Network pharmacology and molecular analysis of mechanisms underlying the therapeutic effects of Rhubarb in treating atherosclerosis and abdominal aortic aneurysm by Huilin Xu, Jun Huang, Youjie Zeng, Xia Wang, Huilin Lian, Siyi Zhang, Ren Guo

“…The analysis indicated that Rhubarb may be effective in treating AS/AAA through processes such as lipids, atherosclerosis, extracellular matrix catabolism, collagenolytic metabolic processes, and the extracellular environment. …”
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Isolation and identification of novel casein-derived bioactive peptides and potential functions in fermented casein with Lactobacillus helveticus by Mengzhu Fan, Tingting Guo, Wanru Li, Jing Chen, Fushuo Li, Chao Wang, Yi Shi, David Xi-an Li, Shaohui Zhang

“…Intracellular peptides are much larger in quantity and more complex in composition than extracellular peptides, between which the correlation reveals proteolytic and metabolic mechanisms.In addition, totally 241 different peptide sequences were identified by Nano LC–MS/MS from casein (212) and Lactobacillus helveticus proteins (29). …”
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Identification of hub genes, non-coding RNAs and pathways in Renal cell carcinoma (RCC): A comprehensive in silico study by Ahmad Golestanifar, Hengameh Khedri, Parisa Noorabadi, Mohammadreza Saberiyan

“…Results: Key findings include the identification of hub genes such as EGFR, FN1, IL6, and ITGAM, which were closely associated with immune responses, cell signaling, and metabolic dysregulation in KIRC. Further analysis indicated that these genes could be potential biomarkers for prognosis and therapeutic targets. …”
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Expression Profile of Genes Potentially Associated with Adequate Glycemic Control in Patients with Type 2 Diabetes Mellitus by Sâmia Cruz Tfaile Corbi, Alliny Souza Bastos, Rafael Nepomuceno, Thamiris Cirelli, Raquel Alves dos Santos, Catarina Satie Takahashi, Cristiane S. Rocha, Silvana Regina Perez Orrico, Claudia V. Maurer-Morelli, Raquel Mantuaneli Scarel-Caminaga

“…Moreover, genes related to lipid metabolisms and DNA replication/repair were influenced by the glycemic control. …”
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Salivary Hormones Leptin, Ghrelin, Glucagon, and Glucagon-Like Peptide 1 and Their Relation to Sweet Taste Perception in Diabetic Patients by Nada K. Al-Ghurayr, Ashjan M. Al-Mowalad, Ulfat M. Omar, Heba M. Ashi, Saad S. Al-Shehri, Abdelrahman A. AlShaikh, Shada M. AlHarbi, Hadeil M. Alsufiani

“…DM may disrupt hormone regulation. Metabolic hormones, leptin, ghrelin, glucagon, and glucagon-like peptide 1, are produced by the salivary glands and taste cells. …”
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Current status of the thyroid hormone measurement items in patients receiving levothyroxine monotherapy by the management based on the thyroid tissue volume by Mitsuru Ito, Hanna Deguchi-Horiuchi, Sawako Takahashi, Mako Hisakado, Kazuyoshi Kohsaka, Eijun Nishihara, Shuji Fukata, Mitsushige Nishikawa, Akira Miyauchi, Takashi Akamizu

“…We and other investigators reported that mild TSH suppression with levothyroxine (LT4) was needed to achieve normal free triiodothyronine (FT3) levels and metabolic euthyroid state in athyreotic patients. Consequently, management methods based on thyroid tissue volume have been implemented for patients receiving LT4 at the Kuma Hospital. …”
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Fabrication of composite ceramic polymeric membranes for agricultural wastewater treatment by Neamatalla M. Azzam, Sahar S. Ali, Gehad G. Mohamed, Mohamed M. Omar, Shereen K. Amin

“…Heavy metals can interfere with human and animal vital organs and metabolic processes. They are also persistent and bioaccumulative. …”
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Synthesis and Physico-Chemical Analysis of Dextran from Maltodextrin via pH Controlled Fermentation by <i>Gluconobacter oxydans</i> by Seung-Min Baek, Bo-Ram Park, Legesse Shiferaw Chewaka, Yun-Sang So, Ji-Hye Jung, Seul Lee, Ji Young Park

“…This dextran could function as a slowly digestible carbohydrate, aiding in postprandial glycemic regulation and mitigating chronic metabolic diseases like diabetes.…”
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Molecular hydrogen reduces dermatitis-induced itch, diabetic itch and cholestatic itch by inhibiting spinal oxidative stress and synaptic plasticity via SIRT1-β-catenin pathway in... by Linlin Zhang, Fangshi Zhao, Yize Li, Zhenhua Song, Lingyue Hu, Yuanjie Li, Rui Zhang, Yonghao Yu, Guolin Wang, Chunyan Wang

“…Chronic itch which is primarily associated with dermatologic, systemic, or metabolic disorders is often refractory to most current antipruritic medications, thus highlighting the need for improved therapies. …”
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Exploring the Role of Salt Supplementation on Milk Composition, Fatty Acids, and Insulin Response in Lactating Camels by Riyadh S. Aljumaah, Ahmed A. K. Salama, Mutassim M. Abdelrahman, Moez Ayadi, Gerardo Caja, Mohammed A. Alshaikh, Mohammed A. Al-Badwi, Abdulkareem M. Matar

