The Toxoplasma rhoptry protein ROP55 is a major virulence factor that prevents lytic host cell death by Margarida T. Grilo Ruivo, Ji-hun Shin, Todd Lenz, Stephanie Y. Matsuno, Katherine Olivia Yanes, Arnault Graindorge, Maguy Hamie, Laurence Berry-Sterkers, Mathieu Gissot, Hiba El Hajj, Karine G. Le Roch, Melissa B. Lodoen, Maryse Lebrun, Diana Marcela Penarete-Vargas

“…ΔROP55 infection also induced RIPK3-dependent necroptosis in human and mouse primary macrophages. Moreover, ΔROP55 parasites were significantly impaired in virulence in female mice and prevented NF-κB activation and parasite clearance in mBMDM. …”
Get full text

Prior Exposure to Immunosuppressors Sensitizes Retinal Microglia and Accelerates Optic Nerve Regeneration in Zebrafish by Ilse Bollaerts, Jessie Van houcke, An Beckers, Kim Lemmens, Sophie Vanhunsel, Lies De Groef, Lieve Moons

“…Here, we used pharmacological immunosuppression methods to study the role of microglia/macrophages during optic nerve regeneration in adult zebrafish. …”
Get full text

The Role of Myeloid Cells on the Development of Hepatic Metastases in Gastrointestinal Cancer by Austin R. Dosch, Mary P. Martos, Samara Singh, Karishma Kodia, Nipun B. Merchant, Nagaraj S. Nagathihalli

“…We further summarize the role of additional myeloid subpopulations such as monocytes and macrophages, dendritic cells, platelets, and eosinophils on promoting disease metastases in GI cancers. …”
Get full text

Roquefort Cheese Proteins Inhibit Chlamydia pneumoniae Propagation and LPS-Induced Leukocyte Migration by Ivan M. Petyaev, Naylia A. Zigangirova, Natalie V. Kobets, Valery Tsibezov, Lydia N. Kapotina, Elena D. Fedina, Yuriy K. Bashmakov

“…These changes were complemented by a reduction in neutrophil count and a relative increase in peritoneal macrophages, suggesting that ingestion of Roquefort could promote regenerative processes at the site of inflammation. …”
Get full text

Single-cell transcriptomics unveils multifaceted immune heterogeneity in early-onset versus late-onset cervical cancer by Qian Chen, Dongfeng Deng, Hong Zhu, Shan Li

“…CD4 + and CD8 + T cells in LOCC demonstrated a heightened activation state, while NK cells exhibited diminished cytotoxicity. Macrophages in LOCC displayed enhanced polarization towards both M1 and M2 phenotypes, along with dendritic cells showing augmented antigen-presenting capacity. …”
Get full text

Microenvironment-confined kinetic elucidation and implementation of a DNA nano-phage with a shielded internal computing layer by Decui Tang, Shuoyao He, Yani Yang, Yuqi Zeng, Mengyi Xiong, Ding Ding, Weijun Wei, Yifan Lyu, Xiao-Bing Zhang, Weihong Tan

“…Finally, we show that DNP can efficiently work in complex human blood samples by shielding the interference of erythrocytes and enhance phagocytosis of macrophages toward target cells by blocking CD47-SIRPα pathway.…”
Get full text

Perspectives on Adipose Tissue, Chagas Disease and Implications for the Metabolic Syndrome by Fnu Nagajyothi, Mahalia S. Desruisseaux, Linda A. Jelicks, Fabiana S. Machado, Streamson Chua, Philipp E. Scherer, Herbert B. Tanowitz

“…The T. cruzi-induced increase in macrophages in adipose tissue taken together with the reduction in adiponectin and the associated cardiomyopathy is reminiscent of the metabolic syndrome.…”
Get full text

BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets by Jaehwi Lee, Man Hee Rhee, Eunji Kim, Jae Youl Cho

“…Primary and cancerous (RAW264.7 cells) macrophages were activated by lipopolysaccharide, a ligand of toll-like receptor 4. …”
Get full text

Coal Worker's Pneumoconiosis Mimicking Lung Cancer in a 75‐Year‐Old Woman With a History of Breast Cancer: A Clinical Case Report by Yeganeh Pakbaz, Farzan Moodi

“…Histopathology showed carbon‐laden macrophages and anthracosis, consistent with CWP. Imaging modalities, including MRI and FDG‐PET/CT, aid in differentiating CWP from cancer. …”
Get full text

The Role of PPARs in Placental Immunology: A Systematic Review of the Literature by Stefan Hutter, Julia Knabl, Ulrich Andergassen, Udo Jeschke

“…Both the innate and the adaptive immune system, and therefore B and T lymphocytes, natural killer cells (NK), macrophages and dendritic cells (DCs) are all involved in trophoblast invasion, pregnancy maintenance, and development of pregnancy disorders. …”
Get full text

