Mechanistic insights into 125I seed implantation therapy for Cholangiocarcinoma: focus on ROS-Mediated apoptosis and the role of GPX2 by Jun Luo, Zheng Yao, Weiren Liang, Danjun Song, Hui Zeng, Yi Jiang, Zhehan Bao, Jiaping Zheng, Yinan Ding

“…Herein, we investigated the mechanism of efficacy of 125I seed implantation therapy in CCA, focusing on the induction of reactive oxygen species (ROS)-mediated apoptosis and the involvement of glutathione peroxidase 2 (GPX2). Materials and methods Human cholangiocarcinoma cell lines QBC939 and RBE were purchased for in vitro studies. …”
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Behavioural components and delivery features of early childhood obesity prevention interventions: intervention coding of studies in the TOPCHILD Collaboration systematic review by Brittany J. Johnson, Paul M. Chadwick, Samantha Pryde, Anna Lene Seidler, Kylie E. Hunter, Mason Aberoumand, Jonathan G. Williams, Hei In Lau, Sol Libesman, Jannik Aagerup, Angie Barba, Louise A. Baur, Samantha Morgillo, Lee Sanders, Sarah Taki, Kylie D. Hesketh, Karen Campbell, Alexandra Manson, Alison Hayes, Angela Webster, Charles Wood, Denise A. O’Connor, Karen Matvienko-Sikar, Kristy Robledo, Lisa Askie, Luke Wolfenden, Rachael Taylor, H. Shonna Yin, Vicki Brown, Alexander Fiks, Alison Ventura, Ata Ghaderi, Barry J. Taylor, Cathleen Stough, Christine Helle, Cristina Palacios, Eliana M. Perrin, Elizabeth Reifsnider, Finn Rasmussen, Ian M. Paul, Jennifer S. Savage, Jessica Thomson, Jinan Banna, Junilla Larsen, Kaumudi Joshipura, Ken K. Ong, Levie Karssen, Li Ming Wen, Márcia Vitolo, Margrethe Røed, Maria Bryant, Maribel Campos Rivera, Mary Jo Messito, Natalia Golova, Nina Cecilie Øverby, Rachel Gross, Rajalakshmi Lakshman, Rebecca Byrne, Russell L. Rothman, Sharleen O’Reilly, Stephanie Anzman-Frasca, Vera Verbestel, Claudio Maffeis, Kayla de la Haye, Sarah-Jeanne Salvy, Seema Mihrshahi, Janani Ramachandran, Paola Seffrin Baratto, Rebecca K. Golley, on behalf of the TOPCHILD Collaboration

“…Trialists from eligible randomised controlled trials of parent-focused, behavioural early obesity prevention interventions shared unpublished intervention materials. Standardised approaches were used to code target behaviours, delivery features and BCTs in both published and unpublished intervention materials. …”
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Indicators of Esophageal pH-Impedance Monitoring and High-Resolution Manometry in Patients with Various Forms of Gastroesophageal Reflux Disease by I. V. Maev, E. V. Barkalova, M. A. Ovsepyan, D. N. Andreev, Yu. A. Kucheryavyi

“…The aim of the study is to analyze the regularities of changes in the basic indicators of esophageal pH-impedance monitoring and high-resolution manometry in patients with non-erosive reflux disease (NERD), erosive reflux disease (ERD) and Barrett’s esophagus (BE) in comparison with healthy individuals.Materials and methods.  69 patients were examined, including 19 patients with NERD, 16 patients with ERD, 14 patients with BE and 20 individuals comprising the control group (CG). …”
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Computational analysis of heat transfer and fluid flow characteristics in a diamond microchannel heat sink with orthogonal ribs by Liang Du, Wenbo Hu, Ningkang Deng, Zhaoyang Zhang, Hongxing Wang

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Diagnostic Effectiveness of Transforming Growth Factor Beta 1 in Assessing the Risk of Developing Graft Dysfunction in Liver Recipient Children by R. M. Kurabekova, O. M. Tsiroulnikova, I. E. Pashkova, A. G. Olefirenko, O. E. Gichkun, L. V. Makarova, R. A. Monakhov, P. O. Shevchenko

“…To determine the diagnostic efficacy of TGF-β1 in blood when assessing the risk of developing graft dysfunction in liver recipient children. Materials and methods. 95 children aged 3 to 73 months with liver cirrhosis of various etiologies were surveyed. …”
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Recent Advances in Fiber-Optic Sensors for the Detection of Inorganic Acidic Gases by Lingnan Kong, Yuanke Gong, Xiaoyu Zhong, Yang Liu, Bo Wan, Quanhua Xie, Yuanyuan He, Xiaoling Peng, Haixing Chang, Dengjie Zhong, Huiling Liu, Nianbing Zhong

