PROTON RADIATION THERAPY: CLINICAL APPLICATION OPPORTUNITIES AND RESEARCH PROSPECTS by M. V. Zabelin, V. A. Klimanov, J. J. Galyautdinova, A. S. Samoilov, A. O. Lebedev, E. V. Shelyhina

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Long-Term Treatment Outcome after Only Popliteal Lymph Node Dissection for Nodal Metastasis in Malignant Melanoma of the Heel: The Only “Interval Node” Dissection Can Be an Adequate Surgical Treatment by Kentaro Tanaka, Hiroki Mori, Mutsumi Okazaki, Aya Nishizawa, Hiroo Yokozeki

“…We present a patient with malignant melanoma on his heel. Wide local excision was performed, along with sentinel lymph node biopsy of the inguinal and popliteal lesions. …”
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Changes in levels of urokinase receptor and other components of fibrinolytic system in brain tissues in urokinase gene-knockout mice with B16/F10 melanoma growing together with chronic neurogenic pain by E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, N. D. Cheryarina, E. I. Surikova, I. V. Neskubina, Yu. A. Pogorelova, L. A. Nemashkalova

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Role of hypothalamic-pituitary-adrenal axis and catecholamine factors in independent and primary multiple types of tumor growth by E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, E. I. Surikova, Yu. A. Pogorelova, N. D. Cheryarina, L. K. Trepitaki, I. V. Neskubina, A. A. Vereskunova, I. M. Kotieva, K. A. Shumarin, A. I. Shikhlyarova, I. V. Goroshinskaya

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Inhibitory Effect on the Tyrosinase Activity and Low Cytotoxicity of Monounsaturated Long-Chain Chelating Fatty Ester by ANTONIO SERGIO C. CARVALHO, TATIANA N. PEDROSA, HERONILDES A. DANTAS FILHO, RAQUEL C. MONTENEGRO, EMERSON S. LIMA, MARNE C. DE VASCONCELLOS, ALBERDAN S. SANTOS

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Multidisciplinary Vulvar Cancer Management: The Dermatologist’s Perspective by Marta Cebolla-Verdugo, Victor Alfredo Cassini-Gómez de Cádiz, Juan Pablo Velasco-Amador, María Zulaika-Lloret, Francisco Manuel Almazán-Fernández, Ricardo Ruiz-Villaverde

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Non-convex optimization with using positive-negative moment estimation and its application for skin cancer recognition with a neural network by P.A. Lyakhov, U.A. Lyakhova, R.I. Abdulkadirov

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Biological Activities and Nutraceutical Potentials of Water Extracts from Different Parts of Cynomorium Coccineum L. (Maltese Mushroom) by Zucca Paolo, Argiolas Antonio, Nieddu Mariella, Pintus Manuela, Rosa Antonella, Sanna Fabrizio, Steri Daniela, Rescigno Antonio

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Targeting Inhibition of Accumulation and Function of Myeloid-Derived Suppressor Cells by Artemisinin via PI3K/AKT, mTOR, and MAPK Pathways Enhances Anti-PD-L1 Immunotherapy in Melanoma and Liver Tumors by Mengqi Zhang, Lulu Wang, Wan Liu, Tian Wang, Francesco De Sanctis, Lifang Zhu, Guizhong Zhang, Jian Cheng, Qin Cao, Jingying Zhou, Aldo Tagliabue, Vincenzo Bronte, Dehong Yan, Xianchun Wan, Guang Yu

“…Although ART is reported to reduce MDSC levels in 4T1 breast tumor model and improve the therapeutic efficacy of anti-PD-L1 antibody in T cell lymphoma-bearing mice, how ART influences MDSC accumulation, function, and molecular pathways as well as MDSC-mediated anti-PD-L1 resistance in melanoma or liver tumors remains unknown. Here, we reported that ART blocks the accumulation and function of MDSCs by polarizing M2-like tumor-promoting phenotype towards M1-like antitumor one. …”
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Hybrid azole-based conjugates as upcoming anticancer and antimicrobial agents by Luís M. T. Frija, Bruno E. C. Guerreiro, Inês C. C. Costa, Vera M. S. Isca, Lucília Saraiva, Beatriz G. Neves, Mariana Magalhães, Célia Cabral, Maria L. S. Cristiano, Patrícia Rijo

