Options of dyslipidemia treatment at non-alcoholic fatty liver disease by M. V. Mayevskaya, M. A. Morozova

“…Omega-3-PUFAs is one more option in the lipid metabolism disorders treatment in this group of patients. …”
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Prevalence of GCKR rs1260326 Variant in Subjects with Obesity Associated NAFLD and T2DM: A Case-Control Study in South Punjab, Pakistan by Tayyaba Nisar, Kashan Arshad, Zahid Abbas, Maira Ali Khan, Sohail Safdar, Rehan Sadiq Shaikh, Ali Saeed

“…The glucokinase regulatory protein (GCKR) regulates glycogen metabolism and insulin secretion, and the GCKR rs1260326 is a putative single nucleotide polymorphism (SNP) associated with metabolic disorders including nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). …”
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PPAR-α Agonist Fenofibrate Decreased Serum Irisin Levels in Type 2 Diabetes Patients with Hypertriglyceridemia by Xiaomeng Feng, Xia Gao, Yumei Jia, Heng Zhang, Qingrong Pan, Zhi Yao, Ning Yang, Jia Liu, Yuan Xu, Guang Wang, Xinchun Yang

“…Irisin is related to insulin resistance and metabolic disorders. The physiologic effects of irisin are partially mediated through peroxisome proliferator-activated receptor-α (PPAR-α). …”
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Beneficial Effect of Fenofibrate in Combination with Silymarin on Parameters of Hereditary Hypertriglyceridemia-Induced Disorders in an Animal Model of Metabolic Syndrome by Jan Soukop, Ludmila Kazdová, Martina Hüttl, Hana Malínská, Irena Marková, Olena Oliyarnyk, Denisa Miklánková, Soňa Gurská, Zuzana Rácová, Martin Poruba, Rostislav Večeřa

“…<b>Conclusions:</b> Our results suggest the potential beneficial use of the combination of FF with SLM in the treatment of hypertriglyceridemia-induced metabolic disorders.…”
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Thalamic Lesions: A Radiological Review by Dimitri Renard, Giovanni Castelnovo, Chantal Campello, Stephane Bouly, Anne Le Floch, Eric Thouvenot, Anne Waconge, Guillaume Taieb

“…Thalamic lesions are seen in a multitude of disorders including vascular diseases, metabolic disorders, inflammatory diseases, trauma, tumours, and infections. …”
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Clinical Insight into Congenital Hypothyroidism Among Children by Hüseyin Anıl Korkmaz

“…Molecular, genetic, and technological advances have led to increased knowledge regarding neonatal thyroid hormone metabolism disorders. Maternal and fetal hypothyroidism, which can cause psychomotor dysfunction syndromes or low IQ levels, can lead to brain damage, reduced fetal growth and incidental fetal death. …”
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The role of peroxisome proliferator-activated receptor in the treatment of non-alcoholic fatty liver disease by Sun Xin, Zhang Yan, Xie Meilin

“…Current studies are targeting new molecular mechanisms that underlie NAFLD and associated metabolic disorders. Many therapeutic targets have been found and used in clinical studies. …”
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Editorial: Weighing the impact of being overweight on female reproductive function and fertility by Theocharis Koufakis, Dimitrios Patoulias, Kulvinder Kochar Kaur, Djordje S. Popovic

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Roles of Chronic Low-Grade Inflammation in the Development of Ectopic Fat Deposition by Lulu Liu, Mei Mei, Shumin Yang, Qifu Li

“…In this review, we have collected the evidence linking inflammation with ectopic fat deposition to get a better understanding of the underlying mechanism, which may provide us with novel therapeutic strategies for metabolic disorders.…”
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The Role of Human Gut Microbe Ruminococcus gnavus in Inflammatory Diseases by Sasmitra Kandasamy, Vengadesh Letchumanan, Kar Wai Hong, Kah-Ooi Chua, Nurul Syakima Ab Mutalib, Alvin Lai Oon Ng, Long Chiau Ming, Hui Xuan Lim, Sivakumar Thurairajasingam, Jodi Woan-Fei Law, Loh Teng-Hern Tan

“… Dysbiosis is a prominent factor in numerous inflammatory conditions, with Ruminococcus gnavus, a prevalent gut microbe, implicated in inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), eczema, metabolic disorders, and rheumatic diseases. R. gnavus contributes to inflammation by producing an inflammatory polysaccharide and degrading mucin. …”
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Clinical and genetic characteristics and medical approach in attenuated form of familial adenomatosis of the colon by A. M. Kuzminov, A. V. Karpukhin, I. Yu. Sachkov, Yu. Yu. Chubarov, T. A. Savel’yeva

