CD47/SIRPα axis: bridging innate and adaptive immunity by Sjoerd H van der Burg, Anneloes van Duijn, Ferenc A Scheeren

“…Furthermore, we discuss the interconnection between the myeloid CD47/SIRPα axis and adaptive T cell responses as well as the potential therapeutic role of the CD47/SIRPα axis in tumors with acquired resistance to the classic immunotherapy through major histocompatibility complex downregulation. Altogether this review provides a profound insight for the optimal exploitation of CD47/SIRPα immune checkpoint therapy.…”
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Antigen Presentation in the Gut by W Doe, P Pavli

“…The induction of T cell responses requires recognition of antigens in association with class II major histocompatibility complex (MHC) proteins and specialized antigen-presenting cells. …”
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Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategies by Venkata Lokesh Battula, Abhishek Maiti, Adishwar Rao, Akriti Agrawal, Gautam Borthakur

“…These cells represent a minor population of T lymphocytes with intrinsic abilities to recognize antigens in a major histocompatibility complex-independent manner and functionally straddle the innate and adaptive immunity interface. …”
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Acetylation Modification Improves Immunoregulatory Effect of Polysaccharide from Seeds of Plantago asiatica L. by Le-Ming Jiang, Shao-Ping Nie, Dan-Fei Huang, Zhi-Hong Fu, Ming-Yong Xie

“…The results showed that Ac-PLCPs with degree of substitution (DS) from 0.06 to 0.1 could not only stimulate the expression of surface molecules major histocompatibility complex class II (MHC II), cluster of differentiation 86 (CD86), and CD80 on DCs (P<0.01) but also increase the secretion of cytokine IL-12p70 (P<0.01). …”
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Self-Centered Function of Adaptive Immunity in Regulation of Immune Responses and in Tolerance by Silvana Balzar

“…However, their activation also requires interaction with a self-specific major histocompatibility complex (MHC) “code,” i.e., the context of MHC molecules. …”
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An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients by Jeffrey Babad, Riyasat Ali, Jennifer Schloss, Teresa P. DiLorenzo

“…Multiple genetic loci contribute to disease susceptibility in humans, with the most responsible locus being the major histocompatibility complex (MHC). Certain MHC alleles are predisposing, including the common HLA-A∗02:01. …”
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Immunogenetic Study in Chinese Population with Ankylosing Spondylitis: Are There Specific Genes Recently Disclosed? by Jiayu Zhai, Ju Rong, Qiuxia Li, Jieruo Gu

“…So far, several genes or genetic regions have now been reported in the Han ethnic Chinese population, containing the major histocompatibility complex (MHC), ERAP1, IL-23R, 12q12, 2p15, 5q14.3, and so on. …”
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The Influence of MHC and Immunoglobulins A and E on Host Resistance to Gastrointestinal Nematodes in Sheep by C. Y. Lee, K. A. Munyard, K. Gregg, J. D. Wetherall, M. J. Stear, D. M. Groth

“…In this paper, we describe the roles of immunoglobulins, in particular IgA and IgE, and the major histocompatibility complex in resistance to gastrointestinal parasites in sheep. …”
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Trogocytosis-mediated immune evasion in the tumor microenvironment by Jeonghyun Kim, Soyeon Park, Jungseo Kim, Yewon Kim, Hong Min Yoon, Bima Rexa Rayhan, Jaekwang Jeong, Alfred L. M. Bothwell, Jae Hun Shin

“…For example, CD4 T cells engaging with antigen-presenting cells undergo trogocytosis, which facilitates the transfer of antigen-loaded major histocompatibility complex (MHC) class II molecules from antigen-presenting cells to CD4 T cells. …”
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IL-6-mediated MHC class II induction on RIN-5AH insulinoma cells by IFN-γ occurs via the G-protein pathway by S. Vassiliadis, G. K. Papadopoulos

“…Major histocompatibility complex (MHC) class II antigen expression has been implicated in the pathogenesis of autoimmune type 1 diabetes. …”
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Immunomodulatory Properties of HLA-G in Infectious Diseases by Laurence Amiot, Nicolas Vu, Michel Samson

“…HLA-G is a nonclassical major histocompatibility complex molecule first described at the maternal-fetal interface, on extravillous cytotrophoblasts. …”
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FABP6 Expression Correlates with Immune Infiltration and Immunogenicity in Colorectal Cancer Cells by Wenping Lian, Zhongquan Wang, Yajie Ma, Yalin Tong, Xinyu Zhang, Huifang Jin, Shuai Zhao, Ruijing Yu, Shaotan Ju, Xinyun Zhang, Xiaona Guo, Tao Huang, Xianfei Ding, Mengle Peng

