Glucosinolates from Seed-Press Cake of <i>Camelina sativa</i> (L.) Crantz Extend Yeast Chronological Lifespan by Modulating Carbon Metabolism and Respiration by Francesco Abbiati, Ivan Orlandi, Stefania Pagliari, Luca Campone, Marina Vai

“…Our study explored the impact of these GSLs purified from Camelina press cake, a by-product of Camelina oil production, on yeast chronological aging, which is the established model for simulating the aging of post-mitotic quiescent mammalian cells. Supplementing yeast cells with GSLs extends the chronological lifespan (CLS) in a dose-dependent manner. …”
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Restoration of Genetic Code in Macular Mouse Fibroblasts via APOBEC1-Mediated RNA Editing by Sonali Bhakta, Hiroko Kodama, Masakazu Mimaki, Toshifumi Tsukahara

“…RNA editing is a significant mechanism underlying genetic variation and protein molecule alteration; C-to-U RNA editing, specifically, is important in the regulation of mammalian genetic diversity. The ability to define and limit accesses of enzymatic machinery to avoid the modification of unintended targets is key to the success of RNA editing. …”
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Species Differences in Paraoxonase Mediated Hydrolysis of Several Organophosphorus Insecticide Metabolites by Russell L. Carr, Mary Beth Dail, Howard W. Chambers, Janice E. Chambers

“…Using serum PON1 from different mammalian species, we compared the hydrolysis of paraoxon with the hydrolysis of the active metabolites (oxons) of two additional organophosphorus insecticides, methyl parathion and chlorpyrifos. …”
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Sestrin2 Signaling Pathway Regulates Podocyte Biology and Protects against Diabetic Nephropathy by Moein Ala

“…Sestrin2 leads to AMP-activated protein kinase- (AMPK-) and GTPase-activating protein activity toward Rags (GATOR) 1-mediated inhibition of mammalian target of rapamycin complex 1 (mTORC1), thereby enhancing autophagy. …”
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Biochemical and histopathological profiling of Wistar rat treated with Brassica napus as a supplementary feed by Kazi Md. Mahmudul Hasan, Nasrin Tamanna, Md. Anwarul Haque

“…Noticeable tissue injury observed in this study is a sign of the relative toxicity of erucic acid containing rapeseed oil to mammalian species. The use of Brassica napus as a supplementary feed ingredient should be, therefore, thoroughly considered Keywords: Rapeseed oil, Rattus norvegicus, Serum enzymes, Erucic acid, Tissue profiling…”
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The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy by Kosuke Yamahara, Mako Yasuda, Shinji Kume, Daisuke Koya, Hiroshi Maegawa, Takashi Uzu

“…Autophagy is a catabolic process that degrades damaged proteins and organelles in mammalian cells and plays a critical role in maintaining cellular homeostasis. …”
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Gαq Regulates the Development of Rheumatoid Arthritis by Modulating Th1 Differentiation by Dashan Wang, Yuan Liu, Yan Li, Yan He, Jiyun Zhang, Guixiu Shi

“…The Gαq-containing G protein, an important member of Gq/11 class, is ubiquitously expressed in mammalian cells. Gαq has been found to play an important role in immune regulation and development of autoimmune disease such as rheumatoid arthritis (RA). …”
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Characterization of Zebrafish von Willebrand Factor Reveals Conservation of Domain Structure, Multimerization, and Intracellular Storage by Arunima Ghosh, Andy Vo, Beverly K. Twiss, Colin A. Kretz, Mary A. Jozwiak, Robert R. Montgomery, Jordan A. Shavit

“…The ability of this organism to generate thousands of offspring and its optical transparency make it unique and complementary to mammalian models of hemostasis. Previously, partial clones of zebrafish vwf have been identified, and some functional conservation has been demonstrated. …”
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Identification and Characterization of TEX101 in Bovine Epididymal Spermatozoa by Subir K. Nagdas, Eric L. McLean, Leeá P. Richardson, Samir Raychoudhury

“…Several studies exhibit the presence of Ricinus Communis Agglutinin I (RCA) binding glycocalyx in mammalian spermatozoa. However, the molecular characterization of RCA binding glycocalyx in sperm membranes and its mechanism of action are poorly understood. …”
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Pitfalls in Early Bioprocess Development Using Shake Flask Cultivations by Gesa Brauneck, Dominik Engel, Luca Antonia Grebe, Maximilian Hoffmann, Philipp Georg Lichtenberg, Anne Neuß, Marcel Mann, Jorgen Barsett Magnus

