LINC01089 governs the miR-1287-5p/HSPA4 axis to negatively regulate osteogenic differentiation of mesenchymal stem cells by Hao Zou, Fei Hu, Xin Wu, Bin Xu, Guifeng Shang, Dong An, Dehao Qin, Xiaolei Zhang, Aofei Yang

“…In this study, we aimed to disclose how LINC01089 functions in human mesenchymal stem cell (hMSC) osteogenic differentiation, and to study the mechanism by which LINC01089 regulates MSC osteogenesis. …”
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Exploring proteomic immunoprofiles: common neurological and immunological pathways in multiple sclerosis and type 1 diabetes mellitus by Fátima Cano-Cano, Almudena Lara-Barea, Álvaro Javier Cruz-Gómez, Francisco Martín-Loro, Laura Gómez-Jaramillo, María Carmen González-Montelongo, María Mar Roca-Rodríguez, Lucía Beltrán-Camacho, Lucía Forero, Javier J. González-Rosa, Mª Carmen Durán-Ruiz, Ana I. Arroba, Manuel Aguilar-Diosdado

“…This pattern underscores the shared mechanisms involved in their immune responses and neurological complications, alongside dysregulation of the autophagy pathway. …”
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Characteristics and multi-omics analysis of spontaneous spondyloarthritis in non-human primates: Case report by Lei Cai, Qing Lv, Ronghua Ma, Wei Liu, Yalun Guan, Zhongqiang Huang, Qingyu Liu, Yunfeng Li, Shuhua Liu, Ge Li, Yu Zhang

“…Its intricate pathological mechanisms have led to a scarcity of animal models capable of replicating the disease progression in humans, making it a prominent area of research interest in the field. …”
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PLGA-based biocompatible nanoparticles improved anti-breast tumor efficacy of 1,25(OH)2D3 through the SOCS3/STAT3/EMT signaling axis by JinJing Pan, Ping Wang, Linghong Xiong, Wenqing Yang, Jie Li, Kai Yang, Bingyan Li

“…Hence, the potential of PLGA encapsulation to augment the anti-breast cancer properties of 1,25(OH)2D3 and the underlying mechanism remain uncertain. In this study, our findings not only demonstrated the effective encapsulation of 1,25(OH)2D3 in PLGA (PLGA-1,25(OH)2D3, PD) but also indicated that the PD has a more potent inhibitory effect on the proliferation and migration of breast cancer cells compared with 1,25(OH)2D3 alone. …”
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Polo-like Kinase 1 Expression as a Biomarker in Colorectal Cancer: A Retrospective Two-Center Study by Lana Jajac Brucic, Vesna Bisof, Majana Soce, Marko Skelin, Ivan Krecak, Andjela Nadinic, Branka Vrbicic, Zivana Puljiz, Suzana Hancic, Slavko Gasparov

“…Further research on these combinations is necessary, as well as the discovery of new potential targets for targeted therapy and the mechanisms of synergistic effects in tumors with PLK-1 overexpression.…”
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Unraveling the immunological landscape and gut microbiome in sepsis: a comprehensive approach to diagnosis and prognosisResearch in context by Yali Luo, Jian Gao, Xinliang Su, Helian Li, Yingcen Li, Wenhao Qi, Xuling Han, Jingxuan Han, Yiran Zhao, Alin Zhang, Yan Zheng, Feng Qian, Hongyu He

“…These changes statistically mediated the association of Bacteroides salyersiae with sepsis, suggesting a potential underlying mechanism. A combined diagnostic model incorporating B.salyersia, NK cells in CD45+ leukocytes, and C-reactive protein (CRP) demonstrated high accuracy in distinguishing sepsis from non-sepsis (area under the receiver operating characteristic curve, AUC = 0.950, 95% CI: 0.811–1.000). …”
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Integrated transcriptomic hypothalamic-pituitary-ovarian axis network analysis reveals the role of energy availability on egg production in layers by Jianling Peng, Yong Cui, Haiping Liang, Shenyijun Xu, Linjian Weng, Meng Ru, Ramlat Ali, Qing Wei, Jiming Ruan, Jianzhen Huang

“…The hypothalamic-pituitary-ovarian (HPO) axis is an energy-sensitive functional axis for follicle development, synthesis, and secretion of reproductive hormones, and plays a key role in modulating sustained ovulation in layers. To investigate the mechanism of integrated network regulation of the HPO axis under energy fluctuation, ninety Hy-line brown layers (265-day-old, 1.92 ± 0.02 kg) were randomly divided into three groups for a 17-day experiment: a control group (Con group) fed ad libitum from days 1 to 17, an energy-deprived group (ED group) that was fed ad libitum from days 1 to 12 and then underwent a fasting period from days 13 to 17 to induce a pause in laying, and a re-fed group (Rf group) that fasted for seven days (specifically, days 1 to 5, day 7, and day 9), had ad libitum access to feed on days 6 and 8, and was continuously fed from days 10 to 17. …”
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HESS Opinions: Towards a common vision for the future of hydrological observatories by P. Nasta, G. Blöschl, G. Blöschl, H. R. Bogena, S. Zacharias, R. Baatz, G. De Lannoy, K. H. Jensen, S. Manfreda, L. Pfister, L. Pfister, A. M. Tarquis, I. van Meerveld, M. Voltz, Y. Zeng, W. Kustas, X. Li, H. Vereecken, N. Romano

