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601
Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic
Published 2025-02-01“…Moreover, oral dysbiosis potentially influencing systemic health through immune-mediated pathways. Regional immunity of periodontium involving neutrophils, T helper cells-17, and immune-related cytokines is crucial for maintaining periodontal homeostasis and responding to microbial imbalances. …”
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602
Building with Jelly, or, Concrete as the Concretion of the Abstract
Published 2025-02-01“…Expanding Jappe’s value-critical analysis of reinforced concrete with Moishe Postone’s account of how the peculiar social ‘self-mediating’ character of abstract labour in capitalism explains the transformation of labour into pure means and of its tools and products in mere objects, I intend to complement the question of cosmotechnics with an explanation of the decline of technodiversity grounded on the abstract logic of capital. …”
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603
The ubiquitin-conjugating enzyme UBE2D maintains a youthful proteome and ensures protein quality control during aging by sustaining proteasome activity.
Published 2025-01-01“…Here, we find that E2s have diverse roles in handling a model aggregation-prone protein (huntingtin-polyQ) in the Drosophila retina: while some E2s mediate aggregate assembly, UBE2D/effete (eff) and other E2s are required for huntingtin-polyQ degradation. …”
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604
The Role of Donations and Education Services in Kabale Municipality Kabale District.
Published 2024“…Some respondents showed that pupils are presented with bursaries, one-off money installments or prizes as part of impetus for enhancing participation and motivation in learning at school Incentives are viewed as more powerful than different mediations since they straightforwardly target children, as opposed to guardians, parental figures or instructors. …”
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605
Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pups
Published 2024“…In conclusion, the administration of EFTI was protective during prenatal aluminum chloride exposure of the liver in Wistar rats, and is mediated by the anti-lipid peroxidative, antiapoptotic, and anti-inflammatory activity of EFTI.…”
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606
The Influence of English Language Developmental Trends on Teaching Morphology in Selected Secondary Schools in Kabale Municipality Kabale District .
Published 2023“…Comprehension skills was more autonomous as being mentioned by the respondents such skills that are academically mediated to transfer communication e.g. skills of reading to skills of writing. …”
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607
Detection and quantification of pathogens in saliva of adolescents with cerebral palsy: a cross-sectional study
Published 2023-12-01“…BackgroundElevated levels of inflammatory mediators in saliva have been described in individuals with cerebral palsy (CP).ObjectiveThe aim of this study was to detect and quantify the pathogens Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum and Prevotella intermedia in the saliva of adolescents with CP.MethodsThis is a cross-sectional study with adolescents with CP to detect periodontopathogens from saliva samples. …”
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608
Impact of sleep deprivation on colon cancer: Unraveling the KynA-P4HA2-HIF-1α axis in tumor lipid metabolism and metastasis
Published 2025-03-01“…Subsequently, mice feces were collected for untargeted metabolomics to screen and identify the key mediator, Kynurenic acid (KynA). Furthermore, HILPDA was screened by transcriptomics, and its potential mechanism was explored through ChIP, co-IP, ubiquitination experiments, phenotyping experiments, etc. …”
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609
Targeting transforming growth factor-β1 by methylseleninic acid/seleno-L-methionine in clear cell renal cell carcinoma: Mechanisms and therapeutic potential
Published 2024-01-01“…These findings suggest that selenium-mediated downregulation of TGF-β1, PD-L1, and VEGF could be a viable therapeutic strategy for ccRCC.…”
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610
Comprehensive three-dimensional microCT and signaling analysis reveal the teratogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on craniofacial bone development in mice
Published 2025-01-01“…Together, our findings demonstrated that TCDD was teratogenic in numerous cranial neural crest cell-derived craniofacial bone development, and disrupted multiple genes for osteogenic differentiation via the TCDD-mediated AhR/ ERα signaling cross-talk.…”
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611
Structural insights into dynamics of the BMV TLS aminoacylation
