Danggui-Shaoyao-San Can Ameliorate Alzheimer’s Disease by Inhibiting Hippocampal Neuron Apoptosis: Findings from Serum Pharmacology by Zhang KX, Zhang JW, Jiang YH, Wang YR, Liu ZL, Ding PL, Wang XY, Cui WQ, Xu XQ, Wang YH

“…Kai-Xin Zhang,1 Ji-Wei Zhang,2 Yan-Hong Jiang,1 Yi-Ran Wang,1 Zhen-Ling Liu,1 Peng-Li Ding,1 Xiang-Ying Wang,1 Wen-Qiang Cui,3 Xiang-Qing Xu,3,* Ya-Han Wang3,* 1First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250000, People’s Republic of China; 2College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, 250000, People’s Republic of China; 3Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiang-Qing Xu, Ya-Han Wang; Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250000, People’s Republic of China, Email happyxiangqing@163.com; sdwangyahan@sina.comBackground: Danggui-Shaoyao-San (DSS) is a traditional Chinese medicine prescription with a history of nearly 2000 years, originally widely used for gynecological diseases, and in recent years research has found that DSS also has a good therapeutic effect on Alzheimer’s disease (AD).Purpose: The objective is to investigate the metabolic components of the DSS in the blood and the potential mechanisms for AD.Materials and Methods: Liquid chromatography‒mass spectrometry (LC-MS) combined with gas chromatography‒mass spectrometry (GC-MS) based non-targeted metabolomics were used to conduct in-depth research. …”
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Optimizing the dose-averaged linear energy transfer for the dominant intraprostatic lesions in high-risk localized prostate cancer patients by Bo Zhao, Nobuyuki Kanematsu, Shuri Aoki, Shinichiro Mori, Hideyuki Mizuno, Takamitsu Masuda, Hideyuki Takei, Hitoshi Ishikawa

“…This study investigated the feasibility of focal dose-averaged linear energy transfer (LETd) boost for prostate carbon-ion radiotherapy to deposit higher LETd to DILs while ensuring desired relative biological effectiveness weighted dose coverage to targets and sparing organs at risk (OARs). Materials and methods: A retrospective planning study was conducted on 15 localized prostate cancer cases. …”
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Connotation, research status, and development directions of clean coal geology in China by Yuegang TANG, Shaoqing WANG, Xiaoshuai WANG, Xin GUO, Yafeng WANG, Liping XUE, Harold H. Schobert

“…In the next decade, important research and development directions will include the spatiotemporal distribution of clean coals; the green, intelligent, quality-based combined production of paragenetic and associated minerals like coal gas; clean coal gasification; coal-based novel materials; underground coal-to-chemicals, and ecological restoration. …”
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Prognostic Value of Inflammatory and Nutritional Indicators in Non-Metastatic Soft Tissue Sarcomas by Yan Y, Zhang Y, Chen Y, Zhong G, Huang W, Zhang Y

“…Yuan Yan,1– 3,* Yunhui Zhang,1– 3,* Yonghan Chen,1– 3,* Guoqing Zhong,2,3 Wenhan Huang,2,3 Yu Zhang1– 3 1School of Medicine, South China University of Technology, Guangzhou, Guangdong, People’s Republic of China; 2Department of Orthopaedics Oncology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 3School of Materials Science and Engineering (National Engineering Research Center for Tissue Restoration and Reconstruction), South China University of Technology, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yu Zhang; Wenhan Huang, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Zhongshan 2nd Road, Guangzhou, Guangdong, People’s Republic of China, Email luck_2001@126.com; wenhanx@126.comBackground: Soft tissue sarcoma (STS) has lacked reliable prognostic indicators. …”
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Pengembangan Aplikasi Berlatih Membaca Cepat Berbahasa Inggris Berbasis Progressive Web App dengan Metode Prototyping by Muhammad Fajar Alfath, Lutfi Fanani, Agi Putra Kharisma

“…The development of an app called 'Speed Reader' was aimed to facilitate the practice of silent speed reading with English materials. Evaluation tests demonstrated the application's compatibility with mobile devices and its cross-browser functionality. …”
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Application of N-Acetyl-Glucosaminil-N-Acetyl-Muramyl Dipeptide during Triple Component Anti-Helicobacter Pylori Therapy in the Period of Coronavirus Infection COVID-19 by M. R. Konorev, E. N. Tyshevich, R. A. Pavlyukov

“…Aim: evaluation of the incidence of COVID-19 infection after three-component H. pylori eradication therapy while taking N-acetyl-glucosaminyl-N-acetyl-muramyl dipeptide (GMDP).Materials and methods. A prospective randomized comparative clinical study was carried out. …”
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Abnormal Expression of Peripheral Blood Leukocyte Surface Markers in Retinopathy of Prematurity Patients by Guo R, Cheng F, Meng XJ, Fan JM, Lu YL, Ma XH, Qiao X, Li JH