Oral mucosal changes caused by nicotine pouches: case series by Sintija Miluna-Meldere, Sarlote Agate Vanka, Ingus Skadins, Juta Kroica, Maris Sperga, Dagnija Rostoka

“…Histopathological analyses revealed parakeratosis with acanthotic epithelium, intraepithelial and connective tissue oedema, and chronic inflammatory infiltration with lymphocytes and macrophages. Participants received information about nicotine cessation and oral health recommendations. …”
Get full text

Increased Apoptosis and Proliferative Capacity are Early Events in Cyst Formation in Autosomal-Dominant, Polycystic Kidney Disease by Salwa Ibrahim

“…Interstitial infiltrates were dense and consisted mainly of CD 68–positive macrophages and CD 45–positive lymphocytes. The present study demonstrated that changes in cell turnover are early events in cyst formation. …”
Get full text

Morphological diversity of tadpoles of fork-tongued frogs (Anura: Dicroglossidae) with different trophic specializations by Anna B. Vassilieva, Trung Duc Nguyen, Pavel A. Sorokin

“…These transformations are common to macrophagous tadpoles of different taxonomic groups and result in greater larval morphological diversity.…”
Get full text

Duodenal Histoplasmosis Presenting with Upper Gastrointestinal Bleeding in an AIDS Patient by Michael A. Spinner, Heather N. Paulin, C. William Wester

“…Biopsy of the lesions revealed small bowel mucosa with granulomatous inflammation and macrophages with small intracellular yeasts consistent with disseminated histoplasmosis. …”
Get full text

Downregulated Copper Homeostasis-Related Gene FOXO1 as a Novel Indicator for the Prognosis and Immune Response of Breast Cancer by Rong Zeng, Bi Peng, Emin Peng

“…Immunoinfiltration analysis indicated that aberrantly expressed FOXO1 showed positive correlations with the subcellular infiltration of macrophages and neutrophils in BRCA. Moreover, FOXO1 expression was positively associated with multiple immune checkpoints, such as sialic acid-binding immunoglobulin-like lectin 15 (SIGLEC15), indoleamine 2,3-dioxygenase 1 (IDO1), programmed cell death 1 ligand 1 (PD-L1/CD274), hepatitis A virus cellular receptor 2 (HAVCR2), programmed cell death 1 (PDCD1), cytotoxic T lymphocyte antigen 4 (CTLA4), and programmed cell death 1 ligand 2 (PDCD1LG2). …”
Get full text

Inflammatory Characteristics of Stenotic Aortic Valves: A Comparison between Rheumatic and Nonrheumatic Aortic Stenosis by Lars Wallby, Thora Steffensen, Lena Jonasson, Mats Broqvist

“…The RAS valves revealed a lower degree of T lymphocyte infiltration compared with the NRAS valves. Infiltration of macrophages was seen in all valves and there were no differences regarding deposition of apolipoprotein. …”
Get full text

Nanoparticles Modulating the Immune Microenvironment in Breast Cancer Treatment by Guo LJ, Wu J, Lu W, Li J, Wang Y, Yang H, Wang TZ

“…We then provide strategies of nanoparticles for targeting immune cells such as macrophages, dendritic cells, and T-cells. The role of nanoparticles in enhancing immune checkpoint blockade (ICB) and their application in cancer vaccines is also examined. …”
Get full text

Local inflammation, lethality and cytokine release in mice injected with Bothrops atrox venom by S. F. Barros, I. Friedlanskaia, V. L. Petricevich, T. L. Kipnis

“…In vitro the cells from the mice injected and challenged with the venom only released IL-10 while peritoneal macrophages released IL-10, INF-γ and less amounts of IL-6; (c) establishment of local inflammation and necrosis induced by the venom, coincides with the peaks of TNF-α, IFN-γ and NO and the damage was neutralized when the venom was incubated with a monoclonal antibody against a 60 kDa haemorrhagic factor. …”
Get full text

Multi-omics and machine learning-driven CD8+ T cell heterogeneity score for head and neck squamous cell carcinoma by Di He, Zhan Yang, Tian Zhang, Yaxian Luo, Lianjie Peng, Jiatao Yan, Tao Qiu, Jingyu Zhang, Luying Qin, Zhichao Liu, Mouyuan Sun

“…Single-cell analysis of HNSCC tissues and peripheral blood, along with spatial transcriptome analysis, revealed that OLR1 predominantly functions in macrophages, modulating the immune microenvironment of HNSCC. …”
Get full text

Intermittent Fasting Protects Against the Progression from Acute Kidney Injury to Chronic Kidney Disease by Yoonjoo Jang, Young Suk Kim, Seo Rin Kim, Dong Won Lee, Soo Bong Lee, Il Young Kim

“…IF also reduced levels of TGF-β1, phosphorylated NF-κB p65, inflammatory cytokines, and F4/80-positive macrophages, along with markers of oxidative stress. …”
Get full text