Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study by Taylor Roh, Sungeun Ju, So Young Park, Yeonghwan Ahn, Jiyun Chung, Miyako Nakano, Gyoungah Ryu, Young Jae Kim, Geumseo Kim, Hyewon Choi, Sung-Gwon Lee, In Soo Kim, Song-I Lee, Chaeuk Chung, Takashi Shimizu, Eiji Miyoshi, Sung-Soo Jung, Chungoo Park, Sho Yamasaki, Seung-Yeol Park, Eun-Kyeong Jo

“…Single-cell RNA sequencing identifies a distinct macrophage-like cell population with increased expressions of inflammatory mediators and FUT4 in response to Fu-Hp. Additionally, Mincle, a C-type lectin receptor, interacts with Fu-Hp to amplify the inflammatory responses and signaling. …”
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Six events that shaped antibody approvals in oncology by Suman Paul, Suman Paul, Shibin Zhou, Shibin Zhou

“…We detail the generation of the ADC and BsAb formats that dramatically augmented antibody-mediated precision cytotoxicity. Finally, we explore the development of ipilimumab, the first immune checkpoint-inhibiting antibody that activates the immune system to kill cancer cells, and the discovery that allowed the use of checkpoint inhibitors across all cancer types based on the presence of genetic markers. …”
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Analysis and Characterization of the Immunogenicity of Rhoptry Protein 18 by Masoud Foroutan, Amir Karimipour-Saryazdi, Ali Dalir Ghaffari, Hamidreza Majidiani, Arezo Arzani Birgani, Elaheh Karimzadeh-Soureshjani, Shahrzad Soltani, Hany M Elsheikha

“…Predictions using the C-ImmSim server suggest that TgROP18 can stimulate humoral and cell-mediated immune responses, based on antibody titers and cytokine profiles following antigen administration. …”
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Heterologous expression of SpsTAC2 in Arabidopsis affected branch angle and secondary vascular system development by Fangshu Niu, Mengru Yuan, Hongxia Zhao, Zhi Pang, Jie Yan, RuiXie Ning, Lin Shi, Fengqiang Yu, Dongshan Wei, Rong Yang, Runming Zhang, Haifeng Yang

“…The subcellular localization of SpsTAC2 was analyzed via Agrobacterium-mediated transient expression in onion (Allium cepa L.) epidermal cells. …”
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Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle by Vishnu Kumarasamy, Jianxin Wang, Michelle Roti, Yin Wan, Adam P. Dommer, Hanna Rosenheck, Sivasankar Putta, Alec Trub, John Bisi, Jay Strum, Patrick Roberts, Seth M. Rubin, Costakis Frangou, Karen McLean, Agnieszka K. Witkiewicz, Erik S. Knudsen

“…CRISPR screens identify CDK2 loss as a mediator of resistance to a CDK2 inhibitor, INX-315. …”
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Levels of IL-6 and IL-1β in Umbilical Cord Blood in Relation to Mode of Birth by Ebru Aslan Patlakoğlu, Sündüz Özlem ALTINKAYA, Mustafa Uğur, Cuma Taşın, Nezaket Kadıoğlu

“…CONCLUSION: In healthy and term pregnancies, the exposition of spontaneous vaginal delivery and labor is not associated with activation of inflammatory mediators compared to cesarean. The data of the present study did not support the increasing ratio of newborn complications (respiratory distress syndrome, bronchopulmonary dysplasia, the need for prolonged oxygen therapy and neonatal intensive care unit, allergic diseases of infancy period) after cesarean delivery due to inadequate increasing levels of cytokines in newborns delivered by cesarean. …”
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Chromatin remodeling (SWI/SNF) complexes, cancer, and response to immunotherapy by Razelle Kurzrock, Shumei Kato, Nithya Krishnamurthy, Scott Lippman

“…The SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex subfamily mediates nucleosome reorganization and hence activation/repression of critical genes. …”
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Immunoinformatic strategy for developing multi-epitope subunit vaccine against Helicobacter pylori. by Md Nahian, Md Rasel Khan, Fabiha Rahman, Hossain Mohammed Reza, Imren Bayil, Tanjum Ahmed Nodee, Tabassum Basher, Mostafizur Rahaman Sany, Rabeya Najnin Munmun, S M Ariful Habib, Lincon Mazumder, Mrityunjoy Acharjee

“…Additionally, immune simulations showed elevated levels of cell-mediated immunity, while repeated exposure simulations indicated rapid antigen clearance. …”
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Gamification with Codeathon for Productivity Toward Sustainable Development Goal 8 – Decent Work and Economic Growth by Swati Tayal, K Rajagopal