“…Rui Guo,1 Fang Cheng,1 Xiang-Jie Meng,2,3 Jun-Mei Fan,4 Ya-Ling Lu,5 Xiao-Hui Ma,6 Xin Qiao,6 Jun-Hong Li7 1Department of Ophthalmology, Children’s Hospital of Shanxi and Women Health Center of Shanxi, Affiliated to Shanxi Medical University, Taiyuan, 030000, People’s Republic of China; 2Department of Pediatric Stomatology, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People’s Republic of China; 3Department of Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People’s Republic of China; 4Department of Reproductive Medicine Center, Children’s Hospital of Shanxi and Women Health Center of Shanxi, Affiliated to Shanxi Medical University, Taiyuan, 030000, People’s Republic of China; 5School of Basic Medicine, Shanxi Medical University, Taiyuan, 030001, People’s Republic of China; 6Department of Shanxi Province Key Laboratory of Ophthalmology, Shanxi Eye Hospital Affiliated to Shanxi Medical University, Taiyuan, 030002, People’s Republic of China; 7Department of Strabismus and Pediatric Ophthalmology, Shanxi Eye Hospital, Affiliated to Shanxi Medical University, Taiyuan, 030002, People’s Republic of ChinaCorrespondence: Jun-Hong Li, Department of Strabismus and Pediatric Ophthalmology, Shanxi Eye Hospital Affiliated to Shanxi Medical University, No. 100 Fudong Street, Taiyuan, 030002, People’s Republic of China, Tel +8613834131099, Email junhongliljh@126.comObjective: Our study compares immune cell profiles in preterm infants with and without severe ROP, identifying risk factors for its development to explore both immunological aspects and determinants of ROP in preterm infants.Methods: Infants born between January 2023 to December 2023 at the Children’s Hospital of Shanxi were enrolled in this study according to the inclusion criteria. …”
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Comparative Evaluation of the Effectiveness of Manual and Electric Toothbrushes in Blind Children: A Randomised Controlled Trial by PS Thanalakshme, R Ramesh

“…Aim: To evaluate the effectiveness of manual and electric toothbrushes in promoting better oral hygiene in visually impaired children in Palayamkottai, Tirunelveli District. Materials and Methods: A randomised controlled clinical trial conducted at a high school for the blind in Palayamkottai, Tirunelveli district, Tamil Nadu, India on 120 blind chidren aged 6-12 years. …”
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COVID-19 Pandemic and IBS. Results of the All-Russian Observational Non-interventional Program to Study the Effectiveness of the Drug Kolofort® in Real Clinical Practice in Patient... by V. T. Ivashkin, R. A. Abdulkhakov, I. G. Bakulin, S. V. Zaitsev, V. I. Luchina, S. N. Mekhtiyev, S. G. Peshekhonov, E. A. Poluektova, T. I. Semenova, S. N. Serikova, G. N. Tarasova, E. A. Trush, Y. P. Uspenskiy, I. B. Khlynov, V. V. Tsukanov, N. P. Chernus

“…Aim: to study the effectiveness and safety of using the drug Kolofort® in outpatients with irritable bowel syndrome (IBS) after a new coronavirus infection.Materials and methods. An observational non-interventional program was conducted in patients with exacerbation of IBS symptoms after a new coronavirus infection. …”
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Bacteriological Profile of Chronic Suppurative Otitis Media and its Antibiotic Sensitivity Pattern at a Tertiary Care Hospital by Geeta Geeta, Naveen G, Apoorva P, Harish MO, Arathi Nair, Harshitha MC, Kiran Revankar, Girish PB

“…Aim of this study was to identify the bacteriological profile and determine antibiotic susceptibility pattern of aerobic bacterial isolates in patients of chronic suppurative otitis media. Materials and methods: Observational cross-sectional study was conducted at the outpatient department of ENT in collaboration with the department of Microbiology from December 2022 to March 2023. …”
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Stress and Coping of Parents with Children Seeking Treatment from a Tertiary Care Mental Health Institute by Stuti Sharma Lohar, Arunjyoti Baruah, Sandeep Kollipara

“…To find out the association of stress, ways of coping of parents with selected demographic variables and to determine the correlation between stress and coping of parents. Materials and Methods: A quantitative approach and descriptive research design were adopted for this study. …”
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Validation of insurance claims data on aetiology, surgical type and prosthesis for isolated valve surgery: a retrospective observational surgery by Shao-Wei Chen, Victor Chien-Chia Wu, Pao-Hsien Chu, An-Hsun Chou, Chun-Yu Chen, Feng-Cheng Chang, Yi‐Hsin Chan, Chia-Pin Lin, Yu-Ting Cheng, Bo-Cheng Hou, Jo-Ting Huang

“…Claims data, including ICD diagnostic codes, ICD procedural codes and NHI supply codes for surgical materials, were validated. Positive predictive values (PPVs) were calculated as the number of true positives divided by the total claims data.Results The PPVs (95% CI) for aortic valve (AV) surgery aetiologies were as follows: infectious endocarditis (IE), 94.1% (87.6%–97.7%); rheumatic heart disease (RHD), 88.2% (67.3%–97.5%); bicuspid AV, 93.3% (83.3%–98.1%); and degeneration, 91.7% (85.3%–95.8%). …”
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Pengembangan Media Pembelajaran Video Animasi 2 Dimensi dengan Model ADDIE pada Mata Pelajaran Teknik Pengolahan Audio dan Video Kelas XII Multimedia SMKN 12 Malang by Pratama Aprilianto, Satrio Hadi Wijoyo, Faizatul Amalia

