Granuloma Caused by Carbon Deposition in the Dermis by Rintaro Shibuya, Yuichiro Endo, Akihiro Fujisawa, Miki Tanioka, Yoshiki Miyachi

“…Previous case reports presented pencil core granuloma resembling malignant melanoma, haemangioma, or soft tissue sarcoma. We present a case of pencil core granuloma arising from the palm 25 years after the initial injury. …”
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A Rare Presentation of Checkpoint Inhibitor Induced Distal RTA by Andrew V. Doodnauth, Miriam M. Klar, Zohra R. Malik, Krunal H. Patel, Samy I. McFarlane

“…This report presents a case of a 68-year-old woman with a known history of metastatic melanoma undergoing treatment with ipilimumab+nivolumab, who developed distal renal tubular acidosis requiring stress dose steroids and sodium bicarbonate for treatment. …”
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Exclusive Cutaneous and Subcutaneous Sarcoidal Granulomatous Inflammation due to Immune Checkpoint Inhibitors: Report of Two Cases with Unusual Manifestations and Review of the Lit... by Narciss Mobini, Rummit Dhillon, Jason Dickey, Jordan Spoon, Kaviyon Sadrolashrafi

“…The second patient is a male with melanoma of eyelid conjunctiva who was treated prophylactically with ipilimumab. …”
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Improving Medical Image Quality Using a Super-Resolution Technique with Attention Mechanism by Dong Yun Lee, Jang Yeop Kim, Soo Young Cho

“…To address this challenge, this study proposes a convolutional neural network (CNN)-based super-resolution architecture, utilizing a melanoma dataset to enhance image resolution through deep learning techniques. …”
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The Immune Response to Tumors as a Tool toward Immunotherapy by F. Pandolfi, R. Cianci, D. Pagliari, F. Casciano, C. Bagalà, A. Astone, R. Landolfi, C. Barone

“…Herein we will review some of the recent achievement of immunotherapy in such aggressive cancers as melanoma, prostatic cancer, colorectal carcinoma, and hematologic malignancies. …”
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Brunelli (Dorsoulnar) Flap for the Reconstruction of Defect of the Thumb Nail Unit After Oncological Resections With Mohs Micrographic Surgery by Felipe Mesa, MD, PhD, Oscar Leal, MD, María Elena Ramos, MD

“…We present a case series of 11 patients in whom a Brunelli flap was performed for postoncological reconstruction, melanoma in situ, and invasive squamous cell carcinoma of the thumb nail unit associated with Mohs micrographic surgery. …”
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Anti-melanogenic effects of hydroxyethyl chrysin through the inhibition of tyrosinase activity: In vitro and in silico approaches by Yuna Lee, Ha-Yeon Song, Eui-Baek Byun

“…In the present study, we explored whether HE-chrysin has antioxidant and anti-melanogenic capacity using in vitro B16F10 murine melanoma cells and in silico molecular docking. HE-chrysin exhibited enhanced antioxidant capacity in DPPH, ABTS, and FRAP assays, and it decreased cellular H2O2-stimulated reactive oxygen species levels in comparison to original chrysin. …”
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Decrease in Self-Reported Tanning Frequency among Utah Teens following the Passage of Utah Senate Bill 41: An Analysis of the Effects of Youth-Access Restriction Laws on Tanning Be... by Rebecca G. Simmons, Kristi Smith, Meghan Balough, Michael Friedrichs

“…Adolescent use of indoor tanning facilities is associated with an increased risk in later development of melanoma skin cancers. States that have imposed age restrictions on access to indoor tanning generally show lower self-reported rates of indoor tanning than states with no restrictions, but currently no studies have assessed indoor tanning use before and after such restrictions. …”
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Unfavorable Tumor Responses to Immunotherapy in the Liver: Lessons Learned from Clinical and Preclinical Studies by Li-Chun Lu, Gen-Sheng Feng, Chih-Hung Hsu

“…Results: In patients with advanced hepatocellular carcinoma or esophageal cancer, non-small cell lung cancer, or melanoma with liver metastases, the efficacy of ICI-based therapy was generally lower in the liver than in other organs. …”
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Green Biosynthesis of Silver Nanoparticles from Moringa oleifera Leaves and Its Antimicrobial and Cytotoxicity Activities by Gufran Mahmood Mohammed, Sumaiya Naeema Hawar

“…Moringa oleifera AgNPs inhibited human melanoma cells A375 line significant concentration-dependent cytotoxic effects. …”
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The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis by Chee Wai Wong, Danielle E. Dye, Deirdre R. Coombe

