Endoplasmic reticulum stress-related super enhancer promotes epithelial-mesenchymal transformation in hepatocellular carcinoma through CREB5 mediated activation of TNC by Anqi Wang, Sitong Yan, Jiatao Liu, Xiang Chen, Mengyao Hu, Xiao Du, Weijia Jiang, Zhipeng Pan, Lulu Fan, Guoping Sun

“…In summary, our findings suggest that ERS activation promotes EMT in liver cancer cells via SE-mediated upregulation of the CREB5/TNC pathway. This result provides a new direction for uncovering how ERS regulates EMT and a foundation for preventing the progression of EMT in HCC.…”
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Electroacupuncture regulates ferroptosis to improve postoperative cognitive dysfunction in mice through mediating GRX1/GSK-3β/Nrf2 axis by Xiaqing Zhang, Afen Zhang, Rui Li, Mingna Jiao, Rou Wen, Rongzhi Zheng

“…In addition, GRX1 silencing and erastin abolished EA-mediated alterations of improving POCD in mice. Conclusion: EA suppressed ferroptosis by regulating GRX1/GSK-3β/Nrf2 pathway to improve postoperative cognitive dysfunction of POCD mice.…”
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The Effect of Dynamic Service Innovation Capabilities on Firm Performance: The Moderating Role of Perceived Environmental Dynamism and the Mediating Role of Service Innovation and Competitive Advantage by Rasoul Nosratpanah, Samad Barani, Aref Ashrafzadeh, Gholamhosein Atashi

“…The findings also confirmed the mediating role of service innovation and competitive advantage. …”
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YTHDF2 mediates the protective effects of MG53 on myocardial infarction injury via recognizing the m6A modification of MG53 by Zhaojie Li, Kai Li, Jianqiang Zhao

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AN EMPIRICAL ANALYSIS OF THE LEADER-MEMBER EXCHANGE AND QUITTING INTENTION MEDIATED BY JOB SATISFACTION AND ORGANIZATIONAL COMMITMENT: EVIDENCE FROM SELF-FINANCED PUBLIC UNIVERSITIES by Danh Nam Nguyen, Thi Ngoc Lan Uong

“… This study investigates the effect of leader-member exchange on quitting intention as mediated by job satisfaction and organizational commitment in Vietnamese self-financed public universities. …”
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Influence of symptom burden on social alienation in lung cancer patients receiving chemotherapy: the chain mediating effect of perceived social support and positive psychological capital by Jiahao Wei, Ziye Bai, Mengru Bu, Guining Dang, Xiumei Wu, Jin Zhou

“…Results The analysis revealed that the burden of symptoms significantly exacerbates social alienation, as evidenced in the mediation effects model (Bootstrap 95% CI: 0.031, 0.092). …”
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Edaravone dexborneol alleviates pericyte-mediated fibrosis depositing extracellular matrix through TGF-β1/IL-11 in cerebral small vessel disease by Qingrui Duan, Zhiyang Liu, Yuxuan Xing, Haifeng Huang, Lin Zhu, Jiaxuan Liu, Peikun He, Guixian Ma, Yuhu Zhang, Kun Nie, Yuyuan Gao, Lijuan Wang

“…Conclusions Our findings reveal the role of pericyte-mediated fibrosis in depositing ECM in the pathogenesis of CSVD. …”
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Influence of social support on technophobia in older adults in urban communities: the mediating role of self-efficacy and e-health literacy, a cross-sectional study by Jin Li, Chen Wang, Dan Luo, Yan Shi, Hua Qing Guo, Zhi Guang Duan

“…In addition, self-efficacy (β=−0.080) and e-health literacy (β=−0.098) significantly mediated the relationship between social support and technophobia.Conclusion Social support was found to affect technophobia in older adults via the independent or chained mediating effects of self-efficacy and e-health literacy.…”
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The tryptophan-aspartate (WD) repeat domain of bovine Coronin-1A promotes mycobacterial survival by inhibiting calcium signaling-mediated phagosome-lysosome fusion by Jing Yang, Zhunan Li, Aicong Li, Yayi Liu, Xinyan Zhang, Yong Zhang, Yuanpeng Gao

