Randomization and placebo effects in clinical trials of major depressive disorder by James A. Rogers, Stephen Senn

Get full text

Study of Life Events and Quality of Life in Patients of Major Depressive Disorder by Alkesh Patil, Aparna Sengupta, Ashwini Mule, Sagar Karia

“…Objectives: The aim of this research was to study the relationship of major depressive disorder with quality of life and stressful life events in adults. …”
Get full text

Oxidative alterations in exfoliated oral mucosa cells of patients with major depressive disorder by Lukas Mendes de Abreu, Cintia Rodrigues da Silva, Ana Laura Ferreira Bortoleto, Giovana Barros Nunes, Matheus Martins Gracia, Rafael Akira Tzanno Murayama, Daniel Galera Bernabé, Gisele Zoccal Mingoti

Subjects: “…Major depressive disorder…”
Get full text

Treatments for partial remission of major depressive disorder: a systematic review and meta-analysis by Marlies E Brouwer, Gert J Geurtsen, Damiaan A J P Denys, Joost Gülpen, Eva A M van Dis, Claudi L Bockting

“…Question Partial remission of major depressive disorder (MDD) is a debilitating and distressing clinical state related to chronicity, morbidity and relapse. …”
Get full text

Classification of schizophrenia, bipolar disorder and major depressive disorder with comorbid traits and deep learning algorithms by Xiangning Chen, Yimei Lu, Joan Manuel Cue, Mira V. Han, Vishwajit L. Nimgaonkar, Daniel R. Weinberger, Shizhong Han, Zhongming Zhao, Jingchun Chen

“…In this study, we use polygenic risk scores (PRSs) of 42 traits comorbid with schizophrenia (SCZ), bipolar disorder (BIP), and major depressive disorder (MDD) to evaluate their utilities. …”
Get full text

Beneath the surface: unveiling the gut–brain axis in anorexia and depression by Fatima Shahid, Zain Afridi, Muhammad Ali, Muhammad Nabeel Saddique, Javed Iqbal, Anurag Jha

Subjects: Get full text

Interactions between ABC gene polymorphisms and processing speed in predicting depression severity by Meijiang Jin, Lei Ji, Maojia Ran, Yan Bi, Hang Zhang, Yuanmei Tao, Hanmei Xu, Shoukang Zou, Hong Zhang, Tao Yu, Li Yin

Subjects: “…Major depressive disorder (MDD)…”
Get full text

Individualized resting-state functional connectivity abnormalities unveil two major depressive disorder subtypes with contrasting abnormal patterns of abnormality by Keke Fang, Lianjie Niu, Baohong Wen, Liang Liu, Ya Tian, Huiting Yang, Ying Hou, Shaoqiang Han, Xianfu Sun, Wenzhou Zhang

“…Abstract Modern neuroimaging research has recognized that major depressive disorder (MDD) is a connectome disorder, characterized by altered functional connectivity across large-scale brain networks. …”
Get full text

Beneficial and harmful effects of duloxetine versus placebo, ‘active placebo’ or no intervention for adults with major depressive disorder: a systematic review with meta-analysis and trial sequential analysis of randomised clinical trials by Christian Gluud, Marija Barbateskovic, Joanna Moncrieff, Faiza Siddiqui, Janus C Jakobsen, Mathias Maagaard, Sophie Juul, Johanne Juul Petersen, Caroline Barkholt Kamp, Mark Abie Horowitz, Kiran Kumar Katakam

“…Objectives To assess the beneficial and harmful effects of duloxetine versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder.Design Systematic review with meta-analysis and trial sequential analysis of randomised trials.Data sources Cochrane Central Register of Controlled Trials, MEDLINE, Embase, PsycINFO and other relevant databases up until January 2023. …”
Get full text

Understanding adolescent depression in Singapore: a qualitative study by Ngar Yee Poon, Cheryl Bee-Lock Loh

“…Methods: Semi-structured interviews were conducted with 14 adolescents, aged between 13 and 19 years, who were diagnosed and treated for diagnostic and statistical manual of mental disorders, 5th edition major depressive disorder and clinically judged to have recovered at the time of recruitment. …”
Get full text

EVALUATION OF THE THERAPEUTIC EFFECTS OF SALVIA ROSMARINUS ESSENTIAL OIL ON NERVOUS SYSTEM DISORDERS by Malina Mihaela Visternicu, Viorica Rarinca, Vasile Burlui, Alin Ciobica