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Comparison Between Convolutional Neural Network CNN and SVM in Skin Cancer Images Recognition by Zaid Ghazi Hadi, Ahmed R. Ajel, Ayad Q. Al-Dujaili

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Interdependence of coagulation with immunotherapy and BRAF/MEK inhibitor therapy: results from a prospective study by Malte Beckmann, Julian Schlüter, Michael Erdmann, Rafaela Kramer, Sarah Cunningham, Holger Hackstein, Robert Zimmermann, Lucie Heinzerling

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From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments by Zhenlin Li, Zhenlin Li, Zhenlin Li, Zhenlin Li, Fangqi Lu, Fangqi Lu, Fangqi Lu, Fangqi Lu, Fujin Zhou, Fujin Zhou, Fujin Zhou, Dekun Song, Dekun Song, Dekun Song, Lunhui Chang, Lunhui Chang, Lunhui Chang, Lunhui Chang, Weiying Liu, Guorong Yan, Guorong Yan, Guorong Yan, Guolong Zhang, Guolong Zhang, Guolong Zhang, Guolong Zhang

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Evaluation of Anti-Cancer, Pro-Apoptotic, and Anti-Metastatic Effects of Synthetic Analogue Compound 2-Imino-7-Methoxy-4-(4-fluorophenyl)-2H-1,3-Thiazino [3,2-a] Benzimidazole on Pancreatic PaCa-2 and Melanoma A375 Cancer Cells by Mpho Ndou, Marthe C. D. Fotsing, Michael H. K. Kengne, Edwin M. Mmutlane, Derek T. Ndinteh, Mthokozisi B.C. Simelane, Lesetja Motadi, Mpho Choene

“…This study aims to explore in vitro anti-proliferative, pro-apoptotic, and anti-metastatic effects of 2-imino-7-methoxy-4-(4-fluorophenyl)-2h-1,3-thiazine [3,2-a] benzimidazole against pancreatic and melanoma cancer cell lines. Cell viability assays were conducted using Alamar blue assay. …”
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Recent global patterns in skin cancer incidence, mortality, and prevalence by Mingyue Wang, Xinghua Gao, Li Zhang, Lishao Guo, Xiangxiang Pan

“…The incidence and mortality rates of skin cancer (melanoma of skin and non-melanoma skin cancer) in GLOBOCAN 2022 were reviewed. …”
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Diagnosis and Management of Lentigo Maligna: Clinical Presentation and Comprehensive Review by Piyu Parth Naik

“…If left untreated, LM will progress to lentigo maligna melanoma (LMM), a form of invasive melanoma with the same prognosis as other forms of invasive melanoma. …”
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Melanonychia by Julie Jefferson, Phoebe Rich

“…Regrettably, patients with nail apparatus melanoma are often initially misdiagnosed, and due to diagnostic delays of an average of 2 years, melanoma of the nail unit carries a poor prognosis. …”
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Reflectance Confocal Microscopy in Tinea Nigra: A Diagnostic Teaching Point by Samuel Ibáñez, Dominga Peirano, Rosario Agüero, Cristián Navarrete-Dechent, Álvaro Abarzúa-Araya

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Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis by Catarina Araújo, Cristina Resende, Francisco Pardal, Celeste Brito

“…The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis. …”
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In Vivo Noninvasive Imaging of Healthy Lower Lip Mucosa: A Correlation Study between High-Definition Optical Coherence Tomography, Reflectance Confocal Microscopy, and Histology by Alejandra García-Hernández, Rodrigo Roldán-Marín, Pablo Iglesias-Garcia, Josep Malvehy

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