METTL14 modulates the progression and ferroptosis of colitis by regulating the stability of m6A-modified GPX4 by Yuhua Chen, Weicong Fan, Ying Lyu, Jingsheng Liao, Ying Zhou

“…In addition, METTL14 enhanced GPX4 mRNA stability through mediating m6A modification, and the interplay between METTL14 and GPX4 through m6A modification introduced innovative therapeutic approaches for UC management.…”
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Exploring the anticancer potential of Hewittia malabarica through phytochemical analysis and molecular docking study by Shiji Thozhukkad Moosaripparambil, Kannan Vadakkadath Meethal

“…These results indicate that the mechanism of cytotoxicity observed may be mediated through induction of apoptosis in cancer cell lines. …”
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A peripheral subepithelial network for chemotactile processing in the predatory sea slug Pleurobranchaea californica. by Tigran Norekian, Yichen Liu, Ekaterina D Gribkova, Jilai Cui, Rhanor Gillette

“…Ciliary clusters likely drive the sensory nerve spikes via SeN, mediating appetitive and stimulus place codes to CNS. …”
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Defensive healthcare practice: systematic review of qualitative evidence by James Thomas, Melissa Harden, Theo Lorenc, Claire Khouja, Helen Fulbright

“…The qualitative evidence calls into question the view of defensive practice as a key mediator linking litigation risk to inappropriate treatment and excess costs.…”
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ENHANCING PROFESSIONAL DEVELOPMENT THROUGH INTERNATIONAL COLLABORATIVE DIALOGUE: A STUDY OF MALAYSIAN AND AUSTRALIAN PRE-SERVICE TEACHERS by Vegneskumar Maniam, Tay Gerard, Ingrid Harrington, Hayley Trenchard, Susan Bennett

“…Findings - Analysis of the interview data revealed six key themes: (1) Games in the Classroom, (2) Inclusive Mindsets, (3) Planning in Teaching and Learning, (4) Computer-Mediated Communication (CMC), (5) International and Comparative Education, and (6) Workshop Sustainability. …”
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Efficacy of CLT4A variants as immunoregulatory molecules among Vitiligo patients in Saudi Arabia by Amal F. Alshammary, Ghada BinSaif, Imran Ali Khan

“…Abstract Vitiligo is a skin depigmentation condition caused by the immune-mediated perdition of melanocytes. In vitiligo, cytotoxic T-lymphocytes damage melanocytes, causing skin depigmentation. …”
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Osteosíntesis de radio y ulna con placa bloqueada en oso hormiguero gigante (Myrmecophaga tridactyla) by Sarah Manuela Stuart Gomez, Kelvin Pinto Acero, Gaston Roberto Gómez Castro

“…La resolución se aborda mediate osteosíntesis de ambas estructuras óseas con un sistema de doble placa bloqueada de titanio bajo plan anestésico de ketamina 4mg/Kg, dexmedetomidina 0.025 mg/kg y midazolam 0.1 mg/Kg; el mantenimiento se realizó con isoflurano a razón de 3% como inicio de la anestesia y 1.5% de mantenimiento. …”
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Association of loneliness with the risk of pain in older Chinese adults by Aijun Song, Siying Yu, Yao Shen, Zongyan Guo, Jian Shi

“…Abstract This study investigates the long-term effects of loneliness on pain experiences in older Chinese adults, focusing on the mediating role of depression. Data from the China Health and Retirement Longitudinal Study (2013–2020) included 1,592 participants aged 60 and above. …”
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Influence of Kinship on Family Stability in Kagunga Sub-County Rukungiri District. by Mugarura, Junior

“…Both older and younger respondents recognize the importance of these relationships in providing emotional support, sharing resources, and mediating conflicts. Kinship networks contribute significantly to the well-being of family members by offering a support system that helps stabilize the family unit during times of need. …”
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Effects of B-Blockers on the Sympathetic and Cytokines Storms in Covid-19. by Al-kuraishy, Hayder M., Al-Gareeb, Ali Ismail, Mostafa-Hedeab, Gomaa, Keneth Iceland, Kasozi, Zirintunda, Gerald, Aslam, Akhmed, Allahyani, Mamdouh, Welburn, Susan Christina, Batiha, Gaber El-Saber

“…In conclusion, b-blockers interrupt this interaction through inhibition of several mediators of CS and SS with prevention development of neural-cytokine loop in SARS-CoV-2 infection. …”
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Cervical heterotopic heart transplantation in mice using a novel suture technique by Hao Dun, MD MSc, Maura Sticco-Ivins, Yuriko Terada, MD PhD, Amber Berning, MD, Kory J. Lavine, MD PhD, Daniel Kreisel, MD PhD, Benjamin J. Kopecky, MD PhD

“…Background: Vascularized transplantation models in mice are critical to understand mechanisms that mediate rejection and to develop new therapeutics. …”
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Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases by Jialian Lv, Xinyue Song, Zixin Luo, Duoqin Huang, Li Xiao, Kang Zou