“…The already existing monitoring infrastructures have provided an enormous amount of hydrometeorological data, facilitating detailed insights into the causal mechanisms of hydrological processes, the testing of scientific theories and hypotheses, and the revelation of the physical laws governing catchment behavior. …”
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Within- and between-day test–retest reliability of responses to rapid bilateral anterolateral magnetic phrenic nerve stimulation in healthy humans (ReStim) by Kyle G. P. J. M. Boyle, Andrea A. Beglinger, Heinrich Häusler, Anna Stahel, Esther I. Schwarz, Esther I. Schwarz, Christina M. Spengler, Christina M. Spengler

“…BackgroundMechanical ventilation can lead to lung injury and diaphragmatic dysfunction. …”
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Designing a model of effective marketing capabilities based on communication by Yoones Banisaeed, Ghanbar Amirnejad, Morteza mousakhani, Leila Andervazh

“…Doah et al, (2023) showed that elucidating the underlying mechanisms through which marketing capability affects firm performance contributes to the growing body of knowledge about marketing strategy. …”
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戶外教育課程評估指標建構之研究 Indicators for Evaluating Outdoor Education Curricula by 鄭智明 Chi Meng Cheang, 陳美燕 Mei-Yen Chen, 郭雄軍 Husing-Chun Kuo

“…Finally, safety and risk management mechanisms are consistently embedded throughout the curriculum of outdoor education. …”
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Call for Papers: How attractive are political parties and trade unions to young people? by IF and FRFG

“…They provide fundamental linkage mechanisms of representation and participation that connect citizens with the state (Keman 2014; Webb 2000). …”
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Deciphering the effect of exercise timing on glucose metabolism: a randomised controlled trial by Fabienne Bruggisser, Denis Infanger, Henner Hanssen, Raphael Knaier

“…This is possibly due to the influence of circadian rhythms on metabolic mechanisms. However, further in-depth understanding of the underlying metabolic mechanisms is needed to establish a robust scientific foundation for this approach. …”
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Presenting a model based on media and social networks in the management of intelligent electricity consumption by Ahmad shojaee arzaneee, Mohamad Hemati, Ali akbar Amin beydokhti

“…Managing consumption and rationalizing the appropriate and timely use of electricity, by predicting the necessary mechanisms, is a way to provide a part of the main and necessary future needs for electricity. …”
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Designing a Policy Making Model in Iran' Sport with the Approach of Sport for All Development by Behdad Sadeghi, Rahmatollah Gholipour, Mojtaba Amiri, Marjan Saffari

“…In Iran, 'sport for all' and organized recreation have received limited attention, and currently, there is no mechanism for monitoring sports policies and their continuous implementation. …”
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Eicosapentaenoic Acid and Docosahexaenoic Acid as an Antimicrobial Agent in Orthopedics—An In Vitro Study About the Race for Surface by Christopher Spiegel, Burak Ünalan, Andreas Kaserbacher, Rohit Arora, Débora C. Coraça-Huber

“…Its capability of forming biofilms and developing mechanisms against antibiotics is one of the most dangerous clinical topics being currently discussed. …”
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Clinical Significance of Negative Costimulatory Molecule PD-1/PD-L1 on Peripheral Blood Regulatory T Cell Levels among Patients with Pulmonary Tuberculosis by Chenchen Yang, Fanchao Dai, Rexiti Pulati, Yan Jiao, Qian Xu

“…Our findings provide insights into the illustration of pathogenic mechanisms and immunotherapy of active pulmonary TB.…”
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Pembingkaian Perjuangan Tanah Orang Mentawai Dalam Konflik Kehutanan by Nurhayati Nurhayati, Afrizal Afrizal, Jendrius Jendrius

“…Implementation of economic growth in land control through market mechanisms and state intervention. State intervention in the land and forestry sectors changes the land use map on Siberut Island. …”
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Optimization design of an acoustic cover layer for a cylindrical cavity based on porous materials by Bohan ZHANG, Jili RONG, Xiuyan CHENG

“…The underlying sound absorption mechanisms of the porous materials were analyzed to explain these improvements. …”
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Characterization of the bioaccumulation and toxicity of copper pyrithione, an antifouling compound, on juveniles of rainbow trout by Bourdon, Charlotte, Cachot, Jérôme, Gonzalez, Patrice, Couture, Patrice

“…Among them, copper pyrithione (CuPT) is used, but its mechanisms of toxicity remain little known. This project aimed to identify and measure the impacts of aqueous exposure to CuPT, an organic compound, and compare it to ionic Cu2+ added in the form of its inorganic salt CuSO4, in equivalent Cu2+ molar concentrations, on rainbow trout (Oncorhynchus mykiss) juveniles under controlled laboratory conditions. …”
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