Published 2025-02-01“…Upon binding, TLS undergoes dynamic rearrangements, particularly with helices B3 and E pivoting, mediated by the unpaired A36 residue, ensuring effective recognition by TyrRS. …”
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612
Search for electroweak production of a vector-like T quark using fully hadronic final states
Published 2020-01-01“…Upper limits at 95% confidence level are set on the cross sections for T quark-mediated production of tHQq, tZQq, and their sum, where Q is the associated top or bottom heavy quark and q is another associated quark. …”
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613
Antitumor effects of natural killer cells derived from gene-engineered human-induced pluripotent stem cells on hepatocellular carcinoma
Published 2025-02-01“…The TRAIL and perforin/granzyme B pathways are largely involved in this cytotoxic mechanism, as indicated by the reduction in cytotoxicity induced by TRAIL inhibitory antibodies and concanamycin A, which inhibits perforin/granzyme B-mediated cytotoxicity. Our data suggest that eNK cells, whose functions have been enhanced by genetic engineering, have the potential to improve HCC treatment.…”
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614
CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models
Published 2025-02-01“…Altogether, our data indicate that navarixin blocks CCL21/CCR7-mediated neuron-microglia communication and could be used as a therapeutic strategy against PD. …”
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615
Secretory phospholipase A2 inhibitory activity in Tragia hispida: A novel and promising therapeutic agent for dengue fever
Published 2025-02-01“…Secretory phospholipase A2 (sPLA2), an inflammatory enzyme, plays a critical role in producing platelet-activating factor (PAF), a key mediator of vascular leak. Elevated sPLA2 activity has been linked to the progression of DHF. …”
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616
Salivary Levels of Interleukin-17 in Iranian Patients With Systemic Sclerosis
Published 2024-12-01“… Systemic sclerosis (SSc) is a rare immune-mediated rheumatic disease in which the skin, muscles, blood vessels, and internal organs are damaged through chronic inflammation. …”
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617
CHOLINE TRANSPORTER-RELATED 4 (CTR4) Is Involved in Drought and Saline Tolerance in Rice
Published 2025-01-01“…These findings suggest that CTR4 mediates choline transport and influences cell membrane formation, thereby enhancing rice defenses against drought and salt stress by maintaining lipid homeostasis.…”
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618
Immunoglobulin G4-related disease with pleural involvement in an 80-year-old female patient: A case report and literature review
Published 2025-03-01“…Background: Immunoglobulin G4-related disease (IgG4-RD), a rare immune-mediated disease affecting multiple organs, rarely involves the pleura. …”
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619
«Så sitter du der og plutselig leser for alle» – en nærstudie av barnehageansatte som litteraturformidlere
Published 2025-02-01“…ENGLISH ABSTRACT “All of the Sudden You Are Sitting There Reading for Everyone” – A Close Study of Pedagogical Staff as Literature Mediators Recent studies of pedagogical staff investigate practices that inform read-alouds in kindergartens (Alatalo & Westlund, 2021; Damber, 2015; Dybvik et al., 2022; Tjäru, 2023). …”
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620
Public satisfaction with Healthy China Action Plan implementation: a web-based cross-sectional survey in southwest China
Published 2025-02-01“…Therefore, we intend to conduct an assessment based in southwest China.Design A population-based, cross-sectional survey was performed between 1 June 2023 and 31 July 2023.Setting Community members of all 14 prefecture-level cities within Guangxi, China, during June 2023 to July 2023.Participants A total of 62 4016 participants were included for analysis based on exclusion criteria, with 44.4% aged 18–35 and a male to female ratio of 3:2.Primary outcome measure ‘Public satisfaction with the Healthy China (Guangxi) Action Plan implementation’ was measured by the combination of ‘Willingness to join health promotion’ and ‘Satisfaction to overall medical implementation measures and services’ using a structural equation model with a multiple-indicator, multiple-cause approach in R software.Results The study proposed a comprehensive five-factor model to evaluate the public satisfaction with Healthy China (Guangxi) Action Plan implementation. With the mediator of ‘awareness of Healthy China (Guangxi) Action Plan’, health education/promotion demonstrated important effect on overall public satisfaction with Healthy China (Guangxi) Action Plan implementation. …”
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