“…Pengembangan media pembelajaran dilakukan menggunakan model ADDIE dengan tahap antara lain (1) Melakukan analisis karakter peserta didik, analisis media dan analisis pembelajaran yang dilakukan; (2) Merancang desain karakter, skenario media dan merancang lembar instrumen; (3) Melakukan tahap development video animasi, perekaman audio dan finalisasi video; (4) Melakukan implementasi pada kegiatan pembelajaran tatap muka maupun daring; dan (5) Melakukan kegiatan evaluasi pembelajaran dan pengujian validitas media dan materi kepada 3 ahli media dan 2 ahli materi. Pengujian dilakukan mendapatkan hasil pada validitas media dengan kategori Cukup valid berjumlah 1 butir, Valid berjumlah 6 butir dan Sangat Valid berjumlah 13 butir, sedangkan pada pengujian validitas materi mendapatkan hasil dengan kategori Valid berjumlah 13 butir dan Sangat Valid berjumlah 7 butir. …”
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Athermal Tantalum Pentoxide Mach-Zehnder Interferometers Based on Structural Compensation Method by Mingjian You, Zhenyu Liu, Weiren Cheng, Xingyu Tang, Ning Ding, Zhengqi Li, Min Wang, Li Shen, Qiancheng Zhao

“…Unlike previous structural compensation studies that were applied on the thermal sensitive materials such as silicon, this work is implemented in tantalum pentoxide (Ta₂O₅) platform whose thermo-optic coefficient is low. …”
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SPA14 liposomes combining saponin with fully synthetic TLR4 agonist provide adjuvanticity to hCMV vaccine candidate by Ernesto Luna, Sophie Ruiz, Marie Garinot, Cyril Chavagnac, Pankaj Agrawal, John Escobar, Laurent Revet, Marie-Jeanne Asensio, Fabienne Piras, Francis G. Fang, Donald R. Drake, Bachra Rokbi, Daniel Larocque, Jean Haensler

“…Furthermore, E6020 is a single molecule, well-characterized fully synthetic TLR4 agonist constructed in eight synthetic steps from entirely crystalline starting materials and intermediates via an optimized high-yield synthetic route. …”
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Predictors and Prognostic Effects of Perioperative Myocardial Injury After Transcatheter Aortic Valve Replacement According to VARC-3 Criteria by Hu X, Zhao Z, Wang C, Feng D, Chen Y, Niu G, Zhou Z, Zhang H, Li Z, Ye Y, Wang M, Wu Y

“…This study aimed to investigate the incidence, risk factors, and prognosis of PPMI in patients with severe aortic who underwent TAVR in China.Materials and Methods: Between September 2012 and November 2021, 516 patients with severe aortic stenosis who underwent TAVR at the Fuwai Hospital were consecutively enrolled. …”
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Detecting gene copy number alterations by Oncomine Comprehensive genomic profiling in a comparative study on FFPE tumor samples by Fabio Bozzi, Elena Conca, Marco Silvestri, Gianpaolo Dagrada, Alice Ardore, Donata Penso, Daniele Lorenzini, Chiara Costanza Volpi, Desirè Viola Trupia, Adele Busico, Iolanda Capone, Federica Perrone, Elena Tamborini, Andrea Vingiani, Luca Agnelli, Giancarlo Pruneri

“…The detection of CNAs by NGS in FFPE material is, nonetheless, a complex issue, which still requires validation studies. …”
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Community Work Participation and Outcomes in Nyagatare District, Rwanda. by Jean Marie Vianney, Ruzindana

“…Among the challenges included limited equipment and materials to use while carrying out community work activities in the study area and the culture of the people especially those from the traditional loyal wealth families posed a challenge to community work in the study area. …”
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Modelling and Analysis of Bioretention Systems for Removal of Stormwater Pollutants by Nuwagaba, Emmanuel, Abdulkadir, Taofeeq Sholagberu, Agwe, Michael Tobby, Philip, Tibenderana, Ako, Terseer, Moses N., Twesigye-omwe

“…The plants were introduced into columns C leaving out B as control experiment. Materials used in the media structure were analyzed to meet the standards according to the design manual. …”
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Comprehensive characterization of tobacco-induced changes in enamel surface topography by Tamanna Kaur, Ramya Ramadoss, Nitya Krishnasamy, Sandhya Sundar, Suganya Panneer Selvam, Hema Shree K

“…To assess these changes, various methods such as visual examinations, digital photography, spectrophotometry, stylus profilometry, and atomic force microscopy (AFM) are utilized. Materials and methods: This study analyzed human enamel samples, including one unstained sample (Grade 0) and three tobacco-stained samples (Grades 1–3) according to Modified Lobene Stain Index (MLSI), to investigate the impact of tobacco exposure on enamel structure. …”
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