Mechanistic insights into connexin-mediated neuroglia crosstalk in neurodegenerative diseases by Simona Denaro, Simona D’Aprile, Nunzio Vicario, Rosalba Parenti

“…Neuroglial crosstalk is physiologically ensured by extracellular mediators and by the activity of connexins (Cxs), the forming proteins of gap junctions (Gjs) and hemichannels (HCs), which maintain intracellular and extracellular homeostasis. …”
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New strategy for gastrointestinal protection based on gaseous mediators application by O. N. Sulaieva, J. L. Wallace

“…To assess protective mechanisms and efficacy of gaseous mediators based antiinflammatory therapy. Key points. …”
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Theranostic nanoemulsions suppress macrophage-mediated acute inflammation in rats by Riddhi Vichare, Yalcin Kulahci, Rebecca McCallin, Fatih Zor, Fatma Nurefsan Selek, Lu Liu, Caitlin Crelli, Anneliese Troidle, Michele Herneisey, James M. Nichols, Andrew J. Shepherd, Vijay S. Gorantla, Jelena M. Janjic

“…In vitro, we showed that curcumin-loaded nanoemulsion suppressed polarization of macrophages towards M1-like phenotype, consequently decreasing the release of pro-inflammatory cytokines and mediators like IL-6, IL- $$\:\beta\:,$$ TNF- $$\:\alpha\:$$ , and nitric oxide (NO). …”
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Formation of volatile compounds in salt-mediated naturally fermented cassava by Alberta N.A. Aryee, Christabel Tachie, Aleksei Kaleda

“…The addition of salt can be used to control acidification, adopted as an effective preservation technique, and mediate VOCs production during cassava fermentation.…”
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Gravity-mediated scalar Dark Matter in warped extra-dimensions by Miguel G. Folgado, Andrea Donini, Nuria Rius

“…We assume that both, the Dark Matter and the Standard Model, are localized in the TeV brane and only interact via gravitational mediators, namely the graviton Kaluza-Klein modes and the radion. …”
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Principles of Self-Regulation in EFL mediated by Dialogic Tutoring Sessions by Imelda Zorro Rojas

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Knowledge, attitude, and practice toward vitiligo among vitiligo patients: a mediation analysis by Hua Feng, Xiulian Xu, Shuzhen Qi, Kun Chen, Mei Ju, Xiaofang Li, Shuxian Shang

“…The mean knowledge, attitude, and practice scores were 5.45 ± 2.74 (possible range: 0–10), 23.15 ± 6.78 (possible range: 8–40), and 37.13 ± 6.78 (possible range: 10–50), respectively. Mediation analysis indicated that knowledge (β = 0.24, P = 0.023), attitude (β=-0.28, P < 0.001), disease duration (β=-1.49, P < 0.001), and negative emotions (β=-1.54, P = 0.008) had direct effects on practice. …”
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The association between visceral fat metabolic score and stroke: mediation by declining kidney function by Yue Cao, Weixing Wen, Hao Zhang, Weiwen Li, Guolin Huang, Yuli Huang

“…A non-linear relationship was observed, with stroke risk sharply increasing when METS-VF exceeded 7.00. Mediation analysis revealed that declining eGFR mediated 26.72% of the METS-VF-stroke association. …”
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Mediators of intercellular interactions and histological signs of chronic viral liver disease by P. V. Koroy, A. V. Yagoda, G. I. Gilyazova, I. S. Mukhoramova

“…To establish interrelation of intercellular interaction mediators with histological changes at chronic viral liver disease.Material and methods. …”
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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome by Kira A Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Meaghan CS Courvan, Taylor Jones, Deepa Ajit, Matthew D Galbraith, Joaquín M Espinosa, David Bentley, Mary Ann Allen, Robin D Dowell, Dylan J Taatjes

“…We also discovered that CDK8/CDK19 affect splicing, a novel means by which Mediator kinases control gene expression. To further probe Mediator kinase function, we completed cytokine screens and metabolomics experiments. …”
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Detection by Single-Cell RNA Sequencing of Virally Mediated Skin Diseases by Linda Zhou, Thomas H. Leung