“…Here we examine the steps in the metastatic pathway focusing on how the Ig-SF members, melanoma cell adhesion molecule (MCAM), L1CAM, neural CAM (NCAM), leukocyte CAM (ALCAM), intercellular CAM-1 (ICAM-1) and platelet endothelial CAM-1 (PECAM-1) could play a role. …”
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Desmosomal Molecules In and Out of Adhering Junctions: Normal and Diseased States of Epidermal, Cardiac and Mesenchymally Derived Cells by Sebastian Pieperhoff, Mareike Barth, Steffen Rickelt, Werner W. Franke

“…Finally, we emphasize the occurrence of the desmosomal transmembrane glycoprotein, desmoglein Dsg2, out of the context of any junction as dispersed cell surface molecules in certain types of melanoma cells and melanocytes. This broadening of our knowledge on the diversity of AJ structures indicates that it may still be too premature to close the textbook chapters on cell-cell junctions.…”
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Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation by Kong-Bing Tan, Sze-Hwa Tan, Derrick Chen-Wee Aw, Huma Jaffar, Thiam-Chye Lim, Shu-Jin Lee, Yoke-Sun Lee

“…Benign mimics of SCC include pseudoepitheliomatous hyperplasia, eccrine squamous syringometaplasia, inverted follicular keratosis, and keratoacanthoma, while malignant mimics of SCC include basal cell carcinoma, melanoma, and metastatic carcinoma. The careful application of time-honored diagnostic criteria, close clinicopathological correlation and a selective request for a further, deeper, or wider biopsy remain the most useful strategies to clinch the correct diagnosis. …”
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Unlocking Dabrafenib’s Potential: A Quality by Design (QBD) Journey to Enhance Permeation and Oral Bioavailability through Nanosponge Formulation by Konda Sri Chaya Reddy, Darna Bhikshapathi, Jaini Pavan Kumar

“…The use of DBF-loaded NSPs holds promise as an effective strategy for enhancing release and bioavailability in the treatment of melanoma.…”
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The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese Population by Wei-Chiao Chang, Peng Yeong Woon, Yu-Wen Hsu, Shengyu Yang, Yi-Ching Chiu, Ming Feng Hou

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Epidemiological Patterns of Skin Disease in Saudi Arabia: A Systematic Review and Meta-Analysis by Mohammad Almohideb

“…Basal cell carcinoma and squamous cell carcinoma were the most common malignant neoplasm in Saudi Arabia (51.4% and 22.5% of the malignant neoplasm, respectively), while malignant melanoma represents only 3.8% of the malignant skin cancer. …”
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Unintended Sunburn: A Potential Target for Sun Protection Messages by Geraldine F. H. McLeod, Anthony I. Reeder, Andrew R. Gray, Rob McGee

“…New Zealand (NZ) has the highest melanoma incidence rate in the world. Primary prevention efforts focus on reducing sunburn incidence and increasing sun protective practices in the population. …”
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Cathelicidins: Opportunities and Challenges in Skin Therapeutics and Clinical Translation by Lenka Dzurová, Edita Holásková, Hana Pospíšilová, Gabriela Schneider Rauber, Jitka Frébortová

“…Cathelicidins of different origins have shown potential in treating various skin conditions, including melanoma, acne, and diabetic foot ulcers. Despite their promising therapeutic potential, cathelicidins face significant challenges in clinical application. …”
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Safe Transition to Pembrolizumab following Ipilimumab-Induced Guillain-Barré Syndrome: A Case Report and Review of the Literature by Nicholas Gravbrot, Katalin Scherer, Srinath Sundararajan

“…A 71-year-old gentleman with recurrent, stage IIIB melanoma was started on ipilimumab (cytotoxic T lymphocyte antigen-4 inhibitor) for adjuvant treatment following radical neck dissection and radiation therapy. …”
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<i>Cordyceps militaris</i>-Derived Bioactive Gels: Therapeutic and Anti-Aging Applications in Dermatology by Trung Quang Nguyen, Thinh Van Pham, Yusuf Andriana, Minh Ngoc Truong

“…These compounds exhibit multiple bioactivities, including apoptosis induction, cell cycle arrest, and anti-inflammatory effects, which have been shown to be particularly effective against melanoma and other skin cancers. Additionally, the antioxidant properties of <i>C. militaris</i> enhance skin resilience by scavenging reactive oxygen species, reducing oxidative stress, and promoting collagen synthesis, thereby addressing skin health and anti-aging requirements. …”
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