, Jiankang Gan, Kunyu Liu, Zhengfen Zhang, Hai Xiang, Wei Liu, Qiong Yin, Siyu Chen, Hui Yu, Hua Li

“…GWAS results revealed 28 significant SNPs associated with body weight, feed intake, metabolic weight, weight gain, feed conversion ratio, and residual feed intake. …”
Get full text

Explainable Machine Learning for Efficient Diabetes Prediction Using Hyperparameter Tuning, SHAP Analysis, Partial Dependency, and LIME by Md. Manowarul Islam, Habibur Rahman Rifat, Md. Shamim Bin Shahid, Arnisha Akhter, Md Ashraf Uddin, Khandaker Mohammad Mohi Uddin

“…ABSTRACT Diabetes is a chronic metabolic disease characterized by elevated blood glucose levels and poses significant health risks, such as cardiovascular disease and cognitive damage. …”
Get full text

Liver cancer risk and changes in lifestyle habits after successful hepatitis C virus therapy post-DAA HCV therapy: lifestyle changes and liver cancer risk by Núria Granel, Gemma Iserte, Concepció Bartres, Neus Llarch, Anna Pla, Víctor Sapena, Zoe Mariño, Sabela Lens, Ramón Vilana, Isabel Nuñez, Anna Darnell, Ernest Belmonte, Ángeles García-Criado, Alba Díaz, Marco Sanduzzi-Zamparelli, Carla Fuster, Sergio Muñoz-Martínez, Carmen Ayuso, Jordi Rimola, Alejandro Forner, Alexandre Soler, Ferran Torres, José Ríos, Jordi Bruix, Andrew M. Moon, Xavier Forns, María Reig

“…These post-SVR changes raise concerns that the chemopreventive benefits of HCV cure may be counterbalanced by increased risks of liver disease progression and LC development from metabolic risk factors and alcohol use. Post-SVR, patients may benefit from intensive counseling and pharmacotherapy to address obesity and alcohol use. …”
Get full text

A comprehensive analysis of percutaneous liver biopsy characteristics and pathological manifestations in a large patient cohort (2009–2024) by Minling Cao, Jiayi Zeng, Jiayu Wang, Junmin Jiang

“…Results Since 2020, a gradual increase has been observed in the proportion of cases involving concurrent hepatitis B complicated by metabolic-associated steatohepatitis (MASLD), along with an elevation in the incidence of MASLD alone. …”
Get full text

Positive Expression of IGFBP2 as a Novel Prognostic Biomarker for Patients with Lower-Grade Gliomas by Yanguo Li, Jiawei Fan, Zhuo Shen, Jun Zhang, Xuemei Yin, Fang Han, Wenfei Li

“…GSEA results revealed that five differential pathways involved in collagen binding, collagen-containing extracellular matrix, collagen metabolic process, collagen trimer, and extracellular structure organization were significantly enriched in patients with glioma with high IGFBP2 expression.Conclusion: Our study is the first to show that overexpression IGFBP2 could be an independent glioma biomarker. …”
Get full text

The Relationship Between Body Composition, Physical Activity, Self-Esteem, and Body Image in Female and Male Adolescents by Ligia Rusu, Denisa Piele, Eva Ilie, Gheorghe Ionescu, Mihnea Ion Marin, Mihai Robert Rusu, Mirela Lucia Calina

“…Conclusions: The degree of obesity and therefore the risk of developing cardiovascular disease and metabolic syndrome were higher in males than in females. …”
Get full text

Hotspots and research trends of gut microbiome in polycystic ovary syndrome: a bibliometric analysis (2012–2023) by Ruishan Wu, Zhensheng Mai, Xiaoyan Song, Wenzhong Zhao

“…Additionally, “gut dysbiosis,” “phenotypes,” “adolescents,” “metabolomics,” “metabolites,” “fecal microbiota transplantation,” and “IL-22” have emerged as the primary keywords reflecting recent research trends.ConclusionThis bibliometric analysis explores how the gut microbiome influences endocrine and metabolic disorders related to PCOS, emphasizing its role in the development of PCOS and treatments targeting the gut microbiome. …”
Get full text

Exploring the boundaries of anastomotic leak: experience in a high-volume center by Carolina Riscanevo Bobadilla, Gloria Flórez Dussan, Jorge Vargas, Liliana Suarez, German Jimenez, Carlos Gonzalez, Andrea Carolina Córdoba, Wilmar Martín, Diego Olivera, Raúl Guevara

“…Total gastrectomy with lymphadenectomy is the standard treatment, with advancements in surgery shifting towards minimally invasive techniques to reduce surgical trauma and metabolic response. Esophagojejunal anastomotic leak is a frequent complication of gastrectomy, significantly increasing morbidity and mortality rates by up to 64%. …”
Get full text

Anti-NMDAR-Positive Small-Cell Lung Cancer Paraneoplastic Limbic Encephalitis: A Case Report and Literature Review by Raman Sohal, Steven H. Adams, Vishal Phogat, Abha Harish, Carlos Ynigo D. Lopez, Michael P. A. Williams, Kamal K. Khurana, Basel Abuzuaiter, Nia Jagroop, Bhavya Narapureddy

“…Given that PLE can precede the diagnosis of cancer, it is very important that once infectious, metabolic, nutritional, or structural disorders associated with short-term memory loss are ruled out that vigorous effort must be made to rule out underlying malignancy. …”
Get full text

IL-1β Pretreatment Improves the Efficacy of Mesenchymal Stem Cells on Acute Liver Failure by Enhancing CXCR4 Expression by He Nie, Fangmei An, Jie Mei, Cheng Yang, Qiang Zhan, Qinglin Zhang

“…Mesenchymal stem cells (MSCs), with the powerful metabolic and functional supporting abilities for inflammatory diseases, may be an effective therapeutic strategy for acute liver failure (ALF). …”
Get full text

A patient choice‐driven lifestyle intervention lowers HbA1c in type 2 diabetes: A feasibility study by Nathan R. Weeldreyer, Mindy L. McEntee, Matthew P. Martin, Chong D. Lee, Farshad Fani Marvasti, Glenn A. Gaesser, Rodger Kessler, Siddhartha S. Angadi

“…Abstract Type 2 diabetes (T2D) is a common metabolic disorder in which only 25% of patients meet management targets. …”
Get full text