Analysis of CYP701A1 genes in gossypium species and functional characterization through gene silencing by Zhao Liang, Di Jiachun, Guo Qi, Xu Zhenzhen, Zhao Jun, Xu Peng, Xu Jianwen, Liu Jianguang, Shen Xinlian, Chen Xusheng

“…The cytochrome P450 enzyme family is recognized for its significance in plant metabolic processes. Specifically, CYP701s, a subgroup of CYP71, encode ent-kaurene oxidase in the gibberellin synthesis pathway. …”
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Multi-gene precision editing tool using CRISPR-Cas12a/Cpf1 system in Ogataea polymorpha by Senqin Hou, Shibin Yang, Wenqin Bai

“…Conclusions This novel multiplexed genome-editing tool mediated by CRISPR-Cpf1 can realize the deletion and integration of multiple genes, which holds great promise for accelerating engineering efforts on this non-conventional methylotrophic yeast for metabolic engineering and genomic evolution towards its application as an industrial cell factory.…”
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Benefits of Immobilized Bacteria in Bioremediation of Sites Contaminated with Toxic Organic Compounds by Emanuel Gheorghita Armanu, Simone Bertoldi, Łukasz Chrzanowski, Irina Volf, Hermann J. Heipieper, Christian Eberlein

“…Therefore, bioremediation combined with bacterial immobilization offers a comprehensive solution for environmental cleanup by harnessing the specialized metabolic activities of microorganisms while ensuring their retention and efficacy at target sites. …”
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Anthocyanins as functional food components by R. S. Yudina, E. I. Gordeeva, O. Yu. Shoeva, M. A. Tikhonova, E. K. Khlestkina

“…However, studies showed that in humans and animals, these compounds are actively metabolized and the bioavailability, estimated taking into account their metabolites, exceeded 12 %. …”
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Swine manure management by bokashi fermentation and composting with biological activators in a Colombian High Mountain Region by Patricia Martinez-Nieto, Carlos Abaunza, Gustavo Garcia

“…., focused on small-scale swine production, Bokashi fermentation with active dry yeast and in-vessel composting were evaluated using two microbial inoculants and a sterile metabolic stimulant. In addition, these treatments were compared with a non-inoculated composting process used in the study area (control). …”
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THE RELATIONSHIP BETWEEN STRESS LEVELS AND SLEEP QUALITY WITH THE MENSTRUAL CYCLE ON NURSING STUDENTS by Dianna Ika Ernawati, Heny Ekawati, Wahyu Retno Gumelar, Alvi Rahmadani

“…Menstrual cycle disorders indicate metabolic and endocrine system irregularities. The impact that often occurs due to menstrual cycle disorders is infertility and difficulty identifying the fertile period. …”
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Modification of Gene Expression Involved in Alkaloid Production in Opium Poppy by VIGS Combined With Pretreatment of Macerozyme Enzyme by Deniz Ece Özcan, Deniz Köm, Ozan Doğan, Semiha Erişen, Selma Onarici

“…The combination of VIGS and enzymatic pretreatment provides a robust platform for targeted metabolic engineering, offering insights into the regulation of morphine biosynthesis and paving the way for advancements in pharmaceutical alkaloid production and functional genomics in medicinal plants.…”
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Promoter engineering with programmable upstream activating sequences in Aspergillus Niger cell factory by Xiaomei Zheng, Yuting Guo, Meiling Chen, Yudan Lu, Yimou Du, Yu Lei, Ping Zheng, Jibin Sun

“…A wide dynamic range of promoters, particularly strong promoters, are required for fine-tuning the regulation of gene expression to balance metabolic flux and achieve the high yields of desired products. …”
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Melatonin Ameliorates Organellar Calcium Homeostasis, Improving Endoplasmic Reticulum Stress-Mediated Apoptosis in the Vastus Lateralis Muscle of Both Sexes of Obese Diabetic Rats by Diego Salagre, Miguel Navarro-Alarcón, Luis Gerardo González, Mohamed A. Elrayess, Marina Villalón-Mir, Rocío Haro-López, Ahmad Agil

“…Endoplasmic reticulum (ER) stress is a crucial factor in the progression of obesity-related type 2 diabetes (diabesity), contributing to skeletal muscle (SKM) dysfunction, calcium imbalance, metabolic inflexibility, and muscle atrophy. The ER and mitochondria together regulate intracellular calcium levels, and melatonin, a natural compound with antioxidant properties, may alleviate these challenges. …”
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The Effects of Hyperacute Serum on the Elements of the Human Subchondral Bone Marrow Niche by Melinda Simon, Bálint Major, Gabriella Vácz, Olga Kuten, István Hornyák, Adél Hinsenkamp, Dorottya Kardos, Marcell Bagó, Domonkos Cseh, Adrienn Sárközi, Denes Horvathy, Stefan Nehrer, Zsombor Lacza

“…Monolayer MSCs showed significantly higher metabolic activity following 5 days’ incubation in HAS, and osteoblast-specific mRNA expression was markedly increased, while cells also retained their MSC-specific cell surface markers. …”
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Assessment of the effect of agro-industrial by-products rich in polyphenols on in vitro fermentation and methane reduction in sheep by Alessandro Vastolo, Blandine Mora, Dieu donné Kiatti, Martina Nocerino, Serkos Haroutounian, Rania D. Baka, Panagiota Ligda, Monica Isabella Cutrignelli, Vincent Niderkorn, Vincent Niderkorn, Serena Calabrò

