SARS-CoV-2 ORF3a accessory protein is a water-permeable channel that induces lysosome swelling by Antonio Michelucci, Luigi Sforna, Riccardo Focaia, Maria Vittoria Leonardi, Angela Di Battista, Giorgia Rastelli, Simone Vespa, Simona Boncompagni, Manlio Di Cristina, Luigi Catacuzzeno

“…Consistent with this, N82L and N82W mutations abolish ORF3a-mediated water permeation. Finally, ORF3a expression in HEK293 cells leads to lysosomal volume increase, mitochondrial damage, and accumulation of intracellular membranes, all alterations reverted by the N82W mutation. …”
Get full text

Factors influencing emotional driving: examining the impact of arousal on the interplay between age, personality, and driving behaviors by Zhegong Shangguan, Xiao Han, Younesse El Mrhasli, Nengchao Lyu, Adriana Tapus

“…Extraversion significantly mediated the relationship between age and driving behaviors, with this relationship being moderated by arousal states. …”
Get full text

DIRECT AND INDIRECT EFFECT OF BRAND CREDIBILITY, BRAND COMMITMENT AND LOYALTY INTENTIONS ON BRAND EQUITY by Veeva Mathew, Sam Thomas, Joseph I Injodey

“…Using Sequential Chi-square Difference Test in Structural Equations Modelling, the researchers identified the mediating role of brand commitment and loyalty intentions, in the formation of brand equity. …”
Get full text

DIRECT AND INDIRECT EFFECT OF BRAND CREDIBILITY, BRAND COMMITMENT AND LOYALTY INTENTIONS ON BRAND EQUITY by Veeva Mathew, Sam Thomas, Joseph I Injodey

“…Using Sequential Chi-square Difference Test in Structural Equations Modelling, the researchers identified the mediating role of brand commitment and loyalty intentions, in the formation of brand equity. …”
Get full text

The refugees and health crisis: migration policy management and government response to Afghan migrants by Kalsoom B. Sumra, Muhammad Mumtaz, Naqib Ullah Khan, Helen Huifen Cai, Qiong Yuan

“…Unavailability of relief packages and lack of risk communication mediates the effect of refugees’ crisis on vulnerability. …”
Get full text

Prognostic value of FCER1G expression and M2 macrophage infiltration in esophageal squamous cell carcinoma by Wei Peng, Yali Zhao, Ningning Yang, Yan Fang, Yintong Wu, Zhenzhong Feng, Qiang Wu, Xian Wang

“…Abstract Background FCER1G as an immune-associated protein, which belongs to the immunoglobulin superfamily and is involved in mediating and executing antibody-mediated immune responses. …”
Get full text

KLF5 silencing restrains proliferation, invasion, migration and angiogenesis of gallbladder carcinoma cells by transcriptional regulation of PDGFA by Xiaowei Lu, Kui Hu, Dandan Zhang, Xuefeng Yin, Jifeng Nie, Kai Zhao

“…Abstract Background Krüppel-like factor 5 (KLF5) is recognized as a tumor mediator in multiple types of tumors. Nevertheless, whether KLF5 plays a role in gallbladder cancer (GBC) remains to be elucidated. …”
Get full text

GGCT participates in the malignant process of hepatocellular cancer cells by regulating the PTEN/PI3K/AKT pathway through binding to EZH2 by Junbo He, Liangzhi Wang, Mengjia Lv, Yiming Yuan

“…In addition, GGCT silencing inhibited PTEN/PI3K/AKT pathway-mediated glycolysis. EZH2 was highly expressed in HCC cells and the interaction of GGCT and EZH2 was verified. …”
Get full text

Supply chain performance in the age of Industry 4.0 by Tahsina Khan, Md Mehedi Hasan Emon

“… Goal: This study investigates the impact of Industry 4.0 adoption on supply chain performance in Bangladesh’s manufacturing sector, emphasizing the mediating roles of digital supply chain integration, supply chain innovation, and supply chain visibility. …”
Get full text