“…For this variant of adenomatosis absence of metabolic disorders and development of cancer after 50 years is typical that requires onset of treatment by endoscopic polypectomy with subsequent extensive resections of the colon if necessary.…”
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Placental Implications of Peroxisome Proliferator-Activated Receptors in Gestation and Parturition by Valerie Borel, Denis Gallot, Geoffroy Marceau, Vincent Sapin, Loïc Blanchon

“…., chorioamnionitis), metabolic disorders (e.g., diabetes), and parturition.…”
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Impact of Incretin-Based Therapies on Adipokines and Adiponectin by Habib Yaribeygi, Mina Maleki, Stephen L. Atkin, Tannaz Jamialahmadi, Amirhossein Sahebkar

“…Adipokines are closely involved in most metabolic pathways and play an important modulatory role in lipid and carbohydrate homeostasis as they are involved in the pathophysiology of most metabolic disorders. Incretin-based therapy is a newly introduced class of antidiabetic drugs that restores euglycemia through several cellular processes; however, its effect on adipokines expression/secretion is not fully understood. …”
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Encapsulated human islets in alginate fiber maintain long-term functionality by Junko Nishida, Takahiro Tsuno, Shigeharu G. Yabe, Tatsuya Kin, Satsuki Fukuda, Fujie Takeda, Jun Shirakawa, Hitoshi Okochi

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AICAR Protects against High Palmitate/High Insulin-Induced Intramyocellular Lipid Accumulation and Insulin Resistance in HL-1 Cardiac Cells by Inducing PPAR-Target Gene Expression by Ricardo Rodríguez-Calvo, Manuel Vázquez-Carrera, Luis Masana, Dietbert Neumann

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Impaired RelA signaling and lipid metabolism dysregulation in hepatocytes: driving forces in the progression of metabolic dysfunction-associated steatotic liver disease by Yihuai He, Jinlian Jiang, Lili Ou, Yunfen Chen, Aikedaimu Abudukeremu, Guimei Chen, Weiwei Zhong, Zhigang Jiang, Nuerbiye Nuermaimaiti, Yaqun Guan

“…This study explored the relationship between impaired RelA signaling and lipid metabolism disorders in hepatocytes, and how they synergistically contribute to the advancement of MASLD. …”
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Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus by Muhammad U. Sohail, Asmaa Althani, Haseeb Anwar, Roberto Rizzi, Hany E. Marei

“…A change in microbial diversity, referred as microbial dysbiosis, alters the gut fermentation profile and intestinal wall integrity and causes metabolic endotoxemia, low-grade inflammation, autoimmunity, and other affiliated metabolic disorders. This article aims to summarize the role of the gut microbiome in the pathogenesis of diabetes. …”
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Peptide with Dual Roles in Immune and Metabolic Regulation: Liver-Expressed Antimicrobial Peptide-2 (LEAP-2) by Yitong Li, Ying Liu, Meng Gou

“…LEAP-2 alone or the LEAP-2/ghrelin molar ratio showed potential as therapeutic targets for obesity, diabetes, and metabolic disorders. This review explores the recent advances of LEAP-2 in immune modulation and energy regulation, highlighting its potential in treating the above diseases.…”
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Research Progress in Short-Chain Fatty Acid Modulation of the Gut-Bone Axis in Bone Metabolism by ZHANG Xuan, YANG Xue, LI Xinke, MENG Lu, WANG Jiaqi, ZHENG Nan

“…As global aging intensifies, the incidence of age-related bone metabolic disorders, such as osteoporosis, continues to climb. …”
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Intricating connections: the role of ferroptosis in systemic lupus erythematosus by Guowang Zhao, Xinghai Li, Ying Zhang, Ying Zhang, Xingzi Wang, Li Deng, Juan Xu, Shumei Jin, Zan Zuo, Zan Zuo, Linting Xun, Linting Xun, Mei Luo, Mei Luo, Fan Yang, Jialong Qi, Jialong Qi, Jialong Qi, Jialong Qi, Ping Fu

“…Although ferroptosis, an iron-dependent form of cell death, has numerous pathophysiological features similar to those of SLE, such as intracellular iron accumulation, mitochondrial dysfunction, lipid metabolism disorders and concentration of damage associated-molecular patterns (DAMPs), only a few reports have demonstrated that ferroptosis is involved in SLE progression and that the role of ferroptosis in SLE pathogenesis continues to be neglected. …”
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