“…This review explores the therapeutic potential of rosemary in alleviating nervous system disorders such as Alzheimer's disease (AD), major depressive disorder (MDD), epilepsy, Parkinson's disease (PD), addiction, and attention-deficit hyperactivity disorder (ADHD). …”
Get full text

Dhat Syndrome: Epidemiology, Risk Factors, Comorbidities, Diagnosis, Treatment, and Management by Yukino N. Strong, Angel Li, Michael E. White, Abrahim N. Razzak, Danyon J. Anderson, Alan D. Kaye, Edwin W. Herron, Nazih P. Khater, Elyse M. Cornett, Ivan Urits

“…Treatment for Dhat syndrome is the same as treatments for major depressive disorder.…”
Get full text

Prediction of individual patient outcomes to psychotherapy vs medication for major depression by Devon LoParo, Boadie W. Dunlop, Charles B. Nemeroff, Helen S. Mayberg, W. Edward Craighead

“…Abstract Treatments for major depressive disorder (MDD) include antidepressant medications and evidence-based psychotherapies, which are approximately equally efficacious. …”
Get full text

LSD and psilocybin for chronic nociplastic pain: A narrative review of the literature supporting the use of classic psychedelic agents in chronic pain by J Van Der Walt, R Parker

“…The new wave of research into psychedelics for major depressive disorder provides an opportunity to investigate and understand the potential for incorporating these drugs into chronic pain management pathways. …”
Get full text

An Active Inference Model of the Optimism Bias by Elizabeth L. Fisher, Christopher J. Whyte, Jakob Hohwy

“…Associated with improved quality of life, optimism bias is considered to be adaptive and is a promising avenue of research for mental health interventions in conditions where individuals lack optimism such as major depressive disorder. Here we lay the groundwork for future research on optimism as an intervention by introducing a domain general formal model of optimism bias, which can be applied in different task settings. …”
Get full text

Mindfulness-based (non-contact) boxing therapy (MBBT) for depression and anxiety: A feasibility study. by Johny Bozdarov, Brett D M Jones, Madeha Umer, Daniel M Blumberger, Ishrat M Husain

“…The current study tested the acceptability and feasibility of delivering MBBT to adults with major depressive disorder (MDD) or generalized anxiety disorder (GAD).…”
Get full text

Role of Ketamine in the Treatment of Psychiatric Disorders by Sahar Derakhshanian, Maxine Zhou, Alexander Rath, Rachel Barlow, Sarah Bertrand, Caroline DeGraw, Christopher Lee, Jamal Hasoon, Alan D. Kaye

“…It covers the epidemiology, risk factors, pathophysiology, and current treatment modalities regarding Major Depressive Disorder (MDD) and TRD. It provides background on the mechanism of action of ketamine, its history, current approved and off-label indications in the field of psychiatry, and then provides an overview of the existing evidence for the use of ketamine in the treatment of TRD…”
Get full text

Factors related to painful somatic symptoms in patients with depression: The role of gender and anhedonia by A. Pérez-Morenilla, A. Salazar, I. Failde, F. González-Sáiz, J.A. Micó

“…Background: Pain is common in Major Depressive Disorder (MDD), but other related factors have received scant attention. …”
Get full text

RNA editing-based biomarker blood test for the diagnosis of bipolar disorder: protocol of the EDIT-B study by Andrea Miranda-Mendizabal, Diana Vetter, Juan Zambrano, Jeff Zarp, Victor Chavarría, Anna Giménez-Palomo, Meritxell Gonzalez-Campos, Marc Valenti, Lara Walczer Baldinazzo, Sara Siddi, Maurizio Ferrari, Dinah Weissmann, Chantal Henry, Josep Maria Haro, Lars Vedel Kessing, Eduard Vieta

“…Objective diagnostic tests or precise tools to diagnose BD and distinguish it from major depressive disorder (MDD) in depressed patients are lacking. …”
Get full text

Mental health and substance use among rehabilitation sciences students during the COVID-19 pandemic by Itumeleng Ntatamala, Saajida Khan, Zenzo Chakara

“…Diagnoses included major depressive disorders (13.27%) and anxiety disorders (11.50%). …”
Get full text