Multitarget Effects of Danqi Pill on Global Gene Expression Changes in Myocardial Ischemia by Qiyan Wang, Hui Meng, Qian Zhang, Tianjiao Shi, Xuefeng Zhang, Mingyan Shao, Linghui Lu, Jing Wang, Wei Wang, Chun Li, Yong Wang

“…This indicated that energy metabolic disorders occurred in rats with MI. In the DQP group, expressions of genes in the altered pathways were regulated back towards normal levels. …”
Get full text

Pleiotrophin deletion prevents high-fat diet-induced cognitive impairment, glial responses, and alterations of the perineuronal nets in the hippocampus by Héctor Cañeque-Rufo, Teresa Fontán-Baselga, Milagros Galán-Llario, Agata Zuccaro, María Gracia Sánchez-Alonso, Esther Gramage, María del Pilar Ramos-Álvarez, Gonzalo Herradón

“…Obesity and metabolic disorders, such as metabolic syndrome (MetS) facilitate the development of neurodegenerative diseases and cognitive decline. …”
Get full text

The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insights by Zhuo Huang, Zhuo Huang, Qinyan Yao, Qinyan Yao, Shuang Ma, Shuang Ma, Jinjie Zhou, Jinjie Zhou, Xiaoxuan Wang, Xiaoxuan Wang, Qingguo Meng, Qingguo Meng, Yaxin Liu, Yaxin Liu, Zihan Yu, Zihan Yu, Xin Chen, Xin Chen

“…Dysbiosis of the gut microbiota has been linked to metabolic disorders such as type 2 diabetes, obesity, metabolic-associated fatty liver disease (MAFLD) and metabolic heart disease. …”
Get full text

Cordyceps militaris solid medium extract alleviates lipopolysaccharide-induced acute lung injury via regulating gut microbiota and metabolism by Xiaoya Wang, Kang Zhang, Jingyan Zhang, Guowei Xu, Zhiting Guo, Xiaorong Lu, Chunhua Liang, Xueyan Gu, Liping Huang, Shuqi Liu, Lei Wang, Jianxi Li

“…Therefore, CMME may improve lung injury by regulating intestinal flora and correcting metabolic disorders, providing new insights into its mechanism of action.…”
Get full text

Glycogen Storage Disease Type IX in a 6-year-old Male: A Case Report by Shahab Noorian, Hossein Moravej, Zhila Afshar, Afagh Hassanzadeh Rad, Setila Dalili

“…Background: Glycogen storage diseases (GSDs) are a group of inherited metabolic disorders caused by enzyme deficiencies affecting glycogen synthesis or breakdown. …”
Get full text

Liver fibrosis and markers of endothelial function at metabolic syndrome and early disorders of carbohydrate metabolism by L. V. Chesnokova, I. M. Petrov, Ye. A. Sidorova, I. A. Troshina, Yu. A. Petrova

“…Overall 67 patients with metabolic syndrome (MS) in combination to early carbohydrate metabolism disorders (71,6% women), mean age was 47,5 (42–49 years), body mass index — 34,6 kg/m2 (32,4–38,4 kg/m2) were investigated. …”
Get full text

Case report: Cerebrotendinous Xanthomatosis masquerading as adult ADHD in psychiatric practice by Jongtae Kim, Yun Jeong Hong, Si Baek Lee, Seong Hoon Kim, Myung Ah Lee, Eunbuel Ko, Jeong Wook Park

“…Psychiatrists should consider rare metabolic disorders like CTX in similar cases, which may enable timely intervention and improve patient outcomes.…”
Get full text

High-fat diet and neuroinflammation: The role of mitochondria by Mingxue Song, Yao Bai, Fuyong Song

“…Thus, in-depth elucidation of the role and underlying mechanisms of mitochondrial dysfunction in HFD-induced metabolic disorders may not only expand our understanding of the mechanistic linkages between HFD and etiology of neurodegenerative diseases, but also help develop the specific strategies for the prevention and treatment of neurodegenerative diseases.…”
Get full text

Exosomal non-coding RNAs in the regulation of bone metabolism homeostasis: Molecular mechanism and therapeutic potential by Chengxiong Huang, Yu Xiao, Liming Qing, Juyu Tang, Panfeng Wu

“…Bone metabolism is a dynamic balance between bone formation and absorption regulated by osteoblasts/osteoclasts. Bone metabolic disorders can lead to metabolic bone disease. …”
Get full text

Tumor Microenvironment‐Responsive Nanoparticles Enhance IDO1 Blockade Immunotherapy by Remodeling Metabolic Immunosuppression by Mengna Wang, Yuhong Liu, Yanshi Li, Tao Lu, Min Wang, Zhaobo Cheng, Lin Chen, Tongling Wen, Min Pan, Guohua Hu