“…Luteolin exhibits therapeutic effects on various pulmonary disease models through multiple molecular mechanisms; these include inhibition of activation of the PI3K/Akt-mediated Nuclear Factor kappa-B (NF-κB) and MAPK signaling pathways, as well as the promotion of regulatory T cell (Treg) function and enhancement of alveolar epithelial sodium channel (ENaC) activity (alleviating inflammation and oxidative stress responses). …”
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Common and unique network basis for externally and internally driven flexibility in cognition: From a developmental perspective by Ziyi Huang, Dazhi Yin

“…We found similar quadratic effects of age on reactive and spontaneous flexibility, which were mediated by the functional connectivity strength and nodal flexibility of the frontoparietal network. …”
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Exploring BCL2 regulation and upstream signaling transduction in venetoclax resistance in multiple myeloma: potential avenues for therapeutic intervention by Rodrigo Fonseca, Yuan Xiao Zhu, Laura A. Bruins, Joseph Ahmann, Cecilia de Bonolo Campos, Esteban Braggio, Xianfeng Chen, Mariano Arribas, Susie Darvish, Seth Welsh, Erin Meermeier, Kiran K. Mangalaparthi, Richard K. Kandasamy, Greg Ahmann, J. Erin Wiedmeier-Nutor, Akhilesh Pandey, Marta Chesi, P. Leif Bergsagel, Rafael Fonseca

“…Simultaneous inhibition of MCL-1, BCL-XL, and upstream PI3K, RTK (FGF, EGF, and IGF1) mediated signaling enhanced VTX sensitivity. Post-translational modifications of MCL-1, particularly its stabilization via acetylation and phosphorylation, were investigated, although their inhibition only marginally increased VTX sensitivity. …”
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A minimal gene set characterizes TIL specific for diverse tumor antigens across different cancer types by Zhen Zeng, Tianbei Zhang, Jiajia Zhang, Shuai Li, Sydney Connor, Boyang Zhang, Yimin Zhao, Jordan Wilson, Dipika Singh, Rima Kulikauskas, Candice D. Church, Thomas H. Pulliam, Saumya Jani, Paul Nghiem, Suzanne L. Topalian, Patrick M. Forde, Drew M. Pardoll, Hongkai Ji, Kellie N. Smith

“…Abstract Identifying tumor-specific T cell clones that mediate immunotherapy responses remains challenging. …”
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The adaptation of rainbow trout to warmer water: Oxidative damage in the germinal line by Vianel Sevastei, Sonia A. Crichigno, M. Victoria Santos, Andrea Trochine, Julio C. Painefilú, Noemí Zaritzky, Víctor E. Cussac

“…Our results suggest that the acquired thermal tolerance traits may be part of a wide spectrum of novel characteristics produced as a consequence of an enhanced mutation rate and/or a different DNA methylation pattern, induced by higher temperatures and mediated by ROS.…”
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Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation by Roberta Ramonda, Leonardo Punzi, Anna Scanu, Francesca Oliviero, Roberto Luisetto, Paola Galozzi, Marta Favero

“…Human studies and experimental models have revealed that a series of inflammatory mediators are released in synovial fluid immediately after the joint trauma. …”
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The geographical variation in grassland forage quality on the eastern Qinghai-Tibet Plateau is driven mainly by climate by Shulan Wu, Xiaotao Lü, Qinghua Liu, Erke Wuda, Liu Li, Chunzhang Zhao, Juanjuan Huang, Shuang Li, Youbang Hu, Wenzhi Du, Hewen Li, Chaoqun Chen, Lin Luo, Ali Raza, Chunying Yin

“…Soil conditions indirectly affected forage quality by mediating the plant community composition. Conclusions This study highlights the role of climate in driving the variation of forage quality in the alpine grasslands. …”
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Mitochondrial Mayhem: How cigarette smoke induces placental dysfunction through MMS19 degradation by Pei Zhou, Feng Jin, Shenshen Yao, Ben Sun, Ni Sun, Hongbo Guan, Xiaomei Liu

“…Transcriptome analysis indicated that dysregulation of the SMAD pathway mediates mitochondrial damage induced by MMS19 KD. …”
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Comparative functional analysis of a new CDR1-like ABC transporter gene in multidrug resistance and virulence between Magnaporthe oryzae and Trichophyton mentagrophytes by Jing Wang, Chenwen Xiao, Shuang Liang, Muhammad Noman, Yingying Cai, Zhen Zhang, Xueming Zhu, Rongyao Chai, Haiping Qiu, Zhongna Hao, Yanli Wang, Jiaoyu Wang, Guolian Bao, Guochang Sun, Fucheng Lin

“…TmCDR1 effectively rescued the drug sensitivity and virulence of ΔMocdr1 and mediated the drug resistance and animal skin infection in T. mentagrophytes. …”
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