“…Results: The study indicated a relationship between Gamification and Productivity among IT employees, where Autonomy was a mediator factor. Limitations of the investigation: This study primarily focused on the information technology sector among Generation Z and Y, but future research can explore other industries and countries. …”
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THE ROLE OF US IN CHINA – TAIWAN CRISIS by EDGAR AGUBAMAH

“…Be that as it may this work recommended that the US should abandon her partial strategic ambiguity (that is they will not commit to go to war to defend Taiwan, nor will they take the war option off the table if Taiwan is attacked) and other subtle supports to Taiwan and play a clear and transparent mutual meditative role in China-Taiwan crisis so that the issue between China and Taiwan can be settled amicably. A truthful mediator must prove herself or himself impartial. …”
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Lower urinary dysfunction as a long-term effect of childhood vincristine treatment, with potential influences by sex and dose by Nao Iguchi, Ali Teimouri, Duncan T. Wilcox, Anna P. Malykhina, Nicholas G. Cost

“…Noteworthy functional changes were observed in bladder strips from the VCR group, including decreased nerve-mediated contraction, heightened contractile responses to cholinergic and purinergic agonists, enhanced responsiveness to histamine—primarily via histamine receptor 1 (Hrh1)—and an augmented relaxation effect with compound 48/80 (a mast cell degranulator), relative to the control group. …”
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Sulfatase modifying factor 2 as a predictive biomarker for urothelial carcinoma by Wei-Ting Kuo, Yi-Chen Lee, Jia-Bin Liao, Ching-Jiunn Tseng, Yi-Fang Yang

“…Abstract Sulfatases mediate the sulfation level of cell-surface heparan sulfates to regulate signal transduction, thereby promoting cancer progression. …”
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Navigating the medical journey: Insights into medical students' psychological wellbeing, coping, and personality. by Aisha Ali Hawsawi, Neil Nixon, Elena Nixon

“…Notably, problem-focused coping partially mediated the relationship between stress and depression. …”
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Центральные и гормональные механизмы адаптации к десинхронизационному стрессу by Парвин Асад кызы Зульфугарова, Ариф Алиовсад оглы Мехтиев

“…В первой серии исследований изучалось влияние десинхронизации на уровень белка 2, опосредующего активность коллапсина (collapsin-response mediator protein 2 (CRMP2)) в гипоталамусе и эпифизе, методом твердофазного непрямого иммуноферментного анализа (НИФА). …”
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Pan-caspase inhibitors induce secretion of HIV-1 latency reversal agent lymphotoxin-alpha from cytokine-primed NK cells by Zamaneh Hajikhezri, Ioannis Zygouras, Anders Sönnerborg, Robert van Domselaar

“…Natural killer (NK) cells, with their ability to mediate cytotoxicity independent of antigen specificity, offer a promising avenue for enhancing the shock-and-kill approach. …”
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CREDIT RISK MANAGEMENT AND PROFITABILITY OF DEPOSIT MONEY BANKS IN NIGERIA by Alade Ayodeji ADEMOKOYA, Mubarak Olajide SALAMI, Halimat Bukola ISAU, Habeeb Abiola IBRAHIM

“… Banks in all climes are primarily faced with problem of credit risk whenever they mediate between the surplus and the deficit units of the economy. …”
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Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review by Shangwu Liu, Runhong Zhang, Jamal Hallajzadeh

“…Exercise has shown promise in preventing neurodegenerative diseases (NDs), and ncRNAs and exosomal ncRNAs are emerging as potential mediators of these benefits. In review, we explored how ncRNAs and exosomal ncRNAs play a role in enhancing the impacts of activity on neurodegenerative disorders for future treatments. …”
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Background and Foreground: Connections and Distinctions When Health Professions Faculty Teach Both Interprofessional Collaborative Practice and Quality Improvement—A Case Study by Katherine Stevenson, Johan Thor, Marcel D’Eon, Linda A Headrick, Boel Andersson Gäre

“…Furthermore, they described the relationship between QI and ICP as one mediated by systems thinking, where ICP is backgrounded as a critical pre-requisite and QI is foregrounded as a vector for developing interprofessional competencies. …”
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Biology of selective caries removal: a systematic scoping review protocol by Helge Knüttel, Matthias Widbiller, Rita Weiler, Kerstin M Galler, Wolfgang Buchalla, Konstantin J Scholz

“…During the entire procedure, two reviewers independently screened the articles, and controversies were mediated by vote of a third reviewer. Eventually, it became apparent that different biological explanations can be organised into four categories: pulp response, cavity seal, remaining bacteria and cavity liner. …”
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Examining the Chemical and Optical Properties of Biomass-burning Aerosols and their Impact on Oxidative Potential by Suman Yadav, Taveen Singh Kapoor, Pradnya Vernekar, Harish C. Phuleria

“…Exposure to emissions from biomass cooking is linked with adverse respiratory health outcomes - likely mediated through the oxidative potential of particulate matter (PM). …”
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