“…Abstract An acidic gas is an important basic chemical raw material used for synthesizing fertilizers, insecticides, explosives, dyes, and salts. …”
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Magnetic hybrid chitin-horse manure humic acid for optimized Cd(II) and Pb(II) adsorption from aquatic environment by Rahmat Basuki, Yusuf Bramastya Apriliyanto, Elva Stiawan, Adya Rizky Pradipta, Bambang Rusdiarso, Budi Riza Putra

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The Use of L-Menthol in Endoscopic Transpapillary Interventions. Prospective Randomized Dual-Center Study by M. A. Anishchenko, M. A. Nazmeev, S. G. Shapovalyants, S. A. Budzinsky, A. V. Rogov, R. R. Zaynutdinov, A. S. Melnikova, E. D. Fedorov, E. N. Platonova

“…Aim: to study the effect of L-menthol on duodenal peristalsis, the results of cannulation of the papilla, the effectiveness and safety of endoscopic retrograde transpapillary interventions (ERTI).Materials and methods. A prospective two-center randomized placebo-controlled trial was carried out from January to November 2022 in two centers. …”
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Metabolic syndrome in type 1 diabetes: higher time above range and glycemic variability revealed by continuous glucose monitoring (CGM) by Yayu Fang, Wei Liu, Xiaoling Cai, Yu Zhu, Mingxia Zhang, Siqian Gong, Xiangqing Wang, Chu Lin, Rui Zhang, Sai Yin, Juan Li, Yongran Huo, Xiaodan Hu, Xiaoqi Xie, Linong Ji

“…Abstract Aims To investigate the glucose profile of Chinese individuals with type 1 diabetes (T1D) who also have metabolic syndrome. Materials and methods Type 1 diabetes participants from Peking University People’s Hospital were recruited from Jan 2017 to Jan 2024. …”
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Impact of leachate from boiled-water-treated plastic products on male reproductive health: Insights from transcriptomic and metabolomic profiling by Xinghua Yu, Rui Yao, Ge Meng, Lingan Zeng, Leyi Zhou, Yingkang Shen, Amali Upekshika Wijayaraja, Reshmi Hareendra Kariyapperuma, Wentao Xu, Yuxiang Mei, Xinyan Gu, Wen-Long Lei, Pengfei Zhang, Fei Sun

“…Given the extensive use of plastic materials in modern society, there is an escalating concern about the potential risks associated with exposure to plastic products. …”
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Dexmedetomidine versus Dexamethasone as Perineural Adjuvants in Supraclavicular Brachial Plexus Block: An Interventional Study by Charmi Hitenbhai Shah, Jinesh Pareshbhai Kothari, Nilesh Vrajmohan Shah, Rajsi Rajan Shah, Sara Mary Thomas

“…Aim: To compare the effects of perineural dexamethasone versus perineural dexmedetomidine added to a local anaesthetic mixture in supraclavicular brachial plexus block for upper limb surgeries. Materials and Methods: This interventional study was conducted in the Department of Anaesthesiology at Dhiraj Hospital, Vadodara, Gujarat, India from October 2023 to April 2024 on 80 patients with American Society of Anaesthesiologists (ASA) physical status I and II, aged 18 to 65 years, scheduled for surgery under supraclavicular brachial plexus block. …”
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A stratified two-stage tumor molecular profiling algorithm to identify clinically actionable molecular alterations in pancreatic cancer☆ by S. Hussung, D. Akhoundova, C. Pistoni, D. Lenggenhager, A. Töpfer, C. Pauli, B. Pestalozzi, C. Britschgi, M. Zoche, M. Rechsteiner, H. Moch, A. Weber, R. Fritsch

“…Moreover, the magnitude of benefit and the cost-effectiveness of comprehensive next-generation sequencing panels for PC are under debate. Materials and methods: We implemented a stratified two-stage TMP algorithm for advanced PC. …”
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Research on carbon emission accounting model for open-pit mines in alpine ecologically fragile areas by Guoqing LI, Bin BAI, Guiqi LI, Kai GUAN, Jie HOU, Chunping LIN

“…Additionally, beneficiation processes involving the separation and refinement of raw materials are highly energy-consuming, increasing indirect emissions. …”
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Effect of trilaciclib administered before chemotherapy in patients with extensive-stage small-cell lung cancer: A pooled analysis of four randomized studies by Ying Liu, Lin Wu, Dingzhi Huang, Qiming Wang, Chen Yang, Li Zhou, Shuguang Sun, Xiaomei Jiang, Ying Cheng

“…Moreover, myeloprotection effect in 1 L, 2 L/3 L population and effect by risk category were explored. Materials and Methods: Patients with ES-SCLC who received trilaciclib were included. …”
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Call for Papers - Advancing Astropharmacy and Sports Pharmacy by Ashley Anderson, Ahmer Raza, Shireen Aziz, Misbah Noreen

