OSM May Serve as a Biomarker of Poor Prognosis in Clear Cell Renal Cell Carcinoma and Promote Tumor Cell Invasion and Migration by Shuzhang Wei, Yin Chen, Xiaokai Shi, Li Zuo, Lifeng Zhang

“…Signaling pathways and single-cell analysis revealed that OSM might promote ccRCC invasion and migration through M2 macrophages. Conclusion. In conclusion, OSM may serve as an independent poor prognostic biomarker in ccRCC and promote tumor cell invasion and migration. …”
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Bioactivity of plants used traditionally in the treatment and management of men’s sexual health by Tsumbedzo Nemandalali, Monde A. Nyila, Thilivhali E. Tshikalange

“…Methods: Acetone extracts were investigated for their antioxidant activity, anti-inflammatory activity against 15-lipoxygenase, inhibition of nitric oxide production on RAW 264.7 macrophages and antimicrobial activity against Neisseria gonorrhoeae and Candida albicans. …”
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Cardiac-Restricted IGF-1Ea Overexpression Reduces the Early Accumulation of Inflammatory Myeloid Cells and Mediates Expression of Extracellular Matrix Remodelling Genes after Myoca... by Enrique Gallego-Colon, Robert D. Sampson, Susanne Sattler, Michael D. Schneider, Nadia Rosenthal, Joanne Tonkin

“…Infiltration of inflammatory cells, which direct the remodelling process, was also altered; in particular there was a notable reduction in inflammatory Ly6C+ monocytes at day 3 and an increase in anti-inflammatory CD206+ macrophages at day 7. Taken together, these results indicate that the IGF-1Ea transgene shifts the balance of innate immune cell populations early after infarction, favouring a reduction in inflammatory myeloid cells. …”
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The role of delays in innate and adaptive immunity to intracellular bacterial infection by Simeone Marino, Edoardo Beretta, Denise E. Kirschner

“…This reflects, for example, active killing by a class of cells known as macrophages, and will allow us to determine the relevance of delays for adaptive immunity. …”
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Transcriptional Profiling of Testis Development in Pre-Sexually-Mature Hezuo Pig by Zunqiang Yan, Qiaoli Yang, Pengfei Wang, Shuangbao Gun

“…Additionally, chemokine, B cell receptor, activation of immune response, and enzyme binding were enriched in macrophages. Our study investigated transcriptional alterations across different cell types during spermatogenesis, yielding new understandings of spermatogenic processes and cell development. …”
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TLR2 Expression in Relation to IL-6 and IL-1β and their Natural Regulators Production by PMN and PBMC in Patients with Lyme Disease by Ewa Jablonska, Magdalena Marcinczyk

“…Recently, it has been reported that TLR2 on macrophages plays a unique role in the inflammatory response and host defense to infection with Borrelia burgdorferi (Bb) which is an etiologic agent of Lyme disease. …”
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Kounis Syndrome Secondary to Medicine-Induced Hypersensitivity by Parackrama Karunathilake, Udaya Ralapanawa, Thilak Jayalath, Shamali Abeyagunawardena

“…Kounis syndrome is mediated by mast cells that interact with macrophages and T-lymphocytes, causing degranulation and inflammation with cytokine release. …”
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CD169 Expression in Lymph Nodes is Associated with Increased Infiltration of CD8+ T Cells in Tumors: A Systematic Review and Meta-Analysis by Yong Wang, Xiao-Ting Wu, Jing Chen

“…The density of CD169+ macrophages has been reported to positively correlate with the number of CD8+ T cells, although this remains controversial. …”
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Therapeutic Benefit in Rheumatoid Cachexia Illustrated Using a Novel Primary Human Triple Cell Coculture Model by Tracey Ollewagen, Gareth S. Tarr, Kathryn H. Myburgh, Helmuth Reuter, Carine Smith

“…The loss of muscle mass in rheumatoid arthritis (RA), termed rheumatoid cachexia, is predicted to result from the complex interactions between different cell types involved in the maintenance of skeletal muscle mass, namely, myoblasts, fibroblasts, and macrophages. The complexity within the muscle is further highlighted by the incidence of nonresponsiveness to current RA treatment strategies. …”
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A Novel In Situ Dendritic Cell Vaccine Triggered by Rose Bengal Enhances Adaptive Antitumour Immunity by Lanlin Zhang, Jiangyuan Du, Qian Song, Chufan Zhang, Xianghua Wu

“…., CD4+, CD8+, and memory T cells) infiltration and attenuating the accumulation of immunosuppressive cells (i.e., Tregs, macrophages, and myeloid-derived suppressor cells (MDSCs)) in the TME. …”
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The pathogenesis of COVID-19: Hypercoagulation and D-dimer in thrombotic complications by Leonid DUBEY, Halyna LYTVYN, Olha DOROSH, Nataliya DUBEY, Olena KOZLOVA, Michal PRUC, Nina KUBIKOWSKA, Lukasz SZARPAK, Kavita BATRA, Francesco CHIRICO, Gabriella NUCERA, Svitlana DOAN, Uljana SHEVTSIV