“…Its appeal lies in its simple handling and highly versatile application for a wide range of cell types—from bacteria to mammalian cells. In recent decades, extensive research has been conducted on the shake flask, to not perform processes blindly but to gain a deeper understanding of the various process parameters, phenomena, and their impact on the process. …”
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Systemic factors associated with antler growth promote complete wound healing by Qianqian Guo, Guokun Zhang, Jing Ren, Jiping Li, Zhen Wang, Hengxing Ba, Zihao Ye, Ying Wang, Junjun Zheng, Chunyi Li

“…Abstract Deer antlers are the only mammalian appendages that can fully regenerate from periosteum of pedicles (PP). …”
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Synthesis, antiproliferative and antiplasmodial evaluation of new chloroquine and mefloquine-based harmiquins by Pavić Kristina, Poje Goran, Carvalho Lais Pessanha De, Held Jana, Rajić Zrinka

“…Screening of the antiplasmodial activities of UT harmiquins against erythrocytic stages of the Plasmodium life cycle identified CQ-based UT harmiquine 12 as a novel antiplasmodial hit because it displayed low IC50 values in the submicromolar range against CQ-sensitive and resistant strains (IC50 0.06 ± 0.01, and 0.19 ± 0.02 μmol L−1, respectively), and exhibited high selectivity against Plasmodium, compared to mammalian cells (SI = 92).…”
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Targeting quorum sensing for manipulation of commensal microbiota by Zachary Ziegert, Matthew Dietz, Max Hill, Marjais McBride, Elizabeth Painter, Mikael H. Elias, Christopher Staley

“…We highlight host-microbe interactions facilitated by QS and describe cross-talk between QS and the mammalian endocrine and immune systems, as well as host surveillance of QS. …”
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The molecular view of mechanical stress of brain cells, local translation, and neurodegenerative diseases by T. M. Khlebodarova

“…The roles of the mTOR (mammalian target of rapamycin) signaling pathway; the RNA-binding FMRP protein; the CYFIP1 protein, interacting with FMRP; the family of small GTPases; and the WAVE regulatory complex in the regulation of translation initiation and actin cytoskeleton rearrangements in dendritic spines of the activated synapse are discussed. …”
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Evaluation of Recombinant Antibody Production Efficiency in CHO Cells with Sleeping Beauty Transposon Vector System by Pelin Kolçak Yaşlı, Seda Kulabaş, Evren Doruk Engin

“…Chinese hamster ovary (CHO) mammalian cell lines are widely used as cell platforms in biopharmaceutical productions. …”
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Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133? by Jana Karbanová, Kristina Thamm, Christine A. Fargeas, Ilker A. Deniz, Aurelio Lorico, Denis Corbeil

“…Cell biological studies on mammalian prominin-1, a cholesterol-binding membrane glycoprotein, have helped to reveal new donor membranes as sources of EVs. …”
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Antiplasmodial, Antitrypanosomal, and Cytotoxic Effects of Anthonotha macrophylla, Annickia polycarpa, Tieghemella heckelii, and Antrocaryon micraster Extracts by Aboagye Kwarteng Dofuor, Emmanuel Kofi Kumatia, Jersley Didewurah Chirawurah, Frederick Ayertey

“…We have, therefore, evaluated the antiplasmodial, antitrypanosomal, and cytotoxic activities of four African medicinal plant extracts namely, Anthonotha macrophylla leaf (AML), Annickia polycarpa leaf (APLE), Tieghemella heckelii stem bark (THBE), and Antrocaryon micraster stem bark (AMSBE) extracts in vitro against P. falciparum (W2mef laboratory strain), T. brucei (GUTat 3.1 strain), and mammalian RAW 264.7 macrophage cell line, respectively. …”
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Potential Role of Peptidylarginine Deiminase Enzymes and Protein Citrullination in Cancer Pathogenesis by Sunish Mohanan, Brian D. Cherrington, Sachi Horibata, John L. McElwee, Paul R. Thompson, Scott A. Coonrod

“…Citrullination can significantly affect biochemical pathways by altering the structure and function of target proteins. Five mammalian PAD family members (PADs 1–4 and 6) have been described and show tissue-specific distribution. …”
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Temporal Requirements of cMyc Protein for Reprogramming Mouse Fibroblasts by Corey Heffernan, Huseyin Sumer, Luis F. Malaver-Ortega, Paul J. Verma

“…Exogenous expression of Oct4, Sox2, Klf4, and cMyc forces mammalian somatic cells to adopt molecular and phenotypic characteristics of embryonic stem cells, commencing with the required suppression of lineage-associated genes (e.g., Thy1 in mouse). …”
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Length and PKA Dependence of Force Generation and Loaded Shortening in Porcine Cardiac Myocytes by Kerry S. McDonald, Laurin M. Hanft, Timothy L. Domeier, Craig A. Emter

“…Overall, the bimodal distribution of myocyte length-tension relationships and the PKA-mediated changes in myocyte length-tension and power are likely important modulators of Frank-Starling relationships in mammalian hearts.…”
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