Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome. by Brittany E Jewell, An Xu, Dandan Zhu, Mo-Fan Huang, Linchao Lu, Mo Liu, Erica L Underwood, Jun Hyoung Park, Huihui Fan, Julian A Gingold, Ruoji Zhou, Jian Tu, Zijun Huo, Ying Liu, Weidong Jin, Yi-Hung Chen, Yitian Xu, Shu-Hsia Chen, Nino Rainusso, Nathaniel K Berg, Danielle A Bazer, Christopher Vellano, Philip Jones, Holger K Eltzschig, Zhongming Zhao, Benny Abraham Kaipparettu, Ruiying Zhao, Lisa L Wang, Dung-Fang Lee

“…Transcriptome analysis of RTS osteoblasts validated decreased bone morphogenesis while revealing aberrantly upregulated mitochondrial respiratory complex I gene expression. RTS osteoblast metabolic assays demonstrated elevated mitochondrial respiratory complex I function, increased oxidative phosphorylation (OXPHOS), and increased ATP production. …”
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Fourier Transform Infrared Spectroscopy Analysis as a Tool to Address Aβ Impact on Extracellular Vesicles by Margarida Vaz, Tânia Soares Martins, Kevin Leandro, Luís Pereira de Almeida, Odete A. B. da Cruz e Silva, Alexandra Nunes, Ana Gabriela Henriques

“…Nonetheless, limited research has explored Aβ direct effects on neurons and extracellular vesicles metabolic profiles. Hence, this study aims to investigate Aβ impact on the spectroscopic profiles of neuronal-like cells (N2a) and N2a-derived extracellular vesicles, employing FTIR spectroscopy and focusing on the 1280–900 cm⁻¹ region. …”
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Novel (Q)SAR models for prediction of reversible and time-dependent inhibition of cytochrome P450 enzymes by Sadegh Faramarzi, Arianna Bassan, Kevin P. Cross, Xinning Yang, Glenn J. Myatt, Donna A. Volpe, Lidiya Stavitskaya

“…Furthermore, five quantitative structure-activity relationship (QSAR) models were developed to predict not only time-dependent inhibition of CYP3A4, an enzyme that metabolizes approximately 50% of all marketed drugs, but also reversible inhibition of 3A4, 2C9, 2C19 and 2D6. …”
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Therapeutic potential of 4-hexylresorcinol in reducing sarcopenia in diabetic masseter muscle by Dhouha Gaida, Young-Wook Park, Yei-Jin Kang, Seong-Gon Kim

“…Immunohistochemistry demonstrated that 4HR treatment significantly increased Glut4 and phosphorylated AMPKα (p-AMPKα) expression in diabetic muscle, indicating enhanced glucose uptake and metabolic activity. Conclusions 4HR effectively alleviates diabetes-induced sarcopenia by preserving muscle volume, enhancing glycogen storage, and upregulating Glut4 and p-AMPKα expression. …”
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An epigenetic memory at the CYP1A gene in cancer-resistant, pollution-adapted killifish by Samantha Carrothers, Rafael Trevisan, Nishad Jayasundara, Nicole Pelletier, Emma Weeks, Joel N. Meyer, Richard Di Giulio, Caren Weinhouse

“…In PAH-tolerant fish, CYP1A induction is blunted. Since CYP1A metabolically activates PAH, this memory protects these fish from PAH-mediated cancer. …”
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Effects of Seed Priming with Zinc Sulfate on Nutritional Enrichment and Biochemical Fingerprints of Momordica charantia by Shazia Anwer Bukhari, Nabila Farah, Saqib Mahmood, Javaria Altaf, Ghulam Mustafa

“…Zinc is an essential element for plant growth and development as it plays an important role in various metabolic processes with nutritional enrichment. The treatment with zinc sulfate is also economic. …”
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Changes in Cardiac Tone Regulation with Fatigue after Supra-Maximal Running Exercise by Pierre-Marie Leprêtre, Philippe Lopes, Claire Thomas, Christine Hanon

“…Thus, it appears that fatigue rather than metabolic stresses occurring during a supramaximal exercise could explain the delayed postexercise parasympathetic reactivation in longer sprint runs.…”
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A Review on The Impact of Thermal Stress on Fish Biochemistry by Manoj Kumar Pati, Mohammad Aftabuddin, Prasun Roychowdhury

“…Enzymes involved in metabolic pathways have optimal temperature and pH ranges altered by thermal stress. …”
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The Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population by Jae Woong Sull, Seung-Ju Yang, Soriul Kim, Sun Ha Jee

“…Elevated serum uric acid levels are associated with a variety of adverse health outcomes, including gout, hypertension, diabetes mellitus, metabolic syndrome, and cardiovascular diseases. Several genome-wide association studies on uric acid levels have implicated the ATP-binding cassette, subfamily G, member 2 (ABCG2) gene as being possibly causal. …”
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46,XY Disorder of Sex Development Caused by 17α-Hydroxylase/17,20-Lyase Deficiency due to Homozygous Mutation of CYP17A1 Gene: Consequences of Late Diagnosis by Giampaolo Papi, Rosa Maria Paragliola, Paola Concolino, Carlo Di Donato, Alfredo Pontecorvi, Salvatore Maria Corsello