“…The WD repeat domain mediated a decrease in intracellular calcium levels, which reduced levels of calmodulin-dependent kinase II (CaMKII) and its activated forms, thereby inhibiting lysosomal delivery. …”
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Tangeretin offers neuroprotection against colchicine-induced memory impairment in Wistar rats by modulating the antioxidant milieu, inflammatory mediators and oxidative stress in the brain tissue by Olalekan Bukunmi Ogunro, Mojisola Esther Karigidi, Gideon Ampoma Gyebi, Areej Turkistani, Ahmad H. Almehmadi

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Dietary index for gut microbiota and its protective role against kidney stones: evidence of diabetes as a mediator from NHANES cross-sectional data by Lei Wang, Junjun Wu, Ziwen Jiang, Chao Wang, Fuxiang Lin, Yuxiang Zhong, Pengpeng Zhao, Wei Wei, Jianhua Huang, Zhanping Xu

“…The role of DI-GM and its mediation by diabetes in KS pathogenesis remains unclear.ObjectiveTo investigate the association between DI-GM and KS prevalence, assess the mediation effect of diabetes, and explore subgroup-specific effects and underlying mechanisms.MethodsA cross-sectional analysis of NHANES (2007–2018) data was conducted using a stratified, multistage probability sampling design. …”
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VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1 by Zongfu Pan, Jinming Chen, Tong Xu, Anqi Cai, Bing Han, Ying Li, Ziwen Fang, Dingyi Yu, Shanshan Wang, Junyu Zhou, Yingying Gong, Yulu Che, Xiaozhou Zou, Lei Cheng, Zhuo Tan, Minghua Ge, Ping Huang

“…However, the mechanism how VSIG4+ TAMs mediate immune evasion in aggressive cancers have not been fully elucidated. …”
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Coupling cobalt single-atom catalyst with recyclable LiBr redox mediator enables stable LiOH-based Li-O2 batteries by Kang Huang, Zhixiu Lu, Shilong Dai, Chunyu Cui, Nam Dong Kim, Huilong Fei

“…Herein, we for the first time introduce LiBr redox mediator (RM) into the Co-SACs-catalyzed LOB system to facilitate the decomposition of LiOH. …”
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Regulation of ER stress-induced apoptotic and inflammatory responses via YAP/TAZ-mediated control of the TRAIL-R2/DR5 signaling pathway by Y. El Yousfi, F. J. Fernández-Farrán, F. J. Oliver, A. López-Rivas, R. Yerbes

“…Mechanistically, YAP/TAZ regulates apoptosis induced by ER stress in tumor cells by controlling the activation of the TRAIL-R2/DR5-mediated extrinsic apoptotic pathway through a dual mechanism. …”
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Effect of tree size attributes on fruit production and animal-mediated seed dispersal web in Melia azedarach L. (Chinaberry) in north-west Himalaya, India by Sukumaran Arun, Sasidharan Sarath, Khanduri Vinod Prasad, Suraj, Rawat Shweta, Chand Vaisakhy Prem

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Lying flat to play on smartphone excessively: the role of self-esteem by Shuhua Zhu, Lishen Wang, Yulu Gan

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Risk factors for Clostridioides difficile infection among patients diagnosed with inflammatory intestinal and rheumatological diseases in the biologic era by Helena Martínez-Lozano, Paula Saralegui-Gonzalez, Elena Reigadas, Pablo Ramón Fueyo-Peláez, Aurea García-García, José Miranda-Bautista, Luis Alcalá, Juan Carlos Nieto, María Elena Lobato-Matilla, Ignacio Marín-Jiménez, Patricia Muñoz, Luis Menchén

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All Iron Battery 3.0 by Dipak Koirala, Surendra K. Gautam, I. Francis Cheng, Peter B. Allen

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Growth mindset of anxiety and avoidant coping as mediators of anxiety across the first year of college: A longitudinal survey of college students in the context of the COVID-19 pandemic by Erin Henshaw, Susan Kennedy, Andrea Lourie, Drexler James, Folly Folivi

“… # Results Path analysis indicate that growth mindset of anxiety and avoidant coping partially mediate the relationship between baseline anxiety and later anxiety outcomes…”
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Exploring the mediating role of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) in the association between obesity and sleep-disordered breathing by Ying Cui, Ziyi Cheng

“…Abstract Purpose Exploring novel mediators affecting the relationship between obesity and sleep-disordered breathing (SDB) is necessary. …”
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