“…In addition, plasmin is involved in the pathophysiology of acute respiratory distress syndrome (ARDS) in SARS and promotes the secretion of cytokines, such as IL-6 and TNF, from activated macrophages. The focus of existing treatment to alleviate fibrinolysis in patients with COVID-19 is the use of systemic fibrinolytic therapy given thrombotic pathology in severe forms of COVID-19 which may lead to death. …”
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Quality of commercialized dry extracts of blood orange juice in Brazilian compounding pharmacies: Dry extracts of blood orange juice by Lídia Cristina Merlin de Meneses, Maria Izabel Lamego Neta, Jhenifer Luisa Miniuki, Ingrid Vicente Farias, Larissa Benvenutti, Otto Mauricio Santos Gerlach, Flávio H. Reginatto, Angela Malheiros, José Roberto Santin, Tania Mari Bellé Bresolin

“…The composition of the samples was analyzed by LC-UV and LC-MS, total anthocyanin content (TAC), antioxidant activity (DPPH assay), and in vitro anti-inflammatory effect, by NO production in macrophages. C3G was detected only in the reference sample (1.6%), the TAC values were 1.45%, 0.1% and 0.01% in the reference, A1, and A2, respectively. …”
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Cytokine and eicosanoid regulation by Schistosoma mansoniduring LSE penetration by A. C. Fusco, B. Salafsky, T. Shibuya

“…It is concluded that cercarial penetration causes a release of IL-1α consistent with skin trauma; however, schistosomulae may regulate the production of chemotactic (neutrophils, macrophages, T-cells, etc.) and activation factors such as IL-8 and LTB4.…”
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Design and Optimization of the Circulatory Cell-Driven Drug Delivery Platform by Pengyu Gao, Dan Zou, Ansha Zhao, Ping Yang

“…This review specifically covers (a) the properties of red blood cells, monocytes, macrophages, neutrophils, natural killer cells, T lymphocytes, and mesenchymal stem cells; (b) the loading strategies to balance cargo amounts and cell function balance; (c) the cascade strategies to improve cell-driven targeting delivery efficiency; and (d) the features and applications of cell membranes, artificial cells, and extracellular vesicles in cancer treatment.…”
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Deep-insights: Nanoengineered gel-based localized drug delivery for arthritis management by Anitha Sriram, Harshada Ithape, Pankaj Kumar Singh

“…Furthermore, this review discusses the influence of nanocarrier pharmacokinetics on the localization and therapeutic manipulation of macrophages mediated by nanocarriers. The ELVIS (extravasation through leaky vasculature and inflammatory cell-mediated sequestration) effect associated with arthritis is advantageous in drug delivery. …”
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In Silico Design of a Trans-Amplifying RNA-Based Vaccine against SARS-CoV-2 Structural Proteins by Fatemeh Nafian, Ghazal Soleymani, Zahra Pourmanouchehri, Mahnaz Kiyanjam, Simin Nafian, Sayed Mohammad Mohammadi, Hanie Jeyroudi, Sharareh Berenji Jalaei, Fatemeh Sabzpoushan

“…Overall, the immune response simulation detected that activated B and T lymphocytes and increased memory cell formation. Macrophages and dendritic cells proliferated continuously, and IFN-γ and cytokines like IL-2 were released highly.…”
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A systematic in vitro study of the effect of normoglycaemic and hyperglycaemic conditions on the biochemical and cellular interactions of clinically-available wound dressings with... by Shirin Saberianpour, Gianluca Melotto, Rachel Forss, Lucy Redhead, Susan Sandeman, Nadia Terrazzini, Dipak Sarker, Matteo Santin

“…Dressings presenting absorbent layers made of synthetic, non-woven fibres supported the adhesion of monocytes macrophages and stimulate the release of factors known to play a role in the chronic inflammation. …”
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Experimental trichuriasis: Changes in the immune response and bacterial translocation during acute phase development illustrated with 3D model animation. by Dayane Alvarinho de Oliveira, Renato Oliveira, Brunna Vianna Braga, Lorian Cobra Straker, Luciana Silva Rodrigues, Lilian Lacerda Bueno, Ricardo Toshio Fujiwara, Eduardo José Lopes-Torres

“…We showed a mixed immune response (Th1, Th2, and Th17) initiated by larval-induced lesions in the intestine tissue and modulated by L4 larvae and adult worms in the cecum, with systemic changes observed in the mesenteric lymph nodes, peritoneal macrophages, and spleen. Despite the disruption of the intestinal mucosa within the first 10 days post-infection (d.p.i.), bacterial invasion becomes evident only after the development of the nematode into the L3 larval stage (17 d.p.i.), intensifying with lesions caused by the L4 larvae (22 d.p.i.) and adult worms (35 d.p.i.). …”
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Microvesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Enhance Alveolar Type II Cell Proliferation and Attenuate Lung Inflammation in a Rat Model of Bronchopulmonar... by Ou Zhou, Jingyi You, Xiaochuan Xu, Jiang Liu, Huijun Qiu, Chang Hao, Wenjing Zou, Wenjie Wu, Zhou Fu, Daiyin Tian, Lin Zou

“…Furthermore, MVs were large vesicles with a diameter of 100-900 nanometers and mostly uptaken by alveolar epithelial type II cells (AT2) and macrophages. Compared with the LPS-exposed group, MVs restored the AT2 cell number and SP-C expression in vivo and promoted the proliferation of AT2 cells in vitro. …”
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Implementation Nutrigenomic of Vitamin D in Periodontitis by Hervina Hervina, I Dewa Made Sukrama, I Made Jawi

“…The anti-microbial effect of vitamin D results from the binding of 1,25(OH)2D3 with VDR which then induces cAMP, b-def-2 and b-def-3 peptides by macrophages, monocytes, gingival epithelium and periodontal ligament epithelium. …”
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