“…A 40-year-old Chinese woman was referred to the Endocrine Unit for the work-up of a syndrome characterized by long-lasting and multidrug resistant high blood pressure, severe hypokalemia with metabolic alkalosis, and primary amenorrhea. The patient presented with sexual infantilism, lack of breast development, absence of axillary and pubic hair, tall stature, and slenderness. …”
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Nutrition in neonatal and pediatric patients on extracorporeal membrane oxygenation: A survey of current practice in the US and Canada by Jamie M. Furlong-Dillard, Michael D. Facciolo, Caroline P. Ozment, and the Pediatric ECMO (PediECMO) Subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and Extracorporeal Life Support Organization (ELSO)

“…Background: Patients requiring extracorporeal membrane oxygenation (ECMO) are at increased risk of malnutrition due to high rates of protein catabolism, unclear metabolic needs, and safety risks with both parenteral and enteral nutrition (EN). …”
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Body composition and CO2 dietary emissions by Silvia García, Silvia García, Silvia García, Margalida Monserrat-Mesquida, Margalida Monserrat-Mesquida, Margalida Monserrat-Mesquida, Sebastián Mas-Fontao, Sebastián Mas-Fontao, Esther Cuadrado-Soto, Esther Cuadrado-Soto, María Ortiz-Ramos, Pilar Matía-Martín, Pilar Matía-Martín, Lidia Daimiel, Lidia Daimiel, Lidia Daimiel, Clotilde Vázquez, Clotilde Vázquez, Josep A. Tur, Josep A. Tur, Josep A. Tur, Cristina Bouzas, Cristina Bouzas, Cristina Bouzas

“…BackgroundThe amount and quality of foods consumed not only impact on individual health, as reflected in body composition, but they could influence on greenhouse gas emissions and then, on environment.AimThis study aims to assess the relationship between the body composition and the CO2 emissions resulting from the dietary choices of an adult population.DesignA cross-sectional study on baseline data from 778 participants aged 55–75 years old, with metabolic syndrome (MetS) as part of the PREDIMED-Plus study.MethodsFood intake was registered using a validated semi quantitative 143-item food frequency questionnaire. …”
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Xanthomonas citri subsp. citri requires a polyketide cyclase to activate the type III secretion system for virulence by Shuying Zhu, Siyu Wu, Yanmin Liu, Zaibao Zhang, Huasong Zou

“…A deletion mutation was created to explore the role of PKC in virulence and metabolic change. Results The PKC was determined to have a signal peptide, a START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) domain, and a GyrI-like small molecule binding domain. …”
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Autophagic flux-lipid droplet biogenesis cascade sustains mitochondrial fitness in colorectal cancer cells adapted to acidosis by Xiaojie Liu, Xue Sun, Wenqing Mu, Yanan Li, Wenqing Bu, Tingting Yang, Jia Zhang, Rui Liu, Jiayu Ren, Jin Zhou, Peishan Li, Yufang Shi, Changshun Shao

“…Our findings provide insight into the pro-survival metabolic plasticity in cancer cells under microenvironmental or therapeutic stress and imply that this pro-survival cascade may potentially be targeted in cancer therapy.…”
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Effect of grape seed extract on β -catenin gene expression and hyperglycemia in rats induced by streptozotocin by Elif Gulbahce-Mutlu, Emine Arslan, Hilal Arikoglu

“…<b>Aim: </b>Type 2 Diabetes Mellitus is a metabolic disorder characterized by high blood sugar in case of insulin resistance and/or insulin deficiency or insufficiency. …”
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Associations between White Blood Cell Count and the Development of Incidental Nonalcoholic Fatty Liver Disease by Goh Eun Chung, Jeong Yoon Yim, Donghee Kim, Min-Sun Kwak, Jong In Yang, Su Jin Chung, Sun Young Yang, Joo Sung Kim

“…We demonstrated that the risk of developing NAFLD was significantly associated with WBC counts independently of metabolic factors. This finding provides novel evidence indicating that serum WBC counts may be potential surrogate markers of NAFLD.…”
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Validity of Self-reported Participation in Cancer Screenings and Health Checkups in Japan by Isao Muraki, Tomotaka Sobue, Kazumasa Yamagishi, Shoichiro Tsugane, Norie Sawada, Hiroyasu Iso

“…Background: The participation rate for screening is regarded as a useful indicator for preventing cancer and cardio-metabolic disease. However, the validity of self-reported screening participation has not yet been thoroughly evaluated in Japan. …”
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A Liquid Chromatography with Tandem Mass Spectrometry-Based Proteomic Analysis of Primary Cultured Cells and Subcultured Cells Using Mouse Adipose-Derived Mesenchymal Stem Cells by Yoshiki Nakashima, Saifun Nahar, Chika Miyagi-Shiohira, Takao Kinjo, Naoya Kobayashi, Issei Saitoh, Masami Watanabe, Jiro Fujita, Hirofumi Noguchi

“…A total of 256 proteins were classified as cellular process-related proteins, while 179 were classified as metabolic process-related proteins in P0. These were considered to be adaptive responses of the cells to an in vitro environment. …”
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Toll-Like Receptor-4 Mediated Inflammation Is Involved in the Cardiometabolic Alterations Induced by Intermittent Hypoxia by Laureline Poulain, Vincent Richard, Patrick Lévy, Maurice Dematteis, Claire Arnaud

“…Conclusion. IH induces metabolic and vascular alterations that involve TLR4 mediated inflammation. …”
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The effects and predictive values of novel anthropometric parameters on uric acid levels and hyperuricemia in adults by Li Hongwei, Shen Zhenhai, Jiang Wei, Jia Bing, Li Shaolei, Zhang Ping, Wang Liuyu, Yuan Peng, Lu Yun

“…Abstract Novel anthropometric indices are more closely related to metabolic abnormalities than traditional anthropometric indices. …”
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