Mitochondrial proteins: Potential pathophysiological mechanisms of malignant progression in HCC by Yicun Liu, Yawen Shao, Xudong Zhu, Zhouming Shen, Zhaolian Bian

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Molecular mechanisms of MAZ targeting up-regulation of NDUFS3 expression to promote malignant progression in melanoma by Yu Feng, Qinxuan Ni, Na Wu, Taiyu Xie, Fang Yun, Xuedan Zhang, Lingnan Gao, Yanlong Gai, Enjiang Li, Xiaojia Yi, Junlin Xie, Qiao Zhang, Zhe Yang, Buqing Sai, Yingmin Kuang, Yuechun Zhu

“…Abstract Myc-associated Zinc-finger Protein (MAZ) has been implicated in the malignant progression of various tumors. However, its expression and functional relationship of MAZ in melanoma have not been previously investigated. …”
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Flavokawain A suppresses the malignant progression of neuroblastoma in vitro depending on inactivation of ERK/VEGF/MMPs signaling pathway by Mengyao Dong, Gaiqin Li, Geng Geng, Ming Ming, Yongtao Xu

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EHMT2‐mediated R‐loop formation promotes the malignant progression of prostate cancer via activating Aurora B by Yuyang Zhang, Mingqin Su, Yiming Chen, Li Cui, Wei Xia, Renfang Xu, Dong Xue, Xiansheng Zhang, Xingliang Feng

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Author Correction: Molecular mechanisms of MAZ targeting up-regulation of NDUFS3 expression to promote malignant progression in melanoma by Yu Feng, Qinxuan Ni, Na Wu, Taiyu Xie, Fang Yun, Xuedan Zhang, Lingnan Gao, Yanlong Gai, Enjiang Li, Xiaojia Yi, Junlin Xie, Qiao Zhang, Zhe Yang, Buqing Sai, Yingmin Kuang, Yuechun Zhu

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USP8‐mediated PTK7 promotes PIK3CB‐related pathway to accelerate the malignant progression of non‐small cell lung cancer by Wencui Kong, Xuegang Feng, Zongyang Yu, Xingfeng Qi, Zhongquan Zhao

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USP5‐dependent HDAC1 promotes cisplatin resistance and the malignant progression of non–small cell lung cancer by regulating RILP acetylation levels by Rongguo Lu, Yulin Jin, Mingfeng Zheng

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IGF2BP2 binding to CPSF6 facilitates m6A‐mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer by Xin Luo, Qinglv Wei, Lingcui Xie, Ningxuan Chen, Bin Gu, Jiani Xu, Xiaoyan Jiang, Xinzhao Zuo, Hongyan Zhao, Xiaoyi Liu, Yu Yang, Tao Liu, Yong Zhu, Ping Yi, Jing Xu

“…PUM2 promotes the malignant progression of OC through its m6A methylation and APA processing.…”
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Pan-cancer analysis of oncogenic role of MAGOH and experiment validation in hepatocellular carcinoma by Zezhi Qiu, Yi Le, Yanyu Liao, Xiao Chen, Xing Xin, Fengting Nie, Xianpin Wei, Heng Wang, Ziling Fang

“…Abstract Several studies have highlighted that Mago-nashi homolog (MAGOH) contributed greatly to cell development, growth, and malignant progression in multiple cancer types. Nevertheless, the role of MAGOH in pan-cancer datasets, particularly in hepatocellular carcinoma (HCC), remains uninvestigated. …”
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IGF2BP1-mediated methylation of ABCA1 facilitates tumor progression by affecting cholesterol metabolism in lung adenocarcinoma by Shaohua Xu, Kai Liu, Zhao Chen, Weijian Tang, Zhoumiao Chen

“…Moreover, in vivo and in vitro experiments further confirmed that IGF2BP1 affected cholesterol metabolism by regulating the expression of ABCA1, thereby facilitating the malignant progression of LUAD. Overall, our research revealed that IGF2BP1 affects cholesterol metabolism by reducing the stability of ABCA1 mRNA through m6A modification, thereby boosting the malignant progression of LUAD and formulating a theoretical basis for subsequent LUAD treatment.…”
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Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis by Qingqing Qin, Huaibin Zhang, Min Lai, Jiantong Wei, Jun Qian, Xingchao Chen, Xin Wang, Yongping Wang

