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441
Exploring the Ancient Persian/Unani Theory of Connection between Gastrointestinal and Respiratory Tracts: Current Evidence and Future Directions
Published 2024-12-01“…The interaction between the respiratory and gastrointestinal systems can occur through several mechanisms, including commonalities in embryonic sources, role of identical mediators and receptors, influence of common pathogens in the lungs and gut, similarity of microbiota patterns and changes, and same inflammatory and mucosal responses. …”
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442
Constraint on the total width of the Higgs boson from Higgs boson and four-top-quark measurements in pp collisions at s = 13 TeV with the ATLAS detector
Published 2025-02-01“…This Letter presents a constraint on the total width of the Higgs boson (ΓH) using a combined measurement of on-shell Higgs boson production and the production of four top quarks, which involves contributions from off-shell Higgs boson-mediated processes. This method relies on the assumption that the tree-level Higgs-top Yukawa coupling strength is the same for on-shell and off-shell Higgs boson production processes, thereby avoiding any assumptions about the relationship between on-shell and off-shell gluon fusion Higgs production rates, which were central to previous measurements. …”
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443
Inhibition of GPR68 induces ferroptosis and radiosensitivity in diverse cancer cell types
Published 2025-02-01“…Our results suggest that GPR68 is a key mediator of cancer cell radioresistance activated by acidic tumor microenvironment.…”
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444
Treatment of irritable bowel syndrome: the past, present and future
Published 2015-03-01“…Agonists of peripheral opioid receptors normalize motility of gastro-intestinal tract and increase a threshold of pain sensitivity mediated by glutamate synaptic receptors of spinal cord posterior horns that prevents development of central and peripheral sensitization. …”
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445
Targeting ceramide transfer protein sensitizes AML to FLT3 inhibitors via a GRP78-ATF6-CHOP axis
Published 2025-02-01“…The synergistic effects are found to be mediated by the endoplasmic reticulum stress-GRP78/ATF6/CHOP axis and mitophagy. …”
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446
The Hippo pathway promotes platinum-based chemotherapy by inhibiting MTF1-dependent heavy metal response
Published 2025-02-01“…This resistance is mitigated by Hippo pathway-mediated phosphorylation of MTF1. Moreover, pharmacological activation of the Hippo pathway sensitizes cancer cells to platinum-based compounds. …”
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447
Acute particulate matter exposure diminishes executive cognitive functioning after four hours regardless of inhalation pathway
Published 2025-02-01“…Inhalation method did not significantly mediate effects, suggesting that short-term PM pollution affects cognitive function through lung-brain mechanisms, either directly or indirectly.…”
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448
Facile colorimetric detection of As(V) in Rice with immobilized acid phosphatase on hollow metal-organic frameworks hybrid with peroxidase-like activity
Published 2025-01-01“…Then, based on the inhibition of As(V) on immobilized ACP and cascade reaction mediated by ACP and AuHT, a colorimetric biosensor was established with excellent simplicity. …”
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449
The trust paradox: An exploration of consumer psychology and behavior in cross-border shopping using E-commerce mobile applications
Published 2025-04-01“…The findings emphasize the pivotal role of satisfaction as a mediating variable, which effectively mitigates uncertainty and enhances behavioral intention within the cross-border shopping context. …”
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450
Inhibition of lanosterol synthase linking with MAPK/JNK signaling pathway suppresses endometrial cancer
Published 2025-02-01“…In this study, we identified lanosterol synthase (LSS) as a key mediator in cholesterol metabolism associated with EC. …”
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451
Cybertoxicology, molecular docking, and experimental verification reveal the mechanism of action of chlorpyrifos on skin damage
Published 2025-01-01“…In conclusion, our study suggests that CPF exposure primarily induces skin damage by disrupting tissue structure and function, mediated through apoptosis and proliferation processes in skin cells, alongside aberrant angiogenesis and heightened inflammatory response. …”
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452
Probiotics in the Modern World
Published 2020-07-01“…Alike normal microflora, probiotic strains incorporate into general metabolism by mediating a spectrum of functions, e.g. maintaining colonisation resistance, nutrient metabolism, supplying the host with vital metabolites, regulation of local and adaptive immune responses, enhancing the intestinal barrier. …”
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453
Orbital-order as the driving mechanism for superconductivity in ruthenates
Published 2025-02-01“…Our results suggest that phonons strongly coupled to electrons, such as those involved in charge disproportionation or Jahn-Teller effects and inducing band gaps in various oxides, could also serve as mediators of Cooper pairs in metallic phases.…”
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454
Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
Published 2017-11-01“…Here we show that STAT5 dimers are sufficient for NK cell development, whereas STAT5 tetramers mediate NK cell maturation and the expression of maturation-associated genes. …”
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455
Adoptive cell transfer of piezo-activated macrophage rescues immunosuppressed rodents from life-threating bacterial infections
Published 2025-02-01“…We show that piezoNPs strongly interact with macrophages within subcutaneous abscesses caused by Staphylococcus aureus (S. aureus) infections, and demonstrate that this interaction enhances the macrophage-mediated antibacterial phagocytosis and killing activity through intracellular piezocatalysis. …”
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456
Laser-induced coherent spin change due to spin-orbit coupling
Published 2025-02-01“…Our findings highlight the SOC-mediated coherent spin dynamics, advancing ultrafast spintronic technology.…”
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457
Expanding Viral Diversity in Rice Fields by Next-Generation Sequencing
Published 2025-01-01“…These analyses greatly expand our understanding of viruses in rice fields and provide valuable insights for developing efficient strategies to manage insect pests and virus-mediated rice diseases.…”
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458
4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models
Published 2025-02-01“…Selective monoclonal antibody (mAb)-mediated depletions of immune cell populations, neutralizing interferon alpha/beta receptor 1 (IFNAR-I) IFNAR and interferon (IFN)-γ mAbs and gene-modified mice (4-1BB−/−) were used to delineate the immune cell subsets and mechanisms required for efficacy. 67Ga labeled muFAP-4-1BBL tracked by SPECT-CT was used to study biodistribution. …”
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459
Effects of hydrogen water and psychological treatment in a sample of women with panic disorder: a randomized and controlled clinical trial
Published 2022-05-01“…Research suggests that inflammation is an important mediator in the pathophysiology of anxiety disorders. …”
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460
Digital Storytelling: Resistive Stories and the “Measurement” of Change
Published 2015-10-01“…What form the final narrative takes in any digital storytelling project is often shaped by the interests of these “mediators” who turn “judges of narratives” when they mould and package these stories to be more palatable to their specific audiences and consumption needs. …”
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