“…Anderson worked for the US Anti-Doping Agency, answering calls on the Drug Reference Line, creating drug information materials for elite athletes and the public, and leading the ingredient management for the search engine called Global DRO. …”
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Comparison of plasma start-up with high Z and low Z first wall in WEST by C. Guillemaut, K. Afonin, G. Bodner, J. Bucalossi, Y. Corre, P. Devynck, A. Diallo, M. Diez, N. Fedorczak, A. Gallo, B. Guillermin, V. Lapleigne, R. Lunsford, P. Maget, J. Morales, Ph. Moreau, the WEST Team, the EUROfusion Tokamak Exploitation Team

“…The choice of first wall material is of paramount importance for the plasma start-up conditions in ITER and future fusion power plants. …”
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Hymecromone Administration in Real Clinical Practice: Results of the Prospective Multicentre Observational Study in the Republic of Kazakhstan by A. V. Nersesov, D. A. Kaybullaeva, V. S. Rakhmetova, I. A. Lozinskaya, A. K. Kurmangalieva, V. S. Ayupova, A. B. Orazbaeva, A. K. Kanabaeva, Yu. O. Shulpekova

“…The objectives of the study included collection of clinical characteristics of patients, evaluation of Odeston effects in treatment of biliary pain and changes in the gallbladder emptying, evaluation of compliance to therapy, and treatment effect satisfaction.Materials and methods. The study was conducted from July 2020 to April 2021 at the premises of 60 study sites in 4 cities of the Republic of Kazakhstan. …”
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Impact of incorporating wheat straw together with basal nitrogen ratio on panicle formation and grain yield in rice by Li Qin, Chenyu Wang, Hong Zhao, Shenqi Zhou, Kun Liu, Lijun Liu

“…In this experiment, hybrid rice Fengyouxiangzhan (FY) and Yongyou 2640 (YY) were used as materials. Under the condition of total nitrogen application rate of 270 kg ha− 2, the effects of local farmers’ fertilizer practice (FP, basal fertilizer: tillering fertilizer: panicle fertilizer = 5: 1: 4) and improving basal fertilizer proportion (IP, basal fertilizer: tillering fertilizer: panicle fertilizer = 7: 1: 2) on the grain yield, branch and spikelet differentiation and degeneration of the above rice varieties were studied under the conditions of non-wheat straw returning (NR) and wheat straw full returning (WR). …”
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Development of a Sensitive Quantum Dot-Linked Immunoassay for the Multiplex Detection of Biochemical Markers in a Microvolumeric Format by Kalvaityte U, Bagdonas E, Kirdaite G, Kausaite-Minkstimiene A, Uzieliene I, Ramanaviciene A, Popov A, Butkiene G, Karabanovas V, Denkovskij J, Mobasheri A, Bernotiene E

“…Ursule Kalvaityte,1 Edvardas Bagdonas,1 Gailute Kirdaite,2 Asta Kausaite-Minkstimiene,3,4 Ilona Uzieliene,1 Almira Ramanaviciene,3,4 Anton Popov,3,4 Greta Butkiene,1,5 Vitalijus Karabanovas,1,5 Jaroslav Denkovskij,1 Ali Mobasheri,1,6– 8 Eiva Bernotiene1,9 1Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, LT-08406, Lithuania; 2Department of Personalised Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; 3Department of Immunology and Bioelectrochemistry, State Research Institute Centre for Innovative Medicine, Vilnius, LT-08406, Lithuania; 4NanoTechnas - Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Vilnius University, Vilnius, LT-03225, Lithuania; 5Biomedical Physics Laboratory, National Cancer Institute, Baublio 3b, Vilnius, LT-08406, Lithuania; 6Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, 90014, Finland; 7World Health Organization Collaborating Center for Public Health Aspects of Musculoskeletal Health and Aging, Université de Liège, Liège, B-4000, Belgium; 8Department of Joint Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, People’s Republic of China; 9Faculty of Fundamental Sciences, Vilnius Gediminas Technical University, Vilnius, LT-10223, LithuaniaCorrespondence: Eiva Bernotiene, Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Santariskiu G. 5, Vilnius, LT-08406, Lithuania, Tel +37068377130, Email eiva.bernotiene@imcentras.ltPurpose: For the diagnosis of various diseases, simultaneous sensitive detection of multiple biomarkers using low sample volumes is needed. …”
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Retrospective comparative survival analysis of ablation plus systemic therapy versus systemic therapy alone for breast cancer liver metastases, stratified by extrahepatic metastase... by Xuxiazi Zou, Hong-Liang Zou, Xuan Luo, Xu-Wei Chen, Wei-Ling Huang, Chao Zhang, Ge Ren, Jin-Hua Huang, Xue Han, Yi-Quan Jiang

“…Purpose: To assess whether ablation plus systemic therapy (AS) improves survival outcomes in patients with BCLM compared to systemic therapy alone. Materials and methods: This retrospective study analyzed patients with BCLM who received either AS or systemic therapy alone. …”
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