“…FABP6 was negatively correlated with immune infiltration, and knockdown of FABP6 increased major histocompatibility complex (MHC) class 1 expression and promoted immune-related chemokine secretion, indicating the immunogenicity enhancement of tumor cells. …”
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Gut Mesenchymal Stromal Cells in Immunity by Valeria Messina, Carla Buccione, Giulia Marotta, Giovanna Ziccheddu, Michele Signore, Gianfranco Mattia, Rossella Puglisi, Benedetto Sacchetti, Livia Biancone, Mauro Valtieri

“…In Crohn’s disease, intestinal MSCs are tightly stacked in a chronic inflammatory milieu, which causes their enforced expression of Class II major histocompatibility complex (MHC). The absence of Class II MHC is a hallmark for immune-modulator and tolerogenic properties of normal MSCs and, vice versa, the expression of HLA-DR is peculiar to antigen presenting cells, that is, immune-activator cells. …”
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The Missing Heritability in T1D and Potential New Targets for Prevention by Brian G. Pierce, Ryan Eberwine, Janelle A. Noble, Michael Habib, Hennady P. Shulha, Zhiping Weng, Elizabeth P. Blankenhorn, John P. Mordes

“…It is strongly associated with susceptibility haplotypes within the major histocompatibility complex, but this association accounts for an estimated 50% of susceptibility. …”
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Citrullinated Autoantigen–Specific T and B Lymphocytes in Rheumatoid Arthritis: Focus on Follicular T Helper Cells and Expansion by Coculture by Tim Ammon, Julia Zeiträg, Vanessa Mayr, Manuela Benedicic, Hans‐Peter Holthoff, Martin Ungerer

“…Novel combinations of major histocompatibility complex class II citrulline epitope tetramers were developed, which enabled robust detection of CAS T cells and showed increases of CAS‐naive T helper cells, Th1.17 cells, CAS total circulating T follicular helper (cTfh) cells, and cTfh1 cells in ACPA+ patients with RA. …”
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Altered Protein Structures and Neoepitopes in Lupus Neutrophils From Dysregulated Splicing of Messenger RNA by Rayan Najjar, Xiaoxing Wang, Jose Mario Bello Pineda, Hugh Alessi, Alison Bays, Robert K. Bradley, James N. Jarvis, Tomas Mustelin

“…Peptides derived from these novel amino acid sequences were predicted to bind to the individual patients’ class I and II major histocompatibility complex molecules with high affinity. …”
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Unlocking the secrets of the immunopeptidome: MHC molecules, ncRNA peptides, and vesicles in immune response by Arpita Balakrishnan, Arpita Balakrishnan, Gabriela Winiarek, Olga Hołówka, Jakub Godlewski, Agnieszka Bronisz

“…The immunopeptidome, a diverse set of peptides presented by Major Histocompatibility Complex (MHC) molecules, is a critical component of immune recognition and response. …”
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Exploitation of Unconventional CD8 T-Cell Responses Induced by Engineered Cytomegaloviruses for the Development of an HIV-1 Vaccine by Joseph Bruton, Tomáš Hanke

“…Rhesus macaques vaccinated with molecular clone 68-1 of RhCMV (RhCMV68-1) engineered to express simian immunodeficiency virus (SIV) immunogens elicited an unconventional major histocompatibility complex class Ib allele E (MHC-E)-restricted CD8⁺ T-cell response, which consistently protected over half of the animals against a highly pathogenic SIV challenge. …”
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Characterization of Urine-Derived Stromal/Stem Cells from Healthy Dogs and Dogs Affected by Chronic Kidney Disease (CKD) by Anna Lange-Consiglio, Filippo Tagliasacchi, Fausto Cremonesi, Claudia Gusmara, Claudia Pollera, Paola Scarpa, Giulia Gaspari, Pietro Riccaboni

“…Cells were able to differentiate into osteogenic, chondrogenic, and adipogenic lines, showed positive expression to mesenchymal/stem markers, negative expression to hematopoietic markers, and major histocompatibility complex (MHCII) antigen. Klotho protein expression was confirmed. …”
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Different MHC class I cell surface expression levels in diverse chicken lines, associations with B blood group, and proposed relationship to antigen-binding repertoire by Michael Kaiser, Jim Kaufman, Susan J. Lamont

“…The Major Histocompatibility Complex (MHC) is a cluster of genes with primarily immune-related functions. …”
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