“…Finally, we interrogate skin biopsies from many established nonvirally mediated inflammatory skin diseases and do not find consistent evidence of viral infection in any condition. …”
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Dark matter annihilation via Breit-Wigner enhancement with heavier mediator by Yu Cheng, Shao-Feng Ge, Jie Sheng, Tsutomu T. Yanagida

“…We propose a new scenario that both the dark matter freeze-out in the early Universe and its possible annihilation for indirect detection around a supermassive black hole are enhanced by a Breit-Wigner resonance. With the mediator mass larger than the total initial dark matter mass, this annihilation is almost forbidden at late times. …”
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Authentic Materials and Tasks as Mediators to Develop EFL Students’ Intercultural Competence by Alix Norely Bernal Pinzón

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Antifungal efficacy of chitosan-mediated fenugreek nanocomposite incorporated in tissue conditioner by Mohika Damle, Ponsekar Abraham Anandapandian, B. Eswaran, Swapnaneel Pradhan, Silvin Joe C J, Shreyas Dhumke

“…Methodology: After synthesizing chitosan mediated fenugreek Nanocomposite, its characterization was performed using SEM, FTIR analysis and UV–Vis spectroscopy. …”
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Cellular rejuvenation protects neurons from inflammation-mediated cell death by Sienna S. Drake, Abdulshakour Mohammadnia, Aliyah Zaman, Christine Gianfelice, Kali Heale, Adam M.R. Groh, Elizabeth M.-L. Hua, Matthew A. Hintermayer, Yuancheng Ryan Lu, David Gosselin, Stephanie Zandee, Alexandre Prat, Jo Anne Stratton, David A. Sinclair, Alyson E. Fournier

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Gingipains protect Porphyromonas gingivalis from macrophage-mediated phagocytic clearance. by Magdalena Widziolek, Anna Mieszkowska, Magdalena Marcinkowska, Bartlomiej Salamaga, Justyna Folkert, Krzysztof Rakus, Magdalena Chadzinska, Jan Potempa, Graham P Stafford, Tomasz K Prajsnar, Craig Murdoch

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The protective role of SGLT2 inhibitors on aortic aneurysm mediated by oxidative stress and inflammation in type 2 diabetes mellitus by Rujie Zheng, Wenjuan Song, Jie Lu, Mingyue Yuan, Xiaotong Sun, Chengzhi Lu

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Hesperidoside abolishes dichlorvos-mediated neurotoxicity in rats by suppressing oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspase-3-mediated apoptosis by Adio J. Akamo, Adetutu O. Ojelabi, Oluwatobi T. Somade, Iyabode A. Kehinde, Adewale M. Taiwo, Boluwatife A. Olagunju, Mushafau A. Akinsanya, Adedayo A. Adebisi, Tobi S. Adekunbi, Abiola F. Adenowo, Florence Anifowose, Olufemi M. Ajagun-Ogunleye, Ofem E. Eteng, Jacob K. Akintunde, Regina N. Ugbaja

“…Hence, this study assessed the likely beneficial impact of hesperidoside (HESP) on the DDVP-mediated cerebral dysfunction in rat model. Method: Randomization was employed to earmark forty-two rats into seven groups: control, DDVP alone (8 mg.kg⁻¹day⁻¹), DDVP plus HESP (50 and 100 mg.kg⁻¹day⁻¹) and reference drug atropine (0.2 mg.kg⁻¹day⁻¹), and HESP alone (50 and 100 mg.kg⁻¹day⁻¹). …”
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UV-induced reorganization of 3D genome mediates DNA damage response by Veysel Oğulcan Kaya, Ogün Adebali

“…We show that adaptive reorganization of the 3D genome is a key mediator of the damage response, providing new insights into the complex interplay of genomic structure and cellular defense mechanisms against UV-induced damage, thereby advancing our understanding of cellular resilience.…”
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The mediating effect of perceived value on customer loyalty of BMT NU East Java by Mohamad Mondir, Siti Habibatur Rahma

“…Meanwhile, perceived value has a significant effect on customer loyalty. Perceived value can mediate the Islamic Marketing mix, service quality, and product quality variables in customer loyalty. …”
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