“…The concentration of polyphenols in the selected agro-industrial by-products could modify fermentation parameters and metabolic pathways, leading to reduced methane production.…”
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Exploration of interstitial fluid proteome in Homo sapiens forearm through a cutting edge intradermal microdialysis and high-throughput proteomics approach: a pilot study by Yu Sakamoto, Naoto Fujii, Junko Shibato, Ravi Gupta, Cheol Woo Min, Sun Tae Kim, Ranjith Kumar Bakku, Randeep Rakwal

“…Interstitial fluid (ISF) is noted as a high potential biofluid for continuous monitoring of cellular microenvironment where various metabolic processes occur. This pilot study collected intradermal dialysate, reflective of ISF conditions, from human dorsal forearm (n = 1) using a novel vented-intradermal microdialysis probe, to analyze proteins, isolate them, and characterize their functions. …”
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A Case of Acquired Reactive Perforating Dermatosis with Complete Resolution of Eruptions on Upper and Lower Limbs During the Treatment of Diabetes Mellitus and Peripheral Artery Di... by Yoshihito Mima, Tsutomu Ohtsuka, Ippei Ebato, Ryosuke Nishie, Satoshi Uesugi, Makoto Sumi, Yoshimasa Nakazato, Yuta Norimatsu

“…ARPD is strongly associated with systemic diseases such as diabetes mellitus (DM) and chronic renal failure, which may contribute to ARPD through factors including microcirculatory disturbances and the deposition of metabolic byproducts, including advanced glycation end-products and calcium. …”
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Genomic insights and comparative analysis of Colletotrichum species associated with anthracnose fruit rot and crown rot of strawberry in North Carolina by Tika B. Adhikari, Norman Muzhinji, Ashley N. Philbrick, Frank J. Louws, Frank J. Louws

“…The predicted gene models included effectors (339 to 480), secondary metabolic gene clusters (67 to 90), and carbohydrate-active enzymes (800 to 1,060), with C. siamense isolates exhibiting the highest numbers in these categories. …”
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Proline Promotes Drought Tolerance in Maize by Pirzada Khan, Ashraf M. M. Abdelbacki, Mohammed Albaqami, Rahmatullah Jan, Kyung-Min Kim

“…Proline also increased the protein content and improved N, P, and K retention by 30%, 40%, and 28%, respectively, in the drought-stressed plants, supporting metabolic and osmotic balance. Additionally, proline improved endogenous proline and sugar levels, facilitating osmotic adjustment and providing energy reserves. …”
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Uncovering the molecular mechanisms of Acer fabri in adjusting to low-temperature stress through integrated physiological and transcriptomic analysis by Gongwei Chen, Dandan Zhang, Fengyuan Chen, Yixiao Zhou, Hongyu Cai, Heng Gu, Yuanzheng Yue, Lianggui Wang, Guohua Liu

“…Differentially expressed genes (DEGs) were significantly enriched in metabolic pathways, phytohormone signaling, and plant mitogen-activated protein kinase (MAPK) signaling pathways. …”
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Salivary metabolomics in oral cancer: A systematic review by Rita Antonelli, Giacomo Setti, Nathaniel S. Treister, Thelma A. Pertinhez, Elena Ferrari, Mariana Gallo, Ronell Bologna-Molina, Paolo Vescovi, Marco Meleti

“…Overall, the presence and/or concentration of more than 100 salivary metabolites was investigated in association with histologically confirmed diagnosis of OSCC.All studies showed a statistically significant correlation between one or more metabolites and OSCC.These results suggest that metabolic analysis of saliva is a promising field for early diagnosis of OSCC, even though more well-conducted studies are needed.…”
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A novel cytoprotective organ perfusion platform for reconstructing homeostasis of DCD liver while alleviating IRI injury by Tingting Lan, Mingxing Yu, Tao Ming, Hong Wang, Juan Deng, Shuhan Cheng, Zhongyang Shen, Deling Kong

“…However, the continuous extrusion forming with the rigid stationary shaft of the peristaltic pumps can damage cells, leading to metabolic disorders and eventual dysfunction of transplanted organs. …”
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The Effects of Extra Virgin Olive Oil on Alanine Aminotransferase, Aspartate Aminotransferase, and Ultrasonographic Indices of Hepatic Steatosis in Nonalcoholic Fatty Liver Disease... by Farzad Shidfar, Samaneh Sadat Bahrololumi, Saeid Doaei, Assieh Mohammadzadeh, Maryam Gholamalizadeh, Ali Mohammadimanesh

“…Studies have shown that there is a strong relation between the increase in the aminotransferase levels and fat accumulation in the liver with cardiovascular complications, independent of all aspects of the metabolic syndrome. This study aimed to examine the effect of virgin olive oil on alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and the severity of steatosis in the NAFLD patients undergoing a weight-loss diet. …”
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Patient Management in Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus by A. E. Bagriy, A. D. Zubov, M. V. Khomenko, E. S. Mikhailichenko, E. A. Pylaeva, N. A. Khaustova, E. V. Bryukhovetskaya

“…NAFLD is associated with an increased cardiovascular risk (due to association with “metabolic syndrome”) and the risks of liver cirrhosis and hepatocellular carcinoma. …”
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