“…Ferroptosis plays a critical role in the malignant progression of OS by regulating iron homeostasis and oxidative stress. …”
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Single‐cell landscape of the intrahepatic ecosystem in alcohol‐related liver disease by Xiaofang Zhao, Senyan Wang, Qi Liu, Wenjuan Wei, Xiaoyan Sun, Hao Song, Jing Xu, Shuijun Zhang, Hongyang Wang, Jing Fu

“…The comprehensive changes of parenchymal and nonparenchymal cells in the ALD livers lay a hidden danger for the further malignant progression.…”
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Pembrolizumab promotes degradation of cyclin dependent kinase 6 and suppresses ovarian cancer progression in vitro by Yi Wu, Ziyan Xu, Zuqiang Kou, Qiuling Ye, Liting Chen, Boyu Gou

“…These findings suggested pembrolizumab efficiently suppressed malignant progression of ovarian cancer cells and facilitated proteasomal degradation of CDK6 and increased cisplatin inhibition of HO-8910 cells proliferation, therefore providing a promising therapeutic strategy for ovarian cancer.…”
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MicroRNA-25 suppresses proliferation, migration, and invasion of osteosarcoma by targeting SOX4 by Bingpeng Chen, Jingjing Liu, Ji Qu, Yang Song, Yuxiang Li, Su Pan

“…Altered expression of the miR-25 has been implicated in many human malignant progression as oncogene or tumor suppressor. However, the precise role of miR-25 in osteosarcoma progression remains largely unclear. …”
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Carnosic acid enhances cisplatin sensitivity and suppresses gastric cancer progression via the TP53/SLC7A11/ALOX12 axis by Li Zhou, Bin Xu, Baojian Li

“…Conclusion CA improved the sensitivity of GC cells to DDP and inhibited their malignant progression by regulating the TP53-mediated SLC7A11/ALOX12 axis, highlighting its potential clinical significance for GC treatment.…”
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NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5 by Selina Gurri, Beat Siegenthaler, Michael Cangkrama, Gaetana Restivo, Marcel Huber, James Saliba, Reinhard Dummer, Volker Blank, Daniel Hohl, Sabine Werner

“…Abstract Epithelial skin cancers are extremely common, but the mechanisms underlying their malignant progression are still poorly defined. Here, we identify the NRF3 transcription factor as a tumor suppressor in the skin. …”
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LINC02679 regulates TRIML2 to promote gastric cancer proliferation and invasion via targeting miR-5004-3p by Yingying Wang, Wenbo Liu, Xiaohan Zhao, Yong Li, Chao Song, Bingjie Huo, Yanru Song, Bibo Tan

“…Emerging evidence showed that long non-coding RNAs (lncRNAs) play roles in the malignant progression of gastric cancer (GC). However, the function and underlying mechanism of LINC02679 in GC are still unclear. …”
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Prognostic value of LncRNA DLGAP1-AS2 in bladder cancer and its regulatory effect on tumor progression by Yuhui Zhao, Xiaotong Wu, Yi Zheng, Huiming Bai, Zhihang Zhang, Mingzhi Li, Xiaofeng He, Chao Yu

“…DLGAP1-AS2 regulates the malignant progression of BLCA via miR-451a.…”
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Pan-cancer landscape of ITGAV and its potential role in gastric cancer by Bin Ke, Peng Jin, Xue-Jun Wang, Ru-peng Zhang, Ning Liu, Gang Ma

“…ITGAV can promote GC malignant progression and could serve as a potential therapeutic target for GC treatment.…”
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Phenotypic profle of monocyte-macrophage lineage cells as a function of respiratory epithelium status by A. A. Fedorov, N. A. Ermak, E. B. Topolnitskiy, N. A. Shefer, E. O. Rodionov, O. V. Pankova, N. V. Cherdyntseva, M. N. Stakheyeva

“…It has been suggested that the relationship between reactive changes in the bronchial mucosa and NSCLC progression may be caused by the functional status of monocytic-macrophage cells as important participants in infammation, which determines both the risk of premalignant changes in the epithelium and malignant progression. The purpose of the study was to investigate the phenotypic profle of peripheral blood monocytes and macrophages induced from monocytes in vitro depending on the state of respiratory epithelium in NSCLC patients. …”
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