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421
Path model explaining the association between fear of falling and health-related quality of life in (pre-)frail older adults
Published 2025-02-01“…Unlike previous studies that examined only few mediating variables, this study aimed to develop a more comprehensive path model explaining the association between FoF and HrQoL. …”
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422
The evolutionarily diverged single-stranded DNA-binding proteins SSB1/SSB2 differentially affect the replication, recombination and mutation of organellar genomes in Arabidopsis th...
Published 2025-01-01“…Based on accurate long-read sequencing results, ssb1 and ssb2 mutants had decreased copy numbers for both mitochondrial DNA (mtDNA) and plastid DNA (ptDNA), accompanied by a slight increase in structural rearrangements mediated by intermediate-sized repeats in mt genome and small-scale variants in both genomes. …”
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423
Multi-locus CRISPRi targeting with a single truncated guide RNA
Published 2025-02-01“…These truncated guides direct CRISPRi-mediated deposition of repressive H3K9me3 marks and disrupt transcription factor binding at most sequence match target sites. …”
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424
Case Report: Dangerous liaisons between splenectomy and eltrombopag-induced chronic thromboembolic pulmonary hypertension in patients with immune thrombocytopenia: report of two ca...
Published 2025-02-01“…IntroductionPrimary immune thrombocytopenia is an autoimmune bleeding disorder characterized by variable immune-mediated platelet destruction. These patients have reported thrombotic complications, both venous and arterial, in addition to bleeding. …”
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425
Sedum alfredii Hance: A cadmium and zinc hyperaccumulating plant
Published 2025-01-01“…Numerous studies have been conducted to uncover the mystery of its hypertolerance and hyperaccumulation using high-throughput sequencing, biochemical and molecular techniques, mainly pointing to the root-microorganism interaction, restrained Cd storage in roots, efficient root-shoot translocation, effective cellular detoxification, and phloem-mediated metal remobilization. This also encourages studies on functional genes involved in metal transport, antioxidant, transcription regulation and stress response, providing candidates for genetic modification. …”
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426
Role of mitochondrial and lysosomal dysfunction in acute pancreatitis pathogenesis
Published 2016-08-01“…Hyperamilasemia, premature intralobular activation of digestive enzymes, accumulation of large vacuoles in acinar cells, activation of proinflammatory mediators, apoptosis and necrosis of acinar cells are the basic pathomorphological signs of AP. …”
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427
Attenuation processes in positive social emotion upregulation: Disentangling functional role of ventrolateral prefrontal cortex
Published 2025-02-01“…Here, we examined the neural processes mediating upregulation of positive social emotions using functional magnetic resonance imaging in healthy female volunteers. …”
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428
An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants
Published 2025-02-01“…This element consists of CTCF binding sites that mediate three-dimensional chromatin looping involving LMNB1 and the recruitment of the PRC2 transcriptional repressor complex. …”
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429
Gen inhibiting the Wnt/Ca2+ signaling pathway alleviates cerebral ischemia/reperfusion injury
Published 2025-02-01“…The knockdown of Frizzled-2 confirmed the pathway’s role in mediating calcium overload and subsequent damage. Our findings suggest that Gen alleviates CIRI by inhibiting the Wnt/Ca2+ signaling pathway, positioning it as a promising candidate for therapeutic intervention in stroke treatment.…”
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430
Prion protein promotes copper toxicity in Wilson disease
Published 2025-02-01“…Here, using genome-wide screening, we identified the cellular prion protein (PrP) as an important mediator of Cu toxicity in WD. Loss of ATP7B stimulates hepatic expression of PrP, which promotes endocytic Cu uptake, leading to toxic Cu overload. …”
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431
Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model
Published 2025-02-01“…It also promotes PPARG expression to blockage of NF-κB pathway-mediated inflammatory response and neuroinflammation.…”
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432
Prenatal exposure to bisphenol A causes reproductive damage in F1 male rabbits due to inflammation and oxidative stress
Published 2025-01-01“…By modulation of the Nrf2 and NF-κB axes, BPA could influence the expression of antioxidant enzymes and inflammatory mediators in the rabbit reproductive system, leading to cell apoptosis and tissue damage. …”
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433
Search for boosted low-mass resonances decaying into hadrons produced in association with a photon in pp collisions at s $$ \sqrt{s} $$ = 13 TeV with the ATLAS detector
Published 2025-01-01“…Abstract Many extensions of the Standard Model, including those with dark matter particles, propose new mediator particles that decay into hadrons. This paper presents a search for such low mass narrow resonances decaying into hadrons using 140 fb −1 of proton-proton collision data recorded with the ATLAS detector at a centre-of-mass energy of 13 TeV. …”
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436
Resilience, Confidence-Building, and Performance:
Published 2024-12-01“…Such an analysis, which considers mediating factors not previously analyzed together in adaptive digital learning studies, such as individual rather than aggregate performance, digital learning platform design differences, resiliency factors, and in-class activities, is an important step in clarifying some of the previously mixed results. …”
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437
The Committee on Public Information: A transmedia war propaganda campaign
Published 2012-07-01“…A discussion about how the expectations of persuasion, truth and amusement relate to each other when mediated in culture, using Lotman’s concept of the semiosphere further develops an understanding of propaganda as a cultural system in relation to other cultural systems – in this case, journalism and popular culture. …”
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438
Competing stakeholder discourses in constructing cultural heritage: The legal case of the house at No. 98 Hai’er Lane, China
Published 2024-12-01“…., adopting a multi-stakeholder approach to mediate various interests of stakeholders. Besides, disputes over heritage protection and promotion need to be understood within the dominant discourses of their time. …”
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439
Transformational Leadership, Compensation, Career Development, & Job Satisfaction: Key Factors in Employee Performance in the F&B Industry
Published 2025-02-01“…Likewise, compensation and career development significantly affect job satisfaction. Job satisfaction mediates the relationship between these variables and employee performance and shows a strong indirect effect. …”
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440
Participatory Budgeting and Financial Accountability in Kabale District Local Government
Published 2020“…Conclusively, there is a strong positive relationship between participatory budgeting and financial accountability, mediated by monitoring and internal control mechanism. …”
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