“…These findings suggest that while moderate salt supplementation may not negatively impact milk yield in dairy camels, it alters both metabolic and milk fat composition variables, with potential implications for the nutritional quality of milk.…”
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Multi-omics analysis reveals the sensitivity of immunotherapy for unresectable non-small cell lung cancer by Rui Wu, Kunchen Wei, Xingshuai Huang, Yinge Zhou, Xiao Feng, Xin Dong, Hao Tang

“…The AUC of metabolomics prediction model was 0.977 and the AUC of proteomics was 0.875 while the AUC of the integrative-omics prediction model was 0.955.ConclusionsMetabolic and protein biomarkers in peripheral blood both have high efficacy and reliability in the prediction of immunotherapy sensitivity in unresectable stage III and IV non-small cell lung cancer, but validation in larger population-based cohorts is still needed.…”
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Herbicidal and Antibacterial Secondary Metabolites Isolated from the <i>Nicotiana tabacum</i>-Derived Endophytic Fungus <i>Aspergillus japonicus</i> TE-739D by Haisu Wang, Xiaolong Yuan, Xinrong Huang, Peng Zhang, Gan Gu

“…These findings indicate that the endophytic fungus <i>A. japonicus</i> TE-739D holds significant metabolic potential to produce bioactive secondary metabolites, which are beneficial, providing survival value to the host plants.…”
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The Effect of the Glucosinolate Sinigrin on Alterations in Molecular Biomarkers of the Myocardium in Swiss Mice by Nikola Ferara, Vedran Balta, Domagoj Đikić, Dyana Odeh, Ana Mojsović-Ćuić, Lana Feher Turković, Dario Dilber, Anđelo Beletić, Irena Landeka Jurčević, Ivana Šola

“…The alterations in myocardial parameters were assessed by measuring metabolic, inflammatory, structural, and antioxidant markers. …”
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Integrative proteomic-transcriptomic analysis revealed the lifestyles of Lactobacillus paracasei H4-11 and Kluyveromyces marxianus L1-1 under co-cultivation conditions by Na Liu, Likang Qin, Haiying Zeng, Anyan Wen, Song Miao

“…Enzyme-linked immunoassay (ELISA) and parallel reaction monitoring (PRM) quantitative analysis respectively verified that 5 key metabolic enzymes and 27 proteins in L. paracasei H4-11 and K. marxianus L1-1 were associated with the characteristic flavor of rice-acid soup, as confirmed by the quantitative results of 4D LFQ.…”
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Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter by Parveen Goyal, KanagaVijayan Dhanabalan, Mariafrancesca Scalise, Rosmarie Friemann, Cesare Indiveri, Renwick CJ Dobson, Kutti R Vinothkumar, Subramanian Ramaswamy

“…Some bacteria scavenge, import, and metabolize Neu5Ac or redeploy it on their cell surfaces for immune evasion. …”
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Comorbidity patterns and mortality in atrial fibrillation: a latent class analysis of the EURopean study of Older Subjects with Atrial Fibrillation (EUROSAF) by Huah Shin Ng, Richard Woodman, Nicola Veronese, Alberto Pilotto, Arduino A. Mangoni

“…The model identified phenotype 1 (hypertensive, other circulatory conditions, metabolic diseases; 33%), phenotype 2 (digestive diseases, infection, injury, non-specific clinical and laboratory abnormalities; 26%), and phenotype 3 (heart failure, respiratory diseases; 41%). …”
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Online resources on gene networks containing human and animal data by E. V. Ignatieva, D. A. Afonnikov, N. A.  Kolchanov

“…On this basis, we compiled and characterized a collection of databases containing information on metabolic and signaling pathways, as well as pathways of regulation of biological processes at the cellular and organismal levels. …”
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SMR-guided molecular subtyping and machine learning model reveals novel prognostic biomarkers and therapeutic targets in non-small cell lung adenocarcinoma by Baozhen Wang, Yichen Yin, Anqi Wang, Weidi Liu, Jing Chen, Tao Li

“…Functional enrichment analysis revealed the complex interplay of cell cycle regulation, DNA repair, immune response, and metabolic reprogramming in the progression of LUAD. …”
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Optimizing Phaeodactylum tricornutum cultivation: integrated strategies for enhancing biomass, lipid, and fucoxanthin production by Mostafa E. Elshobary, Walaa A. Abo-Shanab, Stephan S. W. Ende, Mohammed Alquraishi, Rania A. El-Shenody

“…These findings demonstrate the critical role of precise cultivation conditions in optimizing microalgal metabolic performance for biotechnological applications.…”
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Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons by Eduardo Pérez-Palma, Víctor Andrade, Mario O. Caracci, Bernabé I. Bustos, Camilo Villaman, Matías A. Medina, Miguel E. Ávila, Giorgia D. Ugarte, Giancarlo V. De Ferrari

“…We also studied molecular networks enriched upon Wnt3a activation and detected three highly significant expression modules involved in glycerolipid metabolic process (GO:0046486, p-adjusted = 4.5 × 10−19), learning or memory (GO:0007611, p-adjusted = 4.0 × 10−5), and neurotransmitter secretion (GO:0007269, p-adjusted = 5.3 × 10−12). …”
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