Patient-Centric Structural Determinants of Adherence Rates Among Asthma Populations: Exploring the Potential of Patient Activation and Encouragement Tool TRUSTR to Improve Adherenc... by Asim Zia, Arthur Brassart, Sheila Thomas, Fen Ye, Judith J. Stephenson, C. Daniel Mullins, Christopher A. Jones

“…Patients with poor medical condition are likely to have lower adherence rate, but this direct effect is countered by mediating variables. Further, each additional reward and higher engagement with a mobile app is likely to have a positive total effect on increasing the adherence rate. …”
Get full text

Pain in pancreatitis: issue and ways out by A. V. Okhlobystin

“…Histological study frequently reveals signs of neural damage, inflammatory mediators often can act as pain mediators. Sensitization affect not only nerve terminals, but neurones of spinal cord and brain as well. …”
Get full text

Age Groups and Generations: Lines of Conflict and Potentials for Integration by Martin Kohli

“…The reason why age conflicts are not more pronounced is the mediating function of political parties, unions and families. …”
Get full text

Fear of COVID-19 and its Differential Effect on Attitudes and Intentions towards Online and Face-to-Face Counseling by Jae Hun Shin, Xyle Ku

“…The path analysis results indicated that attitude towards online and face-to-face counseling differentially mediated the relationship between COVID-19 fear and both counseling intentions, even when controlling for other covariates. …”
Get full text

Comparative the effect of bisphenol A and bisphenol S on the development and spectral sensitivity of cone photoreceptors in zebrafish larvae (Danio rerio) by Liguo Qiu, Peng Yu, Qiang Li, Cuiping Wen, Haiyang Wang, Dongying Zhao, Tianyu Zhang, Chenghui Wang, Lixia Liu, Dongxue Li, Shiyong Wen, Yinghui Sun

“…Color vision, which is mediated by cone photoreceptors in vertebrates, is essential for perceiving the external environment. …”
Get full text

South African Rheumatism and Arthritis Association 2024 guidelines for the use of biologic and targeted synthetic disease-modifying antirheumatic drugs by E van Duuren, J Potts, U Brijlal, S Botha, S Didi, K Makan, M van Dam, K Chinniah, B Hodkinson

“…It is recommended that b/tsDMARDs for immune-mediated inflammatory rheumatic diseases are prescribed by a rheumatologist, and all patients must be included in the South African Rheumatism and Arthritis Association biologic registry. …”
Get full text

KLF4: a multifunctional nexus connecting tumor progression and immune regulation by Yunjie Ju, Wen Xiao, Bryan James Mathis, Ying Shi

“…Signaling pathways which mediated by KLF4 and KLF4 have a sophisticated role in tumors due to multiple factors, including the types or stage of tumors. …”
Get full text

Protocol to study chloride regulation in cultured mouse cortical neurons using electrophysiology by Vineeth A. Raveendran, Jessica C. Pressey, Melanie A. Woodin

“…Summary: Inhibitory synaptic transmission mediated by the neurotransmitter γ-aminobutyric acid (GABA) is dependent on the concentration of chloride ions (Cl−) in neurons, which can be assessed by making patch-clamp recordings of the reversal potential for GABA (EGABA). …”
Get full text

Harnessing amino acid pathways to influence myeloid cell function in tumor immunity by Jiongli Pan, Yi Lin, Xinyuan Liu, Xiaozhen Zhang, Tingbo Liang, Xueli Bai

“…Within the tumor microenvironment, amino acid metabolism plays a crucial role in mediating the immunosuppressive functions of myeloid cells, contributing to tumor progression. …”
Get full text

Ander weë tot God? Calvyn oor nie-Christelike godsdienste by P. C. Potgieter

“…He asserts the uniqueness of Christ as the only Mediator and Redeemer for mankind on his unconditional acceptance of Holy Scriptures as the Word of God. …”
Get full text

Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia by Haolin Zheng, Akiko Mizokami, Sergio Romera-Giner, Jaime Llera-Oyola, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Francisco García-García, Takashi Kanematsu

“…Results Sex-dependent differences were observed in miRNA-mediated biological processes, with males exhibiting greater changes. …”
Get full text