“…Abstract The clinical efficacy of immune checkpoint blockade (ICB) therapy is significantly compromised in the metabolically disordered tumor microenvironment (TME), posing a formidable challenge that cannot be ignored in current antitumor strategies. …”
Get full text

Metabolic control of ovarian function through the sympathetic nervous system: role of leptin by Camila Astudillo-Guerrero, Alfonso H. Paredes, Jorge Escobar, Daniela Fernandois, Rafael Barra, Gonzalo Cruz

“…This suggests that the hyperactivation of sympathetic nerves in adulthood, due to metabolic programming, could be a possible cause of reproductive and metabolic disorders, such as polycystic ovary syndrome.…”
Get full text

A ketogenic diet regulates microglial activation to treat drug addiction by Jie Ji, Yi Tang

“…With respect to drug addiction, studies have shown that a KD can alleviate glucose metabolism disorders caused by alcohol use disorders by increasing ketone metabolism, thereby reducing withdrawal symptoms. …”
Get full text

Metabolic and Genetic Determinants of Lipid Metabolism Disruption in Non-Alcoholic Fatty Liver Disease by O. Yu. Kytikova, T. P. Novgorodtseva, Yu. K. Denisenko, D. A. Kovalevsky

“…Progression of NAFLD and the development of NASH are closely related to lipid metabolism disorders caused not only by insufficient alimentary intake of fatty acids, but also by a decrease in the efficiency of their endogenous processing. …”
Get full text

Lipid metabolic reprogramming and associated ferroptosis in osteosarcoma: From molecular mechanisms to potential targets by Zhiyang Yin, Guanlu Shen, Minjie Fan, Pengfei Zheng

“…Osteosarcoma is a common bone tumor in adolescents, which is characterized by lipid metabolism disorders and plays a key role in tumorigenesis and disease progression. …”
Get full text

Dysregulation of Kisspeptin and Leptin, as Anorexigenic Agents, Plays Role in the Development of Obesity in Postmenopausal Women by Andon Hestiantoro, Brilliant P. K. Astuti, Raden Muharam, Gita Pratama, Fiastuti Witjaksono, Budi Wiweko

“…Dysregulation of leptin and kisspeptin signaling as anorexigenic agents is believed to be the connection between metabolic disorders and altered reproductive function. Therefore, this study aimed at investigating the association between leptin, soluble leptin receptor (sOBR), free leptin index, kisspeptin concentrations, and body mass index (BMI) in postmenopausal women. …”
Get full text

Machine learning prediction of obesity-associated gut microbiota: identifying Bifidobacterium pseudocatenulatum as a potential therapeutic target by Hao Wu, Yuan Li, Yuxuan Jiang, Xinran Li, Shenglan Wang, Changle Zhao, Changle Zhao, Ximiao Yang, Baocheng Chang, Juhong Yang, Juhong Yang, Jianjun Qiao, Jianjun Qiao

“…BackgroundThe rising prevalence of obesity and related metabolic disorders highlights the urgent need for innovative research approaches. …”
Get full text

Folate alleviated skin inflammation and fibrosis resulting from impaired homocysteine metabolism by Jiefeng Huang, Wuyan Lu, Shenli Zhao, Zixin Cai, Linxiao Li, Zihao Hu, Yu Jiang, Jinyi Deng, Yiming Tang, Chenzhang Shi, Chen Wang, Guangpeng Liu, Shuaijun Li

“…Collectively, these results indicate that skin fibrosis is associated with Hcy metabolic disorders and suggest that targeting Hcy metabolism or supplementing folate may provide a novel strategy for skin fibrosis.…”
Get full text

Evaluation of Faecal Microbiota Following Probiotics in Infants of Mothers with Gestational Diabetes Mellitus Trial: Protocol for Double-Blind Placebo-Controlled Randomized Trial by Gayatri Athalye-Jape, Chandra Prakash Rath, Harshad Panchal, Archita Mishra, Dorothy Graham, Sanjay Patole

“…The current evidence indicates that GDM, especially in conjunction with maternal overweight, can alter the composition of infants’ gut microbiota, potentially increasing the risk of inflammatory diseases, metabolic disorders, and neurodevelopmental issues later in life. …”
Get full text

Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese Population by Xiaoling Cai, Xueyao Han, Xianghai Zhou, Lingli Zhou, Simin Zhang, Linong Ji

“…Subjects of this study were sampled from the China National Diabetes and Metabolic Disorders Study that was conducted during 2007 and 2008. …”
Get full text

Determination of Blood Glucose, Total Protein, Certain Minerals, and Triiodothyronine during Late Pregnancy and Postpartum Periods in Crossbred Dairy Cows by Shima Essameldin Mohammed, Faisal Omer Ahmad, Ehab A. M. Frah, Imadeldin Elfaki

“…The results can provide indications of the nutritional status of dairy cows and a diagnostic tool to avoid the metabolic disorders that may occur during late pregnancy and the PPP.…”
Get full text